LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
divalent cation transporter, putative
Species:
Leishmania major
UniProt:
Q4Q872_LEIMA
TriTrypDb:
LmjF.28.1940 , LMJLV39_280027200 * , LMJSD75_280026800 *
Length:
677

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

Q4Q872
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q872

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 6
GO:0006811 monoatomic ion transport 4 6
GO:0006812 monoatomic cation transport 5 6
GO:0015693 magnesium ion transport 7 6
GO:0030001 metal ion transport 6 6
GO:0051179 localization 1 6
GO:0051234 establishment of localization 2 6
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 6
GO:0008324 monoatomic cation transmembrane transporter activity 4 6
GO:0015075 monoatomic ion transmembrane transporter activity 3 6
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 6
GO:0022857 transmembrane transporter activity 2 6
GO:0022890 inorganic cation transmembrane transporter activity 4 6
GO:0046873 metal ion transmembrane transporter activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 199 203 PF00656 0.498
CLV_C14_Caspase3-7 230 234 PF00656 0.642
CLV_C14_Caspase3-7 240 244 PF00656 0.475
CLV_NRD_NRD_1 191 193 PF00675 0.706
CLV_NRD_NRD_1 236 238 PF00675 0.800
CLV_NRD_NRD_1 410 412 PF00675 0.743
CLV_NRD_NRD_1 566 568 PF00675 0.321
CLV_PCSK_KEX2_1 190 192 PF00082 0.715
CLV_PCSK_KEX2_1 236 238 PF00082 0.793
CLV_PCSK_KEX2_1 410 412 PF00082 0.743
CLV_PCSK_KEX2_1 566 568 PF00082 0.314
CLV_PCSK_SKI1_1 14 18 PF00082 0.679
CLV_PCSK_SKI1_1 358 362 PF00082 0.655
CLV_PCSK_SKI1_1 484 488 PF00082 0.346
CLV_PCSK_SKI1_1 533 537 PF00082 0.316
CLV_PCSK_SKI1_1 567 571 PF00082 0.321
CLV_PCSK_SKI1_1 87 91 PF00082 0.692
DEG_SPOP_SBC_1 101 105 PF00917 0.523
DEG_SPOP_SBC_1 636 640 PF00917 0.419
DOC_ANK_TNKS_1 307 314 PF00023 0.539
DOC_CDC14_PxL_1 110 118 PF14671 0.552
DOC_CDC14_PxL_1 618 626 PF14671 0.436
DOC_CKS1_1 288 293 PF01111 0.466
DOC_CKS1_1 447 452 PF01111 0.514
DOC_CYCLIN_yCln2_LP_2 115 118 PF00134 0.547
DOC_CYCLIN_yCln2_LP_2 417 423 PF00134 0.613
DOC_CYCLIN_yCln2_LP_2 539 545 PF00134 0.563
DOC_MAPK_FxFP_2 144 147 PF00069 0.518
DOC_MAPK_gen_1 190 196 PF00069 0.504
DOC_MAPK_gen_1 515 523 PF00069 0.609
DOC_MAPK_gen_1 531 540 PF00069 0.451
DOC_MAPK_gen_1 566 572 PF00069 0.460
DOC_MAPK_RevD_3 178 192 PF00069 0.404
DOC_PP2B_LxvP_1 115 118 PF13499 0.603
DOC_PP2B_LxvP_1 538 541 PF13499 0.546
DOC_PP4_FxxP_1 144 147 PF00568 0.629
DOC_PP4_FxxP_1 447 450 PF00568 0.601
DOC_USP7_MATH_1 123 127 PF00917 0.562
DOC_USP7_MATH_1 130 134 PF00917 0.593
DOC_USP7_MATH_1 164 168 PF00917 0.491
DOC_USP7_MATH_1 274 278 PF00917 0.563
DOC_USP7_MATH_1 296 300 PF00917 0.440
DOC_USP7_MATH_1 320 324 PF00917 0.555
DOC_USP7_MATH_1 325 329 PF00917 0.549
DOC_USP7_MATH_1 339 343 PF00917 0.566
DOC_USP7_MATH_1 366 370 PF00917 0.571
DOC_WW_Pin1_4 149 154 PF00397 0.604
DOC_WW_Pin1_4 28 33 PF00397 0.590
DOC_WW_Pin1_4 287 292 PF00397 0.481
