LeishMANIAdb
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Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q867_LEIMA
TriTrypDb:
LmjF.28.1990 , LMJLV39_280027700 , LMJSD75_280027300 *
Length:
747

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005929 cilium 4 9
GO:0042995 cell projection 2 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0110165 cellular anatomical entity 1 9
GO:0120025 plasma membrane bounded cell projection 3 9

Expansion

Sequence features

Q4Q867
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q867

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 9
GO:0008047 enzyme activator activity 3 9
GO:0030234 enzyme regulator activity 2 9
GO:0030695 GTPase regulator activity 4 9
GO:0060589 nucleoside-triphosphatase regulator activity 3 9
GO:0098772 molecular function regulator activity 1 9
GO:0140677 molecular function activator activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 394 398 PF00656 0.789
CLV_NRD_NRD_1 350 352 PF00675 0.609
CLV_NRD_NRD_1 373 375 PF00675 0.597
CLV_NRD_NRD_1 381 383 PF00675 0.634
CLV_NRD_NRD_1 409 411 PF00675 0.861
CLV_NRD_NRD_1 446 448 PF00675 0.853
CLV_NRD_NRD_1 453 455 PF00675 0.867
CLV_NRD_NRD_1 564 566 PF00675 0.658
CLV_NRD_NRD_1 739 741 PF00675 0.726
CLV_PCSK_KEX2_1 17 19 PF00082 0.529
CLV_PCSK_KEX2_1 350 352 PF00082 0.579
CLV_PCSK_KEX2_1 373 375 PF00082 0.597
CLV_PCSK_KEX2_1 381 383 PF00082 0.634
CLV_PCSK_KEX2_1 409 411 PF00082 0.861
CLV_PCSK_KEX2_1 446 448 PF00082 0.853
CLV_PCSK_KEX2_1 453 455 PF00082 0.846
CLV_PCSK_KEX2_1 564 566 PF00082 0.660
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.560
CLV_PCSK_PC7_1 377 383 PF00082 0.651
CLV_PCSK_SKI1_1 33 37 PF00082 0.622
CLV_Separin_Metazoa 228 232 PF03568 0.512
DEG_APCC_DBOX_1 349 357 PF00400 0.598
DEG_Kelch_Keap1_1 701 706 PF01344 0.865
DEG_SCF_FBW7_1 233 239 PF00400 0.607
DEG_SPOP_SBC_1 527 531 PF00917 0.496
DOC_ANK_TNKS_1 392 399 PF00023 0.810
DOC_CDC14_PxL_1 177 185 PF14671 0.526
DOC_CKS1_1 233 238 PF01111 0.609
DOC_CKS1_1 477 482 PF01111 0.765
DOC_CKS1_1 521 526 PF01111 0.772
DOC_CYCLIN_RxL_1 66 77 PF00134 0.585
DOC_MAPK_DCC_7 350 358 PF00069 0.666
DOC_MAPK_gen_1 350 358 PF00069 0.503
DOC_PP2B_LxvP_1 735 738 PF13499 0.764
DOC_PP4_FxxP_1 275 278 PF00568 0.449
DOC_PP4_FxxP_1 335 338 PF00568 0.559
DOC_PP4_FxxP_1 78 81 PF00568 0.536
DOC_USP7_MATH_1 368 372 PF00917 0.525
