Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 20

Species:

Leishmania major

UniProt:

Q4Q8A0_LEIMA

TriTrypDb:

LmjF.28.1650 , LMJLV39_280024400 , LMJSD75_280023900

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q8A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8A0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	553	557	PF00656	0.539
CLV_C14_Caspase3-7	611	615	PF00656	0.671
CLV_C14_Caspase3-7	837	841	PF00656	0.489
CLV_NRD_NRD_1	161	163	PF00675	0.426
CLV_NRD_NRD_1	2	4	PF00675	0.406
CLV_NRD_NRD_1	229	231	PF00675	0.455
CLV_NRD_NRD_1	31	33	PF00675	0.359
CLV_NRD_NRD_1	414	416	PF00675	0.513
CLV_NRD_NRD_1	472	474	PF00675	0.794
CLV_NRD_NRD_1	498	500	PF00675	0.613
CLV_NRD_NRD_1	510	512	PF00675	0.476
CLV_NRD_NRD_1	537	539	PF00675	0.513
CLV_NRD_NRD_1	808	810	PF00675	0.364
CLV_PCSK_KEX2_1	229	231	PF00082	0.437
CLV_PCSK_KEX2_1	31	33	PF00082	0.359
CLV_PCSK_KEX2_1	414	416	PF00082	0.513
CLV_PCSK_KEX2_1	472	474	PF00082	0.801
CLV_PCSK_KEX2_1	510	512	PF00082	0.566
CLV_PCSK_KEX2_1	806	808	PF00082	0.465
CLV_PCSK_PC1ET2_1	806	808	PF00082	0.465
CLV_PCSK_SKI1_1	131	135	PF00082	0.359
CLV_PCSK_SKI1_1	168	172	PF00082	0.398
CLV_PCSK_SKI1_1	235	239	PF00082	0.638
CLV_PCSK_SKI1_1	240	244	PF00082	0.562
CLV_PCSK_SKI1_1	4	8	PF00082	0.394
CLV_PCSK_SKI1_1	539	543	PF00082	0.670
CLV_PCSK_SKI1_1	634	638	PF00082	0.673
CLV_PCSK_SKI1_1	741	745	PF00082	0.640
CLV_PCSK_SKI1_1	768	772	PF00082	0.425
CLV_PCSK_SKI1_1	809	813	PF00082	0.389
CLV_Separin_Metazoa	496	500	PF03568	0.572
DEG_APCC_DBOX_1	234	242	PF00400	0.510
DEG_APCC_DBOX_1	519	527	PF00400	0.572
DEG_APCC_DBOX_1	763	771	PF00400	0.398
DEG_Nend_Nbox_1	1	3	PF02207	0.402
DEG_SPOP_SBC_1	280	284	PF00917	0.647
DEG_SPOP_SBC_1	352	356	PF00917	0.653
DOC_CKS1_1	635	640	PF01111	0.674
DOC_CYCLIN_RxL_1	229	239	PF00134	0.465
DOC_CYCLIN_RxL_1	520	530	PF00134	0.567
DOC_CYCLIN_RxL_1	806	815	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.346
DOC_MAPK_gen_1	162	171	PF00069	0.428
DOC_MAPK_gen_1	3	9	PF00069	0.401
DOC_MAPK_gen_1	55	64	PF00069	0.357
DOC_MAPK_gen_1	809	819	PF00069	0.420
DOC_MAPK_HePTP_8	159	171	PF00069	0.493
DOC_MAPK_MEF2A_6	162	171	PF00069	0.428
DOC_MAPK_RevD_3	148	163	PF00069	0.450
DOC_PP2B_LxvP_1	146	149	PF13499	0.343
DOC_PP2B_LxvP_1	150	153	PF13499	0.352
DOC_PP2B_LxvP_1	698	701	PF13499	0.668
DOC_USP7_MATH_1	185	189	PF00917	0.738
DOC_USP7_MATH_1	228	232	PF00917	0.444
DOC_USP7_MATH_1	272	276	PF00917	0.643
DOC_USP7_MATH_1	296	300	PF00917	0.634
DOC_USP7_MATH_1	306	310	PF00917	0.637
DOC_USP7_MATH_1	350	354	PF00917	0.667
DOC_USP7_MATH_1	408	412	PF00917	0.568
DOC_USP7_MATH_1	443	447	PF00917	0.697
DOC_USP7_MATH_1	600	604	PF00917	0.553
DOC_USP7_MATH_1	644	648	PF00917	0.759
DOC_USP7_MATH_1	665	669	PF00917	0.710
DOC_USP7_MATH_1	732	736	PF00917	0.667
DOC_USP7_MATH_1	743	747	PF00917	0.534
DOC_USP7_UBL2_3	806	810	PF12436	0.423
DOC_WW_Pin1_4	346	351	PF00397	0.620
DOC_WW_Pin1_4	356	361	PF00397	0.657
DOC_WW_Pin1_4	375	380	PF00397	0.516
DOC_WW_Pin1_4	383	388	PF00397	0.601
DOC_WW_Pin1_4	426	431	PF00397	0.575
DOC_WW_Pin1_4	465	470	PF00397	0.676
DOC_WW_Pin1_4	504	509	PF00397	0.662
DOC_WW_Pin1_4	613	618	PF00397	0.759
DOC_WW_Pin1_4	622	627	PF00397	0.735
DOC_WW_Pin1_4	634	639	PF00397	0.586
DOC_WW_Pin1_4	645	650	PF00397	0.596
DOC_WW_Pin1_4	692	697	PF00397	0.767
DOC_WW_Pin1_4	720	725	PF00397	0.712
LIG_14-3-3_CanoR_1	346	350	PF00244	0.591
LIG_14-3-3_CanoR_1	373	379	PF00244	0.670
LIG_14-3-3_CanoR_1	457	464	PF00244	0.655
LIG_14-3-3_CanoR_1	551	558	PF00244	0.557
LIG_14-3-3_CanoR_1	764	768	PF00244	0.476
LIG_Actin_WH2_2	483	501	PF00022	0.576
LIG_Actin_WH2_2	824	841	PF00022	0.479
LIG_APCC_ABBA_1	47	52	PF00400	0.444
LIG_BIR_III_2	614	618	PF00653	0.554
LIG_BRCT_BRCA1_1	284	288	PF00533	0.536
LIG_CtBP_PxDLS_1	703	707	PF00389	0.576
LIG_EVH1_1	698	702	PF00568	0.643
LIG_EVH1_2	575	579	PF00568	0.663
LIG_FHA_1	13	19	PF00498	0.362
LIG_FHA_1	139	145	PF00498	0.462
LIG_FHA_1	281	287	PF00498	0.686
LIG_FHA_1	38	44	PF00498	0.320
LIG_FHA_1	393	399	PF00498	0.713
LIG_FHA_1	482	488	PF00498	0.587
LIG_FHA_1	64	70	PF00498	0.360
LIG_FHA_1	85	91	PF00498	0.393
LIG_FHA_2	203	209	PF00498	0.373
LIG_FHA_2	357	363	PF00498	0.661
LIG_FHA_2	551	557	PF00498	0.509
LIG_FHA_2	594	600	PF00498	0.681
LIG_FHA_2	609	615	PF00498	0.561
LIG_FHA_2	778	784	PF00498	0.471
LIG_FHA_2	835	841	PF00498	0.475
LIG_FHA_2	86	92	PF00498	0.435
LIG_IRF3_LxIS_1	784	789	PF10401	0.437
LIG_LIR_Gen_1	418	428	PF02991	0.563
LIG_LIR_Gen_1	578	587	PF02991	0.647
LIG_LIR_Gen_1	71	81	PF02991	0.359
LIG_LIR_Gen_1	92	103	PF02991	0.386
LIG_LIR_Nem_3	362	368	PF02991	0.565
LIG_LIR_Nem_3	418	423	PF02991	0.548
LIG_LIR_Nem_3	578	582	PF02991	0.768
LIG_LIR_Nem_3	71	76	PF02991	0.361
LIG_LIR_Nem_3	92	98	PF02991	0.419
LIG_MYND_1	696	700	PF01753	0.677
LIG_NRBOX	766	772	PF00104	0.413
LIG_NRBOX	807	813	PF00104	0.461
LIG_PCNA_PIPBox_1	534	543	PF02747	0.495
LIG_PTB_Apo_2	118	125	PF02174	0.439
LIG_SH2_CRK	156	160	PF00017	0.461
LIG_SH2_CRK	365	369	PF00017	0.571
LIG_SH2_STAP1	656	660	PF00017	0.658
LIG_SH2_STAT3	155	158	PF00017	0.386
LIG_SH2_STAT5	365	368	PF00017	0.570
LIG_SH3_1	697	703	PF00018	0.625
LIG_SH3_2	295	300	PF14604	0.590
LIG_SH3_3	145	151	PF00018	0.341
LIG_SH3_3	268	274	PF00018	0.467
LIG_SH3_3	292	298	PF00018	0.588
LIG_SH3_3	358	364	PF00018	0.733
LIG_SH3_3	384	390	PF00018	0.675
LIG_SH3_3	570	576	PF00018	0.705
LIG_SH3_3	620	626	PF00018	0.624
LIG_SH3_3	632	638	PF00018	0.675
LIG_SH3_3	693	699	PF00018	0.700
LIG_SH3_3	706	712	PF00018	0.542
LIG_SH3_3	718	724	PF00018	0.631
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.527
LIG_SUMO_SIM_anti_2	564	570	PF11976	0.548
LIG_SUMO_SIM_anti_2	71	79	PF11976	0.356
LIG_SUMO_SIM_par_1	13	22	PF11976	0.407
LIG_SUMO_SIM_par_1	216	221	PF11976	0.437
LIG_SUMO_SIM_par_1	65	72	PF11976	0.450
LIG_TRAF2_1	39	42	PF00917	0.485
LIG_TRAF2_1	673	676	PF00917	0.656
LIG_TRAF2_1	780	783	PF00917	0.467
LIG_TRAF2_1	97	100	PF00917	0.384
LIG_TYR_ITIM	154	159	PF00017	0.452
LIG_TYR_ITIM	363	368	PF00017	0.563
MOD_CDC14_SPxK_1	429	432	PF00782	0.605
MOD_CDC14_SPxK_1	470	473	PF00782	0.687
MOD_CDC14_SPxK_1	507	510	PF00782	0.606
MOD_CDK_SPK_2	467	472	PF00069	0.634
MOD_CDK_SPK_2	634	639	PF00069	0.724
MOD_CDK_SPK_2	692	697	PF00069	0.614
MOD_CDK_SPxK_1	426	432	PF00069	0.577
MOD_CDK_SPxK_1	467	473	PF00069	0.688
MOD_CDK_SPxK_1	504	510	PF00069	0.613
MOD_CDK_SPxxK_3	465	472	PF00069	0.614
MOD_CDK_SPxxK_3	504	511	PF00069	0.658
MOD_CDK_SPxxK_3	634	641	PF00069	0.724
MOD_CK1_1	251	257	PF00069	0.452
MOD_CK1_1	275	281	PF00069	0.618
MOD_CK1_1	282	288	PF00069	0.675
MOD_CK1_1	290	296	PF00069	0.638
MOD_CK1_1	299	305	PF00069	0.603
MOD_CK1_1	313	319	PF00069	0.654
MOD_CK1_1	353	359	PF00069	0.732
MOD_CK1_1	375	381	PF00069	0.668
MOD_CK1_1	392	398	PF00069	0.686
MOD_CK1_1	613	619	PF00069	0.739
MOD_CK1_1	668	674	PF00069	0.725
MOD_CK1_1	715	721	PF00069	0.730
MOD_CK1_1	72	78	PF00069	0.338
MOD_CK1_1	725	731	PF00069	0.632
MOD_CK1_1	79	85	PF00069	0.375
MOD_CK2_1	444	450	PF00069	0.772
