Putative ribose 5-phosphate isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribose 5-phosphate isomerase, putative

Species:

Leishmania major

UniProt:

Q4Q869_LEIMA

TriTrypDb:

LmjF.28.1970 , LMJLV39_280027500 , LMJSD75_280027100

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q869

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q869

PDB structure(s): 6fxw_A

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006091	generation of precursor metabolites and energy	3	2
GO:0006098	pentose-phosphate shunt	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006739	NADP metabolic process	7	2
GO:0006740	NADPH regeneration	4	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	12
GO:0009117	nucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0019362	pyridine nucleotide metabolic process	5	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046496	nicotinamide nucleotide metabolic process	6	2
GO:0051156	glucose 6-phosphate metabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	12
GO:0072524	pyridine-containing compound metabolic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004751	ribose-5-phosphate isomerase activity	5	8
GO:0016853	isomerase activity	2	12
GO:0016860	intramolecular oxidoreductase activity	3	8
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.510
CLV_PCSK_KEX2_1	3	5	PF00082	0.458
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.458
CLV_PCSK_SKI1_1	4	8	PF00082	0.421
CLV_PCSK_SKI1_1	86	90	PF00082	0.300
DOC_USP7_UBL2_3	168	172	PF12436	0.544
LIG_BIR_II_1	1	5	PF00653	0.381
LIG_FHA_1	123	129	PF00498	0.402
LIG_FHA_1	93	99	PF00498	0.365
LIG_FHA_2	144	150	PF00498	0.467
LIG_FHA_2	40	46	PF00498	0.376
LIG_LIR_Nem_3	43	49	PF02991	0.281
LIG_SH2_CRK	35	39	PF00017	0.421
LIG_SH2_NCK_1	91	95	PF00017	0.297
LIG_SH2_SRC	91	94	PF00017	0.297
LIG_SH2_STAP1	49	53	PF00017	0.369
LIG_SH2_STAT3	49	52	PF00017	0.340
LIG_SH3_3	41	47	PF00018	0.276
LIG_SUMO_SIM_anti_2	143	151	PF11976	0.424
LIG_TYR_ITIM	89	94	PF00017	0.297
LIG_WRC_WIRS_1	124	129	PF05994	0.310
MOD_CK1_1	39	45	PF00069	0.424
MOD_CK2_1	112	118	PF00069	0.285
MOD_CK2_1	143	149	PF00069	0.468
MOD_Cter_Amidation	165	168	PF01082	0.459
MOD_GlcNHglycan	114	117	PF01048	0.455
MOD_GlcNHglycan	161	164	PF01048	0.564
MOD_GlcNHglycan	24	27	PF01048	0.405
MOD_GSK3_1	122	129	PF00069	0.326
MOD_GSK3_1	24	31	PF00069	0.375
MOD_GSK3_1	36	43	PF00069	0.340
MOD_GSK3_1	92	99	PF00069	0.347
MOD_PKA_2	112	118	PF00069	0.314
MOD_PKA_2	136	142	PF00069	0.383
MOD_Plk_1	40	46	PF00069	0.403
MOD_Plk_2-3	143	149	PF00069	0.425
MOD_Plk_4	123	129	PF00069	0.433
MOD_SUMO_for_1	153	156	PF00179	0.459
MOD_SUMO_for_1	58	61	PF00179	0.340
TRG_ENDOCYTIC_2	91	94	PF00928	0.361
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.209

