Putative zinc transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc transporter 3, putative

Species:

Leishmania major

UniProt:

Q4Q873_LEIMA

TriTrypDb:

LmjF.28.1930 , LMJLV39_280027100 , LMJSD75_280026600

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	5
GO:0016020	membrane	2	32
GO:0110165	cellular anatomical entity	1	32

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Expansion

Sequence features

Q4Q873

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q873

Function

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Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	5
GO:0006810	transport	3	5
GO:0006811	monoatomic ion transport	4	5
GO:0006812	monoatomic cation transport	5	5
GO:0006829	zinc ion transport	8	5
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0006875	obsolete intracellular metal ion homeostasis	6	2
GO:0006882	intracellular zinc ion homeostasis	7	2
GO:0009987	cellular process	1	5
GO:0019725	cellular homeostasis	2	2

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	32
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0005385	zinc ion transmembrane transporter activity	7	5
GO:0008324	monoatomic cation transmembrane transporter activity	4	32
GO:0015075	monoatomic ion transmembrane transporter activity	3	32
GO:0015093	ferrous iron transmembrane transporter activity	8	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	32
GO:0022857	transmembrane transporter activity	2	32
GO:0022890	inorganic cation transmembrane transporter activity	4	32
GO:0046873	metal ion transmembrane transporter activity	5	32

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.504
CLV_C14_Caspase3-7	31	35	PF00656	0.560
CLV_C14_Caspase3-7	55	59	PF00656	0.552
CLV_NRD_NRD_1	38	40	PF00675	0.603
CLV_PCSK_KEX2_1	101	103	PF00082	0.287
CLV_PCSK_KEX2_1	37	39	PF00082	0.604
CLV_PCSK_KEX2_1	398	400	PF00082	0.222
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.287
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.254
CLV_PCSK_PC7_1	394	400	PF00082	0.187

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	41%	98%
A0A1X0NR51	Trypanosomatidae	46%	100%
A0A1X0NSB9	Trypanosomatidae	37%	100%
A0A1X0NSI7	Trypanosomatidae	37%	100%
A0A3R7LZX6	Trypanosoma rangeli	40%	100%
A0A3S7X1N7	Leishmania donovani	84%	91%
A0A3S7X501	Leishmania donovani	41%	97%
A0A422MUI2	Trypanosoma rangeli	36%	100%
A4HGP7	Leishmania braziliensis	78%	100%
A4HJU9	Leishmania braziliensis	42%	99%

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