MOD_CK2_1	593	599	PF00069	0.688
MOD_CK2_1	670	676	PF00069	0.746
MOD_CK2_1	751	757	PF00069	0.521
MOD_CK2_1	777	783	PF00069	0.447
MOD_CK2_1	786	792	PF00069	0.382
MOD_CK2_1	85	91	PF00069	0.434
MOD_CK2_1	93	99	PF00069	0.410
MOD_DYRK1A_RPxSP_1	346	350	PF00069	0.565
MOD_DYRK1A_RPxSP_1	634	638	PF00069	0.721
MOD_GlcNHglycan	12	15	PF01048	0.383
MOD_GlcNHglycan	164	167	PF01048	0.580
MOD_GlcNHglycan	187	190	PF01048	0.635
MOD_GlcNHglycan	197	200	PF01048	0.546
MOD_GlcNHglycan	230	233	PF01048	0.441
MOD_GlcNHglycan	289	292	PF01048	0.741
MOD_GlcNHglycan	306	309	PF01048	0.582
MOD_GlcNHglycan	312	315	PF01048	0.646
MOD_GlcNHglycan	319	322	PF01048	0.581
MOD_GlcNHglycan	326	329	PF01048	0.549
MOD_GlcNHglycan	374	377	PF01048	0.667
MOD_GlcNHglycan	391	394	PF01048	0.808
MOD_GlcNHglycan	630	633	PF01048	0.600
MOD_GlcNHglycan	660	663	PF01048	0.705
MOD_GlcNHglycan	685	688	PF01048	0.637
MOD_GlcNHglycan	716	720	PF01048	0.632
MOD_GlcNHglycan	734	737	PF01048	0.627
MOD_GlcNHglycan	753	756	PF01048	0.429
MOD_GlcNHglycan	842	845	PF01048	0.590
MOD_GSK3_1	218	225	PF00069	0.424
MOD_GSK3_1	236	243	PF00069	0.548
MOD_GSK3_1	251	258	PF00069	0.391
MOD_GSK3_1	272	279	PF00069	0.586
MOD_GSK3_1	306	313	PF00069	0.690
MOD_GSK3_1	336	343	PF00069	0.673
MOD_GSK3_1	346	353	PF00069	0.660
MOD_GSK3_1	368	375	PF00069	0.795
MOD_GSK3_1	378	385	PF00069	0.588
MOD_GSK3_1	463	470	PF00069	0.626
MOD_GSK3_1	613	620	PF00069	0.772
MOD_GSK3_1	630	637	PF00069	0.648
MOD_GSK3_1	654	661	PF00069	0.773
MOD_GSK3_1	667	674	PF00069	0.523
MOD_GSK3_1	68	75	PF00069	0.391
MOD_GSK3_1	711	718	PF00069	0.770
MOD_GSK3_1	745	752	PF00069	0.566
MOD_GSK3_1	834	841	PF00069	0.646
MOD_N-GLC_1	10	15	PF02516	0.419
MOD_N-GLC_1	185	190	PF02516	0.610
MOD_N-GLC_1	264	269	PF02516	0.354
MOD_N-GLC_1	324	329	PF02516	0.821
MOD_N-GLC_1	426	431	PF02516	0.575
MOD_NEK2_1	456	461	PF00069	0.714
MOD_NEK2_1	68	73	PF00069	0.577
MOD_NEK2_1	786	791	PF00069	0.451
MOD_NEK2_1	834	839	PF00069	0.439
MOD_PIKK_1	154	160	PF00454	0.355
MOD_PIKK_1	368	374	PF00454	0.788
MOD_PIKK_1	602	608	PF00454	0.707
MOD_PIKK_1	671	677	PF00454	0.777
MOD_PIKK_1	786	792	PF00454	0.405
MOD_PK_1	5	11	PF00069	0.404
MOD_PKA_1	162	168	PF00069	0.461
MOD_PKA_1	472	478	PF00069	0.668
MOD_PKA_2	228	234	PF00069	0.432
MOD_PKA_2	248	254	PF00069	0.425
MOD_PKA_2	299	305	PF00069	0.556
MOD_PKA_2	345	351	PF00069	0.575