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S0	Leptomonas seymouri	61%	100%
A0A0S4JBN8	Bodo saltans	48%	100%
A0A1X0NQT1	Trypanosomatidae	49%	100%
A0A3Q8ID81	Leishmania donovani	93%	100%
A0A422NBD4	Trypanosoma rangeli	47%	100%
A0QXE5	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	34%	100%
A0R757	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	33%	100%
A2RD12	Streptococcus pyogenes serotype M5 (strain Manfredo)	31%	100%
A3CPH6	Streptococcus sanguinis (strain SK36)	32%	100%
A4HGQ2	Leishmania braziliensis	79%	100%
A4I3S4	Leishmania infantum	93%	100%
A4VV69	Streptococcus suis (strain 05ZYH33)	31%	100%
A4W1H6	Streptococcus suis (strain 98HAH33)	31%	100%
A5IUY3	Staphylococcus aureus (strain JH9)	32%	100%
A6QJ38	Staphylococcus aureus (strain Newman)	31%	100%
A6U3S4	Staphylococcus aureus (strain JH1)	32%	100%
A7X578	Staphylococcus aureus (strain Mu3 / ATCC 700698)	32%	100%
A8YYG1	Staphylococcus aureus (strain USA300 / TCH1516)	31%	100%
B1IBZ6	Streptococcus pneumoniae (strain Hungary19A-6)	30%	100%
B2IPT6	Streptococcus pneumoniae (strain CGSP14)	30%	100%
B4U1F9	Streptococcus equi subsp. zooepidemicus (strain MGCS10565)	30%	100%
B5E4T1	Streptococcus pneumoniae serotype 19F (strain G54)	30%	100%
B8ZQ65	Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)	30%	100%
C0M8Q7	Streptococcus equi subsp. equi (strain 4047)	30%	100%
C0MDX5	Streptococcus equi subsp. zooepidemicus (strain H70)	31%	100%
C1C7G1	Streptococcus pneumoniae (strain 70585)	30%	100%
C1CEF3	Streptococcus pneumoniae (strain JJA)	30%	100%
C1CKT8	Streptococcus pneumoniae (strain P1031)	30%	100%
C1CRA5	Streptococcus pneumoniae (strain Taiwan19F-14)	30%	100%
D0A883	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B016	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P0C1R6	Staphylococcus aureus	31%	100%
P0CL19	Coccidioides immitis (strain RS)	30%	100%
P0DC06	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	28%	100%
P0DC07	Streptococcus pyogenes serotype M3 (strain SSI-1)	28%	100%
P0DC08	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	31%	100%
P0DC09	Streptococcus pyogenes serotype M3 (strain SSI-1)	31%	100%
P0DC10	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	33%	100%
P0DC11	Streptococcus pyogenes serotype M3 (strain SSI-1)	33%	100%
P23495	Lactococcus lactis subsp. lactis	31%	100%
P26424	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	31%	100%
P37351	Escherichia coli (strain K12)	45%	100%
P39156	Bacillus subtilis (strain 168)	42%	100%
P47636	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	38%	100%
P53527	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	43%	100%
P65646	Staphylococcus aureus (strain Mu50 / ATCC 700699)	32%	100%
P65647	Staphylococcus aureus (strain N315)	32%	100%
P68797	Staphylococcus aureus (strain MW2)	31%	100%
P9WKD6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	100%
P9WKD7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	100%
Q04KC2	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)	30%	100%
Q1J9U7	Streptococcus pyogenes serotype M12 (strain MGAS2096)	35%	100%
Q1JJZ6	Streptococcus pyogenes serotype M12 (strain MGAS9429)	35%	100%
Q1RJV5	Rickettsia bellii (strain RML369-C)	41%	100%
Q2FET8	Staphylococcus aureus (strain USA300)	31%	100%
Q2G2R0	Staphylococcus aureus (strain NCTC 8325 / PS 47)	31%	100%
Q2YYJ4	Staphylococcus aureus (strain bovine RF122 / ET3-1)	31%	100%
Q3JZ19	Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)	30%	100%
Q48RC2	Streptococcus pyogenes serotype M28 (strain MGAS6180)	28%	100%
Q48RC3	Streptococcus pyogenes serotype M28 (strain MGAS6180)	34%	100%
Q48RW0	Streptococcus pyogenes serotype M28 (strain MGAS6180)	31%	100%
Q4L873	Staphylococcus haemolyticus (strain JCSC1435)	31%	100%
Q4UM83	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	44%	100%
Q5HE11	Staphylococcus aureus (strain COL)	31%	100%
Q5HM36	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	34%	100%
Q5X9Y1	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	28%	100%
Q5X9Y2	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	35%	100%
Q5XAI2	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	31%	100%
Q68X72	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	40%	100%
Q6D8V9	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	38%	100%
Q6G7C0	Staphylococcus aureus (strain MSSA476)	31%	100%
Q6GEN5	Staphylococcus aureus (strain MRSA252)	31%	100%
Q73XM4	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	34%	100%
Q7CMS1	Streptococcus pyogenes serotype M18 (strain MGAS8232)	28%	100%
Q7TYI9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	33%	100%
Q833U3	Enterococcus faecalis (strain ATCC 700802 / V583)	34%	100%
Q833U4	Enterococcus faecalis (strain ATCC 700802 / V583)	29%	100%
Q8CRJ3	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	34%	100%
Q8DPP0	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	30%	100%
Q8DXC1	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	30%	100%
Q8E345	Streptococcus agalactiae serotype III (strain NEM316)	30%	100%
Q8E4R6	Streptococcus agalactiae serotype III (strain NEM316)	31%	100%
Q8NZD8	Streptococcus pyogenes serotype M18 (strain MGAS8232)	33%	100%
Q8NZV7	Streptococcus pyogenes serotype M18 (strain MGAS8232)	30%	100%
Q8XNK6	Clostridium perfringens (strain 13 / Type A)	33%	100%
Q8XNK7	Clostridium perfringens (strain 13 / Type A)	29%	100%
Q92EU5	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	32%	100%
Q92IL8	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	42%	100%
Q97F01	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	24%	100%
Q97F02	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	35%	99%
Q97QL1	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	30%	100%
Q99Y12	Streptococcus pyogenes serotype M1	27%	100%
Q99Y13	Streptococcus pyogenes serotype M1	35%	100%
Q99YH2	Streptococcus pyogenes serotype M1	31%	100%
Q9CBY1	Mycobacterium leprae (strain TN)	35%	100%
Q9ZB26	Brucella abortus (strain 2308)	34%	100%
Q9ZDM8	Rickettsia prowazekii (strain Madrid E)	40%	100%
V5DCW6	Trypanosoma cruzi	50%	100%