Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q865_LEIMA

TriTrypDb:

LmjF.28.2010 , LMJLV39_280028100 , LMJSD75_280027700

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q865

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q865

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.740
CLV_C14_Caspase3-7	40	44	PF00656	0.405
CLV_NRD_NRD_1	16	18	PF00675	0.569
CLV_NRD_NRD_1	291	293	PF00675	0.515
CLV_NRD_NRD_1	320	322	PF00675	0.477
CLV_PCSK_KEX2_1	16	18	PF00082	0.569
CLV_PCSK_KEX2_1	291	293	PF00082	0.515
CLV_PCSK_KEX2_1	319	321	PF00082	0.509
CLV_PCSK_KEX2_1	511	513	PF00082	0.506
CLV_PCSK_KEX2_1	543	545	PF00082	0.557
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.558
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.500
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.550
CLV_PCSK_PC7_1	287	293	PF00082	0.518
CLV_PCSK_SKI1_1	177	181	PF00082	0.340
CLV_PCSK_SKI1_1	232	236	PF00082	0.438
DEG_APCC_DBOX_1	3	11	PF00400	0.355
DEG_COP1_1	119	129	PF00400	0.531
DOC_CKS1_1	388	393	PF01111	0.614
DOC_CKS1_1	422	427	PF01111	0.609
DOC_CYCLIN_RxL_1	509	517	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.694
DOC_MAPK_DCC_7	232	241	PF00069	0.509
DOC_MAPK_gen_1	511	518	PF00069	0.495
DOC_MAPK_MEF2A_6	4	11	PF00069	0.484
DOC_MAPK_MEF2A_6	511	518	PF00069	0.495
DOC_MAPK_NFAT4_5	511	519	PF00069	0.522
DOC_PP4_FxxP_1	350	353	PF00568	0.399
DOC_USP7_MATH_1	125	129	PF00917	0.538
DOC_USP7_MATH_1	32	36	PF00917	0.686
DOC_USP7_MATH_1	371	375	PF00917	0.520
DOC_USP7_MATH_1	423	427	PF00917	0.571
DOC_USP7_MATH_1	442	446	PF00917	0.572
DOC_USP7_MATH_1	479	483	PF00917	0.628
DOC_USP7_MATH_1	496	500	PF00917	0.563
DOC_WW_Pin1_4	111	116	PF00397	0.677
DOC_WW_Pin1_4	167	172	PF00397	0.393
DOC_WW_Pin1_4	239	244	PF00397	0.477
DOC_WW_Pin1_4	349	354	PF00397	0.428
DOC_WW_Pin1_4	387	392	PF00397	0.595
DOC_WW_Pin1_4	421	426	PF00397	0.727
LIG_14-3-3_CanoR_1	184	190	PF00244	0.373
LIG_14-3-3_CanoR_1	265	272	PF00244	0.413
LIG_14-3-3_CanoR_1	372	378	PF00244	0.658
LIG_APCC_ABBA_1	449	454	PF00400	0.431
LIG_BIR_III_2	122	126	PF00653	0.449
LIG_BIR_III_4	397	401	PF00653	0.554
LIG_BRCT_BRCA1_1	185	189	PF00533	0.338
LIG_BRCT_BRCA1_1	211	215	PF00533	0.413
LIG_BRCT_BRCA1_1	255	259	PF00533	0.566
LIG_BRCT_BRCA1_1	444	448	PF00533	0.512
LIG_BRCT_BRCA1_1	7	11	PF00533	0.477
LIG_Clathr_ClatBox_1	343	347	PF01394	0.349
