Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q891_LEIMA

TriTrypDb:

LmjF.28.1750 , LMJLV39_280025300 , LMJSD75_280024800

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q891

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q891

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.625
CLV_C14_Caspase3-7	291	295	PF00656	0.635
CLV_C14_Caspase3-7	381	385	PF00656	0.586
CLV_C14_Caspase3-7	402	406	PF00656	0.674
CLV_C14_Caspase3-7	869	873	PF00656	0.535
CLV_NRD_NRD_1	149	151	PF00675	0.546
CLV_NRD_NRD_1	214	216	PF00675	0.646
CLV_NRD_NRD_1	236	238	PF00675	0.657
CLV_NRD_NRD_1	284	286	PF00675	0.648
CLV_NRD_NRD_1	30	32	PF00675	0.506
CLV_NRD_NRD_1	741	743	PF00675	0.382
CLV_NRD_NRD_1	763	765	PF00675	0.439
CLV_NRD_NRD_1	81	83	PF00675	0.580
CLV_NRD_NRD_1	85	87	PF00675	0.569
CLV_NRD_NRD_1	901	903	PF00675	0.537
CLV_PCSK_FUR_1	82	86	PF00082	0.518
CLV_PCSK_KEX2_1	149	151	PF00082	0.546
CLV_PCSK_KEX2_1	214	216	PF00082	0.630
CLV_PCSK_KEX2_1	236	238	PF00082	0.614
CLV_PCSK_KEX2_1	30	32	PF00082	0.506
CLV_PCSK_KEX2_1	523	525	PF00082	0.641
CLV_PCSK_KEX2_1	600	602	PF00082	0.661
CLV_PCSK_KEX2_1	741	743	PF00082	0.382
CLV_PCSK_KEX2_1	763	765	PF00082	0.439
CLV_PCSK_KEX2_1	819	821	PF00082	0.576
CLV_PCSK_KEX2_1	83	85	PF00082	0.587
CLV_PCSK_KEX2_1	901	903	PF00082	0.537
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.680
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.630
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.576
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.587
CLV_PCSK_SKI1_1	236	240	PF00082	0.743
CLV_PCSK_SKI1_1	249	253	PF00082	0.513
CLV_PCSK_SKI1_1	566	570	PF00082	0.605
CLV_PCSK_SKI1_1	600	604	PF00082	0.654
CLV_PCSK_SKI1_1	764	768	PF00082	0.380
DEG_APCC_DBOX_1	248	256	PF00400	0.640
DEG_SPOP_SBC_1	421	425	PF00917	0.626
DEG_SPOP_SBC_1	842	846	PF00917	0.549
DEG_SPOP_SBC_1	865	869	PF00917	0.632
DEG_SPOP_SBC_1	918	922	PF00917	0.661
DOC_CKS1_1	418	423	PF01111	0.574
DOC_CYCLIN_RxL_1	307	318	PF00134	0.435
DOC_CYCLIN_yClb3_PxF_3	884	890	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	550	556	PF00134	0.533
DOC_MAPK_gen_1	310	319	PF00069	0.430
DOC_MAPK_gen_1	574	584	PF00069	0.578
DOC_MAPK_gen_1	741	751	PF00069	0.346
DOC_PP1_RVXF_1	234	241	PF00149	0.548
DOC_PP2B_LxvP_1	587	590	PF13499	0.657
DOC_PP2B_PxIxI_1	500	506	PF00149	0.542
DOC_SPAK_OSR1_1	822	826	PF12202	0.446
DOC_USP7_MATH_1	115	119	PF00917	0.603
DOC_USP7_MATH_1	219	223	PF00917	0.614
DOC_USP7_MATH_1	298	302	PF00917	0.645
DOC_USP7_MATH_1	334	338	PF00917	0.520
DOC_USP7_MATH_1	398	402	PF00917	0.618
DOC_USP7_MATH_1	450	454	PF00917	0.512
DOC_USP7_MATH_1	515	519	PF00917	0.687
DOC_USP7_MATH_1	535	539	PF00917	0.474
DOC_USP7_MATH_1	546	550	PF00917	0.563
DOC_USP7_MATH_1	593	597	PF00917	0.626
DOC_USP7_MATH_1	609	613	PF00917	0.532
DOC_USP7_MATH_1	662	666	PF00917	0.690
DOC_USP7_MATH_1	842	846	PF00917	0.566
DOC_USP7_MATH_1	865	869	PF00917	0.760
DOC_USP7_MATH_1	871	875	PF00917	0.590
DOC_WW_Pin1_4	191	196	PF00397	0.549
DOC_WW_Pin1_4	417	422	PF00397	0.651
DOC_WW_Pin1_4	428	433	PF00397	0.650
DOC_WW_Pin1_4	46	51	PF00397	0.538
DOC_WW_Pin1_4	531	536	PF00397	0.633
DOC_WW_Pin1_4	566	571	PF00397	0.643
DOC_WW_Pin1_4	57	62	PF00397	0.590
DOC_WW_Pin1_4	643	648	PF00397	0.577
DOC_WW_Pin1_4	674	679	PF00397	0.689
DOC_WW_Pin1_4	706	711	PF00397	0.483
DOC_WW_Pin1_4	71	76	PF00397	0.571
DOC_WW_Pin1_4	859	864	PF00397	0.577
DOC_WW_Pin1_4	877	882	PF00397	0.585
DOC_WW_Pin1_4	919	924	PF00397	0.621
LIG_14-3-3_CanoR_1	237	246	PF00244	0.585
LIG_14-3-3_CanoR_1	290	298	PF00244	0.571
LIG_14-3-3_CanoR_1	313	318	PF00244	0.659
LIG_14-3-3_CanoR_1	329	334	PF00244	0.466
LIG_14-3-3_CanoR_1	400	408	PF00244	0.573
LIG_14-3-3_CanoR_1	441	446	PF00244	0.566
LIG_14-3-3_CanoR_1	524	528	PF00244	0.624
LIG_14-3-3_CanoR_1	601	609	PF00244	0.708
LIG_14-3-3_CanoR_1	641	647	PF00244	0.573
LIG_14-3-3_CanoR_1	685	693	PF00244	0.646
LIG_14-3-3_CanoR_1	820	826	PF00244	0.432
LIG_14-3-3_CanoR_1	84	90	PF00244	0.645
LIG_14-3-3_CanoR_1	917	923	PF00244	0.626
LIG_Actin_WH2_2	731	746	PF00022	0.369
LIG_BIR_III_2	514	518	PF00653	0.626
LIG_BIR_III_2	707	711	PF00653	0.477
LIG_BIR_III_4	854	858	PF00653	0.546
LIG_BRCT_BRCA1_1	221	225	PF00533	0.546
LIG_BRCT_BRCA1_1	714	718	PF00533	0.354
LIG_DLG_GKlike_1	441	448	PF00625	0.553
LIG_FHA_1	102	108	PF00498	0.604
LIG_FHA_1	150	156	PF00498	0.417
LIG_FHA_1	254	260	PF00498	0.687
LIG_FHA_1	3	9	PF00498	0.476
LIG_FHA_1	307	313	PF00498	0.525
LIG_FHA_1	392	398	PF00498	0.675
LIG_FHA_1	431	437	PF00498	0.630
LIG_FHA_1	61	67	PF00498	0.595
LIG_FHA_1	707	713	PF00498	0.419
LIG_FHA_1	781	787	PF00498	0.413
LIG_FHA_1	801	807	PF00498	0.404
LIG_FHA_2	11	17	PF00498	0.485
LIG_FHA_2	343	349	PF00498	0.541
LIG_FHA_2	379	385	PF00498	0.566
LIG_FHA_2	409	415	PF00498	0.643
LIG_FHA_2	450	456	PF00498	0.595
LIG_FHA_2	53	59	PF00498	0.504
LIG_FHA_2	612	618	PF00498	0.639
LIG_FHA_2	732	738	PF00498	0.446
LIG_FHA_2	867	873	PF00498	0.533
LIG_GBD_Chelix_1	831	839	PF00786	0.534
LIG_GBD_Chelix_1	89	97	PF00786	0.539
LIG_LIR_Gen_1	165	175	PF02991	0.426
LIG_LIR_Gen_1	369	376	PF02991	0.571
LIG_LIR_Gen_1	4	15	PF02991	0.594
LIG_LIR_Gen_1	628	637	PF02991	0.488
LIG_LIR_LC3C_4	63	68	PF02991	0.523
LIG_LIR_Nem_3	165	170	PF02991	0.428
LIG_LIR_Nem_3	26	32	PF02991	0.488
LIG_LIR_Nem_3	369	375	PF02991	0.489
LIG_LIR_Nem_3	4	10	PF02991	0.514
LIG_LIR_Nem_3	42	48	PF02991	0.597
LIG_LIR_Nem_3	628	632	PF02991	0.508
LIG_LIR_Nem_3	635	640	PF02991	0.460
LIG_Pex14_1	936	940	PF04695	0.573
LIG_Pex14_2	892	896	PF04695	0.529
LIG_SH2_CRK	25	29	PF00017	0.522
LIG_SH2_CRK	637	641	PF00017	0.470
LIG_SH2_CRK	714	718	PF00017	0.354
LIG_SH2_NCK_1	714	718	PF00017	0.354
LIG_SH2_PTP2	167	170	PF00017	0.377
LIG_SH2_SRC	838	841	PF00017	0.448
LIG_SH2_STAP1	25	29	PF00017	0.535
LIG_SH2_STAP1	714	718	PF00017	0.354
LIG_SH2_STAT5	144	147	PF00017	0.570
LIG_SH2_STAT5	167	170	PF00017	0.377
LIG_SH2_STAT5	22	25	PF00017	0.525
LIG_SH2_STAT5	43	46	PF00017	0.623
LIG_SH2_STAT5	629	632	PF00017	0.502
LIG_SH2_STAT5	639	642	PF00017	0.487
LIG_SH2_STAT5	838	841	PF00017	0.448
LIG_SH3_3	127	133	PF00018	0.620
LIG_SH3_3	266	272	PF00018	0.640
LIG_SH3_3	301	307	PF00018	0.563
LIG_SH3_3	335	341	PF00018	0.529
LIG_SH3_3	392	398	PF00018	0.650
LIG_SH3_3	603	609	PF00018	0.619
LIG_SH3_3	613	619	PF00018	0.614
LIG_SH3_3	669	675	PF00018	0.706
LIG_SH3_3	878	884	PF00018	0.617
LIG_SH3_3	900	906	PF00018	0.606
LIG_Sin3_3	357	364	PF02671	0.522
LIG_Sin3_3	64	71	PF02671	0.523
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.372
LIG_SUMO_SIM_par_1	173	179	PF11976	0.417
LIG_SUMO_SIM_par_1	393	399	PF11976	0.622
LIG_SUMO_SIM_par_1	482	487	PF11976	0.406
LIG_SUMO_SIM_par_1	49	55	PF11976	0.501
LIG_TRAF2_1	678	681	PF00917	0.635
LIG_TRAF2_1	695	698	PF00917	0.627
LIG_TYR_ITIM	712	717	PF00017	0.293
MOD_CDC14_SPxK_1	534	537	PF00782	0.613
MOD_CDK_SPxK_1	531	537	PF00069	0.608
MOD_CK1_1	293	299	PF00069	0.763
MOD_CK1_1	368	374	PF00069	0.633
MOD_CK1_1	399	405	PF00069	0.707
MOD_CK1_1	596	602	PF00069	0.619
MOD_CK1_1	643	649	PF00069	0.612
MOD_CK1_1	687	693	PF00069	0.683
MOD_CK1_1	844	850	PF00069	0.668
MOD_CK1_1	874	880	PF00069	0.636
MOD_CK2_1	10	16	PF00069	0.488
MOD_CK2_1	115	121	PF00069	0.513
MOD_CK2_1	171	177	PF00069	0.499
MOD_CK2_1	342	348	PF00069	0.551
MOD_CK2_1	408	414	PF00069	0.640
MOD_CK2_1	420	426	PF00069	0.558
MOD_CK2_1	611	617	PF00069	0.636
MOD_CK2_1	692	698	PF00069	0.653
MOD_CK2_1	700	706	PF00069	0.558
MOD_CK2_1	731	737	PF00069	0.450
MOD_CK2_1	85	91	PF00069	0.563
MOD_CK2_1	93	99	PF00069	0.520
