SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania major

UniProt:

Q4Q892_LEIMA

TriTrypDb:

LmjF.28.1740 , LMJLV39_280025200 , LMJSD75_280024700

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q892

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q892

Function

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Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.574
CLV_C14_Caspase3-7	86	90	PF00656	0.544
CLV_NRD_NRD_1	109	111	PF00675	0.545
CLV_NRD_NRD_1	139	141	PF00675	0.744
CLV_NRD_NRD_1	174	176	PF00675	0.474
CLV_NRD_NRD_1	179	181	PF00675	0.526
CLV_NRD_NRD_1	210	212	PF00675	0.687
CLV_NRD_NRD_1	26	28	PF00675	0.460
CLV_NRD_NRD_1	285	287	PF00675	0.534
CLV_NRD_NRD_1	310	312	PF00675	0.576

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I291	Leptomonas seymouri	70%	100%
A0A0S4JC42	Bodo saltans	53%	100%
A0A1X0NQY2	Trypanosomatidae	58%	100%
A0A3S7X1L9	Leishmania donovani	92%	100%
A0A422NZ09	Trypanosoma rangeli	57%	100%
A4HGM7	Leishmania braziliensis	82%	100%
A4I3Q1	Leishmania infantum	91%	100%
D0A8B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AZZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O14039	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%

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