Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q867_LEIMA

TriTrypDb:

LmjF.28.1990 , LMJLV39_280027700 , LMJSD75_280027300

Length:

747

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

Q4Q867

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q867

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	9
GO:0008047	enzyme activator activity	3	9
GO:0030234	enzyme regulator activity	2	9
GO:0030695	GTPase regulator activity	4	9
GO:0060589	nucleoside-triphosphatase regulator activity	3	9
GO:0098772	molecular function regulator activity	1	9
GO:0140677	molecular function activator activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.789
CLV_NRD_NRD_1	350	352	PF00675	0.609
CLV_NRD_NRD_1	373	375	PF00675	0.597
CLV_NRD_NRD_1	381	383	PF00675	0.634
CLV_NRD_NRD_1	409	411	PF00675	0.861
CLV_NRD_NRD_1	446	448	PF00675	0.853
CLV_NRD_NRD_1	453	455	PF00675	0.867
CLV_NRD_NRD_1	564	566	PF00675	0.658
CLV_NRD_NRD_1	739	741	PF00675	0.726
CLV_PCSK_KEX2_1	17	19	PF00082	0.529
CLV_PCSK_KEX2_1	350	352	PF00082	0.579
CLV_PCSK_KEX2_1	373	375	PF00082	0.597
CLV_PCSK_KEX2_1	381	383	PF00082	0.634
CLV_PCSK_KEX2_1	409	411	PF00082	0.861
CLV_PCSK_KEX2_1	446	448	PF00082	0.853
CLV_PCSK_KEX2_1	453	455	PF00082	0.846
CLV_PCSK_KEX2_1	564	566	PF00082	0.660
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.560
CLV_PCSK_PC7_1	377	383	PF00082	0.651
CLV_PCSK_SKI1_1	33	37	PF00082	0.622
CLV_Separin_Metazoa	228	232	PF03568	0.512
DEG_APCC_DBOX_1	349	357	PF00400	0.598
DEG_Kelch_Keap1_1	701	706	PF01344	0.865
DEG_SCF_FBW7_1	233	239	PF00400	0.607
DEG_SPOP_SBC_1	527	531	PF00917	0.496
DOC_ANK_TNKS_1	392	399	PF00023	0.810
DOC_CDC14_PxL_1	177	185	PF14671	0.526
DOC_CKS1_1	233	238	PF01111	0.609
DOC_CKS1_1	477	482	PF01111	0.765
DOC_CKS1_1	521	526	PF01111	0.772
DOC_CYCLIN_RxL_1	66	77	PF00134	0.585
DOC_MAPK_DCC_7	350	358	PF00069	0.666
DOC_MAPK_gen_1	350	358	PF00069	0.503
DOC_PP2B_LxvP_1	735	738	PF13499	0.764
DOC_PP4_FxxP_1	275	278	PF00568	0.449
DOC_PP4_FxxP_1	335	338	PF00568	0.559
DOC_PP4_FxxP_1	78	81	PF00568	0.536
DOC_USP7_MATH_1	368	372	PF00917	0.525
DOC_USP7_MATH_1	442	446	PF00917	0.802
DOC_USP7_MATH_1	490	494	PF00917	0.777
DOC_USP7_MATH_1	503	507	PF00917	0.695
DOC_USP7_MATH_1	607	611	PF00917	0.799
DOC_USP7_MATH_1	661	665	PF00917	0.807
DOC_USP7_MATH_1	687	691	PF00917	0.842
DOC_USP7_MATH_1	719	723	PF00917	0.735
DOC_USP7_MATH_1	729	733	PF00917	0.668
DOC_USP7_MATH_2	467	473	PF00917	0.627
DOC_USP7_UBL2_3	104	108	PF12436	0.564
DOC_USP7_UBL2_3	305	309	PF12436	0.625
DOC_USP7_UBL2_3	534	538	PF12436	0.705
DOC_WW_Pin1_4	232	237	PF00397	0.573
DOC_WW_Pin1_4	276	281	PF00397	0.538
DOC_WW_Pin1_4	424	429	PF00397	0.851
DOC_WW_Pin1_4	438	443	PF00397	0.688
DOC_WW_Pin1_4	460	465	PF00397	0.833
DOC_WW_Pin1_4	476	481	PF00397	0.798
DOC_WW_Pin1_4	520	525	PF00397	0.775
DOC_WW_Pin1_4	579	584	PF00397	0.817
DOC_WW_Pin1_4	683	688	PF00397	0.847
DOC_WW_Pin1_4	727	732	PF00397	0.792
LIG_14-3-3_CanoR_1	436	442	PF00244	0.794
LIG_14-3-3_CanoR_1	446	455	PF00244	0.673
LIG_14-3-3_CanoR_1	478	484	PF00244	0.783
LIG_14-3-3_CanoR_1	60	68	PF00244	0.546
LIG_14-3-3_CanoR_1	683	687	PF00244	0.821
LIG_14-3-3_CanoR_1	740	744	PF00244	0.848
LIG_APCC_ABBA_1	255	260	PF00400	0.435
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BIR_III_4	331	335	PF00653	0.403
LIG_BIR_III_4	639	643	PF00653	0.746
LIG_BRCT_BRCA1_1	743	747	PF00533	0.838
LIG_Clathr_ClatBox_1	296	300	PF01394	0.496
LIG_FHA_1	211	217	PF00498	0.447
LIG_FHA_1	235	241	PF00498	0.501
LIG_FHA_1	252	258	PF00498	0.469
LIG_FHA_1	264	270	PF00498	0.439
LIG_FHA_1	309	315	PF00498	0.516
LIG_FHA_1	367	373	PF00498	0.537
LIG_FHA_1	42	48	PF00498	0.536
LIG_FHA_1	527	533	PF00498	0.700
LIG_FHA_1	594	600	PF00498	0.826
LIG_FHA_1	676	682	PF00498	0.778
LIG_FHA_1	684	690	PF00498	0.811
LIG_FHA_2	392	398	PF00498	0.804
LIG_FHA_2	461	467	PF00498	0.842
LIG_FHA_2	521	527	PF00498	0.769
LIG_FHA_2	554	560	PF00498	0.635
LIG_FHA_2	59	65	PF00498	0.562
LIG_FHA_2	677	683	PF00498	0.839
LIG_LIR_Apic_2	75	81	PF02991	0.596
LIG_LIR_Gen_1	618	626	PF02991	0.743
LIG_LIR_Nem_3	618	622	PF02991	0.769
LIG_LIR_Nem_3	630	634	PF02991	0.779
LIG_LRP6_Inhibitor_1	92	98	PF00058	0.539
LIG_PCNA_yPIPBox_3	321	329	PF02747	0.535
LIG_SH2_CRK	190	194	PF00017	0.390
LIG_SH2_CRK	619	623	PF00017	0.739
LIG_SH2_CRK	631	635	PF00017	0.659
LIG_SH2_NCK_1	375	379	PF00017	0.732
LIG_SH2_PTP2	357	360	PF00017	0.501
LIG_SH2_SRC	646	649	PF00017	0.621
LIG_SH2_STAT3	172	175	PF00017	0.449
LIG_SH2_STAT3	648	651	PF00017	0.834
LIG_SH2_STAT5	12	15	PF00017	0.429
LIG_SH2_STAT5	172	175	PF00017	0.436
LIG_SH2_STAT5	357	360	PF00017	0.501
LIG_SH2_STAT5	366	369	PF00017	0.513
LIG_SH2_STAT5	646	649	PF00017	0.621
LIG_SH3_3	461	467	PF00018	0.716
LIG_SH3_3	521	527	PF00018	0.730
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.527
LIG_SUMO_SIM_par_1	127	133	PF11976	0.390
LIG_SUMO_SIM_par_1	154	159	PF11976	0.428
LIG_SUMO_SIM_par_1	212	217	PF11976	0.432
LIG_SUMO_SIM_par_1	295	300	PF11976	0.417
LIG_SUMO_SIM_par_1	69	75	PF11976	0.583
LIG_TRAF2_1	317	320	PF00917	0.610
LIG_TRAF2_1	429	432	PF00917	0.839
LIG_TYR_ITIM	188	193	PF00017	0.390
LIG_TYR_ITIM	245	250	PF00017	0.341
LIG_TYR_ITIM	629	634	PF00017	0.751
LIG_UBA3_1	297	305	PF00899	0.433
LIG_UBA3_1	532	538	PF00899	0.515
LIG_Vh1_VBS_1	502	520	PF01044	0.658
LIG_WW_3	723	727	PF00397	0.750
MOD_CDC14_SPxK_1	582	585	PF00782	0.807
MOD_CDK_SPK_2	438	443	PF00069	0.868
MOD_CDK_SPK_2	476	481	PF00069	0.790
MOD_CDK_SPxK_1	579	585	PF00069	0.810
MOD_CK1_1	420	426	PF00069	0.839
MOD_CK1_1	437	443	PF00069	0.854
MOD_CK1_1	462	468	PF00069	0.834
MOD_CK1_1	486	492	PF00069	0.809
MOD_CK1_1	579	585	PF00069	0.828
MOD_CK1_1	63	69	PF00069	0.495
MOD_CK1_1	670	676	PF00069	0.824
MOD_CK2_1	424	430	PF00069	0.852
MOD_CK2_1	553	559	PF00069	0.591
MOD_CK2_1	676	682	PF00069	0.799
MOD_DYRK1A_RPxSP_1	424	428	PF00069	0.775
MOD_GlcNHglycan	13	16	PF01048	0.565
MOD_GlcNHglycan	287	290	PF01048	0.455
MOD_GlcNHglycan	448	451	PF01048	0.873
MOD_GlcNHglycan	471	474	PF01048	0.747
MOD_GlcNHglycan	488	491	PF01048	0.695
MOD_GlcNHglycan	578	581	PF01048	0.784
MOD_GlcNHglycan	587	590	PF01048	0.845
MOD_GlcNHglycan	611	614	PF01048	0.809
MOD_GlcNHglycan	702	706	PF01048	0.837
