J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q876_LEIMA

TriTrypDb:

LmjF.28.1900 , LMJLV39_280026800 , LMJSD75_280026300

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q876

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q876

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.771
CLV_C14_Caspase3-7	233	237	PF00656	0.633
CLV_C14_Caspase3-7	334	338	PF00656	0.609
CLV_C14_Caspase3-7	465	469	PF00656	0.591
CLV_C14_Caspase3-7	480	484	PF00656	0.725
CLV_NRD_NRD_1	230	232	PF00675	0.771
CLV_NRD_NRD_1	306	308	PF00675	0.767
CLV_NRD_NRD_1	385	387	PF00675	0.845
CLV_NRD_NRD_1	427	429	PF00675	0.748
CLV_NRD_NRD_1	491	493	PF00675	0.607
CLV_NRD_NRD_1	523	525	PF00675	0.700
CLV_NRD_NRD_1	612	614	PF00675	0.823
CLV_PCSK_FUR_1	382	386	PF00082	0.850
CLV_PCSK_FUR_1	610	614	PF00082	0.739
CLV_PCSK_KEX2_1	230	232	PF00082	0.761
CLV_PCSK_KEX2_1	306	308	PF00082	0.791
CLV_PCSK_KEX2_1	384	386	PF00082	0.851
CLV_PCSK_KEX2_1	427	429	PF00082	0.669
CLV_PCSK_KEX2_1	491	493	PF00082	0.607
CLV_PCSK_KEX2_1	523	525	PF00082	0.700
CLV_PCSK_KEX2_1	612	614	PF00082	0.823
CLV_PCSK_SKI1_1	226	230	PF00082	0.671
CLV_PCSK_SKI1_1	649	653	PF00082	0.679
DEG_SPOP_SBC_1	311	315	PF00917	0.664
DEG_SPOP_SBC_1	563	567	PF00917	0.775
DOC_CDC14_PxL_1	402	410	PF14671	0.807
DOC_CYCLIN_yClb3_PxF_3	262	268	PF00134	0.823
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.738
DOC_MAPK_DCC_7	20	28	PF00069	0.460
DOC_MAPK_gen_1	20	28	PF00069	0.460
DOC_MAPK_MEF2A_6	20	28	PF00069	0.460
DOC_PP2B_LxvP_1	21	24	PF13499	0.458
DOC_PP2B_LxvP_1	260	263	PF13499	0.731
DOC_PP2B_LxvP_1	321	324	PF13499	0.602
DOC_PP2B_LxvP_1	37	40	PF13499	0.428
DOC_PP2B_LxvP_1	561	564	PF13499	0.582
DOC_PP4_FxxP_1	503	506	PF00568	0.617
DOC_USP7_MATH_1	218	222	PF00917	0.746
DOC_USP7_MATH_1	311	315	PF00917	0.680
DOC_USP7_MATH_1	417	421	PF00917	0.612
DOC_USP7_MATH_1	517	521	PF00917	0.801
DOC_USP7_MATH_1	58	62	PF00917	0.547
DOC_USP7_MATH_1	605	609	PF00917	0.771
DOC_WW_Pin1_4	130	135	PF00397	0.561
DOC_WW_Pin1_4	253	258	PF00397	0.710
DOC_WW_Pin1_4	262	267	PF00397	0.621
DOC_WW_Pin1_4	294	299	PF00397	0.790
DOC_WW_Pin1_4	413	418	PF00397	0.798
DOC_WW_Pin1_4	564	569	PF00397	0.763
DOC_WW_Pin1_4	591	596	PF00397	0.793
LIG_14-3-3_CanoR_1	179	187	PF00244	0.405
LIG_14-3-3_CanoR_1	30	38	PF00244	0.456
LIG_14-3-3_CanoR_1	477	485	PF00244	0.623
LIG_14-3-3_CanoR_1	491	501	PF00244	0.669
LIG_14-3-3_CanoR_1	509	517	PF00244	0.724
LIG_14-3-3_CanoR_1	523	532	PF00244	0.616
LIG_14-3-3_CanoR_1	542	552	PF00244	0.500
LIG_APCC_ABBA_1	168	173	PF00400	0.529
LIG_BIR_III_2	366	370	PF00653	0.751
LIG_BRCT_BRCA1_1	180	184	PF00533	0.529
LIG_BRCT_BRCA1_1	264	268	PF00533	0.798
LIG_BRCT_BRCA1_1	528	532	PF00533	0.611
LIG_EVH1_2	328	332	PF00568	0.812
LIG_EVH1_2	361	365	PF00568	0.819
LIG_EVH1_2	406	410	PF00568	0.813
LIG_FHA_1	496	502	PF00498	0.707
