DUF3342 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3342), putative

Species:

Leishmania major

UniProt:

Q4Q8A2_LEIMA

TriTrypDb:

LmjF.28.1630 , LMJLV39_280024100 , LMJSD75_280023600

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.376
CLV_C14_Caspase3-7	206	210	PF00656	0.497
CLV_C14_Caspase3-7	389	393	PF00656	0.536
CLV_NRD_NRD_1	295	297	PF00675	0.535
CLV_NRD_NRD_1	365	367	PF00675	0.423
CLV_PCSK_KEX2_1	295	297	PF00082	0.513
CLV_PCSK_KEX2_1	365	367	PF00082	0.416
CLV_PCSK_SKI1_1	313	317	PF00082	0.548
CLV_PCSK_SKI1_1	33	37	PF00082	0.374
CLV_PCSK_SKI1_1	399	403	PF00082	0.294
DEG_APCC_DBOX_1	32	40	PF00400	0.330
DEG_COP1_1	434	442	PF00400	0.577
DEG_SPOP_SBC_1	571	575	PF00917	0.794
DEG_SPOP_SBC_1	66	70	PF00917	0.304
DOC_AGCK_PIF_2	402	407	PF00069	0.277
DOC_CYCLIN_yClb5_NLxxxL_5	141	150	PF00134	0.417
DOC_MAPK_FxFP_2	388	391	PF00069	0.342
DOC_MAPK_gen_1	365	373	PF00069	0.381
DOC_PP2B_LxvP_1	236	239	PF13499	0.509
DOC_PP2B_LxvP_1	320	323	PF13499	0.528
DOC_PP4_FxxP_1	388	391	PF00568	0.447
DOC_USP7_MATH_1	202	206	PF00917	0.587
DOC_USP7_MATH_1	212	216	PF00917	0.687
DOC_USP7_MATH_1	230	234	PF00917	0.468
DOC_USP7_MATH_1	274	278	PF00917	0.721
DOC_USP7_MATH_1	460	464	PF00917	0.647
DOC_USP7_MATH_1	479	483	PF00917	0.734
DOC_USP7_MATH_1	494	498	PF00917	0.603
DOC_USP7_MATH_1	569	573	PF00917	0.756
DOC_USP7_MATH_1	579	583	PF00917	0.712
DOC_USP7_MATH_1	597	601	PF00917	0.728
DOC_USP7_MATH_1	603	607	PF00917	0.792
DOC_USP7_MATH_1	616	620	PF00917	0.662
DOC_USP7_MATH_1	66	70	PF00917	0.349
DOC_USP7_MATH_2	65	71	PF00917	0.315
DOC_WW_Pin1_4	313	318	PF00397	0.581
DOC_WW_Pin1_4	339	344	PF00397	0.459
DOC_WW_Pin1_4	418	423	PF00397	0.520
DOC_WW_Pin1_4	442	447	PF00397	0.504
DOC_WW_Pin1_4	490	495	PF00397	0.643
DOC_WW_Pin1_4	552	557	PF00397	0.608
DOC_WW_Pin1_4	573	578	PF00397	0.664
DOC_WW_Pin1_4	60	65	PF00397	0.342
DOC_WW_Pin1_4	612	617	PF00397	0.668
LIG_14-3-3_CanoR_1	153	161	PF00244	0.382
LIG_14-3-3_CanoR_1	248	254	PF00244	0.543
LIG_14-3-3_CanoR_1	261	271	PF00244	0.546
LIG_14-3-3_CanoR_1	380	388	PF00244	0.502
LIG_14-3-3_CanoR_1	540	547	PF00244	0.621
LIG_14-3-3_CanoR_1	578	586	PF00244	0.530
LIG_14-3-3_CanoR_1	596	602	PF00244	0.591
LIG_Actin_WH2_2	139	155	PF00022	0.430
LIG_APCC_ABBA_1	168	173	PF00400	0.460
LIG_BRCT_BRCA1_1	111	115	PF00533	0.300
LIG_BRCT_BRCA1_1	137	141	PF00533	0.373
LIG_CaM_NSCaTE_8	351	358	PF13499	0.389
LIG_CSL_BTD_1	222	225	PF09270	0.625
LIG_deltaCOP1_diTrp_1	349	353	PF00928	0.328
LIG_FHA_1	146	152	PF00498	0.383
LIG_FHA_1	235	241	PF00498	0.545
LIG_FHA_1	263	269	PF00498	0.608
LIG_FHA_1	314	320	PF00498	0.580
LIG_FHA_1	343	349	PF00498	0.495
LIG_FHA_1	4	10	PF00498	0.598
LIG_FHA_1	473	479	PF00498	0.601
LIG_FHA_2	21	27	PF00498	0.376
LIG_FHA_2	250	256	PF00498	0.464
LIG_FHA_2	468	474	PF00498	0.542
LIG_FHA_2	5	11	PF00498	0.585
LIG_LIR_Gen_1	112	121	PF02991	0.300
LIG_LIR_Gen_1	397	407	PF02991	0.312
LIG_LIR_Gen_1	6	15	PF02991	0.654
LIG_LIR_Gen_1	86	94	PF02991	0.302
LIG_LIR_Nem_3	397	403	PF02991	0.392
LIG_LIR_Nem_3	614	620	PF02991	0.695
LIG_LIR_Nem_3	86	90	PF02991	0.302
LIG_NRBOX	369	375	PF00104	0.442
LIG_PTB_Apo_2	2	9	PF02174	0.557
LIG_SH2_CRK	425	429	PF00017	0.573
LIG_SH2_CRK	617	621	PF00017	0.682
LIG_SH2_STAT5	128	131	PF00017	0.351
LIG_SH2_STAT5	191	194	PF00017	0.370
LIG_SH2_STAT5	361	364	PF00017	0.312
LIG_SH2_STAT5	400	403	PF00017	0.403
LIG_SH2_STAT5	407	410	PF00017	0.425
LIG_SH2_STAT5	48	51	PF00017	0.398
LIG_SH2_STAT5	508	511	PF00017	0.550
LIG_SH2_STAT5	525	528	PF00017	0.419
LIG_SH3_3	21	27	PF00018	0.385
LIG_SH3_3	268	274	PF00018	0.603
LIG_SH3_3	434	440	PF00018	0.572
LIG_SH3_3	59	65	PF00018	0.376
LIG_SUMO_SIM_anti_2	519	524	PF11976	0.527
LIG_SUMO_SIM_par_1	16	23	PF11976	0.441
LIG_SUMO_SIM_par_1	316	321	PF11976	0.569
LIG_SUMO_SIM_par_1	369	375	PF11976	0.442
LIG_SUMO_SIM_par_1	434	441	PF11976	0.608
LIG_SUMO_SIM_par_1	514	521	PF11976	0.533
LIG_TYR_ITIM	398	403	PF00017	0.317
LIG_UBA3_1	126	134	PF00899	0.385
LIG_UBA3_1	90	97	PF00899	0.328
LIG_WRC_WIRS_1	439	444	PF05994	0.585
MOD_CDK_SPK_2	573	578	PF00069	0.645
MOD_CDK_SPxK_1	418	424	PF00069	0.490
MOD_CK1_1	13	19	PF00069	0.635
MOD_CK1_1	205	211	PF00069	0.588
MOD_CK1_1	266	272	PF00069	0.650
MOD_CK1_1	277	283	PF00069	0.621
MOD_CK1_1	329	335	PF00069	0.581
MOD_CK1_1	342	348	PF00069	0.417
MOD_CK1_1	4	10	PF00069	0.581
MOD_CK1_1	483	489	PF00069	0.637
MOD_CK1_1	493	499	PF00069	0.691
MOD_CK1_1	572	578	PF00069	0.725
MOD_CK1_1	588	594	PF00069	0.490
MOD_CK1_1	619	625	PF00069	0.661
MOD_CK1_1	68	74	PF00069	0.476
MOD_CK2_1	26	32	PF00069	0.352
MOD_CK2_1	266	272	PF00069	0.623
MOD_CK2_1	4	10	PF00069	0.552
MOD_CK2_1	441	447	PF00069	0.748
MOD_CK2_1	456	462	PF00069	0.624
MOD_CK2_1	467	473	PF00069	0.546
MOD_Cter_Amidation	293	296	PF01082	0.538
MOD_GlcNHglycan	129	132	PF01048	0.473
MOD_GlcNHglycan	13	16	PF01048	0.631
MOD_GlcNHglycan	172	177	PF01048	0.469
MOD_GlcNHglycan	232	235	PF01048	0.643
MOD_GlcNHglycan	268	271	PF01048	0.617
MOD_GlcNHglycan	276	279	PF01048	0.621
MOD_GlcNHglycan	330	334	PF01048	0.576
MOD_GlcNHglycan	425	428	PF01048	0.659
MOD_GlcNHglycan	458	461	PF01048	0.658
MOD_GlcNHglycan	482	485	PF01048	0.691
MOD_GlcNHglycan	541	544	PF01048	0.545
MOD_GlcNHglycan	547	550	PF01048	0.570
MOD_GlcNHglycan	587	590	PF01048	0.683
MOD_GlcNHglycan	94	97	PF01048	0.352
MOD_GSK3_1	101	108	PF00069	0.310
MOD_GSK3_1	137	144	PF00069	0.496
