Putative hydrolase, alpha/beta fold family

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family, putative

Species:

Leishmania major

UniProt:

Q4Q8A8_LEIMA

TriTrypDb:

LmjF.28.1570 , LMJLV39_170017800 , LMJSD75_170017500

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4Q8A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8A8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016787	hydrolase activity	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.382
CLV_NRD_NRD_1	19	21	PF00675	0.645
CLV_NRD_NRD_1	279	281	PF00675	0.375
CLV_PCSK_KEX2_1	54	56	PF00082	0.435
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.459
CLV_PCSK_SKI1_1	245	249	PF00082	0.305
CLV_PCSK_SKI1_1	33	37	PF00082	0.497
CLV_PCSK_SKI1_1	54	58	PF00082	0.447
DOC_MAPK_MEF2A_6	181	189	PF00069	0.402
DOC_MAPK_MEF2A_6	280	289	PF00069	0.251
DOC_MAPK_MEF2A_6	319	328	PF00069	0.413
DOC_PP1_RVXF_1	311	318	PF00149	0.357
DOC_PP2B_LxvP_1	124	127	PF13499	0.312
DOC_PP4_FxxP_1	116	119	PF00568	0.393
DOC_PP4_FxxP_1	63	66	PF00568	0.357
DOC_SPAK_OSR1_1	207	211	PF12202	0.200
DOC_USP7_MATH_1	27	31	PF00917	0.571
DOC_USP7_MATH_1	6	10	PF00917	0.695
DOC_USP7_UBL2_3	277	281	PF12436	0.211
DOC_WW_Pin1_4	22	27	PF00397	0.471
LIG_14-3-3_CanoR_1	123	127	PF00244	0.346
LIG_14-3-3_CanoR_1	181	186	PF00244	0.307
LIG_14-3-3_CanoR_1	20	26	PF00244	0.627
LIG_14-3-3_CanoR_1	220	228	PF00244	0.287
LIG_Actin_WH2_2	74	89	PF00022	0.180
LIG_AP2alpha_1	39	43	PF02296	0.447
LIG_APCC_ABBA_1	89	94	PF00400	0.190
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BRCT_BRCA1_1	109	113	PF00533	0.377
LIG_BRCT_BRCA1_1	84	88	PF00533	0.408
LIG_DLG_GKlike_1	181	188	PF00625	0.410
LIG_eIF4E_1	303	309	PF01652	0.402
LIG_FHA_1	2	8	PF00498	0.746
LIG_FHA_1	284	290	PF00498	0.261
LIG_FHA_2	109	115	PF00498	0.355
LIG_FHA_2	60	66	PF00498	0.368
LIG_FXI_DFP_1	113	117	PF00024	0.366
LIG_GBD_Chelix_1	73	81	PF00786	0.441
LIG_LIR_Apic_2	114	119	PF02991	0.404
LIG_LIR_Apic_2	62	66	PF02991	0.385
LIG_LIR_Gen_1	110	121	PF02991	0.409
LIG_LIR_Gen_1	40	50	PF02991	0.433
LIG_LIR_Gen_1	57	66	PF02991	0.262
LIG_LIR_Gen_1	85	93	PF02991	0.372
LIG_LIR_Nem_3	110	116	PF02991	0.395
LIG_LIR_Nem_3	40	46	PF02991	0.420
LIG_LIR_Nem_3	57	63	PF02991	0.288
LIG_LIR_Nem_3	85	91	PF02991	0.332
LIG_LIR_Nem_3	94	100	PF02991	0.308
LIG_MYND_2	118	122	PF01753	0.190
LIG_Pex14_1	226	230	PF04695	0.402
LIG_Pex14_2	39	43	PF04695	0.356
LIG_Pex14_2	88	92	PF04695	0.345
LIG_SH2_GRB2like	102	105	PF00017	0.317
LIG_SH2_STAP1	205	209	PF00017	0.394
LIG_SH2_STAP1	84	88	PF00017	0.180
LIG_SH2_STAT3	230	233	PF00017	0.402
LIG_SH2_STAT5	138	141	PF00017	0.305
LIG_SH2_STAT5	230	233	PF00017	0.378
LIG_SH2_STAT5	246	249	PF00017	0.219
LIG_SH2_STAT5	98	101	PF00017	0.271
LIG_SH3_3	194	200	PF00018	0.470
LIG_SH3_3	279	285	PF00018	0.305
LIG_SH3_3	292	298	PF00018	0.306
LIG_SH3_3	312	318	PF00018	0.334
LIG_SH3_3	63	69	PF00018	0.427
LIG_UBA3_1	337	344	PF00899	0.276
LIG_WRC_WIRS_1	60	65	PF05994	0.345
MOD_CK1_1	22	28	PF00069	0.593
MOD_CK2_1	128	134	PF00069	0.356
MOD_CK2_1	246	252	PF00069	0.447
MOD_Cter_Amidation	52	55	PF01082	0.460
MOD_GlcNHglycan	215	218	PF01048	0.337
MOD_GSK3_1	1	8	PF00069	0.697
MOD_GSK3_1	12	19	PF00069	0.649
MOD_GSK3_1	22	29	PF00069	0.394
MOD_GSK3_1	45	52	PF00069	0.471
MOD_N-GLC_1	22	27	PF02516	0.549
MOD_N-GLC_1	338	343	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.746
MOD_NEK2_1	162	167	PF00069	0.360
MOD_NEK2_1	338	343	PF00069	0.412
MOD_NEK2_1	77	82	PF00069	0.384
MOD_PIKK_1	108	114	PF00454	0.424
MOD_PIKK_1	229	235	PF00454	0.385
MOD_PIKK_1	27	33	PF00454	0.293
MOD_PKA_1	54	60	PF00069	0.455
MOD_PKA_2	122	128	PF00069	0.198
MOD_PKA_2	19	25	PF00069	0.602
MOD_PKA_2	219	225	PF00069	0.417
MOD_PKA_2	54	60	PF00069	0.411
MOD_Plk_1	12	18	PF00069	0.558
MOD_Plk_1	338	344	PF00069	0.470
MOD_Plk_4	198	204	PF00069	0.405
MOD_Plk_4	283	289	PF00069	0.273
MOD_Plk_4	338	344	PF00069	0.547
MOD_Plk_4	77	83	PF00069	0.417
MOD_ProDKin_1	22	28	PF00069	0.459
MOD_SUMO_rev_2	34	44	PF00179	0.416
TRG_ENDOCYTIC_2	205	208	PF00928	0.377
TRG_ENDOCYTIC_2	60	63	PF00928	0.352
TRG_ENDOCYTIC_2	97	100	PF00928	0.333
TRG_NES_CRM1_1	146	158	PF08389	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	29%	80%
A0A0N0P3S4	Leptomonas seymouri	38%	95%
A0A0N1PA10	Leptomonas seymouri	68%	100%
A0A0N1PCQ2	Leptomonas seymouri	45%	100%
A0A0S4JQB3	Bodo saltans	39%	100%
A0A1X0NSR3	Trypanosomatidae	37%	77%
A0A1X0NSS6	Trypanosomatidae	45%	100%
A0A1X0NT85	Trypanosomatidae	29%	70%
A0A3Q8IAY1	Leishmania donovani	36%	89%
A0A3R7KKJ0	Trypanosoma rangeli	42%	100%
A0A3S5IRR1	Trypanosoma rangeli	33%	85%
A0A3S7WUJ3	Leishmania donovani	43%	100%
A0A3S7WUK0	Leishmania donovani	31%	80%
A0A3S7X1K2	Leishmania donovani	94%	100%
A0A422NS41	Trypanosoma rangeli	37%	80%
A4H956	Leishmania braziliensis	44%	96%
A4H959	Leishmania braziliensis	31%	81%
A4H960	Leishmania braziliensis	37%	89%
A4HGL0	Leishmania braziliensis	79%	100%
A4HXH8	Leishmania infantum	43%	100%
A4HXI1	Leishmania infantum	31%	80%
A4HXI2	Leishmania infantum	36%	89%
A4I3N6	Leishmania infantum	94%	100%
A4JPX5	Burkholderia vietnamiensis (strain G4 / LMG 22486)	26%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	86%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	80%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	89%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P00632	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	26%	100%
P24640	Moraxella sp. (strain TA144)	26%	100%
P47229	Paraburkholderia xenovorans (strain LB400)	24%	100%
Q4QE86	Leishmania major	38%	89%
Q4QE87	Leishmania major	32%	80%
Q4QE90	Leishmania major	42%	100%
Q52011	Pseudomonas furukawaii	24%	100%
Q52532	Pseudomonas sp.	24%	100%
Q54528	Streptomyces purpurascens	28%	100%
Q54809	Streptomyces peucetius	29%	100%
Q55217	Streptomyces sp. (strain C5)	29%	100%
Q59093	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	25%	100%
Q59695	Pseudomonas putida	27%	94%
Q83WC8	Acinetobacter calcoaceticus	25%	100%
V5AZB9	Trypanosoma cruzi	38%	81%
V5BER0	Trypanosoma cruzi	43%	100%
V5BNU9	Trypanosoma cruzi	29%	85%