LeishMANIAdb
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N2227 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
N2227 domain-containing protein
Gene product:
Putative methyltransferase, putative
Species:
Leishmania major
UniProt:
Q4Q879_LEIMA
TriTrypDb:
LmjF.28.1870 , LMJLV39_280026500 * , LMJSD75_280026000
Length:
672

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q879
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q879

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 1
GO:0032259 methylation 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0008168 methyltransferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016741 transferase activity, transferring one-carbon groups 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 377 381 PF00656 0.643
CLV_C14_Caspase3-7 432 436 PF00656 0.334
CLV_NRD_NRD_1 519 521 PF00675 0.411
CLV_NRD_NRD_1 75 77 PF00675 0.543
CLV_PCSK_KEX2_1 456 458 PF00082 0.280
CLV_PCSK_KEX2_1 519 521 PF00082 0.411
CLV_PCSK_KEX2_1 74 76 PF00082 0.554
CLV_PCSK_PC1ET2_1 456 458 PF00082 0.261
CLV_PCSK_SKI1_1 226 230 PF00082 0.652
CLV_PCSK_SKI1_1 666 670 PF00082 0.496
CLV_PCSK_SKI1_1 79 83 PF00082 0.381
DEG_Nend_UBRbox_2 1 3 PF02207 0.557
DEG_SPOP_SBC_1 335 339 PF00917 0.551
DEG_SPOP_SBC_1 98 102 PF00917 0.482
DOC_CKS1_1 168 173 PF01111 0.673
DOC_CKS1_1 350 355 PF01111 0.565
DOC_CKS1_1 361 366 PF01111 0.622
DOC_CYCLIN_RxL_1 17 28 PF00134 0.380
DOC_MAPK_gen_1 530 538 PF00069 0.397
DOC_PP2B_LxvP_1 330 333 PF13499 0.456
DOC_PP4_FxxP_1 135 138 PF00568 0.377
DOC_USP7_MATH_1 169 173 PF00917 0.570
DOC_USP7_MATH_1 183 187 PF00917 0.752
DOC_USP7_MATH_1 230 234 PF00917 0.692
DOC_USP7_MATH_1 335 339 PF00917 0.567
DOC_USP7_MATH_1 340 344 PF00917 0.604
DOC_USP7_MATH_1 371 375 PF00917 0.658
DOC_USP7_MATH_1 383 387 PF00917 0.524
DOC_USP7_MATH_1 390 394 PF00917 0.294
DOC_USP7_MATH_1 48 52 PF00917 0.443
DOC_USP7_MATH_1 523 527 PF00917 0.600
DOC_USP7_MATH_1 98 102 PF00917 0.478
DOC_WW_Pin1_4 147 152 PF00397 0.642
DOC_WW_Pin1_4 153 158 PF00397 0.664
DOC_WW_Pin1_4 167 172 PF00397 0.565
DOC_WW_Pin1_4 179 184 PF00397 0.607
DOC_WW_Pin1_4 185 190 PF00397 0.829
DOC_WW_Pin1_4 237 242 PF00397 0.676
DOC_WW_Pin1_4 259 264 PF00397 0.643
DOC_WW_Pin1_4 266 271 PF00397 0.613
DOC_WW_Pin1_4 342 347 PF00397 0.616
DOC_WW_Pin1_4 349 354 PF00397 0.580
DOC_WW_Pin1_4 360 365 PF00397 0.580
DOC_WW_Pin1_4 404 409 PF00397 0.292
DOC_WW_Pin1_4 461 466 PF00397 0.315
LIG_14-3-3_CanoR_1 184 188 PF00244 0.684
LIG_14-3-3_CanoR_1 291 300 PF00244 0.528
LIG_14-3-3_CanoR_1 519 523 PF00244 0.540
LIG_14-3-3_CanoR_1 561 566 PF00244 0.512
LIG_14-3-3_CanoR_1 6 12 PF00244 0.468
LIG_Actin_WH2_2 650 668 PF00022 0.384
LIG_APCC_ABBA_1 119 124 PF00400 0.374
LIG_APCC_ABBAyCdc20_2 118 124 PF00400 0.371
LIG_BIR_III_4 630 634 PF00653 0.494
LIG_BRCT_BRCA1_1 232 236 PF00533 0.540
LIG_BRCT_BRCA1_1 293 297 PF00533 0.445
LIG_CtBP_PxDLS_1 364 368 PF00389 0.640
LIG_EH_1 136 140 PF12763 0.461
LIG_EH1_1 308 316 PF00400 0.352
