SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania major

UniProt:

Q4Q892_LEIMA

TriTrypDb:

LmjF.28.1740 , LMJLV39_280025200 , LMJSD75_280024700

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q892

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q892

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	2
GO:0031167	rRNA methylation	5	2
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0070475	rRNA base methylation	6	2
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.574
CLV_C14_Caspase3-7	86	90	PF00656	0.544
CLV_NRD_NRD_1	109	111	PF00675	0.545
CLV_NRD_NRD_1	139	141	PF00675	0.744
CLV_NRD_NRD_1	174	176	PF00675	0.474
CLV_NRD_NRD_1	179	181	PF00675	0.526
CLV_NRD_NRD_1	210	212	PF00675	0.687
CLV_NRD_NRD_1	26	28	PF00675	0.460
CLV_NRD_NRD_1	285	287	PF00675	0.534
CLV_NRD_NRD_1	310	312	PF00675	0.576
CLV_NRD_NRD_1	348	350	PF00675	0.299
CLV_NRD_NRD_1	417	419	PF00675	0.726
CLV_NRD_NRD_1	427	429	PF00675	0.581
CLV_NRD_NRD_1	436	438	PF00675	0.551
CLV_NRD_NRD_1	491	493	PF00675	0.250
CLV_PCSK_FUR_1	136	140	PF00082	0.704
CLV_PCSK_FUR_1	172	176	PF00082	0.454
CLV_PCSK_KEX2_1	138	140	PF00082	0.744
CLV_PCSK_KEX2_1	174	176	PF00082	0.462
CLV_PCSK_KEX2_1	181	183	PF00082	0.517
CLV_PCSK_KEX2_1	206	208	PF00082	0.704
CLV_PCSK_KEX2_1	210	212	PF00082	0.694
CLV_PCSK_KEX2_1	310	312	PF00082	0.368
CLV_PCSK_KEX2_1	348	350	PF00082	0.242
CLV_PCSK_KEX2_1	355	357	PF00082	0.261
CLV_PCSK_KEX2_1	427	429	PF00082	0.629
CLV_PCSK_KEX2_1	436	438	PF00082	0.600
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.705
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.532
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.761
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.271
CLV_PCSK_PC7_1	423	429	PF00082	0.492
CLV_PCSK_SKI1_1	184	188	PF00082	0.450
CLV_PCSK_SKI1_1	206	210	PF00082	0.730
CLV_PCSK_SKI1_1	287	291	PF00082	0.681
CLV_PCSK_SKI1_1	381	385	PF00082	0.267
CLV_PCSK_SKI1_1	492	496	PF00082	0.250
CLV_PCSK_SKI1_1	525	529	PF00082	0.250
CLV_Separin_Metazoa	522	526	PF03568	0.536
DEG_APCC_DBOX_1	309	317	PF00400	0.423
DEG_Nend_UBRbox_2	1	3	PF02207	0.397
DOC_CYCLIN_RxL_1	19	29	PF00134	0.423
DOC_CYCLIN_RxL_1	486	498	PF00134	0.494
DOC_MAPK_gen_1	155	164	PF00069	0.374
DOC_MAPK_MEF2A_6	158	166	PF00069	0.404
DOC_PP2B_LxvP_1	151	154	PF13499	0.516
DOC_PP2B_LxvP_1	333	336	PF13499	0.448
DOC_PP2B_PxIxI_1	335	341	PF00149	0.528
DOC_SPAK_OSR1_1	563	567	PF12202	0.502
DOC_USP7_MATH_1	117	121	PF00917	0.717
DOC_USP7_MATH_1	193	197	PF00917	0.741
