Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q899_LEIMA

TriTrypDb:

LmjF.28.1660 , LMJLV39_280024500 , LMJSD75_280024000

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q899

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q899

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	481	485	PF00656	0.443
CLV_NRD_NRD_1	402	404	PF00675	0.575
CLV_NRD_NRD_1	62	64	PF00675	0.503
CLV_PCSK_KEX2_1	348	350	PF00082	0.430
CLV_PCSK_KEX2_1	402	404	PF00082	0.587
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.430
CLV_PCSK_PC7_1	344	350	PF00082	0.426
CLV_PCSK_SKI1_1	255	259	PF00082	0.563
CLV_PCSK_SKI1_1	59	63	PF00082	0.502
CLV_PCSK_SKI1_1	639	643	PF00082	0.414
CLV_PCSK_SKI1_1	85	89	PF00082	0.432
DEG_APCC_DBOX_1	302	310	PF00400	0.469
DEG_Nend_UBRbox_3	1	3	PF02207	0.526
DOC_CKS1_1	105	110	PF01111	0.589
DOC_CKS1_1	144	149	PF01111	0.540
DOC_CKS1_1	240	245	PF01111	0.584
DOC_MAPK_gen_1	708	715	PF00069	0.476
DOC_MAPK_MEF2A_6	590	598	PF00069	0.544
DOC_MAPK_MEF2A_6	708	715	PF00069	0.433
DOC_PP2B_LxvP_1	264	267	PF13499	0.646
DOC_PP2B_LxvP_1	415	418	PF13499	0.510
DOC_PP2B_LxvP_1	596	599	PF13499	0.541
DOC_PP4_FxxP_1	371	374	PF00568	0.472
DOC_SPAK_OSR1_1	382	386	PF12202	0.492
DOC_USP7_MATH_1	150	154	PF00917	0.626
DOC_USP7_MATH_1	172	176	PF00917	0.643
DOC_USP7_MATH_1	188	192	PF00917	0.711
DOC_USP7_MATH_1	200	204	PF00917	0.841
DOC_USP7_MATH_1	210	214	PF00917	0.628
DOC_USP7_MATH_1	22	26	PF00917	0.626
DOC_USP7_MATH_1	274	278	PF00917	0.698
DOC_USP7_MATH_1	289	293	PF00917	0.606
DOC_USP7_MATH_1	301	305	PF00917	0.444
DOC_USP7_MATH_1	384	388	PF00917	0.444
DOC_USP7_MATH_1	405	409	PF00917	0.512
DOC_USP7_MATH_1	489	493	PF00917	0.420
DOC_USP7_MATH_1	519	523	PF00917	0.446
DOC_USP7_MATH_1	98	102	PF00917	0.692
DOC_USP7_UBL2_3	535	539	PF12436	0.408
DOC_WW_Pin1_4	104	109	PF00397	0.695
DOC_WW_Pin1_4	143	148	PF00397	0.779
DOC_WW_Pin1_4	178	183	PF00397	0.755
DOC_WW_Pin1_4	239	244	PF00397	0.629
DOC_WW_Pin1_4	277	282	PF00397	0.654
DOC_WW_Pin1_4	295	300	PF00397	0.636
DOC_WW_Pin1_4	485	490	PF00397	0.433
LIG_14-3-3_CanoR_1	303	307	PF00244	0.494
LIG_14-3-3_CanoR_1	336	345	PF00244	0.396
LIG_14-3-3_CanoR_1	406	413	PF00244	0.622
LIG_14-3-3_CanoR_1	525	530	PF00244	0.433
LIG_14-3-3_CanoR_1	585	590	PF00244	0.573
LIG_14-3-3_CanoR_1	6	13	PF00244	0.613
LIG_Actin_WH2_2	124	141	PF00022	0.354
LIG_Actin_WH2_2	211	227	PF00022	0.535
LIG_BIR_III_2	285	289	PF00653	0.623
LIG_BIR_III_2	617	621	PF00653	0.454
LIG_BIR_III_2	640	644	PF00653	0.435
LIG_eIF4E_1	616	622	PF01652	0.459
LIG_FHA_1	150	156	PF00498	0.639
LIG_FHA_1	303	309	PF00498	0.497
LIG_FHA_1	316	322	PF00498	0.377
LIG_FHA_1	449	455	PF00498	0.469
LIG_FHA_1	485	491	PF00498	0.587
LIG_FHA_1	49	55	PF00498	0.469
LIG_FHA_1	521	527	PF00498	0.418
LIG_FHA_1	64	70	PF00498	0.527
LIG_FHA_2	144	150	PF00498	0.524
LIG_FHA_2	179	185	PF00498	0.659
LIG_FHA_2	228	234	PF00498	0.649
LIG_FHA_2	529	535	PF00498	0.416
LIG_FHA_2	576	582	PF00498	0.566
LIG_GSK3_LRP6_1	239	244	PF00069	0.582
LIG_LIR_Apic_2	370	374	PF02991	0.473
LIG_LIR_Apic_2	662	666	PF02991	0.412
