Putative zinc transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc transporter 3, putative

Species:

Leishmania major

UniProt:

Q4Q873_LEIMA

TriTrypDb:

LmjF.28.1930 , LMJLV39_280027100 , LMJSD75_280026600

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	5
GO:0016020	membrane	2	32
GO:0110165	cellular anatomical entity	1	32

Expansion

Sequence features

Q4Q873

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q873

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	5
GO:0006810	transport	3	5
GO:0006811	monoatomic ion transport	4	5
GO:0006812	monoatomic cation transport	5	5
GO:0006829	zinc ion transport	8	5
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0006875	obsolete intracellular metal ion homeostasis	6	2
GO:0006882	intracellular zinc ion homeostasis	7	2
GO:0009987	cellular process	1	5
GO:0019725	cellular homeostasis	2	2
GO:0030001	metal ion transport	6	5
GO:0030003	intracellular monoatomic cation homeostasis	5	2
GO:0034220	monoatomic ion transmembrane transport	3	5
GO:0042592	homeostatic process	3	2
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	2
GO:0048878	chemical homeostasis	4	2
GO:0050801	monoatomic ion homeostasis	5	2
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055065	obsolete metal ion homeostasis	7	2
GO:0055069	obsolete zinc ion homeostasis	8	2
GO:0055076	obsolete transition metal ion homeostasis	8	2
GO:0055080	monoatomic cation homeostasis	6	2
GO:0055082	intracellular chemical homeostasis	3	2
GO:0055085	transmembrane transport	2	5
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071577	zinc ion transmembrane transport	6	5
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	2
GO:0072507	obsolete divalent inorganic cation homeostasis	7	2
GO:0098655	monoatomic cation transmembrane transport	4	5
GO:0098660	inorganic ion transmembrane transport	4	5
GO:0098662	inorganic cation transmembrane transport	5	5
GO:0098771	inorganic ion homeostasis	6	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	32
GO:0005385	zinc ion transmembrane transporter activity	7	5
GO:0008324	monoatomic cation transmembrane transporter activity	4	32
GO:0015075	monoatomic ion transmembrane transporter activity	3	32
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	32
GO:0022857	transmembrane transporter activity	2	32
GO:0022890	inorganic cation transmembrane transporter activity	4	32
GO:0046873	metal ion transmembrane transporter activity	5	32
GO:0046915	transition metal ion transmembrane transporter activity	6	5
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.504
CLV_C14_Caspase3-7	31	35	PF00656	0.560
CLV_C14_Caspase3-7	55	59	PF00656	0.552
CLV_NRD_NRD_1	38	40	PF00675	0.603
CLV_PCSK_KEX2_1	101	103	PF00082	0.287
CLV_PCSK_KEX2_1	37	39	PF00082	0.604
CLV_PCSK_KEX2_1	398	400	PF00082	0.222
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.287
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.254
CLV_PCSK_PC7_1	394	400	PF00082	0.187
CLV_PCSK_SKI1_1	351	355	PF00082	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.355
DOC_MAPK_gen_1	101	108	PF00069	0.574
DOC_MAPK_MEF2A_6	101	108	PF00069	0.422
DOC_MAPK_MEF2A_6	294	302	PF00069	0.265
DOC_MAPK_MEF2A_6	321	330	PF00069	0.546
DOC_MAPK_NFAT4_5	321	329	PF00069	0.483
DOC_PP4_FxxP_1	334	337	PF00568	0.305
DOC_USP7_MATH_1	10	14	PF00917	0.373
DOC_USP7_MATH_1	29	33	PF00917	0.401
DOC_USP7_MATH_1	316	320	PF00917	0.499
DOC_USP7_MATH_1	360	364	PF00917	0.269
DOC_USP7_MATH_2	4	10	PF00917	0.387
LIG_14-3-3_CanoR_1	107	112	PF00244	0.418
LIG_14-3-3_CanoR_1	37	43	PF00244	0.437
LIG_APCC_ABBA_1	25	30	PF00400	0.385
LIG_BRCT_BRCA1_1	136	140	PF00533	0.206
LIG_Clathr_ClatBox_1	381	385	PF01394	0.432
LIG_deltaCOP1_diTrp_1	154	160	PF00928	0.216
LIG_DLG_GKlike_1	107	115	PF00625	0.382
LIG_eIF4E_1	376	382	PF01652	0.321
LIG_FHA_1	119	125	PF00498	0.368
LIG_FHA_1	13	19	PF00498	0.351
LIG_FHA_1	342	348	PF00498	0.267
LIG_FHA_1	356	362	PF00498	0.245
LIG_FHA_2	225	231	PF00498	0.512
LIG_FHA_2	29	35	PF00498	0.414
LIG_LIR_Apic_2	333	337	PF02991	0.305
LIG_LIR_Gen_1	154	164	PF02991	0.211
LIG_LIR_Gen_1	357	366	PF02991	0.322
LIG_LIR_Nem_3	154	159	PF02991	0.265
LIG_LIR_Nem_3	278	283	PF02991	0.360
LIG_LIR_Nem_3	357	362	PF02991	0.349
LIG_PDZ_Wminus1_1	418	420	PF00595	0.354
LIG_Pex14_1	156	160	PF04695	0.463
LIG_Pex14_2	302	306	PF04695	0.381
LIG_Pex14_2	379	383	PF04695	0.371
LIG_SH2_CRK	359	363	PF00017	0.216
LIG_SH2_NCK_1	359	363	PF00017	0.216
LIG_SH2_SRC	111	114	PF00017	0.514
LIG_SH2_STAT5	111	114	PF00017	0.499
LIG_SH2_STAT5	376	379	PF00017	0.300
LIG_SH3_1	189	195	PF00018	0.413
LIG_SH3_3	189	195	PF00018	0.516
LIG_SH3_3	249	255	PF00018	0.573
LIG_SUMO_SIM_anti_2	233	239	PF11976	0.382
LIG_SUMO_SIM_anti_2	325	330	PF11976	0.447
LIG_SxIP_EBH_1	89	102	PF03271	0.340
LIG_TYR_ITSM	355	362	PF00017	0.216
LIG_UBA3_1	95	101	PF00899	0.248
LIG_WRC_WIRS_1	331	336	PF05994	0.278
MOD_CK1_1	355	361	PF00069	0.311
MOD_CK1_1	52	58	PF00069	0.530
MOD_CK2_1	145	151	PF00069	0.233
MOD_Cter_Amidation	99	102	PF01082	0.321
MOD_GlcNHglycan	12	15	PF01048	0.604
MOD_GlcNHglycan	30	34	PF01048	0.775
MOD_GlcNHglycan	334	337	PF01048	0.361
MOD_GlcNHglycan	354	357	PF01048	0.366
MOD_GlcNHglycan	362	365	PF01048	0.316
MOD_GlcNHglycan	44	47	PF01048	0.804
MOD_GlcNHglycan	54	57	PF01048	0.784
MOD_GlcNHglycan	8	11	PF01048	0.729
MOD_GSK3_1	14	21	PF00069	0.558
MOD_GSK3_1	29	36	PF00069	0.591
MOD_GSK3_1	316	323	PF00069	0.502
MOD_GSK3_1	38	45	PF00069	0.437
MOD_GSK3_1	6	13	PF00069	0.425
MOD_GSK3_1	87	94	PF00069	0.296
MOD_N-GLC_2	202	204	PF02516	0.213
MOD_NEK2_1	272	277	PF00069	0.370
MOD_NEK2_1	285	290	PF00069	0.276
MOD_NEK2_1	330	335	PF00069	0.334
MOD_NEK2_1	354	359	PF00069	0.290
MOD_NEK2_1	87	92	PF00069	0.322
MOD_NEK2_2	316	321	PF00069	0.446
MOD_PIKK_1	18	24	PF00454	0.513
MOD_PKA_1	38	44	PF00069	0.403
MOD_PKA_2	180	186	PF00069	0.523
MOD_PKA_2	38	44	PF00069	0.458
MOD_Plk_1	202	208	PF00069	0.600
MOD_Plk_1	316	322	PF00069	0.430
MOD_Plk_4	107	113	PF00069	0.438
MOD_Plk_4	202	208	PF00069	0.382
MOD_Plk_4	233	239	PF00069	0.389
MOD_Plk_4	275	281	PF00069	0.326
MOD_Plk_4	87	93	PF00069	0.323
MOD_SUMO_for_1	208	211	PF00179	0.382
TRG_DiLeu_BaEn_2	153	159	PF01217	0.256
TRG_ENDOCYTIC_2	359	362	PF00928	0.311
TRG_ENDOCYTIC_2	376	379	PF00928	0.305
TRG_ENDOCYTIC_2	403	406	PF00928	0.373
TRG_ER_diArg_1	37	39	PF00400	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	41%	98%
A0A1X0NR51	Trypanosomatidae	46%	100%
A0A1X0NSB9	Trypanosomatidae	37%	100%
A0A1X0NSI7	Trypanosomatidae	37%	100%
A0A3R7LZX6	Trypanosoma rangeli	40%	100%
A0A3S7X1N7	Leishmania donovani	84%	91%
A0A3S7X501	Leishmania donovani	41%	97%
A0A422MUI2	Trypanosoma rangeli	36%	100%
A4HGP7	Leishmania braziliensis	78%	100%
A4HJU9	Leishmania braziliensis	42%	99%
A4HJV0	Leishmania braziliensis	42%	99%
A4HJV1	Leishmania braziliensis	36%	100%
A4HM27	Leishmania braziliensis	32%	100%
A4I3R9	Leishmania infantum	86%	91%
A4I7B1	Leishmania infantum	41%	97%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	93%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	97%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	97%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
O04089	Arabidopsis thaliana	28%	100%
O23039	Arabidopsis thaliana	30%	100%
O64738	Arabidopsis thaliana	24%	100%
O81123	Arabidopsis thaliana	24%	100%
O81850	Arabidopsis thaliana	25%	100%
O82643	Arabidopsis thaliana	30%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q38856	Arabidopsis thaliana	24%	100%
Q4Q3L6	Leishmania major	34%	100%
Q4Q5V0	Leishmania major	40%	97%
Q4Q5V1	Leishmania major	40%	97%
Q6L8F7	Oryza sativa subsp. japonica	28%	100%
Q6L8G0	Oryza sativa subsp. japonica	29%	100%
Q6L8G1	Oryza sativa subsp. japonica	29%	100%
Q75HB1	Oryza sativa subsp. japonica	28%	100%
Q7XLD4	Oryza sativa subsp. japonica	28%	100%
Q8S3W4	Arabidopsis thaliana	22%	100%
Q8W245	Arabidopsis thaliana	22%	100%
Q8W246	Arabidopsis thaliana	26%	100%
Q9FIS2	Arabidopsis thaliana	26%	100%
Q9SLG3	Arabidopsis thaliana	29%	100%
V5AWN3	Trypanosoma cruzi	38%	100%
V5BC34	Trypanosoma cruzi	36%	100%
V5DCU2	Trypanosoma cruzi	46%	100%