DOC_USP7_MATH_1 442 446 PF00917 0.802
DOC_USP7_MATH_1 490 494 PF00917 0.777
DOC_USP7_MATH_1 503 507 PF00917 0.695
DOC_USP7_MATH_1 607 611 PF00917 0.799
DOC_USP7_MATH_1 661 665 PF00917 0.807
DOC_USP7_MATH_1 687 691 PF00917 0.842
DOC_USP7_MATH_1 719 723 PF00917 0.735
DOC_USP7_MATH_1 729 733 PF00917 0.668
DOC_USP7_MATH_2 467 473 PF00917 0.627
DOC_USP7_UBL2_3 104 108 PF12436 0.564
DOC_USP7_UBL2_3 305 309 PF12436 0.625
DOC_USP7_UBL2_3 534 538 PF12436 0.705
DOC_WW_Pin1_4 232 237 PF00397 0.573
DOC_WW_Pin1_4 276 281 PF00397 0.538
DOC_WW_Pin1_4 424 429 PF00397 0.851
DOC_WW_Pin1_4 438 443 PF00397 0.688
DOC_WW_Pin1_4 460 465 PF00397 0.833
DOC_WW_Pin1_4 476 481 PF00397 0.798
DOC_WW_Pin1_4 520 525 PF00397 0.775
DOC_WW_Pin1_4 579 584 PF00397 0.817
DOC_WW_Pin1_4 683 688 PF00397 0.847
DOC_WW_Pin1_4 727 732 PF00397 0.792
LIG_14-3-3_CanoR_1 436 442 PF00244 0.794
LIG_14-3-3_CanoR_1 446 455 PF00244 0.673
LIG_14-3-3_CanoR_1 478 484 PF00244 0.783
LIG_14-3-3_CanoR_1 60 68 PF00244 0.546
LIG_14-3-3_CanoR_1 683 687 PF00244 0.821
LIG_14-3-3_CanoR_1 740 744 PF00244 0.848
LIG_APCC_ABBA_1 255 260 PF00400 0.435
LIG_BIR_II_1 1 5 PF00653 0.616
LIG_BIR_III_4 331 335 PF00653 0.403
LIG_BIR_III_4 639 643 PF00653 0.746
LIG_BRCT_BRCA1_1 743 747 PF00533 0.838
LIG_Clathr_ClatBox_1 296 300 PF01394 0.496
LIG_FHA_1 211 217 PF00498 0.447
LIG_FHA_1 235 241 PF00498 0.501
LIG_FHA_1 252 258 PF00498 0.469
LIG_FHA_1 264 270 PF00498 0.439
LIG_FHA_1 309 315 PF00498 0.516
LIG_FHA_1 367 373 PF00498 0.537
LIG_FHA_1 42 48 PF00498 0.536
LIG_FHA_1 527 533 PF00498 0.700
LIG_FHA_1 594 600 PF00498 0.826
LIG_FHA_1 676 682 PF00498 0.778
LIG_FHA_1 684 690 PF00498 0.811
LIG_FHA_2 392 398 PF00498 0.804
LIG_FHA_2 461 467 PF00498 0.842
LIG_FHA_2 521 527 PF00498 0.769
LIG_FHA_2 554 560 PF00498 0.635
LIG_FHA_2 59 65 PF00498 0.562
LIG_FHA_2 677 683 PF00498 0.839
LIG_LIR_Apic_2 75 81 PF02991 0.596
LIG_LIR_Gen_1 618 626 PF02991 0.743
LIG_LIR_Nem_3 618 622 PF02991 0.769
LIG_LIR_Nem_3 630 634 PF02991 0.779
LIG_LRP6_Inhibitor_1 92 98 PF00058 0.539
LIG_PCNA_yPIPBox_3 321 329 PF02747 0.535
LIG_SH2_CRK 190 194 PF00017 0.390
LIG_SH2_CRK 619 623 PF00017 0.739
LIG_SH2_CRK 631 635 PF00017 0.659
LIG_SH2_NCK_1 375 379 PF00017 0.732
LIG_SH2_PTP2 357 360 PF00017 0.501
LIG_SH2_SRC 646 649 PF00017 0.621
LIG_SH2_STAT3 172 175 PF00017 0.449
LIG_SH2_STAT3 648 651 PF00017 0.834
LIG_SH2_STAT5 12 15 PF00017 0.429
LIG_SH2_STAT5 172 175 PF00017 0.436
LIG_SH2_STAT5 357 360 PF00017 0.501
LIG_SH2_STAT5 366 369 PF00017 0.513
LIG_SH2_STAT5 646 649 PF00017 0.621
LIG_SH3_3 461 467 PF00018 0.716
LIG_SH3_3 521 527 PF00018 0.730
LIG_SUMO_SIM_anti_2 311 316 PF11976 0.527
LIG_SUMO_SIM_par_1 127 133 PF11976 0.390
LIG_SUMO_SIM_par_1 154 159 PF11976 0.428
LIG_SUMO_SIM_par_1 212 217 PF11976 0.432
LIG_SUMO_SIM_par_1 295 300 PF11976 0.417
LIG_SUMO_SIM_par_1 69 75 PF11976 0.583
LIG_TRAF2_1 317 320 PF00917 0.610
LIG_TRAF2_1 429 432 PF00917 0.839
LIG_TYR_ITIM 188 193 PF00017 0.390
LIG_TYR_ITIM 245 250 PF00017 0.341
LIG_TYR_ITIM 629 634 PF00017 0.751
LIG_UBA3_1 297 305 PF00899 0.433
LIG_UBA3_1 532 538 PF00899 0.515
LIG_Vh1_VBS_1 502 520 PF01044 0.658
LIG_WW_3 723 727 PF00397 0.750
MOD_CDC14_SPxK_1 582 585 PF00782 0.807
MOD_CDK_SPK_2 438 443 PF00069 0.868
MOD_CDK_SPK_2 476 481 PF00069 0.790
MOD_CDK_SPxK_1 579 585 PF00069 0.810
MOD_CK1_1 420 426 PF00069 0.839
MOD_CK1_1 437 443 PF00069 0.854
MOD_CK1_1 462 468 PF00069 0.834
MOD_CK1_1 486 492 PF00069 0.809
MOD_CK1_1 579 585 PF00069 0.828
MOD_CK1_1 63 69 PF00069 0.495
MOD_CK1_1 670 676 PF00069 0.824
MOD_CK2_1 424 430 PF00069 0.852
MOD_CK2_1 553 559 PF00069 0.591
MOD_CK2_1 676 682 PF00069 0.799
MOD_DYRK1A_RPxSP_1 424 428 PF00069 0.775
MOD_GlcNHglycan 13 16 PF01048 0.565
MOD_GlcNHglycan 287 290 PF01048 0.455
MOD_GlcNHglycan 448 451 PF01048 0.873
MOD_GlcNHglycan 471 474 PF01048 0.747
MOD_GlcNHglycan 488 491 PF01048 0.695
MOD_GlcNHglycan 578 581 PF01048 0.784
MOD_GlcNHglycan 587 590 PF01048 0.845
MOD_GlcNHglycan 611 614 PF01048 0.809
MOD_GlcNHglycan 702 706 PF01048 0.837
MOD_GlcNHglycan 716 719 PF01048 0.638
MOD_GSK3_1 210 217 PF00069 0.447
MOD_GSK3_1 232 239 PF00069 0.602
MOD_GSK3_1 373 380 PF00069 0.601
MOD_GSK3_1 381 388 PF00069 0.630
MOD_GSK3_1 399 406 PF00069 0.823
MOD_GSK3_1 413 420 PF00069 0.620
MOD_GSK3_1 434 441 PF00069 0.793
MOD_GSK3_1 442 449 PF00069 0.712
MOD_GSK3_1 479 486 PF00069 0.798
MOD_GSK3_1 528 535 PF00069 0.604
MOD_GSK3_1 536 543 PF00069 0.552
MOD_GSK3_1 572 579 PF00069 0.753
MOD_GSK3_1 607 614 PF00069 0.765
MOD_GSK3_1 661 668 PF00069 0.791
MOD_GSK3_1 670 677 PF00069 0.795
MOD_GSK3_1 683 690 PF00069 0.749
MOD_LATS_1 444 450 PF00433 0.795
MOD_N-GLC_1 134 139 PF02516 0.523
MOD_N-GLC_1 264 269 PF02516 0.443
MOD_N-GLC_1 321 326 PF02516 0.497
MOD_N-GLC_1 593 598 PF02516 0.729
MOD_N-GLC_1 674 679 PF02516 0.755
MOD_N-GLC_2 122 124 PF02516 0.471
MOD_NEK2_1 11 16 PF00069 0.566
MOD_NEK2_1 214 219 PF00069 0.438
MOD_NEK2_1 540 545 PF00069 0.670
MOD_NEK2_1 665 670 PF00069 0.785
MOD_NEK2_1 714 719 PF00069 0.711
MOD_NEK2_1 739 744 PF00069 0.851
MOD_NEK2_2 368 373 PF00069 0.537
MOD_PIKK_1 196 202 PF00454 0.292
MOD_PIKK_1 434 440 PF00454 0.851
MOD_PIKK_1 546 552 PF00454 0.623
MOD_PIKK_1 607 613 PF00454 0.825
MOD_PIKK_1 63 69 PF00454 0.534
MOD_PIKK_1 670 676 PF00454 0.853
MOD_PIKK_1 687 693 PF00454 0.845
MOD_PIKK_1 729 735 PF00454 0.811
MOD_PK_1 417 423 PF00069 0.774
MOD_PKA_1 373 379 PF00069 0.600
MOD_PKA_1 381 387 PF00069 0.631
MOD_PKA_1 446 452 PF00069 0.796
MOD_PKA_2 219 225 PF00069 0.595
MOD_PKA_2 373 379 PF00069 0.600
MOD_PKA_2 381 387 PF00069 0.631
MOD_PKA_2 408 414 PF00069 0.829
MOD_PKA_2 442 448 PF00069 0.809
MOD_PKA_2 491 497 PF00069 0.838
MOD_PKA_2 670 676 PF00069 0.796
MOD_PKA_2 682 688 PF00069 0.811
MOD_PKA_2 739 745 PF00069 0.848
MOD_Plk_1 156 162 PF00069 0.413
MOD_Plk_1 264 270 PF00069 0.421
MOD_Plk_1 321 327 PF00069 0.585
MOD_Plk_1 63 69 PF00069 0.569
MOD_Plk_1 74 80 PF00069 0.454
MOD_Plk_4 168 174 PF00069 0.455
MOD_Plk_4 251 257 PF00069 0.577
MOD_Plk_4 264 270 PF00069 0.421
MOD_Plk_4 528 534 PF00069 0.646
MOD_Plk_4 676 682 PF00069 0.658
MOD_ProDKin_1 232 238 PF00069 0.566
MOD_ProDKin_1 276 282 PF00069 0.533
MOD_ProDKin_1 424 430 PF00069 0.852
MOD_ProDKin_1 438 444 PF00069 0.689
MOD_ProDKin_1 460 466 PF00069 0.833
MOD_ProDKin_1 476 482 PF00069 0.798
MOD_ProDKin_1 520 526 PF00069 0.769
MOD_ProDKin_1 579 585 PF00069 0.819
MOD_ProDKin_1 683 689 PF00069 0.848
MOD_ProDKin_1 727 733 PF00069 0.794
MOD_SUMO_rev_2 32 38 PF00179 0.618
TRG_DiLeu_BaEn_4 348 354 PF01217 0.696
TRG_ENDOCYTIC_2 190 193 PF00928 0.390
TRG_ENDOCYTIC_2 247 250 PF00928 0.348
TRG_ENDOCYTIC_2 619 622 PF00928 0.766
TRG_ENDOCYTIC_2 631 634 PF00928 0.769
TRG_ER_diArg_1 372 374 PF00400 0.581
TRG_ER_diArg_1 453 456 PF00400 0.868
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.520
TRG_Pf-PMV_PEXEL_1 69 74 PF00026 0.375

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NQV7 Trypanosomatidae 44% 100%
A0A3Q8II72 Leishmania donovani 93% 99%
A0A422NBD9 Trypanosoma rangeli 43% 100%
A4HGP9 Leishmania braziliensis 73% 96%
A4I3S6 Leishmania infantum 93% 99%
D0A881 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9B018 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS