Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania major

UniProt:

Q4Q881_LEIMA

TriTrypDb:

LmjF.28.1850 , LMJLV39_280026300 , LMJSD75_280025800

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	7
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q881

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q881

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.572
CLV_C14_Caspase3-7	27	31	PF00656	0.539
CLV_C14_Caspase3-7	55	59	PF00656	0.471
CLV_NRD_NRD_1	190	192	PF00675	0.557
CLV_NRD_NRD_1	208	210	PF00675	0.461
CLV_NRD_NRD_1	22	24	PF00675	0.592
CLV_NRD_NRD_1	323	325	PF00675	0.700
CLV_NRD_NRD_1	381	383	PF00675	0.813
CLV_NRD_NRD_1	70	72	PF00675	0.518
CLV_PCSK_KEX2_1	208	210	PF00082	0.576
CLV_PCSK_KEX2_1	22	24	PF00082	0.657
CLV_PCSK_KEX2_1	323	325	PF00082	0.700
CLV_PCSK_KEX2_1	381	383	PF00082	0.702
CLV_PCSK_KEX2_1	72	74	PF00082	0.493
CLV_PCSK_KEX2_1	778	780	PF00082	0.501
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.493
CLV_PCSK_PC1ET2_1	778	780	PF00082	0.602
CLV_PCSK_SKI1_1	170	174	PF00082	0.549
CLV_PCSK_SKI1_1	448	452	PF00082	0.532
CLV_PCSK_SKI1_1	475	479	PF00082	0.513
CLV_PCSK_SKI1_1	515	519	PF00082	0.404
CLV_PCSK_SKI1_1	569	573	PF00082	0.411
CLV_PCSK_SKI1_1	692	696	PF00082	0.411
CLV_PCSK_SKI1_1	702	706	PF00082	0.411
CLV_PCSK_SKI1_1	778	782	PF00082	0.615
DEG_APCC_DBOX_1	207	215	PF00400	0.550
DEG_SCF_FBW7_1	305	312	PF00400	0.707
DEG_SPOP_SBC_1	589	593	PF00917	0.342
DOC_ANK_TNKS_1	494	501	PF00023	0.411
DOC_CYCLIN_RxL_1	699	706	PF00134	0.411
DOC_MAPK_FxFP_2	365	368	PF00069	0.713
DOC_MAPK_gen_1	189	199	PF00069	0.647
DOC_MAPK_gen_1	227	235	PF00069	0.578
DOC_MAPK_gen_1	32	41	PF00069	0.462
DOC_MAPK_gen_1	666	675	PF00069	0.513
DOC_MAPK_gen_1	692	700	PF00069	0.411
DOC_MAPK_gen_1	738	748	PF00069	0.411
DOC_MAPK_MEF2A_6	741	748	PF00069	0.411
DOC_PP4_FxxP_1	365	368	PF00568	0.713
DOC_USP7_MATH_1	15	19	PF00917	0.760
DOC_USP7_MATH_1	234	238	PF00917	0.711
DOC_USP7_MATH_1	288	292	PF00917	0.724
DOC_USP7_MATH_1	304	308	PF00917	0.771
DOC_USP7_MATH_1	343	347	PF00917	0.774
DOC_USP7_MATH_1	443	447	PF00917	0.638
DOC_USP7_MATH_1	590	594	PF00917	0.428
DOC_USP7_MATH_1	755	759	PF00917	0.513
DOC_WW_Pin1_4	305	310	PF00397	0.714
DOC_WW_Pin1_4	530	535	PF00397	0.443
DOC_WW_Pin1_4	8	13	PF00397	0.685
LIG_14-3-3_CanoR_1	109	117	PF00244	0.552
LIG_14-3-3_CanoR_1	155	160	PF00244	0.624
