Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania major

UniProt:

Q4Q885_LEIMA

TriTrypDb:

LmjF.28.1810 , LMJLV39_280025900 , LMJSD75_280025400

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q885

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q885

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0009895	negative regulation of catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016553	base conversion or substitution editing	6	2
GO:0016554	cytidine to uridine editing	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031330	negative regulation of cellular catabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0043489	RNA stabilization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048255	mRNA stabilization	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1902369	negative regulation of RNA catabolic process	7	2
GO:1902373	negative regulation of mRNA catabolic process	7	2
GO:1903311	regulation of mRNA metabolic process	6	2
GO:1903312	negative regulation of mRNA metabolic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.484
CLV_NRD_NRD_1	28	30	PF00675	0.506
CLV_PCSK_KEX2_1	28	30	PF00082	0.506
CLV_PCSK_SKI1_1	17	21	PF00082	0.449
DEG_Nend_UBRbox_1	1	4	PF02207	0.451
DOC_CKS1_1	51	56	PF01111	0.626
DOC_USP7_MATH_1	104	108	PF00917	0.484
DOC_USP7_MATH_1	11	15	PF00917	0.608
DOC_USP7_MATH_1	18	22	PF00917	0.536
DOC_USP7_MATH_1	60	64	PF00917	0.703
DOC_USP7_MATH_1	67	71	PF00917	0.577
DOC_USP7_MATH_1	86	90	PF00917	0.507
DOC_USP7_UBL2_3	133	137	PF12436	0.434
DOC_WW_Pin1_4	50	55	PF00397	0.712
LIG_14-3-3_CanoR_1	17	25	PF00244	0.716
LIG_FHA_2	7	13	PF00498	0.484
LIG_LIR_Gen_1	100	108	PF02991	0.489
LIG_LIR_Nem_3	100	105	PF02991	0.426
LIG_Pex14_2	131	135	PF04695	0.340
LIG_SH2_STAT5	130	133	PF00017	0.339
LIG_SH2_STAT5	31	34	PF00017	0.560
LIG_SH3_3	53	59	PF00018	0.657
LIG_TRFH_1	30	34	PF08558	0.494
MOD_CK1_1	63	69	PF00069	0.611
MOD_CK2_1	104	110	PF00069	0.524
MOD_GlcNHglycan	12	16	PF01048	0.694
MOD_GlcNHglycan	63	66	PF01048	0.594
MOD_GlcNHglycan	71	74	PF01048	0.442
MOD_GlcNHglycan	88	91	PF01048	0.581
MOD_GSK3_1	63	70	PF00069	0.564
MOD_N-GLC_1	67	72	PF02516	0.576
MOD_NEK2_2	18	23	PF00069	0.476
MOD_Plk_4	119	125	PF00069	0.437
MOD_ProDKin_1	50	56	PF00069	0.709
MOD_SUMO_rev_2	111	121	PF00179	0.402
TRG_ER_diArg_1	28	30	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM51	Leptomonas seymouri	59%	80%
A0A0S4JEB4	Bodo saltans	47%	83%
A0A3Q8ID67	Leishmania donovani	92%	81%
A0A3R7M7X7	Trypanosoma rangeli	51%	72%
A4HGN4	Leishmania braziliensis	79%	99%
A4I3Q7	Leishmania infantum	92%	100%
E9B000	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%