LIG_LIR_Apic_2	68	73	PF02991	0.483
LIG_LIR_Gen_1	318	328	PF02991	0.508
LIG_LIR_Gen_1	423	431	PF02991	0.487
LIG_LIR_Gen_1	492	501	PF02991	0.380
LIG_LIR_Gen_1	547	556	PF02991	0.401
LIG_LIR_Gen_1	614	622	PF02991	0.403
LIG_LIR_Nem_3	318	323	PF02991	0.433
LIG_LIR_Nem_3	340	346	PF02991	0.425
LIG_LIR_Nem_3	387	391	PF02991	0.475
LIG_LIR_Nem_3	423	427	PF02991	0.502
LIG_LIR_Nem_3	459	463	PF02991	0.396
LIG_LIR_Nem_3	492	497	PF02991	0.386
LIG_LIR_Nem_3	544	548	PF02991	0.405
LIG_LIR_Nem_3	614	619	PF02991	0.401
LIG_LIR_Nem_3	654	659	PF02991	0.430
LIG_NRBOX	525	531	PF00104	0.429
LIG_Rb_pABgroove_1	610	618	PF01858	0.390
LIG_SH2_CRK	424	428	PF00017	0.419
LIG_SH2_CRK	527	531	PF00017	0.435
LIG_SH2_CRK	616	620	PF00017	0.464
LIG_SH2_PTP2	320	323	PF00017	0.326
LIG_SH2_SRC	378	381	PF00017	0.396
LIG_SH2_STAP1	424	428	PF00017	0.371
LIG_SH2_STAP1	572	576	PF00017	0.454
LIG_SH2_STAT3	110	113	PF00017	0.456
LIG_SH2_STAT3	392	395	PF00017	0.490
LIG_SH2_STAT5	315	318	PF00017	0.395
LIG_SH2_STAT5	320	323	PF00017	0.393
LIG_SH2_STAT5	338	341	PF00017	0.388
LIG_SH2_STAT5	346	349	PF00017	0.478
LIG_SH2_STAT5	353	356	PF00017	0.381
LIG_SH2_STAT5	424	427	PF00017	0.603
LIG_SH2_STAT5	460	463	PF00017	0.423
LIG_SH2_STAT5	659	662	PF00017	0.445
LIG_SH3_1	234	240	PF00018	0.681
LIG_SH3_3	102	108	PF00018	0.605
LIG_SH3_3	126	132	PF00018	0.473
LIG_SH3_3	141	147	PF00018	0.545
LIG_SH3_3	190	196	PF00018	0.641
LIG_SH3_3	203	209	PF00018	0.716
LIG_SH3_3	215	221	PF00018	0.594
LIG_SH3_3	234	240	PF00018	0.627
LIG_SH3_3	311	317	PF00018	0.495
LIG_SH3_3	325	331	PF00018	0.417
LIG_SH3_3	415	421	PF00018	0.470
LIG_SH3_3	44	50	PF00018	0.498
LIG_SH3_3	588	594	PF00018	0.595
LIG_SH3_3	663	669	PF00018	0.493
LIG_SH3_3	676	682	PF00018	0.424
LIG_SH3_3	692	698	PF00018	0.426
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.460
LIG_SUMO_SIM_anti_2	628	636	PF11976	0.404
LIG_SUMO_SIM_anti_2	670	675	PF11976	0.433
LIG_SUMO_SIM_par_1	126	133	PF11976	0.442
LIG_SUMO_SIM_par_1	496	503	PF11976	0.350
LIG_TRAF2_1	512	515	PF00917	0.366
LIG_TYR_ITSM	316	323	PF00017	0.290
LIG_WRC_WIRS_1	316	321	PF05994	0.384
LIG_WRC_WIRS_1	385	390	PF05994	0.463
LIG_WRC_WIRS_1	545	550	PF05994	0.387
LIG_WW_3	403	407	PF00397	0.556
MOD_CK1_1	101	107	PF00069	0.609
MOD_CK1_1	114	120	PF00069	0.394
MOD_CK1_1	175	181	PF00069	0.736
MOD_CK1_1	213	219	PF00069	0.686
MOD_CK1_1	24	30	PF00069	0.541
MOD_CK1_1	277	283	PF00069	0.633
MOD_CK1_1	359	365	PF00069	0.508
MOD_CK1_1	528	534	PF00069	0.438
MOD_CK1_1	544	550	PF00069	0.399
MOD_CK1_1	706	712	PF00069	0.452
MOD_CK1_1	729	735	PF00069	0.451
MOD_CK2_1	143	149	PF00069	0.715
MOD_CK2_1	289	295	PF00069	0.737
MOD_CK2_1	528	534	PF00069	0.397
MOD_CK2_1	652	658	PF00069	0.445
MOD_GlcNHglycan	112	116	PF01048	0.469
MOD_GlcNHglycan	132	135	PF01048	0.531
MOD_GlcNHglycan	14	17	PF01048	0.566
MOD_GlcNHglycan	152	155	PF01048	0.492
MOD_GlcNHglycan	200	203	PF01048	0.648
MOD_GlcNHglycan	24	27	PF01048	0.628
MOD_GlcNHglycan	251	254	PF01048	0.708
MOD_GlcNHglycan	271	274	PF01048	0.719
MOD_GlcNHglycan	388	391	PF01048	0.571
