Galactose oxidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Galactose oxidase

Gene product:

Galactose oxidase, central domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q8A6_LEIMA

TriTrypDb:

LmjF.28.1590 , LMJLV39_280023700 , LMJSD75_280023200

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8A6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.350
CLV_NRD_NRD_1	157	159	PF00675	0.547
CLV_NRD_NRD_1	41	43	PF00675	0.536
CLV_PCSK_KEX2_1	157	159	PF00082	0.523
CLV_PCSK_KEX2_1	41	43	PF00082	0.536
CLV_PCSK_SKI1_1	371	375	PF00082	0.487
CLV_PCSK_SKI1_1	396	400	PF00082	0.431
DEG_APCC_DBOX_1	157	165	PF00400	0.476
DEG_MDM2_SWIB_1	275	283	PF02201	0.450
DEG_Nend_UBRbox_2	1	3	PF02207	0.461
DOC_CKS1_1	408	413	PF01111	0.613
DOC_CKS1_1	52	57	PF01111	0.397
DOC_CYCLIN_RxL_1	242	250	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.280
DOC_MAPK_MEF2A_6	245	253	PF00069	0.407
DOC_PP1_RVXF_1	353	360	PF00149	0.377
DOC_PP2B_LxvP_1	249	252	PF13499	0.259
DOC_PP4_FxxP_1	253	256	PF00568	0.380
DOC_USP7_MATH_1	131	135	PF00917	0.575
DOC_USP7_MATH_1	234	238	PF00917	0.306
DOC_USP7_MATH_1	24	28	PF00917	0.682
DOC_USP7_MATH_1	376	380	PF00917	0.480
DOC_USP7_MATH_1	60	64	PF00917	0.543
DOC_USP7_MATH_1	86	90	PF00917	0.279
DOC_WW_Pin1_4	170	175	PF00397	0.536
DOC_WW_Pin1_4	184	189	PF00397	0.398
DOC_WW_Pin1_4	20	25	PF00397	0.471
DOC_WW_Pin1_4	232	237	PF00397	0.356
DOC_WW_Pin1_4	238	243	PF00397	0.331
DOC_WW_Pin1_4	297	302	PF00397	0.630
DOC_WW_Pin1_4	371	376	PF00397	0.519
DOC_WW_Pin1_4	385	390	PF00397	0.316
DOC_WW_Pin1_4	407	412	PF00397	0.633
DOC_WW_Pin1_4	51	56	PF00397	0.480
DOC_WW_Pin1_4	79	84	PF00397	0.326
LIG_14-3-3_CanoR_1	157	162	PF00244	0.477
LIG_14-3-3_CanoR_1	245	250	PF00244	0.524
LIG_14-3-3_CanoR_1	273	281	PF00244	0.449
LIG_14-3-3_CanoR_1	329	337	PF00244	0.556
LIG_14-3-3_CanoR_1	87	91	PF00244	0.491
LIG_APCC_ABBA_1	164	169	PF00400	0.482
LIG_BIR_III_2	122	126	PF00653	0.573
LIG_BIR_III_2	171	175	PF00653	0.454
LIG_BRCT_BRCA1_1	249	253	PF00533	0.469
LIG_CtBP_PxDLS_1	55	59	PF00389	0.447
LIG_deltaCOP1_diTrp_1	277	281	PF00928	0.448
LIG_FHA_1	111	117	PF00498	0.386
LIG_FHA_1	161	167	PF00498	0.383
LIG_FHA_1	255	261	PF00498	0.456
LIG_FHA_1	386	392	PF00498	0.375
LIG_FHA_1	415	421	PF00498	0.447
LIG_FHA_1	80	86	PF00498	0.495
LIG_FHA_2	185	191	PF00498	0.452
LIG_FHA_2	298	304	PF00498	0.768
LIG_FHA_2	52	58	PF00498	0.477
LIG_LIR_Apic_2	250	256	PF02991	0.460
LIG_LIR_Gen_1	274	283	PF02991	0.431
LIG_LIR_Gen_1	285	296	PF02991	0.426
LIG_LIR_Gen_1	65	74	PF02991	0.412
LIG_LIR_Nem_3	257	262	PF02991	0.440
LIG_LIR_Nem_3	274	278	PF02991	0.183
LIG_LIR_Nem_3	285	291	PF02991	0.332
LIG_LIR_Nem_3	65	70	PF02991	0.405
LIG_Pex14_2	275	279	PF04695	0.443
LIG_SH2_GRB2like	74	77	PF00017	0.481
LIG_SH2_STAP1	162	166	PF00017	0.473
LIG_SH2_STAT5	146	149	PF00017	0.384
LIG_SH2_STAT5	162	165	PF00017	0.425
LIG_SH2_STAT5	205	208	PF00017	0.349
LIG_SH2_STAT5	221	224	PF00017	0.259