LIG_CSL_BTD_1	388	391	PF09270	0.616
LIG_deltaCOP1_diTrp_1	134	140	PF00928	0.463
LIG_FHA_1	174	180	PF00498	0.355
LIG_FHA_1	22	28	PF00498	0.393
LIG_FHA_1	245	251	PF00498	0.499
LIG_FHA_1	325	331	PF00498	0.713
LIG_FHA_1	343	349	PF00498	0.458
LIG_FHA_1	388	394	PF00498	0.632
LIG_FHA_1	441	447	PF00498	0.666
LIG_FHA_2	117	123	PF00498	0.557
LIG_FHA_2	173	179	PF00498	0.474
LIG_FHA_2	276	282	PF00498	0.435
LIG_FHA_2	38	44	PF00498	0.651
LIG_FHA_2	397	403	PF00498	0.627
LIG_GBD_Chelix_1	340	348	PF00786	0.413
LIG_Integrin_RGD_1	416	418	PF01839	0.590
LIG_LIR_Apic_2	161	167	PF02991	0.449
LIG_LIR_Apic_2	347	353	PF02991	0.376
LIG_LIR_Gen_1	374	383	PF02991	0.480
LIG_LIR_Nem_3	128	132	PF02991	0.429
LIG_LIR_Nem_3	256	262	PF02991	0.507
LIG_LIR_Nem_3	268	274	PF02991	0.454
LIG_LIR_Nem_3	374	380	PF02991	0.606
LIG_LIR_Nem_3	456	461	PF02991	0.505
LIG_LIR_Nem_3	76	81	PF02991	0.479
LIG_NRBOX	339	345	PF00104	0.501
LIG_Pex14_2	448	452	PF04695	0.451
LIG_REV1ctd_RIR_1	49	57	PF16727	0.357
LIG_SH2_CRK	492	496	PF00017	0.593
LIG_SH2_NCK_1	41	45	PF00017	0.369
LIG_SH2_NCK_1	71	75	PF00017	0.585
LIG_SH2_SRC	54	57	PF00017	0.374
LIG_SH2_SRC	71	74	PF00017	0.498
LIG_SH2_STAP1	41	45	PF00017	0.369
LIG_SH2_STAP1	78	82	PF00017	0.553
LIG_SH2_STAT5	156	159	PF00017	0.409
LIG_SH2_STAT5	174	177	PF00017	0.543
LIG_SH2_STAT5	358	361	PF00017	0.355
LIG_SH2_STAT5	41	44	PF00017	0.520
LIG_SH2_STAT5	461	464	PF00017	0.531
LIG_SH2_STAT5	492	495	PF00017	0.526
LIG_SH2_STAT5	54	57	PF00017	0.316
LIG_SH2_STAT5	81	84	PF00017	0.500
LIG_SH3_3	121	127	PF00018	0.406
LIG_SH3_3	266	272	PF00018	0.465
LIG_SH3_3	350	356	PF00018	0.430
LIG_SH3_3	60	66	PF00018	0.408
LIG_SH3_3	98	104	PF00018	0.547
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.370
LIG_SUMO_SIM_par_1	342	347	PF11976	0.369
LIG_SUMO_SIM_par_1	390	395	PF11976	0.509
LIG_TRAF2_1	435	438	PF00917	0.788
LIG_TRAF2_1	44	47	PF00917	0.403
LIG_TRAF2_1	74	77	PF00917	0.592
LIG_WRC_WIRS_1	126	131	PF05994	0.448
MOD_CDK_SPxK_1	421	427	PF00069	0.540
MOD_CDK_SPxxK_3	239	246	PF00069	0.486
MOD_CK1_1	128	134	PF00069	0.429
MOD_CK1_1	226	232	PF00069	0.543
MOD_CK1_1	242	248	PF00069	0.509
MOD_CK1_1	336	342	PF00069	0.454
MOD_CK1_1	39	45	PF00069	0.596
MOD_CK1_1	57	63	PF00069	0.307
MOD_CK2_1	128	134	PF00069	0.431
MOD_CK2_1	135	141	PF00069	0.359
MOD_CK2_1	172	178	PF00069	0.427
MOD_CK2_1	275	281	PF00069	0.432
MOD_CMANNOS	386	389	PF00535	0.550