DOC_USP7_MATH_1	246	250	PF00917	0.448
DOC_USP7_MATH_1	280	284	PF00917	0.713
DOC_USP7_MATH_1	391	395	PF00917	0.450
DOC_USP7_UBL2_3	28	32	PF12436	0.433
DOC_USP7_UBL2_3	284	288	PF12436	0.763
DOC_WW_Pin1_4	145	150	PF00397	0.674
LIG_14-3-3_CanoR_1	158	163	PF00244	0.371
LIG_14-3-3_CanoR_1	210	219	PF00244	0.705
LIG_14-3-3_CanoR_1	257	265	PF00244	0.361
LIG_14-3-3_CanoR_1	356	361	PF00244	0.462
LIG_14-3-3_CanoR_1	381	389	PF00244	0.536
LIG_14-3-3_CanoR_1	427	432	PF00244	0.611
LIG_14-3-3_CanoR_1	93	102	PF00244	0.523
LIG_Actin_WH2_2	159	176	PF00022	0.433
LIG_BIR_III_2	268	272	PF00653	0.516
LIG_BRCT_BRCA1_1	369	373	PF00533	0.472
LIG_Clathr_ClatBox_1	499	503	PF01394	0.461
LIG_FHA_1	159	165	PF00498	0.405
LIG_FHA_1	325	331	PF00498	0.450
LIG_FHA_1	34	40	PF00498	0.402
LIG_FHA_1	382	388	PF00498	0.466
LIG_FHA_1	510	516	PF00498	0.452
LIG_FHA_2	341	347	PF00498	0.536
LIG_FHA_2	398	404	PF00498	0.461
LIG_FHA_2	84	90	PF00498	0.459
LIG_IRF3_LxIS_1	159	165	PF10401	0.481
LIG_LIR_Gen_1	36	44	PF02991	0.374
LIG_LIR_Gen_1	364	373	PF02991	0.463
LIG_LIR_Nem_3	104	109	PF02991	0.417
LIG_LIR_Nem_3	36	40	PF02991	0.382
LIG_LIR_Nem_3	364	368	PF02991	0.465
LIG_LIR_Nem_3	370	376	PF02991	0.411
LIG_LIR_Nem_3	58	63	PF02991	0.390
LIG_REV1ctd_RIR_1	57	63	PF16727	0.434
LIG_SH2_CRK	156	160	PF00017	0.358
LIG_SH2_CRK	37	41	PF00017	0.390
LIG_SH2_CRK	76	80	PF00017	0.372
LIG_SH2_GRB2like	365	368	PF00017	0.461
LIG_SH2_NCK_1	156	160	PF00017	0.358
LIG_SH2_PTP2	365	368	PF00017	0.475
LIG_SH2_SRC	365	368	PF00017	0.475
LIG_SH2_STAP1	76	80	PF00017	0.372
LIG_SH2_STAT3	62	65	PF00017	0.530
LIG_SH2_STAT5	101	104	PF00017	0.416
LIG_SH2_STAT5	315	318	PF00017	0.443
LIG_SH2_STAT5	365	368	PF00017	0.456
LIG_SH2_STAT5	579	582	PF00017	0.468
LIG_SH3_3	111	117	PF00018	0.528
LIG_SH3_3	213	219	PF00018	0.661
LIG_SH3_3	224	230	PF00018	0.425
LIG_SH3_3	231	237	PF00018	0.445
LIG_SUMO_SIM_par_1	270	276	PF11976	0.543
LIG_SUMO_SIM_par_1	51	58	PF11976	0.526
LIG_TRAF2_1	165	168	PF00917	0.489
LIG_TRAF2_1	448	451	PF00917	0.748
LIG_WRC_WIRS_1	499	504	PF05994	0.461
LIG_WW_3	115	119	PF00397	0.552
MOD_CK1_1	141	147	PF00069	0.678
MOD_CK1_1	498	504	PF00069	0.482
MOD_CK1_1	511	517	PF00069	0.394
MOD_CK2_1	162	168	PF00069	0.409
MOD_CK2_1	436	442	PF00069	0.724
MOD_CK2_1	475	481	PF00069	0.591
MOD_CK2_1	511	517	PF00069	0.475
MOD_Cter_Amidation	136	139	PF01082	0.704
MOD_Cter_Amidation	284	287	PF01082	0.569
MOD_GlcNHglycan	140	143	PF01048	0.704
MOD_GlcNHglycan	175	178	PF01048	0.534
MOD_GlcNHglycan	248	251	PF01048	0.443
