Tensin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tensin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q894_LEIMA

TriTrypDb:

LmjF.28.1720 , LMJLV39_280025000 , LMJSD75_280024500

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q894

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q894

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0008289	lipid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.726
CLV_MEL_PAP_1	190	196	PF00089	0.645
CLV_PCSK_SKI1_1	293	297	PF00082	0.446
DEG_APCC_DBOX_1	192	200	PF00400	0.627
DEG_SPOP_SBC_1	134	138	PF00917	0.816
DOC_MAPK_MEF2A_6	186	194	PF00069	0.587
DOC_PP2B_LxvP_1	300	303	PF13499	0.626
DOC_PP4_MxPP_1	1	4	PF00568	0.576
DOC_SPAK_OSR1_1	164	168	PF12202	0.608
DOC_USP7_MATH_1	126	130	PF00917	0.722
DOC_USP7_MATH_1	134	138	PF00917	0.677
DOC_USP7_MATH_1	148	152	PF00917	0.569
DOC_USP7_MATH_1	83	87	PF00917	0.594
DOC_WW_Pin1_4	101	106	PF00397	0.714
DOC_WW_Pin1_4	135	140	PF00397	0.674
DOC_WW_Pin1_4	227	232	PF00397	0.518
DOC_WW_Pin1_4	51	56	PF00397	0.757
LIG_14-3-3_CanoR_1	164	170	PF00244	0.544
LIG_14-3-3_CanoR_1	193	197	PF00244	0.642
LIG_14-3-3_CanoR_1	307	313	PF00244	0.674
LIG_Actin_WH2_2	178	195	PF00022	0.656
LIG_Actin_WH2_2	281	299	PF00022	0.531
LIG_BRCT_BRCA1_1	110	114	PF00533	0.609
LIG_BRCT_BRCA1_1	252	256	PF00533	0.777
LIG_FHA_1	238	244	PF00498	0.567
LIG_FHA_1	62	68	PF00498	0.834
LIG_FHA_2	60	66	PF00498	0.639
LIG_LIR_Apic_2	221	226	PF02991	0.576
LIG_LIR_Gen_1	2	11	PF02991	0.784
LIG_LIR_Gen_1	208	215	PF02991	0.567
LIG_LIR_Gen_1	254	265	PF02991	0.662
LIG_LIR_Nem_3	2	8	PF02991	0.676
LIG_LIR_Nem_3	208	213	PF02991	0.560
LIG_LIR_Nem_3	254	260	PF02991	0.660
LIG_PCNA_yPIPBox_3	204	216	PF02747	0.578
LIG_Pex14_2	256	260	PF04695	0.773
LIG_SH2_GRB2like	278	281	PF00017	0.676
LIG_SH2_PTP2	210	213	PF00017	0.567
LIG_SH2_STAT5	162	165	PF00017	0.506
LIG_SH2_STAT5	210	213	PF00017	0.567
LIG_SH2_STAT5	278	281	PF00017	0.676
LIG_SH2_STAT5	56	59	PF00017	0.770
LIG_SH3_3	140	146	PF00018	0.794
LIG_SH3_3	152	158	PF00018	0.441
LIG_SH3_3	191	197	PF00018	0.562
LIG_SH3_3	225	231	PF00018	0.625
LIG_SH3_3	303	309	PF00018	0.526
MOD_CK1_1	119	125	PF00069	0.590
MOD_CK1_1	137	143	PF00069	0.797
MOD_CK1_1	151	157	PF00069	0.390
MOD_CK1_1	263	269	PF00069	0.781
MOD_CK1_1	54	60	PF00069	0.693
MOD_CK1_1	61	67	PF00069	0.722
MOD_CK2_1	141	147	PF00069	0.788
MOD_CK2_1	59	65	PF00069	0.798
MOD_CK2_1	83	89	PF00069	0.593
MOD_GlcNHglycan	121	124	PF01048	0.664
MOD_GlcNHglycan	272	277	PF01048	0.772
MOD_GlcNHglycan	70	73	PF01048	0.625
MOD_GSK3_1	133	140	PF00069	0.776
MOD_GSK3_1	251	258	PF00069	0.657
MOD_GSK3_1	308	315	PF00069	0.701
MOD_GSK3_1	47	54	PF00069	0.747
MOD_GSK3_1	56	63	PF00069	0.638
MOD_GSK3_1	93	100	PF00069	0.736
MOD_N-GLC_2	218	220	PF02516	0.476
MOD_NEK2_1	165	170	PF00069	0.460
MOD_NEK2_1	173	178	PF00069	0.451
MOD_NEK2_1	192	197	PF00069	0.468
MOD_NEK2_1	237	242	PF00069	0.610
MOD_NEK2_1	260	265	PF00069	0.780
MOD_NEK2_1	296	301	PF00069	0.620
MOD_NEK2_1	67	72	PF00069	0.835
MOD_NEK2_2	126	131	PF00069	0.676
MOD_PIKK_1	137	143	PF00454	0.811
MOD_PIKK_1	282	288	PF00454	0.513
MOD_PKA_2	192	198	PF00069	0.627
MOD_PKA_2	235	241	PF00069	0.617
MOD_PKA_2	296	302	PF00069	0.622
MOD_PKA_2	50	56	PF00069	0.847
MOD_Plk_1	126	132	PF00069	0.693
MOD_Plk_1	282	288	PF00069	0.525
MOD_Plk_4	151	157	PF00069	0.649
MOD_Plk_4	229	235	PF00069	0.618
MOD_Plk_4	296	302	PF00069	0.598
MOD_Plk_4	63	69	PF00069	0.742
MOD_ProDKin_1	101	107	PF00069	0.708
MOD_ProDKin_1	135	141	PF00069	0.675
MOD_ProDKin_1	227	233	PF00069	0.511
MOD_ProDKin_1	51	57	PF00069	0.758
TRG_DiLeu_BaEn_2	282	288	PF01217	0.554
TRG_ENDOCYTIC_2	162	165	PF00928	0.476
TRG_ENDOCYTIC_2	210	213	PF00928	0.567
TRG_ENDOCYTIC_2	257	260	PF00928	0.774

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I3P9	Leishmania infantum	92%	70%
D0A8B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	89%
E9AZZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	68%