Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8A4_LEIMA

TriTrypDb:

LmjF.28.1610 , LMJLV39_280023900 , LMJSD75_280023400

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.544
CLV_NRD_NRD_1	213	215	PF00675	0.625
CLV_NRD_NRD_1	26	28	PF00675	0.439
CLV_NRD_NRD_1	342	344	PF00675	0.661
CLV_PCSK_KEX2_1	213	215	PF00082	0.593
CLV_PCSK_KEX2_1	26	28	PF00082	0.439
CLV_PCSK_KEX2_1	342	344	PF00082	0.661
CLV_PCSK_PC7_1	209	215	PF00082	0.546
CLV_PCSK_SKI1_1	122	126	PF00082	0.629
CLV_PCSK_SKI1_1	215	219	PF00082	0.602
DEG_APCC_DBOX_1	305	313	PF00400	0.681
DEG_APCC_DBOX_1	342	350	PF00400	0.558
DEG_Nend_UBRbox_4	1	3	PF02207	0.452
DEG_SPOP_SBC_1	100	104	PF00917	0.678
DOC_CKS1_1	58	63	PF01111	0.660
DOC_CKS1_1	65	70	PF01111	0.564
DOC_MAPK_DCC_7	11	20	PF00069	0.426
DOC_MAPK_gen_1	213	222	PF00069	0.603
DOC_MAPK_MEF2A_6	11	20	PF00069	0.426
DOC_MAPK_MEF2A_6	118	125	PF00069	0.602
DOC_MAPK_MEF2A_6	213	220	PF00069	0.565
DOC_MAPK_NFAT4_5	213	221	PF00069	0.569
DOC_PP1_RVXF_1	156	163	PF00149	0.591
DOC_PP2B_LxvP_1	312	315	PF13499	0.553
DOC_PP4_FxxP_1	162	165	PF00568	0.598
DOC_USP7_MATH_1	101	105	PF00917	0.806
DOC_USP7_MATH_1	256	260	PF00917	0.762
DOC_USP7_UBL2_3	118	122	PF12436	0.610
DOC_WW_Pin1_4	129	134	PF00397	0.754
DOC_WW_Pin1_4	220	225	PF00397	0.635
DOC_WW_Pin1_4	236	241	PF00397	0.616
DOC_WW_Pin1_4	250	255	PF00397	0.627
DOC_WW_Pin1_4	328	333	PF00397	0.672
DOC_WW_Pin1_4	40	45	PF00397	0.736
DOC_WW_Pin1_4	51	56	PF00397	0.808
DOC_WW_Pin1_4	57	62	PF00397	0.700
DOC_WW_Pin1_4	64	69	PF00397	0.545
LIG_14-3-3_CanoR_1	11	16	PF00244	0.480
LIG_14-3-3_CanoR_1	150	156	PF00244	0.532
LIG_14-3-3_CanoR_1	306	315	PF00244	0.712
LIG_14-3-3_CanoR_1	342	347	PF00244	0.686
LIG_BRCT_BRCA1_1	20	24	PF00533	0.436
LIG_BRCT_BRCA1_1	260	264	PF00533	0.560
LIG_BRCT_BRCA1_1	299	303	PF00533	0.696
LIG_DLG_GKlike_1	342	349	PF00625	0.559
LIG_EVH1_2	323	327	PF00568	0.658
LIG_FHA_1	10	16	PF00498	0.456
LIG_FHA_1	175	181	PF00498	0.530
LIG_FHA_1	183	189	PF00498	0.533
LIG_FHA_1	271	277	PF00498	0.551
LIG_FHA_1	83	89	PF00498	0.652
LIG_FHA_2	130	136	PF00498	0.740
LIG_FHA_2	65	71	PF00498	0.620
LIG_LIR_Apic_2	328	332	PF02991	0.550
LIG_LIR_Nem_3	21	25	PF02991	0.439
LIG_LIR_Nem_3	74	78	PF02991	0.561
LIG_MLH1_MIPbox_1	20	24	PF16413	0.436
LIG_PAM2_1	280	292	PF00658	0.689
LIG_Pex14_2	19	23	PF04695	0.436
LIG_REV1ctd_RIR_1	20	31	PF16727	0.434
LIG_RPA_C_Fungi	204	216	PF08784	0.575
LIG_SH2_CRK	329	333	PF00017	0.545
LIG_SH2_CRK	65	69	PF00017	0.738
LIG_SH2_CRK	75	79	PF00017	0.531
LIG_SH2_CRK	98	102	PF00017	0.715
LIG_SH2_NCK_1	329	333	PF00017	0.545
LIG_SH2_SRC	98	101	PF00017	0.677
LIG_SH2_STAT5	275	278	PF00017	0.600
LIG_SH2_STAT5	87	90	PF00017	0.645
LIG_SH3_2	61	66	PF14604	0.628
LIG_SH3_3	237	243	PF00018	0.738
LIG_SH3_3	246	252	PF00018	0.639
LIG_SH3_3	320	326	PF00018	0.730
LIG_SH3_3	58	64	PF00018	0.671
LIG_SH3_4	118	125	PF00018	0.602
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.580
LIG_TRAF2_1	132	135	PF00917	0.739
LIG_WRC_WIRS_1	19	24	PF05994	0.436
MOD_CDK_SPK_2	64	69	PF00069	0.634
MOD_CK1_1	247	253	PF00069	0.814
MOD_CK1_1	331	337	PF00069	0.547
MOD_CK1_1	351	357	PF00069	0.561
MOD_CK1_1	51	57	PF00069	0.680
MOD_CK2_1	129	135	PF00069	0.735
MOD_CK2_1	194	200	PF00069	0.447
MOD_CK2_1	342	348	PF00069	0.656
MOD_GlcNHglycan	196	199	PF01048	0.581
MOD_GlcNHglycan	202	206	PF01048	0.502
MOD_GlcNHglycan	258	261	PF01048	0.759
MOD_GlcNHglycan	276	279	PF01048	0.541
MOD_GlcNHglycan	351	354	PF01048	0.669
MOD_GlcNHglycan	50	53	PF01048	0.721
MOD_GSK3_1	125	132	PF00069	0.708
MOD_GSK3_1	256	263	PF00069	0.622
MOD_GSK3_1	270	277	PF00069	0.689
MOD_GSK3_1	304	311	PF00069	0.690
MOD_GSK3_1	313	320	PF00069	0.606
MOD_GSK3_1	349	356	PF00069	0.739
MOD_GSK3_1	78	85	PF00069	0.660
MOD_LATS_1	141	147	PF00433	0.680
MOD_N-GLC_1	173	178	PF02516	0.634
MOD_N-GLC_1	304	309	PF02516	0.708
MOD_NEK2_1	124	129	PF00069	0.732
MOD_NEK2_1	18	23	PF00069	0.447
MOD_NEK2_1	194	199	PF00069	0.572
MOD_NEK2_1	276	281	PF00069	0.541
MOD_NEK2_1	349	354	PF00069	0.548
MOD_NEK2_1	78	83	PF00069	0.660
MOD_NEK2_1	9	14	PF00069	0.495
MOD_PIKK_1	101	107	PF00454	0.760
MOD_PIKK_1	136	142	PF00454	0.684
MOD_PIKK_1	353	359	PF00454	0.654
MOD_PK_1	143	149	PF00069	0.738
MOD_PKA_1	342	348	PF00069	0.560
MOD_PKA_2	10	16	PF00069	0.449
MOD_PKA_2	111	117	PF00069	0.700
MOD_PKA_2	341	347	PF00069	0.686
MOD_PKA_2	48	54	PF00069	0.724
MOD_Plk_1	201	207	PF00069	0.581
MOD_Plk_1	83	89	PF00069	0.652
MOD_Plk_4	143	149	PF00069	0.738
MOD_Plk_4	18	24	PF00069	0.458
MOD_Plk_4	270	276	PF00069	0.678
MOD_Plk_4	313	319	PF00069	0.649
MOD_Plk_4	83	89	PF00069	0.652
MOD_ProDKin_1	129	135	PF00069	0.754
MOD_ProDKin_1	220	226	PF00069	0.643
MOD_ProDKin_1	236	242	PF00069	0.613
MOD_ProDKin_1	250	256	PF00069	0.624
MOD_ProDKin_1	328	334	PF00069	0.677
MOD_ProDKin_1	40	46	PF00069	0.738
MOD_ProDKin_1	51	57	PF00069	0.807
MOD_ProDKin_1	64	70	PF00069	0.538
TRG_DiLeu_BaEn_1	187	192	PF01217	0.552
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.592
TRG_DiLeu_LyEn_5	74	79	PF01217	0.658
TRG_ENDOCYTIC_2	75	78	PF00928	0.558
TRG_ER_diArg_1	25	27	PF00400	0.441
TRG_ER_diArg_1	341	343	PF00400	0.566
TRG_NES_CRM1_1	187	200	PF08389	0.564
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID56	Leishmania donovani	90%	100%
A4HGL4	Leishmania braziliensis	73%	100%
A4I3P0	Leishmania infantum	90%	100%
E9AZY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%