DOC_WW_Pin1_4 396 401 PF00397 0.634
DOC_WW_Pin1_4 446 451 PF00397 0.531
DOC_WW_Pin1_4 452 457 PF00397 0.491
DOC_WW_Pin1_4 543 548 PF00397 0.506
DOC_WW_Pin1_4 637 642 PF00397 0.314
DOC_WW_Pin1_4 97 102 PF00397 0.547
LIG_14-3-3_CanoR_1 191 197 PF00244 0.555
LIG_14-3-3_CanoR_1 341 347 PF00244 0.558
LIG_14-3-3_CanoR_1 35 45 PF00244 0.569
LIG_14-3-3_CanoR_1 550 558 PF00244 0.508
LIG_14-3-3_CanoR_1 560 566 PF00244 0.499
LIG_14-3-3_CanoR_1 567 573 PF00244 0.492
LIG_14-3-3_CanoR_1 581 587 PF00244 0.597
LIG_14-3-3_CanoR_1 593 601 PF00244 0.490
LIG_BIR_II_1 1 5 PF00653 0.554
LIG_BIR_III_2 160 164 PF00653 0.612
LIG_BRCT_BRCA1_1 142 146 PF00533 0.464
LIG_BRCT_BRCA1_1 298 302 PF00533 0.449
LIG_EH1_1 647 655 PF00400 0.280
LIG_FHA_1 288 294 PF00498 0.461
LIG_FHA_1 481 487 PF00498 0.530
LIG_FHA_1 512 518 PF00498 0.564
LIG_FHA_1 610 616 PF00498 0.513
LIG_FHA_1 647 653 PF00498 0.364
LIG_FHA_2 168 174 PF00498 0.439
LIG_FHA_2 197 203 PF00498 0.528
LIG_FHA_2 238 244 PF00498 0.547
LIG_FHA_2 632 638 PF00498 0.419
LIG_HP1_1 291 295 PF01393 0.437
LIG_Integrin_RGD_1 211 213 PF01839 0.684
LIG_LIR_Apic_2 143 147 PF02991 0.462
LIG_LIR_Gen_1 108 118 PF02991 0.527
LIG_LIR_Gen_1 640 650 PF02991 0.346
LIG_LIR_Gen_1 76 84 PF02991 0.434
LIG_LIR_Nem_3 108 113 PF02991 0.516
LIG_LIR_Nem_3 143 149 PF02991 0.472
LIG_LIR_Nem_3 243 248 PF02991 0.551
LIG_LIR_Nem_3 639 645 PF02991 0.307
LIG_LIR_Nem_3 76 80 PF02991 0.499
LIG_MAD2 533 541 PF02301 0.546
LIG_MYND_1 114 118 PF01753 0.544
LIG_NRBOX 534 540 PF00104 0.546
LIG_Pex14_2 245 249 PF04695 0.546
LIG_SH2_CRK 254 258 PF00017 0.349
LIG_SH2_CRK 662 666 PF00017 0.598
LIG_SH2_CRK 667 671 PF00017 0.600
LIG_SH2_STAT5 248 251 PF00017 0.466
LIG_SH2_STAT5 383 386 PF00017 0.493
LIG_SH2_STAT5 458 461 PF00017 0.457
LIG_SH2_STAT5 478 481 PF00017 0.546
LIG_SH2_STAT5 603 606 PF00017 0.496
LIG_SH2_STAT5 67 70 PF00017 0.513
LIG_SH3_3 111 117 PF00018 0.608
LIG_SH3_3 285 291 PF00018 0.499
LIG_SH3_3 397 403 PF00018 0.624
LIG_SH3_3 410 416 PF00018 0.435
LIG_SH3_3 447 453 PF00018 0.566
LIG_SH3_3 626 632 PF00018 0.404
LIG_SH3_3 95 101 PF00018 0.549
LIG_SUMO_SIM_anti_2 609 615 PF11976 0.546
LIG_SUMO_SIM_par_1 651 656 PF11976 0.357
LIG_TRAF2_1 172 175 PF00917 0.542
LIG_TYR_ITIM 660 665 PF00017 0.608
LIG_WRC_WIRS_1 301 306 PF05994 0.451
MOD_CDK_SPK_2 396 401 PF00069 0.551
MOD_CDK_SPxK_1 446 452 PF00069 0.516
MOD_CDK_SPxxK_3 28 35 PF00069 0.630
MOD_CDK_SPxxK_3 543 550 PF00069 0.619
MOD_CK1_1 133 139 PF00069 0.607
MOD_CK1_1 152 158 PF00069 0.624
MOD_CK1_1 167 173 PF00069 0.423
MOD_CK1_1 215 221 PF00069 0.585
MOD_CK1_1 266 272 PF00069 0.515
MOD_CK1_1 28 34 PF00069 0.630
MOD_CK1_1 323 329 PF00069 0.552
MOD_CK1_1 342 348 PF00069 0.612
MOD_CK1_1 349 355 PF00069 0.461
MOD_CK1_1 430 436 PF00069 0.522
MOD_CK1_1 470 476 PF00069 0.433
MOD_CK1_1 549 555 PF00069 0.549
MOD_CK1_1 561 567 PF00069 0.470
MOD_CK1_1 588 594 PF00069 0.539
MOD_CK1_1 99 105 PF00069 0.536
MOD_CK2_1 167 173 PF00069 0.476
MOD_CK2_1 213 219 PF00069 0.632