MOD_GlcNHglycan	117	120	PF01048	0.626
MOD_GlcNHglycan	126	129	PF01048	0.586
MOD_GlcNHglycan	260	264	PF01048	0.599
MOD_GlcNHglycan	384	388	PF01048	0.720
MOD_GlcNHglycan	411	414	PF01048	0.655
MOD_GlcNHglycan	525	528	PF01048	0.682
MOD_GlcNHglycan	566	569	PF01048	0.643
MOD_GlcNHglycan	591	594	PF01048	0.657
MOD_GlcNHglycan	596	599	PF01048	0.614
MOD_GlcNHglycan	611	614	PF01048	0.500
MOD_GlcNHglycan	642	645	PF01048	0.560
MOD_GlcNHglycan	664	667	PF01048	0.629
MOD_GlcNHglycan	686	689	PF01048	0.621
MOD_GlcNHglycan	702	705	PF01048	0.542
MOD_GlcNHglycan	911	914	PF01048	0.566
MOD_GSK3_1	115	122	PF00069	0.697
MOD_GSK3_1	124	131	PF00069	0.580
MOD_GSK3_1	149	156	PF00069	0.458
MOD_GSK3_1	187	194	PF00069	0.599
MOD_GSK3_1	198	205	PF00069	0.683
MOD_GSK3_1	227	234	PF00069	0.515
MOD_GSK3_1	288	295	PF00069	0.802
MOD_GSK3_1	315	322	PF00069	0.650
MOD_GSK3_1	374	381	PF00069	0.567
MOD_GSK3_1	417	424	PF00069	0.637
MOD_GSK3_1	426	433	PF00069	0.592
MOD_GSK3_1	531	538	PF00069	0.647
MOD_GSK3_1	589	596	PF00069	0.631
MOD_GSK3_1	600	607	PF00069	0.569
MOD_GSK3_1	639	646	PF00069	0.563
MOD_GSK3_1	687	694	PF00069	0.782
MOD_GSK3_1	71	78	PF00069	0.655
MOD_GSK3_1	841	848	PF00069	0.592
MOD_GSK3_1	867	874	PF00069	0.650
MOD_GSK3_1	876	883	PF00069	0.546
MOD_GSK3_1	905	912	PF00069	0.622
MOD_GSK3_1	917	924	PF00069	0.577
MOD_N-GLC_1	153	158	PF02516	0.454
MOD_N-GLC_1	203	208	PF02516	0.696
MOD_N-GLC_1	409	414	PF02516	0.654
MOD_NEK2_1	10	15	PF00069	0.503
MOD_NEK2_1	231	236	PF00069	0.618
MOD_NEK2_1	238	243	PF00069	0.647
MOD_NEK2_1	273	278	PF00069	0.654
MOD_NEK2_1	408	413	PF00069	0.671
MOD_NEK2_1	541	546	PF00069	0.598
MOD_NEK2_1	640	645	PF00069	0.486
MOD_NEK2_1	712	717	PF00069	0.305
MOD_NEK2_1	77	82	PF00069	0.632
MOD_NEK2_1	830	835	PF00069	0.424
MOD_NEK2_1	876	881	PF00069	0.652
MOD_NEK2_1	93	98	PF00069	0.598
MOD_NEK2_2	144	149	PF00069	0.557
MOD_NEK2_2	203	208	PF00069	0.578
MOD_NEK2_2	227	232	PF00069	0.515
MOD_NEK2_2	821	826	PF00069	0.474
MOD_NEK2_2	896	901	PF00069	0.575
MOD_NMyristoyl	1	7	PF02799	0.535
MOD_OFUCOSY	151	157	PF10250	0.461
MOD_PIKK_1	198	204	PF00454	0.623
MOD_PIKK_1	75	81	PF00454	0.653
MOD_PIKK_1	780	786	PF00454	0.420
MOD_PIKK_1	921	927	PF00454	0.644
MOD_PKA_1	149	155	PF00069	0.475
MOD_PKA_1	523	529	PF00069	0.670
MOD_PKA_1	600	606	PF00069	0.650
MOD_PKA_1	85	91	PF00069	0.591
MOD_PKA_2	149	155	PF00069	0.438
MOD_PKA_2	253	259	PF00069	0.586
MOD_PKA_2	399	405	PF00069	0.645
MOD_PKA_2	523	529	PF00069	0.670
MOD_PKA_2	600	606	PF00069	0.719
MOD_PKA_2	609	615	PF00069	0.613
MOD_PKA_2	640	646	PF00069	0.503
MOD_PKA_2	660	666	PF00069	0.608
MOD_PKA_2	684	690	PF00069	0.661
MOD_PKA_2	821	827	PF00069	0.452
MOD_PKA_2	85	91	PF00069	0.670
MOD_PKB_1	288	296	PF00069	0.599
MOD_PKB_1	915	923	PF00069	0.590
MOD_Plk_1	203	209	PF00069	0.611
MOD_Plk_1	871	877	PF00069	0.571
MOD_Plk_4	171	177	PF00069	0.429
MOD_Plk_4	187	193	PF00069	0.547
MOD_Plk_4	315	321	PF00069	0.632
MOD_Plk_4	334	340	PF00069	0.496
MOD_Plk_4	371	377	PF00069	0.583
MOD_Plk_4	391	397	PF00069	0.481
MOD_Plk_4	441	447	PF00069	0.544
MOD_Plk_4	546	552	PF00069	0.608
MOD_Plk_4	712	718	PF00069	0.370
MOD_Plk_4	731	737	PF00069	0.418
MOD_Plk_4	782	788	PF00069	0.395
MOD_Plk_4	85	91	PF00069	0.591
MOD_ProDKin_1	191	197	PF00069	0.554
MOD_ProDKin_1	417	423	PF00069	0.651
MOD_ProDKin_1	428	434	PF00069	0.650
MOD_ProDKin_1	46	52	PF00069	0.541
MOD_ProDKin_1	531	537	PF00069	0.636
MOD_ProDKin_1	566	572	PF00069	0.645
MOD_ProDKin_1	57	63	PF00069	0.592
MOD_ProDKin_1	643	649	PF00069	0.584
MOD_ProDKin_1	674	680	PF00069	0.692
MOD_ProDKin_1	706	712	PF00069	0.467
MOD_ProDKin_1	71	77	PF00069	0.570
MOD_ProDKin_1	859	865	PF00069	0.577
MOD_ProDKin_1	877	883	PF00069	0.583
MOD_ProDKin_1	919	925	PF00069	0.623
TRG_DiLeu_BaEn_2	627	633	PF01217	0.506
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.586
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.594
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.432
TRG_ENDOCYTIC_2	167	170	PF00928	0.377
TRG_ENDOCYTIC_2	25	28	PF00928	0.530
TRG_ENDOCYTIC_2	29	32	PF00928	0.488
TRG_ENDOCYTIC_2	45	48	PF00928	0.408
TRG_ENDOCYTIC_2	629	632	PF00928	0.502
TRG_ENDOCYTIC_2	637	640	PF00928	0.461
TRG_ENDOCYTIC_2	714	717	PF00928	0.353
TRG_ENDOCYTIC_2	838	841	PF00928	0.448
TRG_ER_diArg_1	213	215	PF00400	0.767
TRG_ER_diArg_1	236	238	PF00400	0.553
TRG_ER_diArg_1	29	31	PF00400	0.495
TRG_ER_diArg_1	741	744	PF00400	0.384
TRG_ER_diArg_1	762	764	PF00400	0.434
TRG_ER_diArg_1	82	85	PF00400	0.588
TRG_ER_diArg_1	820	823	PF00400	0.563
TRG_ER_diArg_1	901	903	PF00400	0.537
TRG_ER_diArg_1	915	918	PF00400	0.602
TRG_NLS_MonoCore_2	81	86	PF00514	0.581
TRG_NLS_MonoExtC_3	81	86	PF00514	0.566
TRG_NLS_MonoExtN_4	283	289	PF00514	0.681
TRG_NLS_MonoExtN_4	82	87	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ4	Leptomonas seymouri	37%	100%
A0A3S7X1L5	Leishmania donovani	88%	100%
A4HGM8	Leishmania braziliensis	61%	100%
A4I3Q2	Leishmania infantum	88%	100%
E9AZZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%