MOD_GSK3_1	230	237	PF00069	0.590
MOD_GSK3_1	262	269	PF00069	0.588
MOD_GSK3_1	274	281	PF00069	0.651
MOD_GSK3_1	438	445	PF00069	0.643
MOD_GSK3_1	456	463	PF00069	0.631
MOD_GSK3_1	479	486	PF00069	0.628
MOD_GSK3_1	490	497	PF00069	0.575
MOD_GSK3_1	569	576	PF00069	0.717
MOD_GSK3_1	584	591	PF00069	0.642
MOD_GSK3_1	605	612	PF00069	0.642
MOD_GSK3_1	616	623	PF00069	0.727
MOD_GSK3_1	9	16	PF00069	0.561
MOD_N-GLC_1	4	9	PF02516	0.553
MOD_N-GLC_1	442	447	PF02516	0.508
MOD_N-GLC_1	545	550	PF02516	0.623
MOD_N-GLC_1	597	602	PF02516	0.754
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	111	116	PF00069	0.385
MOD_NEK2_1	127	132	PF00069	0.409
MOD_NEK2_1	141	146	PF00069	0.439
MOD_NEK2_1	152	157	PF00069	0.495
MOD_NEK2_1	183	188	PF00069	0.426
MOD_NEK2_1	249	254	PF00069	0.482
MOD_NEK2_1	262	267	PF00069	0.595
MOD_NEK2_1	374	379	PF00069	0.440
MOD_NEK2_1	423	428	PF00069	0.626
MOD_NEK2_1	472	477	PF00069	0.757
MOD_NEK2_1	501	506	PF00069	0.630
MOD_NEK2_1	550	555	PF00069	0.625
MOD_NEK2_1	570	575	PF00069	0.674
MOD_NEK2_1	620	625	PF00069	0.660
MOD_NEK2_1	9	14	PF00069	0.588
MOD_PIKK_1	203	209	PF00454	0.511
MOD_PIKK_1	263	269	PF00454	0.560
MOD_PKA_1	386	392	PF00069	0.508
MOD_PKA_2	152	158	PF00069	0.410
MOD_PKA_2	263	269	PF00069	0.664
MOD_PKA_2	379	385	PF00069	0.443
MOD_PKA_2	423	429	PF00069	0.540
MOD_PKA_2	467	473	PF00069	0.528
MOD_PKA_2	539	545	PF00069	0.588
MOD_PKA_2	550	556	PF00069	0.700
MOD_PKA_2	603	609	PF00069	0.682
MOD_PKB_1	607	615	PF00069	0.562
MOD_Plk_1	20	26	PF00069	0.385
MOD_Plk_1	4	10	PF00069	0.552
MOD_Plk_1	545	551	PF00069	0.571
MOD_Plk_1	597	603	PF00069	0.615
MOD_Plk_4	111	117	PF00069	0.395
MOD_Plk_4	183	189	PF00069	0.396
MOD_Plk_4	249	255	PF00069	0.469
MOD_Plk_4	369	375	PF00069	0.536
MOD_Plk_4	4	10	PF00069	0.570
MOD_ProDKin_1	313	319	PF00069	0.587
MOD_ProDKin_1	339	345	PF00069	0.446
MOD_ProDKin_1	418	424	PF00069	0.532
MOD_ProDKin_1	442	448	PF00069	0.503
MOD_ProDKin_1	490	496	PF00069	0.642
MOD_ProDKin_1	552	558	PF00069	0.607
MOD_ProDKin_1	573	579	PF00069	0.657
MOD_ProDKin_1	60	66	PF00069	0.342
MOD_ProDKin_1	612	618	PF00069	0.671
MOD_SUMO_rev_2	392	401	PF00179	0.440
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.376
TRG_ENDOCYTIC_2	400	403	PF00928	0.310
TRG_ENDOCYTIC_2	547	550	PF00928	0.598
TRG_ENDOCYTIC_2	617	620	PF00928	0.680
TRG_ER_diArg_1	295	297	PF00400	0.513
TRG_ER_diArg_1	78	81	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G4	Leptomonas seymouri	44%	96%
A0A3Q8IDU2	Leishmania donovani	90%	100%
A4HGL7	Leishmania braziliensis	73%	100%
A4I3P2	Leishmania infantum	93%	100%
D0A8C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AZY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%