MOD_CK2_1 631 637 PF00069 0.419
MOD_Cter_Amidation 408 411 PF01082 0.779
MOD_GlcNHglycan 1 4 PF01048 0.733
MOD_GlcNHglycan 125 128 PF01048 0.752
MOD_GlcNHglycan 134 138 PF01048 0.776
MOD_GlcNHglycan 233 236 PF01048 0.772
MOD_GlcNHglycan 304 307 PF01048 0.678
MOD_GlcNHglycan 341 344 PF01048 0.818
MOD_GlcNHglycan 354 357 PF01048 0.606
MOD_GlcNHglycan 38 41 PF01048 0.788
MOD_GlcNHglycan 429 432 PF01048 0.717
MOD_GlcNHglycan 472 475 PF01048 0.411
MOD_GlcNHglycan 587 590 PF01048 0.345
MOD_GSK3_1 133 140 PF00069 0.591
MOD_GSK3_1 149 156 PF00069 0.624
MOD_GSK3_1 192 199 PF00069 0.550
MOD_GSK3_1 211 218 PF00069 0.618
MOD_GSK3_1 24 31 PF00069 0.594
MOD_GSK3_1 263 270 PF00069 0.512
MOD_GSK3_1 274 281 PF00069 0.476
MOD_GSK3_1 296 303 PF00069 0.408
MOD_GSK3_1 323 330 PF00069 0.556
MOD_GSK3_1 342 349 PF00069 0.618
MOD_GSK3_1 462 469 PF00069 0.371
MOD_GSK3_1 554 561 PF00069 0.561
MOD_GSK3_1 602 609 PF00069 0.563
MOD_GSK3_1 631 638 PF00069 0.304
MOD_GSK3_1 96 103 PF00069 0.518
MOD_LATS_1 229 235 PF00433 0.572
MOD_N-GLC_1 320 325 PF02516 0.658
MOD_N-GLC_1 46 51 PF02516 0.769
MOD_N-GLC_1 582 587 PF02516 0.363
MOD_N-GLC_2 457 459 PF02516 0.660
MOD_NEK2_1 1 6 PF00069 0.554
MOD_NEK2_1 297 302 PF00069 0.458
MOD_NEK2_1 346 351 PF00069 0.554
MOD_NEK2_1 361 366 PF00069 0.417
MOD_NEK2_1 479 484 PF00069 0.546
MOD_NEK2_1 511 516 PF00069 0.564
MOD_NEK2_1 548 553 PF00069 0.546
MOD_NEK2_1 653 658 PF00069 0.413
MOD_NEK2_2 164 169 PF00069 0.571
MOD_PIKK_1 16 22 PF00454 0.600
MOD_PIKK_1 282 288 PF00454 0.540
MOD_PIKK_1 549 555 PF00454 0.546
MOD_PIKK_1 606 612 PF00454 0.546
MOD_PIKK_1 70 76 PF00454 0.530
MOD_PK_1 192 198 PF00069 0.508
MOD_PKA_2 480 486 PF00069 0.452
MOD_PKA_2 549 555 PF00069 0.523
MOD_PKA_2 565 571 PF00069 0.478
MOD_PKB_1 190 198 PF00069 0.592
MOD_Plk_1 297 303 PF00069 0.462
MOD_Plk_1 320 326 PF00069 0.459
MOD_Plk_1 367 373 PF00069 0.553
MOD_Plk_1 582 588 PF00069 0.563
MOD_Plk_2-3 213 219 PF00069 0.637
MOD_Plk_4 297 303 PF00069 0.462
MOD_Plk_4 467 473 PF00069 0.390
MOD_Plk_4 582 588 PF00069 0.591
MOD_ProDKin_1 149 155 PF00069 0.604
MOD_ProDKin_1 28 34 PF00069 0.587
MOD_ProDKin_1 287 293 PF00069 0.473
MOD_ProDKin_1 396 402 PF00069 0.633
MOD_ProDKin_1 446 452 PF00069 0.530
MOD_ProDKin_1 543 549 PF00069 0.506
MOD_ProDKin_1 637 643 PF00069 0.314
MOD_ProDKin_1 97 103 PF00069 0.547
TRG_DiLeu_BaLyEn_6 111 116 PF01217 0.555
TRG_DiLeu_BaLyEn_6 590 595 PF01217 0.546
TRG_ENDOCYTIC_2 254 257 PF00928 0.386
TRG_ENDOCYTIC_2 662 665 PF00928 0.702
TRG_ER_diArg_1 190 192 PF00400 0.515
TRG_ER_diArg_1 410 412 PF00400 0.545
TRG_ER_diArg_1 565 567 PF00400 0.528
TRG_ER_diArg_1 62 65 PF00400 0.447
TRG_Pf-PMV_PEXEL_1 484 489 PF00026 0.339
TRG_Pf-PMV_PEXEL_1 533 537 PF00026 0.316

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5F0 Leptomonas seymouri 44% 92%
A0A3Q8IEP9 Leishmania donovani 90% 100%
A4HGP8 Leishmania braziliensis 66% 100%
A4I3S1 Leishmania infantum 90% 100%
E9B013 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS