UPF0573 protein C2orf70 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania major

UniProt:

Q4Q880_LEIMA

TriTrypDb:

LmjF.28.1860 , LMJLV39_280026400 , LMJSD75_280025900

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	28
GO:0005815	microtubule organizing center	2	28
GO:0110165	cellular anatomical entity	1	28

Expansion

Sequence features

Q4Q880

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q880

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.533
CLV_C14_Caspase3-7	37	41	PF00656	0.466
CLV_NRD_NRD_1	118	120	PF00675	0.277
CLV_NRD_NRD_1	252	254	PF00675	0.286
CLV_NRD_NRD_1	64	66	PF00675	0.252
CLV_PCSK_FUR_1	210	214	PF00082	0.289
CLV_PCSK_KEX2_1	120	122	PF00082	0.266
CLV_PCSK_KEX2_1	161	163	PF00082	0.304
CLV_PCSK_KEX2_1	212	214	PF00082	0.293
CLV_PCSK_KEX2_1	286	288	PF00082	0.533
CLV_PCSK_KEX2_1	63	65	PF00082	0.249
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.252
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.213
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.293
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.525
CLV_PCSK_SKI1_1	73	77	PF00082	0.229
DOC_CKS1_1	100	105	PF01111	0.498
DOC_MAPK_gen_1	261	269	PF00069	0.509
DOC_MAPK_MEF2A_6	201	209	PF00069	0.385
DOC_PP4_FxxP_1	3	6	PF00568	0.457
DOC_USP7_UBL2_3	257	261	PF12436	0.466
DOC_WW_Pin1_4	128	133	PF00397	0.446
DOC_WW_Pin1_4	191	196	PF00397	0.455
DOC_WW_Pin1_4	73	78	PF00397	0.448
DOC_WW_Pin1_4	81	86	PF00397	0.432
DOC_WW_Pin1_4	99	104	PF00397	0.528
LIG_14-3-3_CanoR_1	126	132	PF00244	0.459
LIG_BRCT_BRCA1_1	281	285	PF00533	0.442
LIG_deltaCOP1_diTrp_1	275	285	PF00928	0.492
LIG_FHA_1	25	31	PF00498	0.496
LIG_FHA_1	278	284	PF00498	0.462
LIG_FHA_2	154	160	PF00498	0.401
LIG_FHA_2	188	194	PF00498	0.436
LIG_FHA_2	236	242	PF00498	0.459
LIG_FHA_2	35	41	PF00498	0.519
LIG_LIR_Apic_2	13	18	PF02991	0.473
LIG_LIR_Apic_2	241	246	PF02991	0.442
LIG_LIR_Gen_1	102	111	PF02991	0.490
LIG_LIR_Nem_3	102	107	PF02991	0.453
LIG_LIR_Nem_3	244	250	PF02991	0.429
LIG_LIR_Nem_3	282	288	PF02991	0.599
LIG_LIR_Nem_3	7	11	PF02991	0.423
LIG_LIR_Nem_3	94	99	PF02991	0.459
LIG_Pex14_1	243	247	PF04695	0.455
LIG_SH2_CRK	129	133	PF00017	0.444
LIG_SH2_CRK	15	19	PF00017	0.473
LIG_SH2_CRK	82	86	PF00017	0.489
LIG_SH2_NCK_1	104	108	PF00017	0.385
LIG_SH2_NCK_1	129	133	PF00017	0.430
LIG_SH2_NCK_1	141	145	PF00017	0.430
LIG_SH2_NCK_1	82	86	PF00017	0.493
LIG_SH2_SRC	104	107	PF00017	0.385
LIG_SH2_SRC	141	144	PF00017	0.403
LIG_SH2_STAP1	141	145	PF00017	0.544
LIG_SH2_STAP1	279	283	PF00017	0.442
LIG_SH2_STAT5	129	132	PF00017	0.447
LIG_SH2_STAT5	153	156	PF00017	0.433
LIG_SH2_STAT5	232	235	PF00017	0.455
LIG_SH2_STAT5	259	262	PF00017	0.506
LIG_SH2_STAT5	279	282	PF00017	0.454
LIG_SH2_STAT5	8	11	PF00017	0.470
LIG_SH2_STAT5	95	98	PF00017	0.480
LIG_SH3_1	174	180	PF00018	0.528
LIG_SH3_2	108	113	PF14604	0.486
LIG_SH3_2	177	182	PF14604	0.457
LIG_SH3_3	105	111	PF00018	0.432
LIG_SH3_3	174	180	PF00018	0.480
LIG_SH3_3	223	229	PF00018	0.454
LIG_SH3_3	257	263	PF00018	0.452
LIG_SH3_3	264	270	PF00018	0.465
LIG_SH3_3	27	33	PF00018	0.475
LIG_TYR_ITSM	100	107	PF00017	0.385
LIG_WW_3	123	127	PF00397	0.403
MOD_CDK_SPxxK_3	128	135	PF00069	0.530
MOD_CK1_1	194	200	PF00069	0.455
MOD_CK1_1	4	10	PF00069	0.449
MOD_CK1_1	83	89	PF00069	0.492
MOD_CK2_1	153	159	PF00069	0.512
MOD_CK2_1	187	193	PF00069	0.430
MOD_CK2_1	235	241	PF00069	0.489
MOD_GlcNHglycan	69	72	PF01048	0.241
MOD_GSK3_1	144	151	PF00069	0.502
MOD_GSK3_1	187	194	PF00069	0.472
MOD_GSK3_1	24	31	PF00069	0.468
MOD_N-GLC_1	73	78	PF02516	0.270
MOD_N-GLC_2	164	166	PF02516	0.147
MOD_NEK2_1	1	6	PF00069	0.311
MOD_NEK2_1	277	282	PF00069	0.463
MOD_NEK2_1	28	33	PF00069	0.509
MOD_NEK2_1	80	85	PF00069	0.505
MOD_NEK2_2	153	158	PF00069	0.443
MOD_PIKK_1	277	283	PF00454	0.463
MOD_PKA_1	261	267	PF00069	0.474
MOD_Plk_2-3	187	193	PF00069	0.528
MOD_Plk_4	153	159	PF00069	0.416
MOD_Plk_4	24	30	PF00069	0.473
MOD_Plk_4	279	285	PF00069	0.469
MOD_Plk_4	4	10	PF00069	0.453
MOD_Plk_4	91	97	PF00069	0.454
MOD_ProDKin_1	128	134	PF00069	0.452
MOD_ProDKin_1	191	197	PF00069	0.455
MOD_ProDKin_1	73	79	PF00069	0.448
MOD_ProDKin_1	81	87	PF00069	0.432
MOD_ProDKin_1	99	105	PF00069	0.528
TRG_ENDOCYTIC_2	104	107	PF00928	0.465
TRG_ENDOCYTIC_2	141	144	PF00928	0.485
TRG_ENDOCYTIC_2	8	11	PF00928	0.466
TRG_ER_diArg_1	118	121	PF00400	0.469
TRG_ER_diArg_1	62	65	PF00400	0.474
TRG_NLS_Bipartite_1	161	177	PF00514	0.475
TRG_NLS_MonoExtC_3	172	177	PF00514	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K0	Leptomonas seymouri	28%	83%
A0A0N1I4L7	Leptomonas seymouri	30%	96%
A0A0N1I8Z0	Leptomonas seymouri	75%	100%
A0A0S4IPI4	Bodo saltans	30%	86%
A0A0S4IYY4	Bodo saltans	32%	99%
A0A0S4KM52	Bodo saltans	43%	99%
A0A1X0NMW4	Trypanosomatidae	32%	97%
A0A1X0NRI3	Trypanosomatidae	57%	100%
A0A1X0P929	Trypanosomatidae	29%	82%
A0A3Q8IGT8	Leishmania donovani	97%	100%
A0A3R7NAQ1	Trypanosoma rangeli	29%	84%
A0A3S5H6B7	Leishmania donovani	31%	94%
A0A3S7X2W5	Leishmania donovani	30%	85%
A0A422NDP9	Trypanosoma rangeli	31%	97%
A0A422NZ19	Trypanosoma rangeli	57%	100%
A4H5J6	Leishmania braziliensis	30%	94%
A4HGN9	Leishmania braziliensis	88%	100%
A4HHQ4	Leishmania braziliensis	31%	85%
A4HTT9	Leishmania infantum	31%	94%
A4I3R2	Leishmania infantum	98%	100%
A4I4W9	Leishmania infantum	30%	71%
C9ZKZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	72%
D0A896	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0A995	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9AEB8	Leishmania major	30%	70%
E9AMM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	94%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q2T9M0	Bos taurus	28%	93%
Q3U1D9	Mus musculus	29%	91%
Q4QI05	Leishmania major	31%	94%
V5BSF6	Trypanosoma cruzi	30%	96%
V5DTV3	Trypanosoma cruzi	27%	84%