MOD_GlcNHglycan	393	396	PF01048	0.266
MOD_GlcNHglycan	464	467	PF01048	0.755
MOD_GlcNHglycan	97	100	PF01048	0.447
MOD_GSK3_1	141	148	PF00069	0.662
MOD_GSK3_1	158	165	PF00069	0.476
MOD_GSK3_1	206	213	PF00069	0.745
MOD_GSK3_1	276	283	PF00069	0.681
MOD_GSK3_1	389	396	PF00069	0.441
MOD_GSK3_1	432	439	PF00069	0.769
MOD_GSK3_1	504	511	PF00069	0.451
MOD_GSK3_1	83	90	PF00069	0.458
MOD_GSK3_1	93	100	PF00069	0.410
MOD_N-GLC_1	17	22	PF02516	0.504
MOD_N-GLC_1	302	307	PF02516	0.712
MOD_N-GLC_1	324	329	PF02516	0.250
MOD_N-GLC_1	87	92	PF02516	0.564
MOD_NEK2_1	432	437	PF00069	0.559
MOD_NEK2_1	495	500	PF00069	0.509
MOD_NEK2_1	562	567	PF00069	0.450
MOD_PIKK_1	221	227	PF00454	0.574
MOD_PIKK_1	325	331	PF00454	0.475
MOD_PKA_1	138	144	PF00069	0.783
MOD_PKA_1	206	212	PF00069	0.762
MOD_PKA_1	33	39	PF00069	0.409
MOD_PKA_1	427	433	PF00069	0.635
MOD_PKA_1	436	442	PF00069	0.597
MOD_PKA_2	117	123	PF00069	0.486
MOD_PKA_2	138	144	PF00069	0.725
MOD_PKA_2	173	179	PF00069	0.582
MOD_PKA_2	206	212	PF00069	0.747
MOD_PKA_2	256	262	PF00069	0.362
MOD_PKA_2	427	433	PF00069	0.635
MOD_PKA_2	436	442	PF00069	0.597
MOD_PKA_2	538	544	PF00069	0.545
MOD_PKA_2	562	568	PF00069	0.502
MOD_Plk_1	475	481	PF00069	0.622
MOD_Plk_4	427	433	PF00069	0.497
MOD_Plk_4	495	501	PF00069	0.511
MOD_Plk_4	97	103	PF00069	0.484
MOD_ProDKin_1	145	151	PF00069	0.660
MOD_SUMO_for_1	479	482	PF00179	0.527
TRG_ENDOCYTIC_2	106	109	PF00928	0.416
TRG_ENDOCYTIC_2	156	159	PF00928	0.360
TRG_ENDOCYTIC_2	365	368	PF00928	0.473
TRG_ENDOCYTIC_2	37	40	PF00928	0.392
TRG_ENDOCYTIC_2	47	50	PF00928	0.352
TRG_ENDOCYTIC_2	76	79	PF00928	0.362
TRG_ER_diArg_1	172	175	PF00400	0.449
TRG_ER_diArg_1	179	182	PF00400	0.530
TRG_ER_diArg_1	310	312	PF00400	0.368
TRG_ER_diArg_1	427	429	PF00400	0.608
TRG_NLS_MonoExtC_3	137	143	PF00514	0.700
TRG_NLS_MonoExtC_3	179	184	PF00514	0.607
TRG_NLS_MonoExtC_3	285	290	PF00514	0.539
TRG_NLS_MonoExtN_4	136	142	PF00514	0.699
TRG_NLS_MonoExtN_4	284	291	PF00514	0.694
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I291	Leptomonas seymouri	70%	100%
A0A0S4JC42	Bodo saltans	53%	100%
A0A1X0NQY2	Trypanosomatidae	58%	100%
A0A3S7X1L9	Leishmania donovani	92%	100%
A0A422NZ09	Trypanosoma rangeli	57%	100%
A4HGM7	Leishmania braziliensis	82%	100%
A4I3Q1	Leishmania infantum	91%	100%
D0A8B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AZZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O14039	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q8GYE8	Arabidopsis thaliana	28%	100%
V5BAN7	Trypanosoma cruzi	59%	100%