LIG_FHA_1 205 211 PF00498 0.635
LIG_FHA_1 237 243 PF00498 0.555
LIG_FHA_1 30 36 PF00498 0.402
LIG_FHA_1 321 327 PF00498 0.394
LIG_FHA_1 462 468 PF00498 0.426
LIG_FHA_1 500 506 PF00498 0.409
LIG_FHA_1 509 515 PF00498 0.272
LIG_FHA_1 6 12 PF00498 0.556
LIG_FHA_1 650 656 PF00498 0.425
LIG_FHA_2 100 106 PF00498 0.547
LIG_FHA_2 634 640 PF00498 0.565
LIG_GBD_Chelix_1 508 516 PF00786 0.315
LIG_IRF3_LxIS_1 569 576 PF10401 0.441
LIG_LIR_Apic_2 134 138 PF02991 0.374
LIG_LIR_Gen_1 114 122 PF02991 0.490
LIG_LIR_Gen_1 285 292 PF02991 0.412
LIG_LIR_Gen_1 294 304 PF02991 0.460
LIG_LIR_Gen_1 562 570 PF02991 0.372
LIG_LIR_Nem_3 114 119 PF02991 0.547
LIG_LIR_Nem_3 129 135 PF02991 0.294
LIG_LIR_Nem_3 285 290 PF02991 0.412
LIG_LIR_Nem_3 294 300 PF02991 0.462
LIG_LIR_Nem_3 556 560 PF02991 0.405
LIG_LIR_Nem_3 562 566 PF02991 0.320
LIG_Pex14_1 305 309 PF04695 0.356
LIG_Pex14_2 135 139 PF04695 0.390
LIG_Pex14_2 14 18 PF04695 0.452
LIG_PTB_Apo_2 433 440 PF02174 0.315
LIG_SH2_CRK 563 567 PF00017 0.360
LIG_SH2_GRB2like 85 88 PF00017 0.385
LIG_SH2_SRC 410 413 PF00017 0.506
LIG_SH2_SRC 429 432 PF00017 0.193
LIG_SH2_SRC 85 88 PF00017 0.385
LIG_SH2_STAP1 500 504 PF00017 0.315
LIG_SH2_STAP1 651 655 PF00017 0.439
LIG_SH2_STAT3 213 216 PF00017 0.524
LIG_SH2_STAT5 410 413 PF00017 0.395
LIG_SH2_STAT5 563 566 PF00017 0.355
LIG_SH2_STAT5 651 654 PF00017 0.440
LIG_SH2_STAT5 85 88 PF00017 0.355
LIG_SH3_3 137 143 PF00018 0.444
LIG_SH3_3 173 179 PF00018 0.665
LIG_SH3_3 231 237 PF00018 0.687
LIG_SH3_3 257 263 PF00018 0.698
LIG_SH3_3 460 466 PF00018 0.345
LIG_SH3_3 60 66 PF00018 0.475
LIG_SH3_CIN85_PxpxPR_1 179 184 PF14604 0.556
LIG_SUMO_SIM_par_1 31 36 PF11976 0.400
LIG_SUMO_SIM_par_1 55 60 PF11976 0.341
LIG_TRAF2_1 126 129 PF00917 0.418
LIG_TRAF2_1 88 91 PF00917 0.374
LIG_TRFH_1 213 217 PF08558 0.518
LIG_UBA3_1 311 320 PF00899 0.370
LIG_WRC_WIRS_1 11 16 PF05994 0.505
LIG_WRC_WIRS_1 132 137 PF05994 0.370
LIG_WRC_WIRS_1 421 426 PF05994 0.315
LIG_WRC_WIRS_1 554 559 PF05994 0.450
LIG_WW_3 71 75 PF00397 0.395
MOD_CDK_SPK_2 179 184 PF00069 0.630
MOD_CDK_SPK_2 242 247 PF00069 0.674
MOD_CDK_SPxxK_3 237 244 PF00069 0.714
MOD_CK1_1 10 16 PF00069 0.613
MOD_CK1_1 100 106 PF00069 0.479
MOD_CK1_1 159 165 PF00069 0.723
MOD_CK1_1 196 202 PF00069 0.730
MOD_CK1_1 204 210 PF00069 0.600
MOD_CK1_1 342 348 PF00069 0.768
MOD_CK1_1 374 380 PF00069 0.709
MOD_CK1_1 382 388 PF00069 0.607
MOD_CK1_1 553 559 PF00069 0.402
MOD_CK1_1 618 624 PF00069 0.461
MOD_CK2_1 123 129 PF00069 0.468
MOD_CK2_1 383 389 PF00069 0.514
MOD_CK2_1 633 639 PF00069 0.577
MOD_CK2_1 85 91 PF00069 0.440
MOD_CK2_1 99 105 PF00069 0.515
MOD_GlcNHglycan 158 161 PF01048 0.588
MOD_GlcNHglycan 165 168 PF01048 0.552
MOD_GlcNHglycan 27 30 PF01048 0.489
MOD_GlcNHglycan 271 274 PF01048 0.554
MOD_GlcNHglycan 342 345 PF01048 0.660
MOD_GlcNHglycan 35 38 PF01048 0.440
MOD_GlcNHglycan 376 379 PF01048 0.609
MOD_GlcNHglycan 380 384 PF01048 0.570
MOD_GlcNHglycan 385 388 PF01048 0.519
MOD_GlcNHglycan 50 53 PF01048 0.356
MOD_GlcNHglycan 525 528 PF01048 0.578
MOD_GlcNHglycan 577 582 PF01048 0.428
MOD_GlcNHglycan 620 623 PF01048 0.558
MOD_GSK3_1 14 21 PF00069 0.427
MOD_GSK3_1 159 166 PF00069 0.597
MOD_GSK3_1 179 186 PF00069 0.649
MOD_GSK3_1 192 199 PF00069 0.567
MOD_GSK3_1 25 32 PF00069 0.392
MOD_GSK3_1 286 293 PF00069 0.550
MOD_GSK3_1 335 342 PF00069 0.685
MOD_GSK3_1 379 386 PF00069 0.616
MOD_GSK3_1 420 427 PF00069 0.315
MOD_GSK3_1 514 521 PF00069 0.454
MOD_GSK3_1 525 532 PF00069 0.534
MOD_GSK3_1 549 556 PF00069 0.463
MOD_GSK3_1 569 576 PF00069 0.279
MOD_GSK3_1 6 13 PF00069 0.571
MOD_GSK3_1 97 104 PF00069 0.462
MOD_N-GLC_1 340 345 PF02516 0.569
MOD_N-GLC_1 371 376 PF02516 0.615
MOD_N-GLC_1 6 11 PF02516 0.535
MOD_N-GLC_1 631 636 PF02516 0.579
MOD_NEK2_1 14 19 PF00069 0.506
MOD_NEK2_1 158 163 PF00069 0.537
MOD_NEK2_1 25 30 PF00069 0.392
MOD_NEK2_1 5 10 PF00069 0.550
MOD_NEK2_1 508 513 PF00069 0.319
MOD_NEK2_1 514 519 PF00069 0.389
MOD_NEK2_1 529 534 PF00069 0.366
MOD_NEK2_1 550 555 PF00069 0.401
MOD_NEK2_1 650 655 PF00069 0.446
MOD_NEK2_1 99 104 PF00069 0.491
MOD_NEK2_2 131 136 PF00069 0.457
MOD_NEK2_2 206 211 PF00069 0.532
MOD_NEK2_2 230 235 PF00069 0.662
MOD_NEK2_2 371 376 PF00069 0.603
MOD_PIKK_1 169 175 PF00454 0.657
MOD_PIKK_1 193 199 PF00454 0.672
MOD_PIKK_1 390 396 PF00454 0.282
MOD_PIKK_1 41 47 PF00454 0.377
MOD_PKA_2 117 123 PF00069 0.489
MOD_PKA_2 183 189 PF00069 0.672
MOD_PKA_2 290 296 PF00069 0.458
MOD_PKA_2 333 339 PF00069 0.667
MOD_PKA_2 5 11 PF00069 0.469
MOD_PKA_2 518 524 PF00069 0.566
MOD_PKA_2 573 579 PF00069 0.496
MOD_Plk_1 14 20 PF00069 0.412
MOD_Plk_1 371 377 PF00069 0.623
MOD_Plk_1 490 496 PF00069 0.345
MOD_Plk_1 543 549 PF00069 0.410
MOD_Plk_1 6 12 PF00069 0.555
MOD_Plk_4 117 123 PF00069 0.567
MOD_Plk_4 131 137 PF00069 0.316
MOD_Plk_4 206 212 PF00069 0.526
MOD_Plk_4 216 222 PF00069 0.478
MOD_Plk_4 300 306 PF00069 0.431
MOD_Plk_4 420 426 PF00069 0.315
MOD_Plk_4 429 435 PF00069 0.315
MOD_Plk_4 490 496 PF00069 0.345
MOD_Plk_4 561 567 PF00069 0.331
MOD_Plk_4 650 656 PF00069 0.425
MOD_ProDKin_1 147 153 PF00069 0.642
MOD_ProDKin_1 167 173 PF00069 0.613
MOD_ProDKin_1 179 185 PF00069 0.631
MOD_ProDKin_1 237 243 PF00069 0.680
MOD_ProDKin_1 259 265 PF00069 0.639
MOD_ProDKin_1 266 272 PF00069 0.612
MOD_ProDKin_1 342 348 PF00069 0.618
MOD_ProDKin_1 349 355 PF00069 0.581
MOD_ProDKin_1 360 366 PF00069 0.579
MOD_ProDKin_1 404 410 PF00069 0.292
MOD_ProDKin_1 461 467 PF00069 0.315
TRG_DiLeu_BaLyEn_6 345 350 PF01217 0.698
TRG_ENDOCYTIC_2 136 139 PF00928 0.460
TRG_ENDOCYTIC_2 563 566 PF00928 0.350
TRG_ENDOCYTIC_2 651 654 PF00928 0.440
TRG_ER_diArg_1 281 284 PF00400 0.542
TRG_ER_diArg_1 73 76 PF00400 0.424
TRG_NES_CRM1_1 111 124 PF08389 0.423
TRG_NLS_Bipartite_1 519 534 PF00514 0.410

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I298 Leptomonas seymouri 48% 90%
A0A3S7X1M1 Leishmania donovani 87% 100%
A4HGP0 Leishmania braziliensis 63% 91%
A4I3R3 Leishmania infantum 87% 100%
E9B006 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS