MI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p21-C-terminal region-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q875_LEIMA

TriTrypDb:

LmjF.28.1910 , LMJLV39_280026900 , LMJSD75_280026400

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q875

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q875

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.668
CLV_C14_Caspase3-7	237	241	PF00656	0.781
CLV_C14_Caspase3-7	261	265	PF00656	0.600
CLV_C14_Caspase3-7	347	351	PF00656	0.460
CLV_C14_Caspase3-7	449	453	PF00656	0.576
CLV_C14_Caspase3-7	488	492	PF00656	0.576
CLV_C14_Caspase3-7	559	563	PF00656	0.530
CLV_C14_Caspase3-7	58	62	PF00656	0.667
CLV_NRD_NRD_1	103	105	PF00675	0.603
CLV_NRD_NRD_1	130	132	PF00675	0.654
CLV_NRD_NRD_1	213	215	PF00675	0.570
CLV_NRD_NRD_1	224	226	PF00675	0.667
CLV_NRD_NRD_1	30	32	PF00675	0.567
CLV_NRD_NRD_1	310	312	PF00675	0.777
CLV_NRD_NRD_1	568	570	PF00675	0.331
CLV_NRD_NRD_1	666	668	PF00675	0.460
CLV_NRD_NRD_1	75	77	PF00675	0.569
CLV_NRD_NRD_1	93	95	PF00675	0.639
CLV_PCSK_FUR_1	621	625	PF00082	0.419
CLV_PCSK_FUR_1	91	95	PF00082	0.558
CLV_PCSK_KEX2_1	101	103	PF00082	0.589
CLV_PCSK_KEX2_1	130	132	PF00082	0.727
CLV_PCSK_KEX2_1	224	226	PF00082	0.793
CLV_PCSK_KEX2_1	28	30	PF00082	0.671
CLV_PCSK_KEX2_1	3	5	PF00082	0.664
CLV_PCSK_KEX2_1	309	311	PF00082	0.773
CLV_PCSK_KEX2_1	623	625	PF00082	0.433
CLV_PCSK_KEX2_1	665	667	PF00082	0.464
CLV_PCSK_KEX2_1	93	95	PF00082	0.675
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.565
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.671
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.664
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.433
CLV_PCSK_SKI1_1	131	135	PF00082	0.728
CLV_PCSK_SKI1_1	462	466	PF00082	0.294
CLV_PCSK_SKI1_1	624	628	PF00082	0.453
CLV_PCSK_SKI1_1	667	671	PF00082	0.408
CLV_PCSK_SKI1_1	77	81	PF00082	0.715
DEG_SCF_TRCP1_1	264	269	PF00400	0.579
DEG_SPOP_SBC_1	49	53	PF00917	0.582
DEG_SPOP_SBC_1	546	550	PF00917	0.440
DOC_ANK_TNKS_1	434	441	PF00023	0.508
DOC_CKS1_1	83	88	PF01111	0.556
DOC_CYCLIN_RxL_1	151	162	PF00134	0.614
DOC_CYCLIN_RxL_1	459	469	PF00134	0.492
DOC_MAPK_DCC_7	3	13	PF00069	0.663
DOC_MAPK_gen_1	101	107	PF00069	0.644
DOC_MAPK_gen_1	3	13	PF00069	0.663
DOC_MAPK_gen_1	460	467	PF00069	0.492
DOC_MAPK_MEF2A_6	369	376	PF00069	0.492
DOC_MAPK_MEF2A_6	472	480	PF00069	0.492
DOC_MAPK_NFAT4_5	369	377	PF00069	0.492
DOC_PP1_RVXF_1	101	108	PF00149	0.641
DOC_PP1_RVXF_1	136	142	PF00149	0.698
DOC_USP7_MATH_1	124	128	PF00917	0.623
DOC_USP7_MATH_1	252	256	PF00917	0.704
DOC_USP7_MATH_1	257	261	PF00917	0.581
DOC_USP7_MATH_1	317	321	PF00917	0.678
DOC_USP7_MATH_1	380	384	PF00917	0.492
DOC_USP7_MATH_1	455	459	PF00917	0.530
DOC_USP7_MATH_1	49	53	PF00917	0.669
DOC_USP7_MATH_1	545	549	PF00917	0.524
DOC_USP7_MATH_1	586	590	PF00917	0.530
DOC_USP7_UBL2_3	74	78	PF12436	0.515