LIG_14-3-3_CanoR_1	332	342	PF00244	0.738
LIG_14-3-3_CanoR_1	456	464	PF00244	0.465
LIG_14-3-3_CanoR_1	617	623	PF00244	0.524
LIG_14-3-3_CanoR_1	636	643	PF00244	0.213
LIG_14-3-3_CanoR_1	666	675	PF00244	0.513
LIG_14-3-3_CterR_2	779	783	PF00244	0.621
LIG_Actin_WH2_2	700	717	PF00022	0.411
LIG_APCC_ABBA_1	561	566	PF00400	0.411
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BIR_III_2	14	18	PF00653	0.717
LIG_BIR_III_3	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	556	560	PF00533	0.411
LIG_BRCT_BRCA1_1	760	764	PF00533	0.411
LIG_DLG_GKlike_1	155	162	PF00625	0.510
LIG_FHA_1	171	177	PF00498	0.542
LIG_FHA_1	308	314	PF00498	0.532
LIG_FHA_1	342	348	PF00498	0.812
LIG_FHA_1	51	57	PF00498	0.704
LIG_FHA_1	653	659	PF00498	0.378
LIG_FHA_1	726	732	PF00498	0.411
LIG_FHA_2	110	116	PF00498	0.655
LIG_FHA_2	149	155	PF00498	0.527
LIG_FHA_2	25	31	PF00498	0.682
LIG_FHA_2	354	360	PF00498	0.741
LIG_FHA_2	53	59	PF00498	0.677
LIG_FHA_2	557	563	PF00498	0.411
LIG_FHA_2	63	69	PF00498	0.559
LIG_IRF3_LxIS_1	653	659	PF10401	0.513
LIG_LIR_Gen_1	426	437	PF02991	0.562
LIG_LIR_Gen_1	470	481	PF02991	0.411
LIG_LIR_Gen_1	557	568	PF02991	0.411
LIG_LIR_Gen_1	576	583	PF02991	0.411
LIG_LIR_Gen_1	623	633	PF02991	0.423
LIG_LIR_Nem_3	426	432	PF02991	0.575
LIG_LIR_Nem_3	470	476	PF02991	0.411
LIG_LIR_Nem_3	484	490	PF02991	0.411
LIG_LIR_Nem_3	557	563	PF02991	0.411
LIG_LIR_Nem_3	597	602	PF02991	0.360
LIG_LIR_Nem_3	623	628	PF02991	0.361
LIG_MYND_1	413	417	PF01753	0.724
LIG_NRBOX	726	732	PF00104	0.411
LIG_PCNA_yPIPBox_3	565	578	PF02747	0.411
LIG_PCNA_yPIPBox_3	57	71	PF02747	0.702
LIG_PDZ_Class_1	778	783	PF00595	0.583
LIG_Pex14_2	467	471	PF04695	0.513
LIG_RPA_C_Fungi	109	121	PF08784	0.412
LIG_RPA_C_Fungi	90	102	PF08784	0.572
LIG_SH2_CRK	225	229	PF00017	0.468
LIG_SH2_CRK	473	477	PF00017	0.411
LIG_SH2_CRK	599	603	PF00017	0.411
LIG_SH2_NCK_1	473	477	PF00017	0.411
LIG_SH2_STAP1	45	49	PF00017	0.706
LIG_SH2_STAP1	473	477	PF00017	0.411
LIG_SH2_STAP1	579	583	PF00017	0.411
LIG_SH2_STAT3	729	732	PF00017	0.513
LIG_SH2_STAT5	225	228	PF00017	0.394
LIG_SH2_STAT5	429	432	PF00017	0.574
LIG_SH2_STAT5	729	732	PF00017	0.411
LIG_SH2_STAT5	734	737	PF00017	0.411
LIG_SH2_STAT5	772	775	PF00017	0.510
LIG_SH3_3	254	260	PF00018	0.589
LIG_SH3_3	272	278	PF00018	0.621
LIG_SH3_3	437	443	PF00018	0.685
LIG_Sin3_3	428	435	PF02671	0.567
LIG_SUMO_SIM_par_1	301	308	PF11976	0.800