LIG_SH2_STAT5	336	339	PF00017	0.405
LIG_SH2_STAT5	387	390	PF00017	0.395
LIG_SH3_3	287	293	PF00018	0.530
LIG_SH3_3	405	411	PF00018	0.646
LIG_SH3_3	46	52	PF00018	0.418
LIG_SH3_3	6	12	PF00018	0.487
LIG_SH3_3	94	100	PF00018	0.428
LIG_SH3_CIN85_PxpxPR_1	240	245	PF14604	0.334
LIG_SUMO_SIM_anti_2	25	40	PF11976	0.554
LIG_SUMO_SIM_par_1	245	250	PF11976	0.478
LIG_SUMO_SIM_par_1	414	419	PF11976	0.436
LIG_TRAF2_1	301	304	PF00917	0.595
LIG_TRAF2_2	293	298	PF00917	0.505
LIG_WRC_WIRS_1	272	277	PF05994	0.466
MOD_CDK_SPxxK_3	238	245	PF00069	0.355
MOD_CK1_1	132	138	PF00069	0.567
MOD_CK1_1	23	29	PF00069	0.491
MOD_CK1_1	235	241	PF00069	0.329
MOD_CK1_1	419	425	PF00069	0.477
MOD_CK1_1	59	65	PF00069	0.617
MOD_CK1_1	75	81	PF00069	0.481
MOD_CK2_1	184	190	PF00069	0.472
MOD_CK2_1	22	28	PF00069	0.644
MOD_CK2_1	297	303	PF00069	0.760
MOD_GlcNHglycan	116	119	PF01048	0.523
MOD_GlcNHglycan	131	134	PF01048	0.603
MOD_GlcNHglycan	332	335	PF01048	0.573
MOD_GlcNHglycan	378	381	PF01048	0.634
MOD_GlcNHglycan	411	414	PF01048	0.564
MOD_GlcNHglycan	421	424	PF01048	0.434
MOD_GlcNHglycan	46	49	PF01048	0.407
MOD_GlcNHglycan	57	61	PF01048	0.620
MOD_GlcNHglycan	79	82	PF01048	0.560
MOD_GSK3_1	110	117	PF00069	0.515
MOD_GSK3_1	20	27	PF00069	0.418
MOD_GSK3_1	210	217	PF00069	0.354
MOD_GSK3_1	234	241	PF00069	0.395
MOD_GSK3_1	282	289	PF00069	0.452
MOD_GSK3_1	328	335	PF00069	0.558
MOD_GSK3_1	387	394	PF00069	0.557
MOD_GSK3_1	56	63	PF00069	0.545
MOD_GSK3_1	75	82	PF00069	0.420
MOD_N-GLC_1	345	350	PF02516	0.539
MOD_N-GLC_1	75	80	PF02516	0.467
MOD_NEK2_1	247	252	PF00069	0.390
MOD_NEK2_1	330	335	PF00069	0.432
MOD_NEK2_1	414	419	PF00069	0.499
MOD_PIKK_1	210	216	PF00454	0.410
MOD_PKA_1	157	163	PF00069	0.419
MOD_PKA_2	157	163	PF00069	0.467
MOD_PKA_2	328	334	PF00069	0.578
MOD_PKA_2	63	69	PF00069	0.439
MOD_PKA_2	86	92	PF00069	0.327
MOD_Plk_2-3	271	277	PF00069	0.358
MOD_Plk_4	111	117	PF00069	0.521
MOD_Plk_4	157	163	PF00069	0.467
MOD_Plk_4	255	261	PF00069	0.418
MOD_Plk_4	332	338	PF00069	0.513
MOD_Plk_4	387	393	PF00069	0.403
MOD_Plk_4	63	69	PF00069	0.482
MOD_Plk_4	86	92	PF00069	0.378
MOD_ProDKin_1	170	176	PF00069	0.536
MOD_ProDKin_1	184	190	PF00069	0.398
MOD_ProDKin_1	20	26	PF00069	0.481
MOD_ProDKin_1	232	238	PF00069	0.356
MOD_ProDKin_1	297	303	PF00069	0.637
MOD_ProDKin_1	371	377	PF00069	0.519
MOD_ProDKin_1	385	391	PF00069	0.307
MOD_ProDKin_1	407	413	PF00069	0.498
MOD_ProDKin_1	51	57	PF00069	0.490
MOD_ProDKin_1	79	85	PF00069	0.322
TRG_DiLeu_BaEn_1	395	400	PF01217	0.441
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.290
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P824	Leptomonas seymouri	53%	100%
A0A1X0NSF3	Trypanosomatidae	35%	100%
A0A3R7MSX4	Trypanosoma rangeli	39%	100%
A0A3S7X1L8	Leishmania donovani	94%	100%
A4HGL2	Leishmania braziliensis	84%	100%
A4I3N8	Leishmania infantum	95%	100%
D0A8C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AVA5	Trypanosoma cruzi	38%	100%