DOC_WW_Pin1_4	253	258	PF00397	0.769
DOC_WW_Pin1_4	376	381	PF00397	0.496
DOC_WW_Pin1_4	597	602	PF00397	0.576
DOC_WW_Pin1_4	62	67	PF00397	0.589
DOC_WW_Pin1_4	82	87	PF00397	0.563
LIG_14-3-3_CanoR_1	102	108	PF00244	0.588
LIG_14-3-3_CanoR_1	147	156	PF00244	0.700
LIG_14-3-3_CanoR_1	214	218	PF00244	0.700
LIG_14-3-3_CanoR_1	29	37	PF00244	0.779
LIG_14-3-3_CanoR_1	533	541	PF00244	0.492
LIG_14-3-3_CanoR_1	624	629	PF00244	0.493
LIG_Actin_RPEL_3	428	447	PF02755	0.492
LIG_Actin_WH2_2	657	673	PF00022	0.376
LIG_BIR_III_4	393	397	PF00653	0.508
LIG_BIR_III_4	491	495	PF00653	0.492
LIG_BRCT_BRCA1_1	646	650	PF00533	0.387
LIG_Clathr_ClatBox_1	334	338	PF01394	0.335
LIG_CtBP_PxDLS_1	475	479	PF00389	0.492
LIG_CtBP_PxDLS_1	601	605	PF00389	0.576
LIG_CtBP_PxDLS_1	86	90	PF00389	0.629
LIG_FHA_1	380	386	PF00498	0.492
LIG_FHA_1	442	448	PF00498	0.497
LIG_FHA_1	477	483	PF00498	0.492
LIG_FHA_1	603	609	PF00498	0.481
LIG_FHA_2	14	20	PF00498	0.586
LIG_FHA_2	393	399	PF00498	0.494
LIG_FHA_2	503	509	PF00498	0.576
LIG_LIR_Gen_1	378	387	PF02991	0.492
LIG_LIR_Gen_1	523	531	PF02991	0.466
LIG_LIR_Nem_3	140	144	PF02991	0.734
LIG_LIR_Nem_3	336	342	PF02991	0.492
LIG_LIR_Nem_3	378	384	PF02991	0.492
LIG_LIR_Nem_3	401	405	PF02991	0.490
LIG_LIR_Nem_3	523	528	PF02991	0.466
LIG_MYND_1	132	136	PF01753	0.657
LIG_SH2_CRK	426	430	PF00017	0.440
LIG_SH2_CRK	654	658	PF00017	0.341
LIG_SH2_NCK_1	377	381	PF00017	0.476
LIG_SH2_STAT3	636	639	PF00017	0.488
LIG_SH2_STAT5	178	181	PF00017	0.656
LIG_SH2_STAT5	470	473	PF00017	0.503
LIG_SH2_STAT5	607	610	PF00017	0.503
LIG_SH3_1	80	86	PF00018	0.651
LIG_SH3_2	142	147	PF14604	0.749
LIG_SH3_3	130	136	PF00018	0.725
LIG_SH3_3	139	145	PF00018	0.748
LIG_SH3_3	436	442	PF00018	0.546
LIG_SH3_3	536	542	PF00018	0.492
LIG_SH3_3	595	601	PF00018	0.576
LIG_SH3_3	60	66	PF00018	0.662
LIG_SH3_3	80	86	PF00018	0.609
LIG_SUMO_SIM_par_1	332	338	PF11976	0.335
LIG_SUMO_SIM_par_1	463	469	PF11976	0.495
LIG_SUMO_SIM_par_1	474	479	PF11976	0.512
LIG_SUMO_SIM_par_1	599	605	PF11976	0.528
LIG_SUMO_SIM_par_1	9	17	PF11976	0.664
LIG_TRAF2_1	202	205	PF00917	0.611
LIG_TRAF2_1	294	297	PF00917	0.730
LIG_TRAF2_1	395	398	PF00917	0.492
LIG_TYR_ITIM	652	657	PF00017	0.339
LIG_UBA3_1	524	530	PF00899	0.501
LIG_UBA3_1	616	623	PF00899	0.489
MOD_CK1_1	140	146	PF00069	0.673
MOD_CK1_1	150	156	PF00069	0.641
MOD_CK1_1	236	242	PF00069	0.677
MOD_CK1_1	265	271	PF00069	0.672
MOD_CK1_1	379	385	PF00069	0.492
MOD_CK1_1	52	58	PF00069	0.793
MOD_CK1_1	576	582	PF00069	0.562
MOD_CK1_1	62	68	PF00069	0.568
MOD_CK2_1	157	163	PF00069	0.710
MOD_CK2_1	18	24	PF00069	0.813
MOD_CK2_1	198	204	PF00069	0.697
MOD_CK2_1	232	238	PF00069	0.781
MOD_CK2_1	291	297	PF00069	0.759
MOD_CK2_1	317	323	PF00069	0.677
MOD_CK2_1	392	398	PF00069	0.494
MOD_CK2_1	502	508	PF00069	0.576
MOD_CK2_1	52	58	PF00069	0.673
MOD_CK2_1	62	68	PF00069	0.572
MOD_GlcNHglycan	119	122	PF01048	0.677
MOD_GlcNHglycan	149	152	PF01048	0.668
MOD_GlcNHglycan	200	203	PF01048	0.572
MOD_GlcNHglycan	264	267	PF01048	0.702
MOD_GlcNHglycan	297	303	PF01048	0.790
MOD_GlcNHglycan	46	49	PF01048	0.663
MOD_GlcNHglycan	54	57	PF01048	0.652
MOD_GlcNHglycan	549	552	PF01048	0.295
MOD_GlcNHglycan	558	561	PF01048	0.288
MOD_GlcNHglycan	590	593	PF01048	0.307
MOD_GSK3_1	14	21	PF00069	0.691
MOD_GSK3_1	146	153	PF00069	0.638
MOD_GSK3_1	194	201	PF00069	0.649
MOD_GSK3_1	232	239	PF00069	0.664
MOD_GSK3_1	253	260	PF00069	0.775
MOD_GSK3_1	262	269	PF00069	0.718
MOD_GSK3_1	376	383	PF00069	0.492
MOD_GSK3_1	44	51	PF00069	0.660
MOD_GSK3_1	441	448	PF00069	0.504
MOD_GSK3_1	547	554	PF00069	0.493
MOD_GSK3_1	576	583	PF00069	0.576
MOD_GSK3_1	588	595	PF00069	0.460
MOD_N-GLC_1	117	122	PF02516	0.716
MOD_N-GLC_1	586	591	PF02516	0.240
MOD_NEK2_1	213	218	PF00069	0.673
MOD_NEK2_1	344	349	PF00069	0.476
MOD_NEK2_1	37	42	PF00069	0.630
MOD_NEK2_1	43	48	PF00069	0.809
MOD_NEK2_1	476	481	PF00069	0.504
MOD_NEK2_1	602	607	PF00069	0.476
MOD_PIKK_1	124	130	PF00454	0.584
MOD_PK_1	59	65	PF00069	0.638
MOD_PKA_1	103	109	PF00069	0.573
MOD_PKA_1	30	36	PF00069	0.561
MOD_PKA_1	580	586	PF00069	0.576
MOD_PKA_2	103	109	PF00069	0.573
MOD_PKA_2	146	152	PF00069	0.754
MOD_PKA_2	213	219	PF00069	0.674
MOD_PKA_2	30	36	PF00069	0.698
MOD_PKA_2	43	49	PF00069	0.782
MOD_PKA_2	532	538	PF00069	0.492
MOD_Plk_1	476	482	PF00069	0.492
MOD_Plk_1	602	608	PF00069	0.484
MOD_Plk_2-3	233	239	PF00069	0.793
MOD_Plk_2-3	291	297	PF00069	0.785
MOD_Plk_4	380	386	PF00069	0.499
MOD_Plk_4	404	410	PF00069	0.492
MOD_Plk_4	413	419	PF00069	0.492
MOD_Plk_4	446	452	PF00069	0.495
MOD_Plk_4	520	526	PF00069	0.492
MOD_Plk_4	59	65	PF00069	0.670
MOD_Plk_4	624	630	PF00069	0.509
MOD_Plk_4	644	650	PF00069	0.392
MOD_Plk_4	85	91	PF00069	0.631
MOD_ProDKin_1	253	259	PF00069	0.773
MOD_ProDKin_1	376	382	PF00069	0.496
MOD_ProDKin_1	597	603	PF00069	0.576
MOD_ProDKin_1	62	68	PF00069	0.585
MOD_ProDKin_1	82	88	PF00069	0.560
MOD_SUMO_rev_2	491	501	PF00179	0.565
TRG_DiLeu_BaEn_4	205	211	PF01217	0.626
TRG_DiLeu_BaEn_4	612	618	PF01217	0.492
TRG_ENDOCYTIC_2	426	429	PF00928	0.453
TRG_ENDOCYTIC_2	654	657	PF00928	0.339
TRG_ER_diArg_1	102	104	PF00400	0.603
TRG_ER_diArg_1	130	132	PF00400	0.724
TRG_ER_diArg_1	29	31	PF00400	0.611
TRG_ER_diArg_1	309	311	PF00400	0.728
TRG_ER_diArg_1	630	633	PF00400	0.457
TRG_ER_diArg_1	664	667	PF00400	0.564
TRG_ER_diArg_1	90	93	PF00400	0.579
TRG_NLS_MonoCore_2	100	105	PF00514	0.642
TRG_NLS_MonoExtC_3	75	80	PF00514	0.651
TRG_NLS_MonoExtN_4	2	7	PF00514	0.663
TRG_NLS_MonoExtN_4	74	80	PF00514	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7I5	Leptomonas seymouri	55%	100%
A0A3Q8IEX8	Leishmania donovani	90%	100%
A4HGP4	Leishmania braziliensis	71%	100%
A4I3R7	Leishmania infantum	90%	100%
E9B010	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%