LIG_SUMO_SIM_par_1	741	747	PF11976	0.411
LIG_TRAF2_1	423	426	PF00917	0.691
LIG_TRAF2_1	481	484	PF00917	0.389
LIG_TRAF2_1	621	624	PF00917	0.436
LIG_TRAF2_1	94	97	PF00917	0.538
LIG_UBA3_1	704	709	PF00899	0.411
LIG_WRC_WIRS_1	464	469	PF05994	0.513
MOD_CDK_SPK_2	530	535	PF00069	0.411
MOD_CK1_1	113	119	PF00069	0.651
MOD_CK1_1	241	247	PF00069	0.677
MOD_CK1_1	291	297	PF00069	0.648
MOD_CK1_1	307	313	PF00069	0.668
MOD_CK1_1	333	339	PF00069	0.706
MOD_CK1_1	341	347	PF00069	0.707
MOD_CK1_1	446	452	PF00069	0.592
MOD_CK1_1	457	463	PF00069	0.393
MOD_CK1_1	465	471	PF00069	0.411
MOD_CK1_1	513	519	PF00069	0.411
MOD_CK1_1	594	600	PF00069	0.350
MOD_CK1_1	647	653	PF00069	0.411
MOD_CK1_1	758	764	PF00069	0.513
MOD_CK2_1	109	115	PF00069	0.553
MOD_CK2_1	148	154	PF00069	0.525
MOD_CK2_1	15	21	PF00069	0.725
MOD_CK2_1	210	216	PF00069	0.609
MOD_CK2_1	353	359	PF00069	0.703
MOD_CK2_1	463	469	PF00069	0.515
MOD_CK2_1	556	562	PF00069	0.411
MOD_CK2_1	618	624	PF00069	0.513
MOD_CK2_1	62	68	PF00069	0.593
MOD_CMANNOS	25	28	PF00535	0.722
MOD_GlcNHglycan	146	149	PF01048	0.607
MOD_GlcNHglycan	176	179	PF01048	0.532
MOD_GlcNHglycan	230	233	PF01048	0.543
MOD_GlcNHglycan	290	293	PF01048	0.764
MOD_GlcNHglycan	298	301	PF01048	0.542
MOD_GlcNHglycan	332	335	PF01048	0.703
MOD_GlcNHglycan	406	409	PF01048	0.692
MOD_GlcNHglycan	445	448	PF01048	0.564
MOD_GlcNHglycan	512	515	PF01048	0.360
MOD_GlcNHglycan	573	576	PF01048	0.411
MOD_GlcNHglycan	594	597	PF01048	0.459
MOD_GlcNHglycan	604	607	PF01048	0.355
MOD_GlcNHglycan	658	661	PF01048	0.513
MOD_GlcNHglycan	686	689	PF01048	0.411
MOD_GSK3_1	109	116	PF00069	0.570
MOD_GSK3_1	13	20	PF00069	0.694
MOD_GSK3_1	144	151	PF00069	0.557
MOD_GSK3_1	170	177	PF00069	0.541
MOD_GSK3_1	234	241	PF00069	0.723
MOD_GSK3_1	282	289	PF00069	0.731
MOD_GSK3_1	290	297	PF00069	0.617
MOD_GSK3_1	304	311	PF00069	0.730
MOD_GSK3_1	330	337	PF00069	0.767
MOD_GSK3_1	442	449	PF00069	0.559
MOD_GSK3_1	454	461	PF00069	0.385
MOD_GSK3_1	463	470	PF00069	0.479
MOD_GSK3_1	550	557	PF00069	0.411
MOD_GSK3_1	585	592	PF00069	0.426
MOD_GSK3_1	594	601	PF00069	0.502
MOD_GSK3_1	602	609	PF00069	0.278
MOD_GSK3_1	634	641	PF00069	0.513
MOD_GSK3_1	652	659	PF00069	0.411
MOD_GSK3_1	768	775	PF00069	0.493
MOD_N-GLC_1	148	153	PF02516	0.529
MOD_N-GLC_1	261	266	PF02516	0.571
MOD_N-GLC_1	374	379	PF02516	0.595
MOD_N-GLC_1	457	462	PF02516	0.411
MOD_N-GLC_1	661	666	PF02516	0.398
MOD_N-GLC_1	684	689	PF02516	0.411
MOD_N-GLC_1	700	705	PF02516	0.411
MOD_NEK2_1	218	223	PF00069	0.502
MOD_NEK2_1	24	29	PF00069	0.621
MOD_NEK2_1	467	472	PF00069	0.513
MOD_NEK2_1	556	561	PF00069	0.411
MOD_NEK2_1	571	576	PF00069	0.411
MOD_NEK2_1	634	639	PF00069	0.513
MOD_NEK2_1	656	661	PF00069	0.411
MOD_NEK2_1	744	749	PF00069	0.375
MOD_NEK2_2	652	657	PF00069	0.411
MOD_PIKK_1	234	240	PF00454	0.707
MOD_PIKK_1	40	46	PF00454	0.613
MOD_PIKK_1	50	56	PF00454	0.592
MOD_PKA_2	110	116	PF00069	0.557
MOD_PKA_2	255	261	PF00069	0.730
MOD_PKA_2	338	344	PF00069	0.703
MOD_PKA_2	635	641	PF00069	0.411
MOD_Plk_1	170	176	PF00069	0.545
MOD_Plk_1	241	247	PF00069	0.653
MOD_Plk_1	606	612	PF00069	0.411
MOD_Plk_1	661	667	PF00069	0.389
MOD_Plk_1	700	706	PF00069	0.411
MOD_Plk_2-3	198	204	PF00069	0.626
MOD_Plk_2-3	210	216	PF00069	0.464
MOD_Plk_2-3	469	475	PF00069	0.411
MOD_Plk_2-3	52	58	PF00069	0.506
MOD_Plk_2-3	550	556	PF00069	0.396
MOD_Plk_4	271	277	PF00069	0.712
MOD_Plk_4	343	349	PF00069	0.772
MOD_Plk_4	536	542	PF00069	0.411
MOD_Plk_4	556	562	PF00069	0.183
MOD_Plk_4	594	600	PF00069	0.280
MOD_Plk_4	725	731	PF00069	0.411
MOD_Plk_4	768	774	PF00069	0.478
MOD_ProDKin_1	305	311	PF00069	0.714
MOD_ProDKin_1	530	536	PF00069	0.443
MOD_ProDKin_1	8	14	PF00069	0.688
MOD_SUMO_rev_2	213	221	PF00179	0.526
MOD_SUMO_rev_2	66	74	PF00179	0.538
TRG_DiLeu_BaEn_1	384	389	PF01217	0.745
TRG_DiLeu_BaEn_1	426	431	PF01217	0.720
TRG_DiLeu_BaEn_4	623	629	PF01217	0.436
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.801
TRG_ENDOCYTIC_2	225	228	PF00928	0.394
TRG_ENDOCYTIC_2	429	432	PF00928	0.574
TRG_ENDOCYTIC_2	473	476	PF00928	0.411
TRG_ENDOCYTIC_2	487	490	PF00928	0.411
TRG_ENDOCYTIC_2	564	567	PF00928	0.353
TRG_ENDOCYTIC_2	579	582	PF00928	0.353
TRG_ENDOCYTIC_2	599	602	PF00928	0.411
TRG_ENDOCYTIC_2	85	88	PF00928	0.562
TRG_ER_diArg_1	22	24	PF00400	0.608
TRG_ER_diArg_1	389	392	PF00400	0.824
TRG_ER_diArg_1	665	668	PF00400	0.513
TRG_ER_diArg_1	71	74	PF00400	0.628
TRG_ER_diArg_1	92	95	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	702	706	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAP4	Leptomonas seymouri	58%	87%
A0A3Q8IDV2	Leishmania donovani	93%	81%
A4HGN8	Leishmania braziliensis	80%	81%
A4I3R1	Leishmania infantum	92%	81%
E9B004	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	81%