LIG_FHA_1	545	551	PF00498	0.646
LIG_FHA_1	556	562	PF00498	0.577
LIG_FHA_2	107	113	PF00498	0.619
LIG_FHA_2	332	338	PF00498	0.608
LIG_FHA_2	414	420	PF00498	0.691
LIG_FHA_2	448	454	PF00498	0.693
LIG_Integrin_RGD_1	231	233	PF01839	0.724
LIG_LIR_Apic_2	45	50	PF02991	0.432
LIG_LIR_Gen_1	181	191	PF02991	0.529
LIG_LIR_Gen_1	32	42	PF02991	0.450
LIG_LIR_Gen_1	572	582	PF02991	0.582
LIG_LIR_Nem_3	181	187	PF02991	0.529
LIG_LIR_Nem_3	189	194	PF02991	0.397
LIG_LIR_Nem_3	32	38	PF02991	0.455
LIG_LIR_Nem_3	572	578	PF02991	0.603
LIG_MYND_1	262	266	PF01753	0.813
LIG_NRBOX	450	456	PF00104	0.695
LIG_Pex14_2	34	38	PF04695	0.457
LIG_SH2_CRK	163	167	PF00017	0.529
LIG_SH2_CRK	47	51	PF00017	0.434
LIG_SH2_CRK	575	579	PF00017	0.733
LIG_SH2_SRC	193	196	PF00017	0.302
LIG_SH2_STAT5	193	196	PF00017	0.480
LIG_SH2_STAT5	242	245	PF00017	0.740
LIG_SH2_STAT5	35	38	PF00017	0.457
LIG_SH3_1	131	137	PF00018	0.635
LIG_SH3_1	279	285	PF00018	0.735
LIG_SH3_1	295	301	PF00018	0.839
LIG_SH3_2	301	306	PF14604	0.754
LIG_SH3_3	131	137	PF00018	0.635
LIG_SH3_3	217	223	PF00018	0.726
LIG_SH3_3	256	262	PF00018	0.816
LIG_SH3_3	279	285	PF00018	0.660
LIG_SH3_3	295	301	PF00018	0.839
LIG_SH3_3	322	328	PF00018	0.787
LIG_SH3_3	341	347	PF00018	0.740
LIG_SH3_3	354	360	PF00018	0.597
LIG_SH3_3	401	407	PF00018	0.721
LIG_SH3_3	443	449	PF00018	0.783
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.531
LIG_TRAF2_1	109	112	PF00917	0.538
LIG_TRAF2_1	577	580	PF00917	0.694
LIG_WW_3	297	301	PF00397	0.828
MOD_CDC14_SPxK_1	297	300	PF00782	0.748
MOD_CDK_SPxK_1	294	300	PF00069	0.761
MOD_CK1_1	152	158	PF00069	0.529
MOD_CK1_1	178	184	PF00069	0.383
MOD_CK1_1	244	250	PF00069	0.784
MOD_CK1_1	251	257	PF00069	0.661
MOD_CK1_1	258	264	PF00069	0.560
MOD_CK1_1	269	275	PF00069	0.610
MOD_CK1_1	277	283	PF00069	0.578
MOD_CK1_1	415	421	PF00069	0.796
MOD_CK1_1	544	550	PF00069	0.610
MOD_CK1_1	555	561	PF00069	0.722
MOD_CK1_1	562	568	PF00069	0.626
MOD_CK1_1	591	597	PF00069	0.766
MOD_CK1_1	608	614	PF00069	0.549
MOD_CK1_1	632	638	PF00069	0.686
MOD_CK2_1	106	112	PF00069	0.641
MOD_CK2_1	186	192	PF00069	0.529
MOD_CK2_1	193	199	PF00069	0.413
MOD_CK2_1	218	224	PF00069	0.723
MOD_CK2_1	447	453	PF00069	0.708
MOD_CK2_1	566	572	PF00069	0.695
MOD_CK2_1	632	638	PF00069	0.559
MOD_GlcNHglycan	123	127	PF01048	0.610
MOD_GlcNHglycan	154	157	PF01048	0.369
MOD_GlcNHglycan	253	256	PF01048	0.762
MOD_GlcNHglycan	274	277	PF01048	0.717
MOD_GlcNHglycan	321	324	PF01048	0.823
MOD_GlcNHglycan	334	337	PF01048	0.679
MOD_GlcNHglycan	419	422	PF01048	0.761
MOD_GlcNHglycan	441	444	PF01048	0.723
MOD_GlcNHglycan	487	490	PF01048	0.827
MOD_GlcNHglycan	512	515	PF01048	0.663
MOD_GlcNHglycan	528	531	PF01048	0.665
MOD_GlcNHglycan	533	537	PF01048	0.670
MOD_GlcNHglycan	561	564	PF01048	0.726
MOD_GlcNHglycan	591	594	PF01048	0.770
MOD_GlcNHglycan	622	625	PF01048	0.704
MOD_GlcNHglycan	631	634	PF01048	0.705
MOD_GlcNHglycan	65	68	PF01048	0.585
MOD_GlcNHglycan	92	95	PF01048	0.717
MOD_GlcNHglycan	98	101	PF01048	0.559
MOD_GSK3_1	174	181	PF00069	0.373
MOD_GSK3_1	210	217	PF00069	0.728
MOD_GSK3_1	241	248	PF00069	0.814
MOD_GSK3_1	249	256	PF00069	0.681
MOD_GSK3_1	258	265	PF00069	0.512
MOD_GSK3_1	266	273	PF00069	0.568
MOD_GSK3_1	332	339	PF00069	0.668
MOD_GSK3_1	386	393	PF00069	0.699
MOD_GSK3_1	411	418	PF00069	0.709
MOD_GSK3_1	519	526	PF00069	0.765
MOD_GSK3_1	537	544	PF00069	0.538
MOD_GSK3_1	555	562	PF00069	0.674
MOD_GSK3_1	563	570	PF00069	0.597
MOD_GSK3_1	58	65	PF00069	0.516
MOD_GSK3_1	587	594	PF00069	0.821
MOD_GSK3_1	604	611	PF00069	0.517
MOD_GSK3_1	620	627	PF00069	0.745
MOD_GSK3_1	629	636	PF00069	0.675
MOD_GSK3_1	80	87	PF00069	0.834
MOD_LATS_1	521	527	PF00433	0.724
MOD_N-GLC_1	174	179	PF02516	0.404
MOD_N-GLC_1	485	490	PF02516	0.749
MOD_N-GLC_1	524	529	PF02516	0.764
MOD_N-GLC_1	85	90	PF02516	0.664
MOD_NEK2_1	186	191	PF00069	0.396
MOD_NEK2_1	243	248	PF00069	0.710
MOD_NEK2_1	350	355	PF00069	0.752
MOD_NEK2_1	42	47	PF00069	0.500
MOD_NEK2_1	485	490	PF00069	0.681
MOD_NEK2_1	510	515	PF00069	0.693
MOD_NEK2_1	532	537	PF00069	0.728
MOD_NEK2_1	552	557	PF00069	0.517
MOD_NEK2_1	604	609	PF00069	0.810
MOD_NEK2_1	85	90	PF00069	0.628
MOD_NEK2_2	58	63	PF00069	0.498
MOD_NEK2_2	605	610	PF00069	0.727
MOD_PIKK_1	73	79	PF00454	0.606
MOD_PKA_1	385	391	PF00069	0.755
MOD_PKA_1	523	529	PF00069	0.619
MOD_PKA_2	178	184	PF00069	0.405
MOD_PKA_2	29	35	PF00069	0.455
MOD_PKA_2	385	391	PF00069	0.800
MOD_PKA_2	426	432	PF00069	0.656
MOD_PKA_2	523	529	PF00069	0.629
MOD_PKA_2	541	547	PF00069	0.619
MOD_PKA_2	582	588	PF00069	0.566
MOD_PKA_2	624	630	PF00069	0.669
MOD_PKB_1	384	392	PF00069	0.838
MOD_Plk_2-3	447	453	PF00069	0.708
MOD_Plk_4	42	48	PF00069	0.437
MOD_ProDKin_1	130	136	PF00069	0.557
MOD_ProDKin_1	253	259	PF00069	0.702
MOD_ProDKin_1	262	268	PF00069	0.626
MOD_ProDKin_1	294	300	PF00069	0.790
MOD_ProDKin_1	413	419	PF00069	0.798
MOD_ProDKin_1	564	570	PF00069	0.761
MOD_ProDKin_1	591	597	PF00069	0.791
MOD_SUMO_rev_2	219	228	PF00179	0.654
MOD_SUMO_rev_2	233	243	PF00179	0.631
TRG_DiLeu_BaEn_1	115	120	PF01217	0.531
TRG_DiLeu_BaEn_1	182	187	PF01217	0.446
TRG_ENDOCYTIC_2	163	166	PF00928	0.529
TRG_ENDOCYTIC_2	35	38	PF00928	0.457
TRG_ENDOCYTIC_2	575	578	PF00928	0.731
TRG_ER_diArg_1	19	22	PF00400	0.478
TRG_ER_diArg_1	229	231	PF00400	0.777
TRG_ER_diArg_1	306	308	PF00400	0.778
TRG_ER_diArg_1	381	384	PF00400	0.834
TRG_ER_diArg_1	491	494	PF00400	0.607
TRG_ER_diArg_1	609	612	PF00400	0.735
TRG_ER_diArg_1	646	649	PF00400	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB27	Leishmania donovani	83%	100%
A4HGP3	Leishmania braziliensis	56%	100%
A4I3R6	Leishmania infantum	82%	100%
E9B009	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%