Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8A9_LEIMA

TriTrypDb:

LmjF.28.1560 , LMJLV39_280023500 , LMJSD75_280023000

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.582
CLV_C14_Caspase3-7	303	307	PF00656	0.682
CLV_C14_Caspase3-7	311	315	PF00656	0.651
CLV_C14_Caspase3-7	552	556	PF00656	0.694
CLV_NRD_NRD_1	21	23	PF00675	0.665
CLV_NRD_NRD_1	223	225	PF00675	0.541
CLV_NRD_NRD_1	361	363	PF00675	0.392
CLV_NRD_NRD_1	415	417	PF00675	0.641
CLV_NRD_NRD_1	429	431	PF00675	0.528
CLV_PCSK_KEX2_1	109	111	PF00082	0.731
CLV_PCSK_KEX2_1	223	225	PF00082	0.541
CLV_PCSK_KEX2_1	361	363	PF00082	0.392
CLV_PCSK_KEX2_1	429	431	PF00082	0.668
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.731
CLV_PCSK_SKI1_1	110	114	PF00082	0.597
CLV_PCSK_SKI1_1	231	235	PF00082	0.467
CLV_PCSK_SKI1_1	82	86	PF00082	0.666
DEG_APCC_DBOX_1	47	55	PF00400	0.644
DEG_Nend_UBRbox_2	1	3	PF02207	0.629
DEG_SCF_FBW7_1	148	154	PF00400	0.665
DEG_SPOP_SBC_1	254	258	PF00917	0.635
DEG_SPOP_SBC_1	518	522	PF00917	0.632
DOC_ANK_TNKS_1	428	435	PF00023	0.537
DOC_CKS1_1	148	153	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	396	402	PF00134	0.534
DOC_MAPK_DCC_7	392	402	PF00069	0.535
DOC_MAPK_gen_1	350	357	PF00069	0.531
DOC_MAPK_gen_1	390	398	PF00069	0.692
DOC_MAPK_MEF2A_6	350	357	PF00069	0.531
DOC_MAPK_MEF2A_6	392	400	PF00069	0.673
DOC_MAPK_NFAT4_5	350	358	PF00069	0.481
DOC_PP2B_LxvP_1	396	399	PF13499	0.593
DOC_PP4_FxxP_1	246	249	PF00568	0.592
DOC_USP7_MATH_1	117	121	PF00917	0.702
DOC_USP7_MATH_1	151	155	PF00917	0.674
DOC_USP7_MATH_1	254	258	PF00917	0.650
DOC_USP7_MATH_1	295	299	PF00917	0.656
DOC_USP7_MATH_1	307	311	PF00917	0.567
DOC_USP7_MATH_1	373	377	PF00917	0.586
DOC_USP7_MATH_1	433	437	PF00917	0.584
DOC_USP7_MATH_1	518	522	PF00917	0.654
DOC_WW_Pin1_4	144	149	PF00397	0.686
DOC_WW_Pin1_4	158	163	PF00397	0.574
DOC_WW_Pin1_4	250	255	PF00397	0.733
DOC_WW_Pin1_4	264	269	PF00397	0.577
DOC_WW_Pin1_4	33	38	PF00397	0.669
DOC_WW_Pin1_4	77	82	PF00397	0.708
DOC_WW_Pin1_4	89	94	PF00397	0.606
LIG_14-3-3_CanoR_1	275	279	PF00244	0.631
LIG_14-3-3_CanoR_1	48	58	PF00244	0.642
LIG_14-3-3_CanoR_1	483	488	PF00244	0.560
LIG_14-3-3_CanoR_1	523	533	PF00244	0.702
LIG_14-3-3_CanoR_1	82	87	PF00244	0.668
LIG_BIR_III_2	28	32	PF00653	0.620
LIG_BIR_III_4	443	447	PF00653	0.643
LIG_BRCT_BRCA1_1	151	155	PF00533	0.683
LIG_BRCT_BRCA1_1	451	455	PF00533	0.675
LIG_FHA_1	134	140	PF00498	0.680
LIG_FHA_1	216	222	PF00498	0.487
LIG_FHA_1	230	236	PF00498	0.443
LIG_FHA_1	488	494	PF00498	0.508
LIG_FHA_1	541	547	PF00498	0.590
LIG_FHA_2	136	142	PF00498	0.775
LIG_FHA_2	173	179	PF00498	0.610
LIG_FHA_2	301	307	PF00498	0.650
LIG_FHA_2	550	556	PF00498	0.707
LIG_Integrin_RGD_1	478	480	PF01839	0.638
LIG_LIR_Apic_2	243	249	PF02991	0.651
LIG_LIR_Gen_1	452	463	PF02991	0.675
LIG_LIR_Nem_3	227	233	PF02991	0.502
LIG_LIR_Nem_3	376	382	PF02991	0.551
LIG_LIR_Nem_3	452	458	PF02991	0.671
LIG_MYND_1	119	123	PF01753	0.671
LIG_SH2_GRB2like	11	14	PF00017	0.583
LIG_SH2_STAP1	11	15	PF00017	0.609
LIG_SH2_STAT5	14	17	PF00017	0.600
LIG_SH2_STAT5	19	22	PF00017	0.626
LIG_SH2_STAT5	38	41	PF00017	0.531
LIG_SH3_1	128	134	PF00018	0.580
LIG_SH3_1	157	163	PF00018	0.719
LIG_SH3_1	91	97	PF00018	0.674
LIG_SH3_3	128	134	PF00018	0.659
LIG_SH3_3	142	148	PF00018	0.645
LIG_SH3_3	157	163	PF00018	0.681
LIG_SH3_3	166	172	PF00018	0.661
LIG_SH3_3	275	281	PF00018	0.566
LIG_SH3_3	326	332	PF00018	0.607
LIG_SH3_3	91	97	PF00018	0.674
LIG_SUMO_SIM_par_1	231	236	PF11976	0.590
LIG_TRAF2_1	489	492	PF00917	0.630
LIG_TYR_ITSM	375	382	PF00017	0.525
LIG_WW_3	280	284	PF00397	0.565
MOD_CDK_SPK_2	77	82	PF00069	0.658
MOD_CK1_1	147	153	PF00069	0.690
MOD_CK1_1	250	256	PF00069	0.686
MOD_CK1_1	33	39	PF00069	0.714
MOD_CK1_1	449	455	PF00069	0.621
MOD_CK1_1	485	491	PF00069	0.651
MOD_CK1_1	527	533	PF00069	0.708
MOD_CK1_1	534	540	PF00069	0.631
MOD_CK1_1	541	547	PF00069	0.568
MOD_CK1_1	57	63	PF00069	0.600
MOD_CK2_1	140	146	PF00069	0.761
MOD_CK2_1	172	178	PF00069	0.610
MOD_CK2_1	485	491	PF00069	0.664
MOD_GlcNHglycan	114	118	PF01048	0.665
MOD_GlcNHglycan	151	154	PF01048	0.657
MOD_GlcNHglycan	250	253	PF01048	0.544
MOD_GlcNHglycan	336	339	PF01048	0.582
MOD_GlcNHglycan	424	428	PF01048	0.584
MOD_GlcNHglycan	435	438	PF01048	0.651
MOD_GlcNHglycan	459	462	PF01048	0.679
MOD_GlcNHglycan	512	515	PF01048	0.593
MOD_GlcNHglycan	62	65	PF01048	0.637
MOD_GSK3_1	113	120	PF00069	0.709
MOD_GSK3_1	140	147	PF00069	0.710
MOD_GSK3_1	149	156	PF00069	0.658
MOD_GSK3_1	250	257	PF00069	0.634
MOD_GSK3_1	263	270	PF00069	0.552
MOD_GSK3_1	296	303	PF00069	0.731
MOD_GSK3_1	334	341	PF00069	0.578
MOD_GSK3_1	449	456	PF00069	0.655
MOD_GSK3_1	457	464	PF00069	0.601
MOD_GSK3_1	482	489	PF00069	0.651
MOD_GSK3_1	50	57	PF00069	0.511
MOD_GSK3_1	524	531	PF00069	0.688
MOD_GSK3_1	533	540	PF00069	0.603
MOD_GSK3_1	541	548	PF00069	0.540
MOD_GSK3_1	551	558	PF00069	0.566
MOD_N-GLC_1	338	343	PF02516	0.649
MOD_N-GLC_1	555	560	PF02516	0.654
MOD_N-GLC_1	60	65	PF02516	0.673
MOD_N-GLC_1	74	79	PF02516	0.566
MOD_NEK2_1	155	160	PF00069	0.726
MOD_NEK2_1	263	268	PF00069	0.610
MOD_NEK2_1	274	279	PF00069	0.696
MOD_NEK2_1	526	531	PF00069	0.642
MOD_NEK2_1	54	59	PF00069	0.594
MOD_NEK2_1	546	551	PF00069	0.642
MOD_PIKK_1	140	146	PF00454	0.680
MOD_PK_1	483	489	PF00069	0.553
MOD_PKA_2	200	206	PF00069	0.572
MOD_PKA_2	274	280	PF00069	0.629
MOD_PKA_2	471	477	PF00069	0.643
MOD_PKA_2	482	488	PF00069	0.557
MOD_PKA_2	524	530	PF00069	0.699
MOD_Plk_1	172	178	PF00069	0.654
MOD_Plk_1	341	347	PF00069	0.601
MOD_Plk_1	374	380	PF00069	0.528
MOD_Plk_1	74	80	PF00069	0.658
MOD_Plk_2-3	555	561	PF00069	0.620
MOD_Plk_4	135	141	PF00069	0.596
MOD_Plk_4	461	467	PF00069	0.651
MOD_Plk_4	50	56	PF00069	0.618
MOD_Plk_4	63	69	PF00069	0.573
MOD_Plk_4	74	80	PF00069	0.673
MOD_Plk_4	82	88	PF00069	0.601
MOD_ProDKin_1	144	150	PF00069	0.686
MOD_ProDKin_1	158	164	PF00069	0.574
MOD_ProDKin_1	250	256	PF00069	0.736
MOD_ProDKin_1	264	270	PF00069	0.577
MOD_ProDKin_1	33	39	PF00069	0.668
MOD_ProDKin_1	77	83	PF00069	0.709
MOD_ProDKin_1	89	95	PF00069	0.607
MOD_SUMO_for_1	349	352	PF00179	0.529
MOD_SUMO_rev_2	17	25	PF00179	0.580
TRG_ENDOCYTIC_2	379	382	PF00928	0.554
TRG_ER_diArg_1	223	226	PF00400	0.542
TRG_ER_diArg_1	360	362	PF00400	0.391
TRG_ER_diArg_1	494	497	PF00400	0.586
TRG_ER_diArg_1	5	8	PF00400	0.607
TRG_ER_diArg_1	502	505	PF00400	0.523
TRG_ER_diArg_1	523	526	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1K0	Leishmania donovani	89%	100%
A4HGK9	Leishmania braziliensis	69%	100%
A4I3N5	Leishmania infantum	89%	100%
E9AZX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%