Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania major

UniProt:

Q4Q889_LEIMA

TriTrypDb:

LmjF.28.1770 , LMJLV39_280025500 , LMJSD75_280025000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q889

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q889

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	64	66	PF00675	0.508
DEG_SCF_TRCP1_1	201	207	PF00400	0.668
DOC_CKS1_1	81	86	PF01111	0.678
DOC_PP2B_LxvP_1	177	180	PF13499	0.490
DOC_USP7_MATH_1	129	133	PF00917	0.589
DOC_USP7_MATH_1	161	165	PF00917	0.520
DOC_USP7_MATH_1	212	216	PF00917	0.652
DOC_USP7_MATH_2	84	90	PF00917	0.628
DOC_USP7_UBL2_3	62	66	PF12436	0.410
DOC_WW_Pin1_4	175	180	PF00397	0.652
DOC_WW_Pin1_4	236	241	PF00397	0.740
DOC_WW_Pin1_4	80	85	PF00397	0.647
DOC_WW_Pin1_4	96	101	PF00397	0.776
LIG_14-3-3_CanoR_1	45	54	PF00244	0.383
LIG_BRCT_BRCA1_1	201	205	PF00533	0.676
LIG_deltaCOP1_diTrp_1	201	209	PF00928	0.689
LIG_FHA_1	18	24	PF00498	0.233
LIG_FHA_1	245	251	PF00498	0.679
LIG_FHA_1	269	275	PF00498	0.674
LIG_FHA_1	279	285	PF00498	0.614
LIG_FHA_1	91	97	PF00498	0.807
LIG_FHA_2	240	246	PF00498	0.754
LIG_FHA_2	81	87	PF00498	0.592
LIG_LIR_Apic_2	123	129	PF02991	0.702
LIG_LIR_Apic_2	37	41	PF02991	0.397
LIG_LIR_Nem_3	155	160	PF02991	0.683
LIG_Pex14_2	205	209	PF04695	0.692
LIG_SH2_CRK	38	42	PF00017	0.369
LIG_SH2_NCK_1	169	173	PF00017	0.726
LIG_SH2_NCK_1	38	42	PF00017	0.397
LIG_SH2_STAP1	36	40	PF00017	0.410
LIG_SH2_STAP1	63	67	PF00017	0.484
LIG_SH3_3	213	219	PF00018	0.732
LIG_SH3_3	235	241	PF00018	0.622
LIG_TRAF2_1	138	141	PF00917	0.709
MOD_CK1_1	132	138	PF00069	0.717
MOD_CK1_1	178	184	PF00069	0.709
MOD_CK1_1	189	195	PF00069	0.632
MOD_CK1_1	236	242	PF00069	0.717
MOD_CK1_1	282	288	PF00069	0.683
MOD_CK1_1	90	96	PF00069	0.690
MOD_CK1_1	99	105	PF00069	0.493
MOD_CK2_1	258	264	PF00069	0.560
MOD_CK2_1	58	64	PF00069	0.441
MOD_CK2_1	80	86	PF00069	0.538
MOD_GlcNHglycan	157	160	PF01048	0.636
MOD_GlcNHglycan	163	166	PF01048	0.582
MOD_GlcNHglycan	196	199	PF01048	0.773
MOD_GlcNHglycan	201	204	PF01048	0.712
MOD_GlcNHglycan	220	223	PF01048	0.632
MOD_GlcNHglycan	225	228	PF01048	0.707
MOD_GlcNHglycan	235	238	PF01048	0.663
MOD_GlcNHglycan	254	257	PF01048	0.506
MOD_GlcNHglycan	42	45	PF01048	0.426
MOD_GlcNHglycan	90	93	PF01048	0.684
MOD_GSK3_1	128	135	PF00069	0.789
MOD_GSK3_1	136	143	PF00069	0.702
MOD_GSK3_1	144	151	PF00069	0.550
MOD_GSK3_1	155	162	PF00069	0.581
MOD_GSK3_1	254	261	PF00069	0.574
MOD_GSK3_1	264	271	PF00069	0.474
MOD_GSK3_1	278	285	PF00069	0.725
MOD_GSK3_1	3	10	PF00069	0.410
MOD_GSK3_1	40	47	PF00069	0.432
MOD_GSK3_1	86	93	PF00069	0.672
MOD_GSK3_1	95	102	PF00069	0.617
MOD_N-GLC_1	47	52	PF02516	0.383
MOD_NEK2_1	268	273	PF00069	0.640
MOD_NMyristoyl	1	7	PF02799	0.508
MOD_PIKK_1	112	118	PF00454	0.653
MOD_PIKK_1	136	142	PF00454	0.815
MOD_PIKK_1	204	210	PF00454	0.714
MOD_PK_1	7	13	PF00069	0.433
MOD_PKA_2	44	50	PF00069	0.374
MOD_Plk_1	17	23	PF00069	0.233
MOD_Plk_1	279	285	PF00069	0.528
MOD_Plk_4	17	23	PF00069	0.411
MOD_Plk_4	212	218	PF00069	0.795
MOD_Plk_4	264	270	PF00069	0.550
MOD_ProDKin_1	175	181	PF00069	0.655
MOD_ProDKin_1	236	242	PF00069	0.742
MOD_ProDKin_1	80	86	PF00069	0.663
MOD_ProDKin_1	96	102	PF00069	0.775
MOD_SUMO_rev_2	61	67	PF00179	0.508
TRG_DiLeu_BaEn_1	18	23	PF01217	0.383
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.410
TRG_ER_diArg_1	31	34	PF00400	0.410
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT1	Leptomonas seymouri	41%	74%
A0A3S7X1K9	Leishmania donovani	88%	100%
A4HGN0	Leishmania braziliensis	59%	97%
A4I3Q4	Leishmania infantum	89%	100%
E9AZZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%