DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase III, putative

Species:

Leishmania major

UniProt:

Q4Q888_LEIMA

TriTrypDb:

LmjF.28.1780 , LMJLV39_280025600 , LMJSD75_280025100

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q888

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q888

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	737	741	PF00656	0.421
CLV_NRD_NRD_1	129	131	PF00675	0.245
CLV_NRD_NRD_1	29	31	PF00675	0.287
CLV_NRD_NRD_1	805	807	PF00675	0.408
CLV_NRD_NRD_1	835	837	PF00675	0.541
CLV_PCSK_KEX2_1	129	131	PF00082	0.231
CLV_PCSK_KEX2_1	29	31	PF00082	0.231
CLV_PCSK_KEX2_1	835	837	PF00082	0.519
CLV_PCSK_SKI1_1	261	265	PF00082	0.314
CLV_PCSK_SKI1_1	272	276	PF00082	0.226
CLV_PCSK_SKI1_1	3	7	PF00082	0.274
CLV_PCSK_SKI1_1	416	420	PF00082	0.362
CLV_PCSK_SKI1_1	524	528	PF00082	0.400
CLV_PCSK_SKI1_1	585	589	PF00082	0.346
CLV_PCSK_SKI1_1	610	614	PF00082	0.352
CLV_PCSK_SKI1_1	620	624	PF00082	0.326
CLV_PCSK_SKI1_1	800	804	PF00082	0.530
DEG_APCC_DBOX_1	260	268	PF00400	0.400
DEG_APCC_DBOX_1	565	573	PF00400	0.352
DEG_SCF_FBW7_1	379	386	PF00400	0.400
DEG_SPOP_SBC_1	52	56	PF00917	0.431
DOC_ANK_TNKS_1	302	309	PF00023	0.292
DOC_CKS1_1	380	385	PF01111	0.259
DOC_MAPK_gen_1	269	279	PF00069	0.262
DOC_MAPK_gen_1	29	36	PF00069	0.423
DOC_MAPK_gen_1	416	426	PF00069	0.259
DOC_MAPK_gen_1	524	533	PF00069	0.352
DOC_MAPK_gen_1	585	593	PF00069	0.397
DOC_MAPK_HePTP_8	169	181	PF00069	0.274
DOC_MAPK_JIP1_4	527	533	PF00069	0.352
DOC_MAPK_MEF2A_6	172	181	PF00069	0.259
DOC_MAPK_MEF2A_6	272	281	PF00069	0.259
DOC_MAPK_MEF2A_6	419	426	PF00069	0.285
DOC_MAPK_MEF2A_6	527	535	PF00069	0.308
DOC_MAPK_MEF2A_6	540	548	PF00069	0.200
DOC_MAPK_MEF2A_6	763	770	PF00069	0.430
DOC_MAPK_NFAT4_5	172	180	PF00069	0.259
DOC_MAPK_RevD_3	792	807	PF00069	0.370
DOC_PP2B_LxvP_1	546	549	PF13499	0.259
DOC_PP4_FxxP_1	641	644	PF00568	0.383
DOC_PP4_FxxP_1	655	658	PF00568	0.258
DOC_PP4_FxxP_1	80	83	PF00568	0.431
DOC_PP4_FxxP_1	815	818	PF00568	0.349
DOC_USP7_MATH_1	236	240	PF00917	0.393
DOC_USP7_MATH_1	334	338	PF00917	0.218
DOC_USP7_MATH_1	383	387	PF00917	0.400
DOC_USP7_MATH_1	651	655	PF00917	0.365
DOC_WW_Pin1_4	207	212	PF00397	0.259
DOC_WW_Pin1_4	379	384	PF00397	0.259
DOC_WW_Pin1_4	385	390	PF00397	0.259
DOC_WW_Pin1_4	409	414	PF00397	0.259
DOC_WW_Pin1_4	43	48	PF00397	0.515
DOC_WW_Pin1_4	818	823	PF00397	0.413
LIG_14-3-3_CanoR_1	322	328	PF00244	0.400
LIG_14-3-3_CanoR_1	515	521	PF00244	0.400
LIG_Actin_WH2_2	162	180	PF00022	0.274
LIG_APCC_ABBAyCdc20_2	251	257	PF00400	0.259
LIG_BRCT_BRCA1_1	60	64	PF00533	0.445
LIG_BRCT_BRCA1_1	745	749	PF00533	0.385
LIG_Clathr_ClatBox_1	244	248	PF01394	0.295
LIG_deltaCOP1_diTrp_1	248	255	PF00928	0.259
LIG_deltaCOP1_diTrp_1	395	400	PF00928	0.344
LIG_FHA_1	104	110	PF00498	0.439
LIG_FHA_1	208	214	PF00498	0.268
LIG_FHA_1	29	35	PF00498	0.521
LIG_FHA_1	292	298	PF00498	0.259
LIG_FHA_1	357	363	PF00498	0.400
LIG_FHA_1	421	427	PF00498	0.285
LIG_FHA_1	54	60	PF00498	0.443
LIG_FHA_1	638	644	PF00498	0.323
LIG_FHA_1	654	660	PF00498	0.330
LIG_FHA_1	730	736	PF00498	0.344
LIG_FHA_1	79	85	PF00498	0.484
LIG_FHA_1	92	98	PF00498	0.399
LIG_FHA_2	145	151	PF00498	0.469
LIG_FHA_2	484	490	PF00498	0.272
LIG_FHA_2	72	78	PF00498	0.431
LIG_FHA_2	778	784	PF00498	0.432
LIG_FHA_2	83	89	PF00498	0.431
LIG_GBD_Chelix_1	14	22	PF00786	0.220
LIG_LIR_Apic_2	638	644	PF02991	0.323
LIG_LIR_Apic_2	653	658	PF02991	0.348
LIG_LIR_Apic_2	77	83	PF02991	0.431
LIG_LIR_Gen_1	149	158	PF02991	0.362
LIG_LIR_Gen_1	440	450	PF02991	0.285
LIG_LIR_Gen_1	514	525	PF02991	0.285
LIG_LIR_Gen_1	578	587	PF02991	0.385
LIG_LIR_Gen_1	592	602	PF02991	0.261
LIG_LIR_Gen_1	660	669	PF02991	0.294
LIG_LIR_Nem_3	149	155	PF02991	0.362
LIG_LIR_Nem_3	229	235	PF02991	0.289
LIG_LIR_Nem_3	352	357	PF02991	0.275
LIG_LIR_Nem_3	395	400	PF02991	0.263
LIG_LIR_Nem_3	440	446	PF02991	0.296
LIG_LIR_Nem_3	46	52	PF02991	0.513
LIG_LIR_Nem_3	514	520	PF02991	0.285
LIG_LIR_Nem_3	578	584	PF02991	0.314
LIG_LIR_Nem_3	592	597	PF02991	0.308
LIG_LIR_Nem_3	601	605	PF02991	0.324
LIG_LIR_Nem_3	660	665	PF02991	0.291
LIG_LYPXL_SIV_4	635	643	PF13949	0.367
LIG_MYND_1	818	822	PF01753	0.413
LIG_NRP_CendR_1	865	866	PF00754	0.620
LIG_PCNA_yPIPBox_3	266	277	PF02747	0.188
LIG_Pex14_2	139	143	PF04695	0.487
LIG_Pex14_2	580	584	PF04695	0.288
LIG_Pex14_2	60	64	PF04695	0.420
LIG_PTB_Apo_2	681	688	PF02174	0.332
LIG_REV1ctd_RIR_1	578	587	PF16727	0.304
LIG_SH2_CRK	517	521	PF00017	0.276
LIG_SH2_CRK	682	686	PF00017	0.336
LIG_SH2_NCK_1	682	686	PF00017	0.336
LIG_SH2_SRC	37	40	PF00017	0.413
LIG_SH2_STAP1	575	579	PF00017	0.322
LIG_SH2_STAT5	190	193	PF00017	0.274
LIG_SH2_STAT5	311	314	PF00017	0.319
LIG_SH2_STAT5	320	323	PF00017	0.267
LIG_SH2_STAT5	324	327	PF00017	0.259
LIG_SH2_STAT5	357	360	PF00017	0.259
LIG_SH2_STAT5	402	405	PF00017	0.259
LIG_SH2_STAT5	484	487	PF00017	0.259
LIG_SH2_STAT5	49	52	PF00017	0.460
LIG_SH2_STAT5	517	520	PF00017	0.274
LIG_SH2_STAT5	558	561	PF00017	0.259
LIG_SH2_STAT5	621	624	PF00017	0.324
LIG_SH2_STAT5	633	636	PF00017	0.318
LIG_SH2_STAT5	734	737	PF00017	0.341
LIG_SH2_STAT5	778	781	PF00017	0.387
LIG_SH3_1	673	679	PF00018	0.301
LIG_SH3_2	380	385	PF14604	0.259
LIG_SH3_3	377	383	PF00018	0.259
LIG_SH3_3	435	441	PF00018	0.274
LIG_SH3_3	522	528	PF00018	0.318
LIG_SH3_3	673	679	PF00018	0.301
LIG_SUMO_SIM_anti_2	294	299	PF11976	0.259
LIG_SUMO_SIM_par_1	4	10	PF11976	0.271
LIG_TRAF2_1	147	150	PF00917	0.369
LIG_TRAF2_1	74	77	PF00917	0.440
LIG_TRAF2_1	780	783	PF00917	0.375
LIG_UBA3_1	263	272	PF00899	0.343
LIG_UBA3_1	430	436	PF00899	0.460
LIG_UBA3_1	490	496	PF00899	0.259
LIG_UBA3_1	535	540	PF00899	0.293
LIG_WRC_WIRS_1	652	657	PF05994	0.379
LIG_WW_1	481	484	PF00397	0.293
MOD_CDK_SPxK_1	379	385	PF00069	0.259
MOD_CDK_SPxxK_3	409	416	PF00069	0.259
MOD_CK1_1	144	150	PF00069	0.460
MOD_CK1_1	17	23	PF00069	0.542
MOD_CK1_1	201	207	PF00069	0.308
MOD_CK1_1	28	34	PF00069	0.502
MOD_CK1_1	282	288	PF00069	0.325
MOD_CK1_1	483	489	PF00069	0.394
MOD_CK1_1	504	510	PF00069	0.386
MOD_CK1_1	603	609	PF00069	0.360
MOD_CK1_1	653	659	PF00069	0.443
MOD_CK1_1	729	735	PF00069	0.337
MOD_CK2_1	10	16	PF00069	0.420
MOD_CK2_1	144	150	PF00069	0.471
MOD_CK2_1	311	317	PF00069	0.400
MOD_CK2_1	385	391	PF00069	0.318
MOD_CK2_1	550	556	PF00069	0.259
MOD_CK2_1	71	77	PF00069	0.449
MOD_CK2_1	777	783	PF00069	0.365
MOD_DYRK1A_RPxSP_1	385	389	PF00069	0.400
MOD_GlcNHglycan	143	146	PF01048	0.220
MOD_GlcNHglycan	385	388	PF01048	0.298
MOD_GlcNHglycan	391	395	PF01048	0.249
MOD_GlcNHglycan	433	436	PF01048	0.331
MOD_GlcNHglycan	602	605	PF01048	0.350
MOD_GlcNHglycan	88	92	PF01048	0.246
MOD_GSK3_1	10	17	PF00069	0.426
MOD_GSK3_1	163	170	PF00069	0.268
MOD_GSK3_1	181	188	PF00069	0.263
MOD_GSK3_1	287	294	PF00069	0.285
MOD_GSK3_1	323	330	PF00069	0.270
MOD_GSK3_1	379	386	PF00069	0.400
MOD_GSK3_1	463	470	PF00069	0.448
MOD_GSK3_1	476	483	PF00069	0.323
MOD_GSK3_1	58	65	PF00069	0.461
MOD_GSK3_1	705	712	PF00069	0.551
MOD_GSK3_1	722	729	PF00069	0.376
MOD_GSK3_1	739	746	PF00069	0.386
MOD_GSK3_1	778	785	PF00069	0.282
MOD_GSK3_1	78	85	PF00069	0.474
MOD_GSK3_1	87	94	PF00069	0.501
MOD_N-GLC_1	163	168	PF02516	0.272
MOD_N-GLC_1	23	28	PF02516	0.309
MOD_N-GLC_1	277	282	PF02516	0.344
MOD_N-GLC_1	349	354	PF02516	0.292
MOD_N-GLC_2	119	121	PF02516	0.220
MOD_N-GLC_2	762	764	PF02516	0.353
MOD_NEK2_1	14	19	PF00069	0.503
MOD_NEK2_1	198	203	PF00069	0.308
MOD_NEK2_1	255	260	PF00069	0.379
MOD_NEK2_1	341	346	PF00069	0.410
MOD_NEK2_1	407	412	PF00069	0.262
MOD_NEK2_1	417	422	PF00069	0.297
MOD_NEK2_1	431	436	PF00069	0.323
MOD_NEK2_1	50	55	PF00069	0.428
MOD_NEK2_1	550	555	PF00069	0.274
MOD_NEK2_1	598	603	PF00069	0.329
MOD_OFUCOSY	721	726	PF10250	0.347
MOD_OFUCOSY	736	743	PF10250	0.348
MOD_PIKK_1	476	482	PF00454	0.259
MOD_PIKK_1	63	69	PF00454	0.529
MOD_PKA_2	265	271	PF00069	0.400
MOD_PKA_2	28	34	PF00069	0.521
MOD_PKA_2	287	293	PF00069	0.259
MOD_Plk_1	198	204	PF00069	0.274
MOD_Plk_1	255	261	PF00069	0.400
MOD_Plk_1	277	283	PF00069	0.293
MOD_Plk_1	330	336	PF00069	0.259
MOD_Plk_1	349	355	PF00069	0.259
MOD_Plk_1	501	507	PF00069	0.259
MOD_Plk_1	637	643	PF00069	0.329
MOD_Plk_1	726	732	PF00069	0.474
MOD_Plk_2-3	10	16	PF00069	0.420
MOD_Plk_4	103	109	PF00069	0.431
MOD_Plk_4	17	23	PF00069	0.481
MOD_Plk_4	198	204	PF00069	0.302
MOD_Plk_4	272	278	PF00069	0.266
MOD_Plk_4	349	355	PF00069	0.279
MOD_Plk_4	357	363	PF00069	0.257
MOD_Plk_4	480	486	PF00069	0.400
MOD_Plk_4	798	804	PF00069	0.524
MOD_ProDKin_1	207	213	PF00069	0.259
MOD_ProDKin_1	379	385	PF00069	0.259
MOD_ProDKin_1	409	415	PF00069	0.259
MOD_ProDKin_1	43	49	PF00069	0.515
MOD_ProDKin_1	818	824	PF00069	0.410
MOD_SUMO_for_1	226	229	PF00179	0.259
MOD_SUMO_rev_2	174	179	PF00179	0.264
MOD_SUMO_rev_2	793	802	PF00179	0.349
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.274
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.344
TRG_ENDOCYTIC_2	195	198	PF00928	0.259
TRG_ENDOCYTIC_2	49	52	PF00928	0.459
TRG_ENDOCYTIC_2	517	520	PF00928	0.276
TRG_ENDOCYTIC_2	636	639	PF00928	0.367
TRG_ENDOCYTIC_2	652	655	PF00928	0.374
TRG_ER_diArg_1	128	130	PF00400	0.469
TRG_ER_diArg_1	251	254	PF00400	0.259
TRG_ER_diArg_1	286	289	PF00400	0.274
TRG_ER_diArg_1	29	32	PF00400	0.490
TRG_ER_diArg_1	551	554	PF00400	0.405
TRG_ER_diArg_1	827	830	PF00400	0.404
TRG_ER_diArg_1	834	836	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0L0P6P7	Candida auris	34%	100%
A0A0N1I0P1	Leptomonas seymouri	87%	100%
A0A0N1PAL1	Leptomonas seymouri	31%	90%
A0A0S4J933	Bodo saltans	68%	99%
A0A0S4JI21	Bodo saltans	31%	89%
A0A1X0NSK9	Trypanosomatidae	74%	100%
A0A1X0P3I0	Trypanosomatidae	32%	93%
A0A3R7KDV1	Trypanosoma rangeli	33%	94%
A0A3S7WW83	Leishmania donovani	23%	100%
A0A3S7X1K1	Leishmania donovani	98%	100%
A0A3S7XB89	Leishmania donovani	32%	91%
A0A422NYW0	Trypanosoma rangeli	72%	100%
A0R5D9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	93%
A4HGN1	Leishmania braziliensis	92%	100%
A4HPI6	Leishmania braziliensis	32%	91%
A4HZ99	Leishmania infantum	23%	100%
A4I3Q5	Leishmania infantum	98%	100%
A4IDA8	Leishmania infantum	32%	91%
C7J0A2	Oryza sativa subsp. japonica	35%	93%
D0A8A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
D0A8E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	94%
E9AT98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	91%
E9AUX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
F4ISQ7	Arabidopsis thaliana	48%	100%
O27661	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	27%	100%
O28469	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O34204	Fervidobacterium islandicum	23%	100%
O51934	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	22%	78%
O58356	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	25%	100%
O60126	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
O61660	Caenorhabditis elegans	36%	100%
O67037	Aquifex aeolicus (strain VF5)	24%	76%
O69548	Mycobacterium leprae (strain TN)	26%	91%
O70157	Mus musculus	36%	86%
O95985	Homo sapiens	48%	100%
O96651	Drosophila melanogaster	45%	99%
P0A621	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	25%	93%
P0C2W6	Staphylococcus aureus (strain bovine RF122 / ET3-1)	24%	100%
P13099	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P14294	Escherichia coli (strain K12)	24%	100%
P34185	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	24%	98%
P40687	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	23%	100%
P43704	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P46799	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	23%	100%
P47368	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	22%	100%
P78032	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	24%	100%
P9WG48	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	93%
P9WG49	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	93%
Q08582	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	22%	69%
Q0J0S6	Oryza sativa subsp. japonica	47%	100%
Q13472	Homo sapiens	35%	87%
Q2FEN5	Staphylococcus aureus (strain USA300)	24%	100%
Q2FW03	Staphylococcus aureus (strain NCTC 8325 / PS 47)	24%	100%
Q49ZH2	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	22%	100%
Q4L8B8	Staphylococcus haemolyticus (strain JCSC1435)	23%	100%
Q4Q199	Leishmania major	33%	100%
Q4QCK3	Leishmania major	23%	100%
Q59046	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q5HDV4	Staphylococcus aureus (strain COL)	24%	100%
Q5HLZ4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	22%	100%
Q5HPU2	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	25%	100%
Q5WAX6	Alkalihalobacillus clausii (strain KSM-K16)	23%	100%
Q6G767	Staphylococcus aureus (strain MSSA476)	24%	100%
Q6GEH9	Staphylococcus aureus (strain MRSA252)	23%	100%
Q7A075	Staphylococcus aureus (strain MW2)	24%	100%
Q7A455	Staphylococcus aureus (strain N315)	24%	100%
Q8CRF7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	22%	100%
Q8CSU3	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	100%
Q8T2T7	Dictyostelium discoideum	36%	100%
Q8Z6F5	Salmonella typhi	23%	100%
Q8ZXT5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	23%	71%
Q99S17	Staphylococcus aureus (strain Mu50 / ATCC 700699)	24%	100%
Q9CP53	Pasteurella multocida (strain Pm70)	23%	100%
Q9HM08	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	29%	100%
Q9KA23	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	24%	100%
Q9KQF5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	22%	100%
Q9LVP1	Arabidopsis thaliana	36%	94%
Q9NG98	Drosophila melanogaster	36%	69%
Q9PHK2	Xylella fastidiosa (strain 9a5c)	23%	100%
Q9UYS8	Pyrococcus abyssi (strain GE5 / Orsay)	26%	100%
Q9UZ86	Pyrococcus abyssi (strain GE5 / Orsay)	22%	71%
Q9YB01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	26%	100%
Q9Z321	Mus musculus	48%	100%
V5AV88	Trypanosoma cruzi	73%	100%