MOD_GlcNHglycan	395	398	PF01048	0.547
MOD_GlcNHglycan	517	520	PF01048	0.512
MOD_GlcNHglycan	728	731	PF01048	0.438
MOD_GlcNHglycan	737	740	PF01048	0.379
MOD_GSK3_1	172	179	PF00069	0.617
MOD_GSK3_1	198	205	PF00069	0.711
MOD_GSK3_1	20	27	PF00069	0.667
MOD_GSK3_1	210	217	PF00069	0.739
MOD_GSK3_1	244	251	PF00069	0.680
MOD_GSK3_1	315	322	PF00069	0.460
MOD_GSK3_1	485	492	PF00069	0.505
MOD_GSK3_1	515	522	PF00069	0.385
MOD_GSK3_1	533	540	PF00069	0.352
MOD_GSK3_1	59	66	PF00069	0.631
MOD_GSK3_1	629	636	PF00069	0.419
MOD_GSK3_1	699	706	PF00069	0.504
MOD_GSK3_1	7	14	PF00069	0.584
MOD_GSK3_1	717	724	PF00069	0.374
MOD_N-GLC_1	277	282	PF02516	0.606
MOD_NEK2_1	183	188	PF00069	0.662
MOD_NEK2_1	214	219	PF00069	0.604
MOD_NEK2_1	224	229	PF00069	0.542
MOD_NEK2_1	302	307	PF00069	0.656
MOD_NEK2_1	448	453	PF00069	0.485
MOD_NEK2_1	461	466	PF00069	0.446
MOD_PIKK_1	114	120	PF00454	0.410
MOD_PIKK_1	461	467	PF00454	0.392
MOD_PIKK_1	533	539	PF00454	0.388
MOD_PIKK_1	98	104	PF00454	0.569
MOD_PKA_1	63	69	PF00069	0.507
MOD_PKA_2	224	230	PF00069	0.599
MOD_PKA_2	248	254	PF00069	0.662
MOD_PKA_2	269	275	PF00069	0.566
MOD_PKA_2	302	308	PF00069	0.509
MOD_PKA_2	356	362	PF00069	0.455
MOD_PKA_2	405	411	PF00069	0.548
MOD_PKB_1	583	591	PF00069	0.572
MOD_Plk_1	111	117	PF00069	0.422
MOD_Plk_1	339	345	PF00069	0.440
MOD_Plk_1	422	428	PF00069	0.496
MOD_Plk_1	533	539	PF00069	0.444
MOD_Plk_4	315	321	PF00069	0.379
MOD_Plk_4	489	495	PF00069	0.397
MOD_Plk_4	525	531	PF00069	0.380
MOD_Plk_4	544	550	PF00069	0.451
MOD_Plk_4	575	581	PF00069	0.564
MOD_Plk_4	629	635	PF00069	0.493
MOD_Plk_4	667	673	PF00069	0.443
MOD_ProDKin_1	104	110	PF00069	0.687
MOD_ProDKin_1	143	149	PF00069	0.784
MOD_ProDKin_1	178	184	PF00069	0.757
MOD_ProDKin_1	239	245	PF00069	0.630
MOD_ProDKin_1	277	283	PF00069	0.650
MOD_ProDKin_1	295	301	PF00069	0.628
MOD_ProDKin_1	485	491	PF00069	0.433
MOD_SUMO_for_1	677	680	PF00179	0.516
MOD_SUMO_rev_2	509	518	PF00179	0.436
TRG_DiLeu_BaEn_1	126	131	PF01217	0.404
TRG_DiLeu_BaEn_1	629	634	PF01217	0.396
TRG_DiLeu_BaEn_4	126	132	PF01217	0.420
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.411
TRG_DiLeu_BaLyEn_6	692	697	PF01217	0.422
TRG_ENDOCYTIC_2	320	323	PF00928	0.367
TRG_ENDOCYTIC_2	353	356	PF00928	0.346
TRG_ENDOCYTIC_2	424	427	PF00928	0.408
TRG_ENDOCYTIC_2	460	463	PF00928	0.435
TRG_ENDOCYTIC_2	527	530	PF00928	0.475
TRG_ENDOCYTIC_2	566	569	PF00928	0.395
TRG_ENDOCYTIC_2	616	619	PF00928	0.489
TRG_ER_diArg_1	267	270	PF00400	0.551
TRG_ER_diArg_1	365	368	PF00400	0.524
TRG_ER_diArg_1	401	403	PF00400	0.627
TRG_ER_diArg_1	468	471	PF00400	0.407
TRG_ER_diArg_1	583	586	PF00400	0.579
TRG_ER_diArg_1	707	710	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE00	Leptomonas seymouri	55%	100%
A0A3S7X1J9	Leishmania donovani	92%	100%
A4HGM0	Leishmania braziliensis	80%	100%
A4HHZ8	Leishmania braziliensis	26%	100%
A4I3P5	Leishmania infantum	91%	100%
E9AZY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	93%
E9B0H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
V5B7S2	Trypanosoma cruzi	26%	100%