Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q896_LEIMA

TriTrypDb:

LmjF.28.1700 , LMJLV39_280024800 , LMJSD75_280024300

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q896

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q896

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.577
CLV_NRD_NRD_1	32	34	PF00675	0.617
CLV_PCSK_KEX2_1	157	159	PF00082	0.582
CLV_PCSK_SKI1_1	117	121	PF00082	0.581
CLV_PCSK_SKI1_1	126	130	PF00082	0.401
CLV_PCSK_SKI1_1	174	178	PF00082	0.561
CLV_PCSK_SKI1_1	21	25	PF00082	0.652
CLV_PCSK_SKI1_1	343	347	PF00082	0.554
CLV_PCSK_SKI1_1	374	378	PF00082	0.448
CLV_PCSK_SKI1_1	459	463	PF00082	0.609
CLV_PCSK_SKI1_1	93	97	PF00082	0.424
DEG_APCC_DBOX_1	6	14	PF00400	0.699
DEG_ODPH_VHL_1	208	219	PF01847	0.550
DOC_CKS1_1	79	84	PF01111	0.533
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.390
DOC_MAPK_DCC_7	158	168	PF00069	0.549
DOC_MAPK_DCC_7	93	103	PF00069	0.452
DOC_MAPK_gen_1	340	349	PF00069	0.493
DOC_MAPK_gen_1	88	96	PF00069	0.389
DOC_MAPK_HePTP_8	156	168	PF00069	0.423
DOC_MAPK_MEF2A_6	159	168	PF00069	0.427
DOC_MAPK_MEF2A_6	343	351	PF00069	0.411
DOC_PP1_RVXF_1	91	97	PF00149	0.411
DOC_PP2B_LxvP_1	24	27	PF13499	0.683
DOC_PP2B_LxvP_1	347	350	PF13499	0.410
DOC_PP2B_LxvP_1	415	418	PF13499	0.534
DOC_USP7_MATH_1	203	207	PF00917	0.664
DOC_USP7_MATH_1	316	320	PF00917	0.608
DOC_USP7_MATH_1	331	335	PF00917	0.753
DOC_USP7_MATH_1	336	340	PF00917	0.624
DOC_USP7_MATH_1	43	47	PF00917	0.730
DOC_USP7_MATH_1	6	10	PF00917	0.590
DOC_USP7_MATH_1	61	65	PF00917	0.630
DOC_USP7_MATH_1	66	70	PF00917	0.568
DOC_USP7_UBL2_3	384	388	PF12436	0.448
DOC_WW_Pin1_4	194	199	PF00397	0.708
DOC_WW_Pin1_4	39	44	PF00397	0.660
DOC_WW_Pin1_4	78	83	PF00397	0.565
DOC_WW_Pin1_4	94	99	PF00397	0.458
LIG_14-3-3_CanoR_1	117	122	PF00244	0.486
LIG_14-3-3_CanoR_1	187	192	PF00244	0.529
LIG_14-3-3_CanoR_1	33	43	PF00244	0.739
LIG_14-3-3_CanoR_1	378	385	PF00244	0.459
LIG_14-3-3_CanoR_1	401	405	PF00244	0.468
LIG_14-3-3_CanoR_1	431	435	PF00244	0.600
LIG_BRCT_BRCA1_1	298	302	PF00533	0.290
LIG_eIF4E_1	283	289	PF01652	0.441
LIG_FHA_1	116	122	PF00498	0.421
LIG_FHA_1	186	192	PF00498	0.496
LIG_FHA_1	259	265	PF00498	0.396
LIG_FHA_1	295	301	PF00498	0.388
LIG_FHA_1	325	331	PF00498	0.566
LIG_FHA_1	365	371	PF00498	0.384
LIG_FHA_1	410	416	PF00498	0.458
LIG_FHA_2	118	124	PF00498	0.498
LIG_FHA_2	223	229	PF00498	0.502
LIG_FHA_2	263	269	PF00498	0.508
LIG_FHA_2	35	41	PF00498	0.712
LIG_GBD_Chelix_1	280	288	PF00786	0.368
LIG_LIR_Apic_2	224	230	PF02991	0.434
LIG_LIR_Apic_2	69	74	PF02991	0.568
LIG_LIR_Gen_1	293	303	PF02991	0.383
LIG_LIR_Nem_3	248	254	PF02991	0.503
LIG_LIR_Nem_3	293	298	PF02991	0.350
LIG_LYPXL_yS_3	251	254	PF13949	0.553
LIG_MYND_1	405	409	PF01753	0.666
LIG_PAM2_1	61	73	PF00658	0.584
LIG_Pex14_2	430	434	PF04695	0.488
LIG_SH2_CRK	136	140	PF00017	0.467
LIG_SH2_CRK	227	231	PF00017	0.428
LIG_SH2_CRK	71	75	PF00017	0.581
LIG_SH2_GRB2like	213	216	PF00017	0.564
LIG_SH2_GRB2like	283	286	PF00017	0.389
LIG_SH2_NCK_1	227	231	PF00017	0.536
LIG_SH2_NCK_1	71	75	PF00017	0.567
LIG_SH2_SRC	134	137	PF00017	0.500
LIG_SH2_STAP1	213	217	PF00017	0.575
LIG_SH2_STAP1	390	394	PF00017	0.444
LIG_SH2_STAT3	152	155	PF00017	0.547
LIG_SH2_STAT3	283	286	PF00017	0.521
LIG_SH2_STAT3	426	429	PF00017	0.539
LIG_SH2_STAT5	134	137	PF00017	0.368
LIG_SH2_STAT5	152	155	PF00017	0.476
LIG_SH2_STAT5	283	286	PF00017	0.423
LIG_SH2_STAT5	365	368	PF00017	0.451
LIG_SH3_1	57	63	PF00018	0.694
LIG_SH3_2	338	343	PF14604	0.591
LIG_SH3_3	195	201	PF00018	0.684
LIG_SH3_3	306	312	PF00018	0.574
LIG_SH3_3	335	341	PF00018	0.696
LIG_SH3_3	53	59	PF00018	0.643
LIG_SH3_3	60	66	PF00018	0.559
LIG_SH3_3	73	79	PF00018	0.534
LIG_SH3_4	384	391	PF00018	0.496
LIG_SH3_CIN85_PxpxPR_1	28	33	PF14604	0.533
LIG_SUMO_SIM_par_1	117	123	PF11976	0.453
LIG_SUMO_SIM_par_1	138	143	PF11976	0.509
LIG_SUMO_SIM_par_1	296	301	PF11976	0.342
LIG_TRAF2_1	102	105	PF00917	0.488
LIG_TRAF2_1	389	392	PF00917	0.417
LIG_UBA3_1	235	239	PF00899	0.454
LIG_WW_2	60	63	PF00397	0.611
LIG_WW_3	416	420	PF00397	0.585
MOD_CDK_SPK_2	94	99	PF00069	0.439
MOD_CK1_1	194	200	PF00069	0.701
MOD_CK1_1	339	345	PF00069	0.667
MOD_CK1_1	36	42	PF00069	0.691
MOD_CK1_1	383	389	PF00069	0.511
MOD_CK2_1	117	123	PF00069	0.526
MOD_CK2_1	262	268	PF00069	0.499
MOD_CK2_1	298	304	PF00069	0.421
MOD_CK2_1	34	40	PF00069	0.789
MOD_CK2_1	386	392	PF00069	0.390
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.566
MOD_GlcNHglycan	205	208	PF01048	0.740
MOD_GlcNHglycan	318	321	PF01048	0.591
MOD_GlcNHglycan	333	336	PF01048	0.729
MOD_GlcNHglycan	412	415	PF01048	0.663
MOD_GlcNHglycan	447	450	PF01048	0.603
MOD_GlcNHglycan	47	50	PF01048	0.706
MOD_GlcNHglycan	83	86	PF01048	0.545
MOD_GSK3_1	187	194	PF00069	0.724
MOD_GSK3_1	258	265	PF00069	0.410
MOD_GSK3_1	290	297	PF00069	0.452
MOD_GSK3_1	321	328	PF00069	0.652
MOD_GSK3_1	35	42	PF00069	0.715
MOD_GSK3_1	364	371	PF00069	0.424
MOD_GSK3_1	43	50	PF00069	0.621
MOD_GSK3_1	440	447	PF00069	0.381
MOD_NEK2_1	19	24	PF00069	0.714
MOD_NEK2_1	193	198	PF00069	0.549
MOD_NEK2_1	294	299	PF00069	0.409
MOD_NEK2_1	430	435	PF00069	0.439
MOD_NEK2_1	47	52	PF00069	0.728
MOD_NEK2_1	86	91	PF00069	0.430
MOD_NEK2_2	213	218	PF00069	0.572
MOD_NEK2_2	222	227	PF00069	0.483
MOD_PIKK_1	1	7	PF00454	0.718
MOD_PK_1	187	193	PF00069	0.529
MOD_PKA_1	33	39	PF00069	0.548
MOD_PKA_2	339	345	PF00069	0.564
MOD_PKA_2	377	383	PF00069	0.443
MOD_PKA_2	400	406	PF00069	0.573
MOD_PKA_2	409	415	PF00069	0.584
MOD_PKA_2	430	436	PF00069	0.470
MOD_PKA_2	6	12	PF00069	0.734
MOD_Plk_1	222	228	PF00069	0.685
MOD_Plk_4	222	228	PF00069	0.456
MOD_Plk_4	298	304	PF00069	0.445
MOD_Plk_4	66	72	PF00069	0.542
MOD_ProDKin_1	194	200	PF00069	0.706
MOD_ProDKin_1	39	45	PF00069	0.661
MOD_ProDKin_1	78	84	PF00069	0.554
MOD_ProDKin_1	94	100	PF00069	0.462
MOD_SUMO_rev_2	386	394	PF00179	0.459
TRG_DiLeu_BaEn_1	104	109	PF01217	0.628
TRG_DiLeu_BaEn_4	104	110	PF01217	0.512
TRG_ENDOCYTIC_2	251	254	PF00928	0.553
TRG_ER_diArg_1	146	149	PF00400	0.448
TRG_ER_diArg_1	156	159	PF00400	0.470
TRG_NES_CRM1_1	290	304	PF08389	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F3	Leptomonas seymouri	53%	90%
A0A1X0NSE8	Trypanosomatidae	35%	100%
A0A3Q8IB15	Leishmania donovani	92%	100%
A0A422NZ46	Trypanosoma rangeli	35%	100%
D0A8B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AHG6	Leishmania infantum	92%	100%
E9AZY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	96%
V5DBC1	Trypanosoma cruzi	35%	100%