MOD_GlcNHglycan	716	719	PF01048	0.638
MOD_GSK3_1	210	217	PF00069	0.447
MOD_GSK3_1	232	239	PF00069	0.602
MOD_GSK3_1	373	380	PF00069	0.601
MOD_GSK3_1	381	388	PF00069	0.630
MOD_GSK3_1	399	406	PF00069	0.823
MOD_GSK3_1	413	420	PF00069	0.620
MOD_GSK3_1	434	441	PF00069	0.793
MOD_GSK3_1	442	449	PF00069	0.712
MOD_GSK3_1	479	486	PF00069	0.798
MOD_GSK3_1	528	535	PF00069	0.604
MOD_GSK3_1	536	543	PF00069	0.552
MOD_GSK3_1	572	579	PF00069	0.753
MOD_GSK3_1	607	614	PF00069	0.765
MOD_GSK3_1	661	668	PF00069	0.791
MOD_GSK3_1	670	677	PF00069	0.795
MOD_GSK3_1	683	690	PF00069	0.749
MOD_LATS_1	444	450	PF00433	0.795
MOD_N-GLC_1	134	139	PF02516	0.523
MOD_N-GLC_1	264	269	PF02516	0.443
MOD_N-GLC_1	321	326	PF02516	0.497
MOD_N-GLC_1	593	598	PF02516	0.729
MOD_N-GLC_1	674	679	PF02516	0.755
MOD_N-GLC_2	122	124	PF02516	0.471
MOD_NEK2_1	11	16	PF00069	0.566
MOD_NEK2_1	214	219	PF00069	0.438
MOD_NEK2_1	540	545	PF00069	0.670
MOD_NEK2_1	665	670	PF00069	0.785
MOD_NEK2_1	714	719	PF00069	0.711
MOD_NEK2_1	739	744	PF00069	0.851
MOD_NEK2_2	368	373	PF00069	0.537
MOD_PIKK_1	196	202	PF00454	0.292
MOD_PIKK_1	434	440	PF00454	0.851
MOD_PIKK_1	546	552	PF00454	0.623
MOD_PIKK_1	607	613	PF00454	0.825
MOD_PIKK_1	63	69	PF00454	0.534
MOD_PIKK_1	670	676	PF00454	0.853
MOD_PIKK_1	687	693	PF00454	0.845
MOD_PIKK_1	729	735	PF00454	0.811
MOD_PK_1	417	423	PF00069	0.774
MOD_PKA_1	373	379	PF00069	0.600
MOD_PKA_1	381	387	PF00069	0.631
MOD_PKA_1	446	452	PF00069	0.796
MOD_PKA_2	219	225	PF00069	0.595
MOD_PKA_2	373	379	PF00069	0.600
MOD_PKA_2	381	387	PF00069	0.631
MOD_PKA_2	408	414	PF00069	0.829
MOD_PKA_2	442	448	PF00069	0.809
MOD_PKA_2	491	497	PF00069	0.838
MOD_PKA_2	670	676	PF00069	0.796
MOD_PKA_2	682	688	PF00069	0.811
MOD_PKA_2	739	745	PF00069	0.848
MOD_Plk_1	156	162	PF00069	0.413
MOD_Plk_1	264	270	PF00069	0.421
MOD_Plk_1	321	327	PF00069	0.585
MOD_Plk_1	63	69	PF00069	0.569
MOD_Plk_1	74	80	PF00069	0.454
MOD_Plk_4	168	174	PF00069	0.455
MOD_Plk_4	251	257	PF00069	0.577
MOD_Plk_4	264	270	PF00069	0.421
MOD_Plk_4	528	534	PF00069	0.646
MOD_Plk_4	676	682	PF00069	0.658
MOD_ProDKin_1	232	238	PF00069	0.566
MOD_ProDKin_1	276	282	PF00069	0.533
MOD_ProDKin_1	424	430	PF00069	0.852
MOD_ProDKin_1	438	444	PF00069	0.689
MOD_ProDKin_1	460	466	PF00069	0.833
MOD_ProDKin_1	476	482	PF00069	0.798
MOD_ProDKin_1	520	526	PF00069	0.769
MOD_ProDKin_1	579	585	PF00069	0.819
MOD_ProDKin_1	683	689	PF00069	0.848
MOD_ProDKin_1	727	733	PF00069	0.794
MOD_SUMO_rev_2	32	38	PF00179	0.618
TRG_DiLeu_BaEn_4	348	354	PF01217	0.696
TRG_ENDOCYTIC_2	190	193	PF00928	0.390
TRG_ENDOCYTIC_2	247	250	PF00928	0.348
TRG_ENDOCYTIC_2	619	622	PF00928	0.766
TRG_ENDOCYTIC_2	631	634	PF00928	0.769
TRG_ER_diArg_1	372	374	PF00400	0.581
TRG_ER_diArg_1	453	456	PF00400	0.868
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NQV7	Trypanosomatidae	44%	100%
A0A3Q8II72	Leishmania donovani	93%	99%
A0A422NBD9	Trypanosoma rangeli	43%	100%
A4HGP9	Leishmania braziliensis	73%	96%
A4I3S6	Leishmania infantum	93%	99%
D0A881	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B018	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%