ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase-like protein

Gene product:

ATPase-like protein

Species:

Leishmania major

UniProt:

Q4Q887_LEIMA

TriTrypDb:

LmjF.28.1790 , LMJLV39_280025700 , LMJSD75_280025200

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005694	chromosome	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q887

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q887

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0007131	reciprocal meiotic recombination	3	2
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	7
GO:0010564	regulation of cell cycle process	5	2
GO:0010639	negative regulation of organelle organization	6	2
GO:0010948	negative regulation of cell cycle process	6	2
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	7
GO:0033043	regulation of organelle organization	5	2
GO:0033313	meiotic cell cycle checkpoint signaling	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035556	intracellular signal transduction	3	2
GO:0035825	homologous recombination	6	2
GO:0040020	regulation of meiotic nuclear division	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0045786	negative regulation of cell cycle	5	2
GO:0045835	negative regulation of meiotic nuclear division	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051129	negative regulation of cellular component organization	5	2
GO:0051445	regulation of meiotic cell cycle	4	2
GO:0051447	negative regulation of meiotic cell cycle	5	2
GO:0051598	meiotic recombination checkpoint signaling	4	2
GO:0051726	regulation of cell cycle	4	2
GO:0051783	regulation of nuclear division	6	2
GO:0051784	negative regulation of nuclear division	7	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0140527	reciprocal homologous recombination	7	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901988	negative regulation of cell cycle phase transition	7	2
GO:1903046	meiotic cell cycle process	2	2
GO:2000241	regulation of reproductive process	3	2
GO:2000242	negative regulation of reproductive process	4	2
GO:0007049	cell cycle	2	5
GO:0051321	meiotic cell cycle	2	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.574
CLV_C14_Caspase3-7	437	441	PF00656	0.449
CLV_C14_Caspase3-7	69	73	PF00656	0.448
CLV_NRD_NRD_1	52	54	PF00675	0.365
CLV_PCSK_KEX2_1	186	188	PF00082	0.345
CLV_PCSK_KEX2_1	268	270	PF00082	0.356
CLV_PCSK_KEX2_1	356	358	PF00082	0.275
CLV_PCSK_KEX2_1	382	384	PF00082	0.460
CLV_PCSK_KEX2_1	52	54	PF00082	0.365
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.345
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.356
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.275
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.409
CLV_PCSK_SKI1_1	213	217	PF00082	0.275
CLV_PCSK_SKI1_1	268	272	PF00082	0.275
CLV_PCSK_SKI1_1	515	519	PF00082	0.352
CLV_PCSK_SKI1_1	587	591	PF00082	0.495
DEG_APCC_DBOX_1	246	254	PF00400	0.275
DEG_APCC_DBOX_1	558	566	PF00400	0.546
DEG_SPOP_SBC_1	468	472	PF00917	0.629
DEG_SPOP_SBC_1	5	9	PF00917	0.583
DOC_CDC14_PxL_1	517	525	PF14671	0.336
DOC_CDC14_PxL_1	70	78	PF14671	0.382
DOC_CYCLIN_RxL_1	365	375	PF00134	0.348
DOC_MAPK_MEF2A_6	19	26	PF00069	0.355
DOC_PP1_RVXF_1	211	218	PF00149	0.325
DOC_PP2B_LxvP_1	117	120	PF13499	0.478
DOC_PP4_FxxP_1	217	220	PF00568	0.275
DOC_PP4_FxxP_1	459	462	PF00568	0.551
DOC_USP7_MATH_1	120	124	PF00917	0.706
DOC_USP7_MATH_1	130	134	PF00917	0.392
DOC_USP7_MATH_1	162	166	PF00917	0.332
DOC_USP7_MATH_1	301	305	PF00917	0.292
DOC_USP7_MATH_1	311	315	PF00917	0.324
DOC_USP7_MATH_1	390	394	PF00917	0.549
DOC_USP7_MATH_1	423	427	PF00917	0.580
DOC_USP7_MATH_1	5	9	PF00917	0.675
DOC_USP7_MATH_2	12	18	PF00917	0.535
DOC_WW_Pin1_4	156	161	PF00397	0.367
DOC_WW_Pin1_4	202	207	PF00397	0.358
DOC_WW_Pin1_4	483	488	PF00397	0.729
DOC_WW_Pin1_4	6	11	PF00397	0.684
LIG_14-3-3_CanoR_1	118	128	PF00244	0.542
LIG_14-3-3_CanoR_1	239	245	PF00244	0.356
LIG_14-3-3_CanoR_1	261	270	PF00244	0.294
LIG_14-3-3_CanoR_1	27	35	PF00244	0.455
LIG_14-3-3_CanoR_1	4	10	PF00244	0.657
LIG_BIR_III_2	72	76	PF00653	0.463
LIG_BRCT_BRCA1_1	181	185	PF00533	0.339
LIG_BRCT_BRCA1_1	204	208	PF00533	0.410
LIG_BRCT_BRCA1_1	259	263	PF00533	0.275
LIG_BRCT_BRCA1_1	455	459	PF00533	0.517
LIG_BRCT_BRCA1_2	455	461	PF00533	0.528
LIG_Clathr_ClatBox_1	21	25	PF01394	0.331
LIG_EH1_1	495	503	PF00400	0.371
LIG_eIF4E_1	245	251	PF01652	0.275
LIG_eIF4E_1	496	502	PF01652	0.362
LIG_FHA_1	16	22	PF00498	0.498
LIG_FHA_1	337	343	PF00498	0.291
LIG_FHA_1	390	396	PF00498	0.584
LIG_FHA_1	65	71	PF00498	0.420
LIG_FHA_2	26	32	PF00498	0.421
LIG_FHA_2	321	327	PF00498	0.275
LIG_FHA_2	442	448	PF00498	0.520
LIG_FHA_2	495	501	PF00498	0.388
LIG_FHA_2	96	102	PF00498	0.359
LIG_GBD_Chelix_1	232	240	PF00786	0.356
LIG_GBD_Chelix_1	317	325	PF00786	0.306
LIG_Integrin_isoDGR_2	513	515	PF01839	0.355
LIG_LIR_Apic_2	456	462	PF02991	0.537
LIG_LIR_Gen_1	167	175	PF02991	0.344
LIG_LIR_Gen_1	17	26	PF02991	0.369
LIG_LIR_Gen_1	210	217	PF02991	0.312
LIG_LIR_Gen_1	44	50	PF02991	0.412
LIG_LIR_Gen_1	96	105	PF02991	0.364
LIG_LIR_LC3C_4	18	23	PF02991	0.393
LIG_LIR_Nem_3	167	173	PF02991	0.360
LIG_LIR_Nem_3	17	23	PF02991	0.406
LIG_LIR_Nem_3	210	214	PF02991	0.325
LIG_LIR_Nem_3	32	38	PF02991	0.372
LIG_LIR_Nem_3	44	48	PF02991	0.359
LIG_NRBOX	561	567	PF00104	0.276
LIG_Pex14_1	170	174	PF04695	0.323
LIG_Pex14_2	259	263	PF04695	0.275
LIG_SH2_CRK	373	377	PF00017	0.487
LIG_SH2_NCK_1	373	377	PF00017	0.458
LIG_SH2_PTP2	359	362	PF00017	0.254
LIG_SH2_PTP2	45	48	PF00017	0.328
LIG_SH2_SRC	561	564	PF00017	0.427
LIG_SH2_STAT5	192	195	PF00017	0.363
LIG_SH2_STAT5	20	23	PF00017	0.412
LIG_SH2_STAT5	359	362	PF00017	0.254
LIG_SH2_STAT5	45	48	PF00017	0.328
LIG_SH2_STAT5	496	499	PF00017	0.366
LIG_SH2_STAT5	561	564	PF00017	0.427
LIG_SH3_3	357	363	PF00018	0.356
LIG_SH3_3	382	388	PF00018	0.399
LIG_SH3_3	473	479	PF00018	0.647
LIG_SH3_3	481	487	PF00018	0.579
LIG_SH3_3	549	555	PF00018	0.511
LIG_SH3_3	58	64	PF00018	0.373
LIG_SH3_3	7	13	PF00018	0.638
LIG_SH3_3	86	92	PF00018	0.336
LIG_SH3_4	461	468	PF00018	0.589
LIG_SH3_5	557	561	PF00018	0.453
LIG_SUMO_SIM_anti_2	332	340	PF11976	0.312
LIG_SUMO_SIM_par_1	20	25	PF11976	0.386