MOD_Cter_Amidation	14	17	PF01082	0.591
MOD_GlcNHglycan	11	14	PF01048	0.514
MOD_GlcNHglycan	225	228	PF01048	0.478
MOD_GlcNHglycan	324	327	PF01048	0.665
MOD_GlcNHglycan	33	37	PF01048	0.607
MOD_GlcNHglycan	360	363	PF01048	0.324
MOD_GlcNHglycan	373	376	PF01048	0.450
MOD_GlcNHglycan	462	465	PF01048	0.621
MOD_GlcNHglycan	498	501	PF01048	0.693
MOD_GlcNHglycan	95	98	PF01048	0.743
MOD_GSK3_1	211	218	PF00069	0.562
MOD_GSK3_1	219	226	PF00069	0.354
MOD_GSK3_1	253	260	PF00069	0.533
MOD_GSK3_1	32	39	PF00069	0.703
MOD_GSK3_1	371	378	PF00069	0.565
MOD_GSK3_1	479	486	PF00069	0.697
MOD_GSK3_1	5	12	PF00069	0.394
MOD_GSK3_1	57	64	PF00069	0.472
MOD_N-GLC_1	184	189	PF02516	0.401
MOD_N-GLC_1	57	62	PF02516	0.461
MOD_NEK2_1	183	188	PF00069	0.351
MOD_NEK2_1	215	220	PF00069	0.440
MOD_NEK2_1	223	228	PF00069	0.548
MOD_NEK2_1	257	262	PF00069	0.545
MOD_NEK2_1	299	304	PF00069	0.468
MOD_NEK2_1	469	474	PF00069	0.557
MOD_NEK2_2	135	140	PF00069	0.345
MOD_NEK2_2	21	26	PF00069	0.385
MOD_PIKK_1	381	387	PF00454	0.594
MOD_PIKK_1	418	424	PF00454	0.629
MOD_PKA_2	183	189	PF00069	0.367
MOD_PKA_2	264	270	PF00069	0.400
MOD_PKA_2	322	328	PF00069	0.548
MOD_PKA_2	371	377	PF00069	0.661
MOD_Plk_1	215	221	PF00069	0.330
MOD_Plk_1	381	387	PF00069	0.542
MOD_Plk_1	57	63	PF00069	0.393
MOD_Plk_4	135	141	PF00069	0.355
MOD_Plk_4	270	276	PF00069	0.468
MOD_Plk_4	5	11	PF00069	0.388
MOD_Plk_4	77	83	PF00069	0.497
MOD_ProDKin_1	111	117	PF00069	0.675
MOD_ProDKin_1	167	173	PF00069	0.381
MOD_ProDKin_1	239	245	PF00069	0.481
MOD_ProDKin_1	349	355	PF00069	0.434
MOD_ProDKin_1	387	393	PF00069	0.595
MOD_ProDKin_1	421	427	PF00069	0.731
TRG_DiLeu_BaEn_1	178	183	PF01217	0.440
TRG_DiLeu_BaEn_1	294	299	PF01217	0.391
TRG_DiLeu_BaEn_1	498	503	PF01217	0.538
TRG_DiLeu_BaEn_3	528	534	PF01217	0.573
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.614
TRG_ENDOCYTIC_2	492	495	PF00928	0.545
TRG_ER_diArg_1	291	293	PF00400	0.509
TRG_ER_diArg_1	320	323	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL93	Leptomonas seymouri	59%	100%
A0A1X0NQS9	Trypanosomatidae	35%	100%
A0A3S7X1P6	Leishmania donovani	88%	100%
A0A422NBH7	Trypanosoma rangeli	38%	100%
A4HGQ5	Leishmania braziliensis	79%	99%
A4I3S9	Leishmania infantum	89%	100%
D0A878	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B021	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DCT5	Trypanosoma cruzi	36%	100%