MOD_PKA_2	372	378	PF00069	0.728
MOD_PKA_2	402	408	PF00069	0.621
MOD_PKA_2	456	462	PF00069	0.838
MOD_PKA_2	472	478	PF00069	0.640
MOD_PKA_2	519	525	PF00069	0.569
MOD_PKA_2	550	556	PF00069	0.554
MOD_PKA_2	658	664	PF00069	0.689
MOD_PKA_2	763	769	PF00069	0.592
MOD_PKA_2	838	844	PF00069	0.576
MOD_PKB_1	195	203	PF00069	0.463
MOD_PKB_1	455	463	PF00069	0.696
MOD_Plk_1	264	270	PF00069	0.362
MOD_Plk_1	408	414	PF00069	0.526
MOD_Plk_1	756	762	PF00069	0.466
MOD_Plk_1	84	90	PF00069	0.442
MOD_Plk_1	93	99	PF00069	0.395
MOD_Plk_2-3	85	91	PF00069	0.447
MOD_Plk_2-3	94	100	PF00069	0.430
MOD_Plk_4	12	18	PF00069	0.367
MOD_Plk_4	251	257	PF00069	0.495
MOD_Plk_4	313	319	PF00069	0.576
MOD_Plk_4	408	414	PF00069	0.550
MOD_Plk_4	63	69	PF00069	0.354
MOD_Plk_4	72	78	PF00069	0.356
MOD_Plk_4	85	91	PF00069	0.415
MOD_Plk_4	99	105	PF00069	0.272
MOD_ProDKin_1	346	352	PF00069	0.614
MOD_ProDKin_1	356	362	PF00069	0.659
MOD_ProDKin_1	375	381	PF00069	0.518
MOD_ProDKin_1	383	389	PF00069	0.598
MOD_ProDKin_1	426	432	PF00069	0.581
MOD_ProDKin_1	465	471	PF00069	0.672
MOD_ProDKin_1	504	510	PF00069	0.661
MOD_ProDKin_1	613	619	PF00069	0.761
MOD_ProDKin_1	622	628	PF00069	0.734
MOD_ProDKin_1	634	640	PF00069	0.587
MOD_ProDKin_1	645	651	PF00069	0.595
MOD_ProDKin_1	692	698	PF00069	0.765
MOD_ProDKin_1	720	726	PF00069	0.712
MOD_SUMO_rev_2	157	165	PF00179	0.436
MOD_SUMO_rev_2	513	518	PF00179	0.610
TRG_DiLeu_BaEn_1	418	423	PF01217	0.548
TRG_DiLeu_BaEn_1	493	498	PF01217	0.566
TRG_DiLeu_BaEn_2	782	788	PF01217	0.404
TRG_DiLeu_BaEn_4	93	99	PF01217	0.460
TRG_ENDOCYTIC_2	156	159	PF00928	0.462
TRG_ENDOCYTIC_2	365	368	PF00928	0.570
TRG_ENDOCYTIC_2	50	53	PF00928	0.359
TRG_ENDOCYTIC_2	95	98	PF00928	0.364
TRG_ER_diArg_1	30	32	PF00400	0.367
TRG_ER_diArg_1	413	415	PF00400	0.525
TRG_ER_diArg_1	471	473	PF00400	0.766
TRG_ER_diArg_1	510	512	PF00400	0.580
TRG_ER_diArg_1	771	774	PF00400	0.441
TRG_NLS_MonoExtC_3	805	810	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	774	779	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	809	814	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM49	Leptomonas seymouri	48%	100%
A0A3S7X1L3	Leishmania donovani	92%	100%
A4HGL9	Leishmania braziliensis	73%	100%
A4I3P4	Leishmania infantum	92%	100%
E9AZY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%