LIG_SUMO_SIM_par_1	332	340	PF11976	0.276
LIG_SUMO_SIM_par_1	66	72	PF11976	0.448
LIG_TRAF2_1	375	378	PF00917	0.316
LIG_TRAF2_1	568	571	PF00917	0.326
LIG_TYR_ITSM	16	23	PF00017	0.439
MOD_CK1_1	123	129	PF00069	0.569
MOD_CK1_1	142	148	PF00069	0.601
MOD_CK1_1	152	158	PF00069	0.433
MOD_CK1_1	257	263	PF00069	0.291
MOD_CK1_1	426	432	PF00069	0.547
MOD_CK1_1	472	478	PF00069	0.670
MOD_CK1_1	6	12	PF00069	0.613
MOD_CK1_1	90	96	PF00069	0.378
MOD_CK2_1	372	378	PF00069	0.365
MOD_CK2_1	441	447	PF00069	0.519
MOD_CK2_1	494	500	PF00069	0.412
MOD_CK2_1	95	101	PF00069	0.357
MOD_Cter_Amidation	266	269	PF01082	0.356
MOD_GlcNHglycan	122	125	PF01048	0.723
MOD_GlcNHglycan	144	147	PF01048	0.588
MOD_GlcNHglycan	151	154	PF01048	0.526
MOD_GlcNHglycan	265	268	PF01048	0.297
MOD_GlcNHglycan	303	306	PF01048	0.299
MOD_GlcNHglycan	491	494	PF01048	0.692
MOD_GlcNHglycan	533	536	PF01048	0.533
MOD_GlcNHglycan	541	544	PF01048	0.698
MOD_GlcNHglycan	547	551	PF01048	0.546
MOD_GlcNHglycan	581	584	PF01048	0.573
MOD_GSK3_1	119	126	PF00069	0.621
MOD_GSK3_1	152	159	PF00069	0.509
MOD_GSK3_1	175	182	PF00069	0.468
MOD_GSK3_1	188	195	PF00069	0.258
MOD_GSK3_1	220	227	PF00069	0.237
MOD_GSK3_1	25	32	PF00069	0.353
MOD_GSK3_1	257	264	PF00069	0.275
MOD_GSK3_1	336	343	PF00069	0.280
MOD_GSK3_1	468	475	PF00069	0.707
MOD_GSK3_1	485	492	PF00069	0.531
MOD_GSK3_1	579	586	PF00069	0.414
MOD_N-GLC_1	340	345	PF02516	0.275
MOD_NEK2_1	197	202	PF00069	0.387
MOD_NEK2_1	240	245	PF00069	0.275
MOD_NEK2_1	263	268	PF00069	0.275
MOD_NEK2_1	337	342	PF00069	0.284
MOD_NEK2_1	372	377	PF00069	0.359
MOD_NEK2_1	41	46	PF00069	0.324
MOD_NEK2_1	491	496	PF00069	0.567
MOD_NEK2_1	529	534	PF00069	0.464
MOD_NEK2_2	311	316	PF00069	0.304
MOD_PIKK_1	320	326	PF00454	0.275
MOD_PIKK_1	581	587	PF00454	0.435
MOD_PKA_2	197	203	PF00069	0.391
MOD_PKA_2	26	32	PF00069	0.416
MOD_PKA_2	3	9	PF00069	0.662
MOD_PKA_2	301	307	PF00069	0.295
MOD_Plk_1	15	21	PF00069	0.478
MOD_Plk_1	36	42	PF00069	0.347
MOD_Plk_1	447	453	PF00069	0.616
MOD_Plk_1	87	93	PF00069	0.354
MOD_Plk_2-3	188	194	PF00069	0.325
MOD_Plk_4	169	175	PF00069	0.329
MOD_Plk_4	188	194	PF00069	0.462
MOD_Plk_4	240	246	PF00069	0.356
MOD_Plk_4	254	260	PF00069	0.275
MOD_Plk_4	390	396	PF00069	0.559
MOD_ProDKin_1	156	162	PF00069	0.361
MOD_ProDKin_1	202	208	PF00069	0.361
MOD_ProDKin_1	483	489	PF00069	0.728
MOD_ProDKin_1	6	12	PF00069	0.676
TRG_DiLeu_BaEn_1	37	42	PF01217	0.414
TRG_DiLeu_BaEn_4	447	453	PF01217	0.538
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.462
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.453
TRG_ENDOCYTIC_2	20	23	PF00928	0.437
TRG_ENDOCYTIC_2	373	376	PF00928	0.486
TRG_ENDOCYTIC_2	45	48	PF00928	0.347
TRG_ER_diArg_1	52	54	PF00400	0.397
TRG_NES_CRM1_1	37	49	PF08389	0.408
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P830	Leptomonas seymouri	54%	100%
A0A3Q8IEP0	Leishmania donovani	94%	100%
A4HGN2	Leishmania braziliensis	82%	100%
E9AHG7	Leishmania infantum	93%	100%
E9AZZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q7XK25	Oryza sativa subsp. japonica	40%	100%