Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 4, putative

Species:

Leishmania major

UniProt:

Q4Q877_LEIMA

TriTrypDb:

LmjF.28.1890 , LMJLV39_280026700 , LMJSD75_280026200

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q877

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q877

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.506
CLV_NRD_NRD_1	146	148	PF00675	0.422
CLV_NRD_NRD_1	159	161	PF00675	0.335
CLV_NRD_NRD_1	279	281	PF00675	0.291
CLV_NRD_NRD_1	321	323	PF00675	0.294
CLV_NRD_NRD_1	424	426	PF00675	0.455
CLV_PCSK_KEX2_1	102	104	PF00082	0.516
CLV_PCSK_KEX2_1	161	163	PF00082	0.424
CLV_PCSK_KEX2_1	320	322	PF00082	0.307
CLV_PCSK_KEX2_1	405	407	PF00082	0.387
CLV_PCSK_KEX2_1	424	426	PF00082	0.426
CLV_PCSK_KEX2_1	437	439	PF00082	0.411
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.521
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.459
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.418
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.472
CLV_PCSK_PC7_1	157	163	PF00082	0.439
CLV_PCSK_SKI1_1	115	119	PF00082	0.454
CLV_PCSK_SKI1_1	411	415	PF00082	0.356
CLV_PCSK_SKI1_1	438	442	PF00082	0.448
CLV_PCSK_SKI1_1	7	11	PF00082	0.481
DEG_SPOP_SBC_1	174	178	PF00917	0.516
DOC_CYCLIN_yClb5_NLxxxL_5	415	421	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.653
DOC_MAPK_gen_1	157	165	PF00069	0.628
DOC_MAPK_gen_1	437	443	PF00069	0.608
DOC_PP2B_LxvP_1	190	193	PF13499	0.252
DOC_USP7_UBL2_3	148	152	PF12436	0.616
LIG_14-3-3_CanoR_1	208	218	PF00244	0.468
LIG_14-3-3_CanoR_1	226	232	PF00244	0.549
LIG_14-3-3_CanoR_1	280	288	PF00244	0.490
LIG_14-3-3_CanoR_1	425	431	PF00244	0.635
LIG_AP2alpha_1	431	435	PF02296	0.570
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BRCT_BRCA1_1	130	134	PF00533	0.634
LIG_BRCT_BRCA1_1	184	188	PF00533	0.447
LIG_deltaCOP1_diTrp_1	195	198	PF00928	0.325
LIG_eIF4E_1	209	215	PF01652	0.401
LIG_FHA_1	11	17	PF00498	0.639
LIG_FHA_1	135	141	PF00498	0.614
LIG_FHA_1	210	216	PF00498	0.399
LIG_FHA_1	339	345	PF00498	0.399
LIG_FHA_1	354	360	PF00498	0.294
LIG_FHA_1	65	71	PF00498	0.703
LIG_FHA_2	255	261	PF00498	0.637
LIG_FHA_2	348	354	PF00498	0.361
LIG_FHA_2	52	58	PF00498	0.702
LIG_GBD_Chelix_1	362	370	PF00786	0.408
LIG_IBAR_NPY_1	407	409	PF08397	0.583
LIG_LIR_Apic_2	177	183	PF02991	0.401
LIG_LIR_Apic_2	231	237	PF02991	0.530
LIG_LIR_Gen_1	141	150	PF02991	0.585
LIG_LIR_Gen_1	185	194	PF02991	0.412
LIG_LIR_Gen_1	195	206	PF02991	0.473
LIG_LIR_Gen_1	267	278	PF02991	0.566
LIG_LIR_Gen_1	324	333	PF02991	0.542
LIG_LIR_Gen_1	350	360	PF02991	0.398
LIG_LIR_Gen_1	383	392	PF02991	0.520
LIG_LIR_Nem_3	13	17	PF02991	0.644
LIG_LIR_Nem_3	131	136	PF02991	0.596
LIG_LIR_Nem_3	141	145	PF02991	0.551
LIG_LIR_Nem_3	185	191	PF02991	0.384
LIG_LIR_Nem_3	195	201	PF02991	0.448
LIG_LIR_Nem_3	267	273	PF02991	0.577
LIG_LIR_Nem_3	324	329	PF02991	0.542
LIG_LIR_Nem_3	350	355	PF02991	0.398
LIG_LIR_Nem_3	383	388	PF02991	0.538
LIG_MLH1_MIPbox_1	130	134	PF16413	0.662
LIG_NRBOX	372	378	PF00104	0.443
LIG_PCNA_PIPBox_1	342	351	PF02747	0.408
LIG_PDZ_Class_1	452	457	PF00595	0.731
LIG_Pex14_1	205	209	PF04695	0.359
LIG_Pex14_2	130	134	PF04695	0.634
LIG_Pex14_2	431	435	PF04695	0.570
LIG_PTB_Apo_2	413	420	PF02174	0.609
LIG_PTB_Phospho_1	413	419	PF10480	0.612
LIG_REV1ctd_RIR_1	411	419	PF16727	0.587
LIG_SH2_CRK	14	18	PF00017	0.575
LIG_SH2_CRK	150	154	PF00017	0.633
LIG_SH2_CRK	166	170	PF00017	0.616
LIG_SH2_CRK	180	184	PF00017	0.288
LIG_SH2_CRK	221	225	PF00017	0.478
LIG_SH2_CRK	419	423	PF00017	0.653
LIG_SH2_GRB2like	168	171	PF00017	0.623
LIG_SH2_NCK_1	150	154	PF00017	0.633
LIG_SH2_NCK_1	229	233	PF00017	0.521
LIG_SH2_PTP2	168	171	PF00017	0.627
LIG_SH2_PTP2	234	237	PF00017	0.600
LIG_SH2_SRC	168	171	PF00017	0.627
LIG_SH2_STAP1	211	215	PF00017	0.349
LIG_SH2_STAP1	221	225	PF00017	0.398
LIG_SH2_STAP1	75	79	PF00017	0.713
LIG_SH2_STAT5	142	145	PF00017	0.586
LIG_SH2_STAT5	168	171	PF00017	0.575
LIG_SH2_STAT5	211	214	PF00017	0.444
LIG_SH2_STAT5	221	224	PF00017	0.371
LIG_SH2_STAT5	234	237	PF00017	0.515
LIG_SH2_STAT5	298	301	PF00017	0.490
LIG_SH3_3	13	19	PF00018	0.593
LIG_SH3_3	34	40	PF00018	0.653
LIG_SH3_4	148	155	PF00018	0.611
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.438
LIG_TRAF2_1	252	255	PF00917	0.695
LIG_TYR_ITIM	12	17	PF00017	0.666
LIG_TYR_ITIM	219	224	PF00017	0.485
LIG_TYR_ITIM	417	422	PF00017	0.644
MOD_CK1_1	2	8	PF00069	0.724
MOD_CK1_1	331	337	PF00069	0.500
MOD_CK2_1	265	271	PF00069	0.597
MOD_CK2_1	347	353	PF00069	0.444
MOD_CK2_1	390	396	PF00069	0.490
MOD_CK2_1	93	99	PF00069	0.692
MOD_CMANNOS	349	352	PF00535	0.536
MOD_Cter_Amidation	145	148	PF01082	0.425
MOD_Cter_Amidation	318	321	PF01082	0.292
MOD_GlcNHglycan	118	121	PF01048	0.396
MOD_GlcNHglycan	180	183	PF01048	0.432
MOD_GlcNHglycan	75	78	PF01048	0.487
MOD_GlcNHglycan	85	88	PF01048	0.461
MOD_GSK3_1	174	181	PF00069	0.479
MOD_GSK3_1	324	331	PF00069	0.533
MOD_GSK3_1	371	378	PF00069	0.434
MOD_GSK3_1	380	387	PF00069	0.394
MOD_GSK3_1	51	58	PF00069	0.735
MOD_GSK3_1	79	86	PF00069	0.681
MOD_NEK2_1	1	6	PF00069	0.748
MOD_NEK2_1	219	224	PF00069	0.404
MOD_NEK2_1	328	333	PF00069	0.341
MOD_NEK2_1	377	382	PF00069	0.376
MOD_NEK2_1	384	389	PF00069	0.508
MOD_NEK2_1	85	90	PF00069	0.704
MOD_PIKK_1	386	392	PF00454	0.536
MOD_PIKK_1	64	70	PF00454	0.706
MOD_PKA_2	265	271	PF00069	0.597
MOD_Plk_1	254	260	PF00069	0.675
MOD_Plk_2-3	254	260	PF00069	0.731
MOD_Plk_4	105	111	PF00069	0.750
MOD_Plk_4	219	225	PF00069	0.403
MOD_Plk_4	265	271	PF00069	0.668
MOD_Plk_4	331	337	PF00069	0.370
MOD_Plk_4	338	344	PF00069	0.344
MOD_Plk_4	371	377	PF00069	0.416
MOD_Plk_4	380	386	PF00069	0.419
MOD_Plk_4	426	432	PF00069	0.556
TRG_ENDOCYTIC_2	14	17	PF00928	0.579
TRG_ENDOCYTIC_2	142	145	PF00928	0.581
TRG_ENDOCYTIC_2	150	153	PF00928	0.583
TRG_ENDOCYTIC_2	166	169	PF00928	0.609
TRG_ENDOCYTIC_2	211	214	PF00928	0.461
TRG_ENDOCYTIC_2	221	224	PF00928	0.370
TRG_ENDOCYTIC_2	418	421	PF00928	0.612
TRG_ER_diArg_1	159	162	PF00400	0.627
TRG_ER_diArg_1	320	322	PF00400	0.561
TRG_ER_diArg_1	424	426	PF00400	0.629
TRG_NES_CRM1_1	267	279	PF08389	0.636
TRG_NLS_Bipartite_1	147	164	PF00514	0.605
TRG_NLS_MonoExtC_3	159	164	PF00514	0.631
TRG_NLS_MonoExtN_4	157	164	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P832	Leptomonas seymouri	64%	99%
A0A1X0NSC8	Trypanosomatidae	40%	92%
A0A3S5ISD2	Trypanosoma rangeli	42%	100%
A0A3S7X1Q3	Leishmania donovani	95%	100%
A4HGP2	Leishmania braziliensis	76%	100%
A4I3R5	Leishmania infantum	95%	100%
D0A893	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9B008	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%