DNA repair protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein-like protein

Species:

Leishmania major

UniProt:

Q4Q883_LEIMA

TriTrypDb:

LmjF.28.1830 , LMJLV39_280026100 , LMJSD75_280025600

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Previous1Next

Expansion

Sequence features

Q4Q883

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q883

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008094	ATP-dependent activity, acting on DNA	2	8
GO:0016491	oxidoreductase activity	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.464
CLV_NRD_NRD_1	254	256	PF00675	0.238
CLV_NRD_NRD_1	334	336	PF00675	0.293
CLV_NRD_NRD_1	442	444	PF00675	0.239
CLV_NRD_NRD_1	531	533	PF00675	0.537
CLV_NRD_NRD_1	591	593	PF00675	0.490
CLV_NRD_NRD_1	651	653	PF00675	0.335
CLV_NRD_NRD_1	862	864	PF00675	0.458
CLV_PCSK_KEX2_1	256	258	PF00082	0.280
CLV_PCSK_KEX2_1	334	336	PF00082	0.293

Previous1 2 3 4 5…30Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFY0	Leptomonas seymouri	67%	74%
A0A0S4IS76	Bodo saltans	40%	83%
A0A3S7X1L6	Leishmania donovani	93%	73%
A4HGN6	Leishmania braziliensis	80%	72%
A4I3Q9	Leishmania infantum	93%	73%
D0A899	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9B002	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O13762	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O60177	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	89%
P0CQ66	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	77%

Previous1 2 3Next