Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q864_LEIMA

TriTrypDb:

LmjF.28.2020 , LMJLV39_280028200 , LMJSD75_280027800

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005814	centriole	5	2
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q864

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q864

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007098	centrosome cycle	3	2
GO:0009987	cellular process	1	2
GO:0010564	regulation of cell cycle process	5	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010824	regulation of centrosome duplication	6	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0031023	microtubule organizing center organization	3	2
GO:0032886	regulation of microtubule-based process	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0044089	positive regulation of cellular component biogenesis	5	2
GO:0045787	positive regulation of cell cycle	5	2
GO:0046599	regulation of centriole replication	6	2
GO:0046601	positive regulation of centriole replication	7	2
GO:0046605	regulation of centrosome cycle	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0051495	positive regulation of cytoskeleton organization	7	2
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090068	positive regulation of cell cycle process	6	2
GO:1902115	regulation of organelle assembly	5	2
GO:1902117	positive regulation of organelle assembly	6	2
GO:1903722	regulation of centriole elongation	6	2
GO:1903724	positive regulation of centriole elongation	7	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.739
CLV_MEL_PAP_1	152	158	PF00089	0.599
CLV_NRD_NRD_1	125	127	PF00675	0.579
CLV_NRD_NRD_1	168	170	PF00675	0.554
CLV_NRD_NRD_1	238	240	PF00675	0.511
CLV_NRD_NRD_1	256	258	PF00675	0.423
CLV_NRD_NRD_1	268	270	PF00675	0.626
CLV_NRD_NRD_1	412	414	PF00675	0.740
CLV_NRD_NRD_1	421	423	PF00675	0.754
CLV_NRD_NRD_1	50	52	PF00675	0.511
CLV_NRD_NRD_1	528	530	PF00675	0.597
CLV_PCSK_KEX2_1	105	107	PF00082	0.462
CLV_PCSK_KEX2_1	125	127	PF00082	0.282
CLV_PCSK_KEX2_1	167	169	PF00082	0.558
CLV_PCSK_KEX2_1	231	233	PF00082	0.546
CLV_PCSK_KEX2_1	267	269	PF00082	0.667
CLV_PCSK_KEX2_1	421	423	PF00082	0.782
CLV_PCSK_KEX2_1	50	52	PF00082	0.524
CLV_PCSK_KEX2_1	528	530	PF00082	0.587
CLV_PCSK_KEX2_1	90	92	PF00082	0.529
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.505
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.597
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.512
CLV_PCSK_SKI1_1	105	109	PF00082	0.482
CLV_PCSK_SKI1_1	147	151	PF00082	0.526
CLV_PCSK_SKI1_1	42	46	PF00082	0.546
DEG_APCC_DBOX_1	70	78	PF00400	0.496
DEG_SCF_TRCP1_1	427	433	PF00400	0.712
DEG_SPOP_SBC_1	454	458	PF00917	0.679
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.645
DOC_MAPK_DCC_7	335	344	PF00069	0.597
DOC_MAPK_gen_1	145	152	PF00069	0.524
DOC_MAPK_gen_1	335	344	PF00069	0.698
DOC_MAPK_MEF2A_6	145	152	PF00069	0.485
DOC_MAPK_NFAT4_5	145	153	PF00069	0.486
DOC_PP2B_LxvP_1	284	287	PF13499	0.680
DOC_USP7_MATH_1	134	138	PF00917	0.535
DOC_USP7_MATH_1	380	384	PF00917	0.788
DOC_USP7_MATH_1	430	434	PF00917	0.754
DOC_USP7_MATH_1	521	525	PF00917	0.624
DOC_USP7_MATH_1	56	60	PF00917	0.625
DOC_WW_Pin1_4	2	7	PF00397	0.761
DOC_WW_Pin1_4	261	266	PF00397	0.750
DOC_WW_Pin1_4	365	370	PF00397	0.784
DOC_WW_Pin1_4	412	417	PF00397	0.652
DOC_WW_Pin1_4	489	494	PF00397	0.752
DOC_WW_Pin1_4	498	503	PF00397	0.596
LIG_14-3-3_CanoR_1	155	163	PF00244	0.524
LIG_14-3-3_CanoR_1	267	273	PF00244	0.703
LIG_14-3-3_CanoR_1	474	479	PF00244	0.699
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	284	288	PF00533	0.692
LIG_FHA_1	373	379	PF00498	0.642
LIG_FHA_1	386	392	PF00498	0.714
LIG_FHA_1	399	405	PF00498	0.646
LIG_FHA_1	430	436	PF00498	0.770
LIG_FHA_1	455	461	PF00498	0.716
LIG_FHA_1	90	96	PF00498	0.610
LIG_FHA_2	125	131	PF00498	0.536
LIG_FHA_2	343	349	PF00498	0.786
LIG_FHA_2	355	361	PF00498	0.605
LIG_FHA_2	377	383	PF00498	0.817
LIG_FHA_2	395	401	PF00498	0.731
LIG_FHA_2	439	445	PF00498	0.709
LIG_FHA_2	501	507	PF00498	0.705
LIG_LIR_Gen_1	162	171	PF02991	0.505
LIG_LIR_Gen_1	238	247	PF02991	0.528
LIG_LIR_Gen_1	252	259	PF02991	0.627
LIG_LIR_Gen_1	313	322	PF02991	0.620
LIG_LIR_Nem_3	162	166	PF02991	0.500
LIG_LIR_Nem_3	238	244	PF02991	0.469
LIG_LIR_Nem_3	252	256	PF02991	0.575
LIG_LIR_Nem_3	313	319	PF02991	0.554
LIG_LIR_Nem_3	444	450	PF02991	0.562
LIG_LYPXL_yS_3	447	450	PF13949	0.669
LIG_MAD2	409	417	PF02301	0.600
LIG_MYND_1	479	483	PF01753	0.676
LIG_PCNA_TLS_4	528	535	PF02747	0.386
LIG_SH2_CRK	163	167	PF00017	0.526
LIG_SH2_CRK	241	245	PF00017	0.585
LIG_SH2_CRK	316	320	PF00017	0.539
LIG_SH2_NCK_1	20	24	PF00017	0.463
LIG_SH2_STAP1	20	24	PF00017	0.463
LIG_SH2_STAP1	568	572	PF00017	0.467
LIG_SH2_STAT3	37	40	PF00017	0.574
LIG_SH2_STAT3	571	574	PF00017	0.616
LIG_SH2_STAT5	116	119	PF00017	0.575
LIG_SH2_STAT5	173	176	PF00017	0.551
LIG_SH2_STAT5	571	574	PF00017	0.584
LIG_SH3_3	277	283	PF00018	0.655
LIG_SH3_3	284	290	PF00018	0.517
LIG_SH3_3	344	350	PF00018	0.752
LIG_SH3_3	477	483	PF00018	0.646
LIG_TRAF2_1	127	130	PF00917	0.582
LIG_TRAF2_1	159	162	PF00917	0.598
LIG_TRAF2_1	461	464	PF00917	0.701
LIG_TRAF2_1	503	506	PF00917	0.734
LIG_WRC_WIRS_1	531	536	PF05994	0.533
MOD_CDC14_SPxK_1	264	267	PF00782	0.680
MOD_CDK_SPxK_1	261	267	PF00069	0.663
MOD_CDK_SPxxK_3	2	9	PF00069	0.719
MOD_CDK_SPxxK_3	261	268	PF00069	0.668
MOD_CDK_SPxxK_3	365	372	PF00069	0.787
MOD_CK1_1	219	225	PF00069	0.592
MOD_CK1_1	362	368	PF00069	0.737
MOD_CK1_1	402	408	PF00069	0.651
MOD_CK1_1	442	448	PF00069	0.672
MOD_CK1_1	469	475	PF00069	0.796
MOD_CK1_1	492	498	PF00069	0.657
MOD_CK2_1	124	130	PF00069	0.581
MOD_CK2_1	342	348	PF00069	0.781
MOD_CK2_1	376	382	PF00069	0.775
MOD_CK2_1	394	400	PF00069	0.725
MOD_CK2_1	425	431	PF00069	0.758
MOD_CK2_1	500	506	PF00069	0.743
MOD_GlcNHglycan	11	14	PF01048	0.615
MOD_GlcNHglycan	157	160	PF01048	0.518
MOD_GlcNHglycan	208	212	PF01048	0.598
MOD_GlcNHglycan	284	287	PF01048	0.726
MOD_GlcNHglycan	290	293	PF01048	0.728
MOD_GlcNHglycan	306	309	PF01048	0.494
MOD_GlcNHglycan	382	385	PF01048	0.796
MOD_GlcNHglycan	404	407	PF01048	0.753
MOD_GlcNHglycan	427	430	PF01048	0.768
MOD_GlcNHglycan	444	447	PF01048	0.444
MOD_GlcNHglycan	511	514	PF01048	0.684
MOD_GlcNHglycan	519	522	PF01048	0.655
MOD_GlcNHglycan	523	526	PF01048	0.610
MOD_GSK3_1	190	197	PF00069	0.625
MOD_GSK3_1	350	357	PF00069	0.767
MOD_GSK3_1	358	365	PF00069	0.752
MOD_GSK3_1	368	375	PF00069	0.694
MOD_GSK3_1	376	383	PF00069	0.739
MOD_GSK3_1	386	393	PF00069	0.628
MOD_GSK3_1	394	401	PF00069	0.659
MOD_GSK3_1	425	432	PF00069	0.794
MOD_GSK3_1	438	445	PF00069	0.644
MOD_GSK3_1	469	476	PF00069	0.697
MOD_GSK3_1	494	501	PF00069	0.632
MOD_GSK3_1	517	524	PF00069	0.607
MOD_GSK3_1	545	552	PF00069	0.501
MOD_N-GLC_1	177	182	PF02516	0.588
MOD_N-GLC_1	333	338	PF02516	0.699
MOD_NEK2_1	1	6	PF00069	0.732
MOD_NEK2_1	133	138	PF00069	0.570
MOD_NEK2_1	192	197	PF00069	0.587
MOD_NEK2_1	199	204	PF00069	0.603
MOD_NEK2_1	216	221	PF00069	0.520
MOD_NEK2_1	354	359	PF00069	0.799
MOD_NEK2_1	399	404	PF00069	0.743
MOD_NEK2_1	438	443	PF00069	0.713
MOD_NEK2_1	509	514	PF00069	0.670
MOD_NEK2_1	515	520	PF00069	0.689
MOD_NEK2_1	545	550	PF00069	0.485
MOD_PIKK_1	192	198	PF00454	0.605
MOD_PIKK_1	199	205	PF00454	0.514
MOD_PIKK_1	216	222	PF00454	0.542
MOD_PKA_1	268	274	PF00069	0.675
MOD_PKA_2	124	130	PF00069	0.581
MOD_PKA_2	14	20	PF00069	0.516
MOD_PKA_2	154	160	PF00069	0.524
MOD_PKA_2	268	274	PF00069	0.675
MOD_PKA_2	334	340	PF00069	0.738
MOD_PKA_2	358	364	PF00069	0.711
MOD_PKA_2	473	479	PF00069	0.699
MOD_PKA_2	56	62	PF00069	0.609
MOD_Plk_1	395	401	PF00069	0.709
MOD_Plk_1	430	436	PF00069	0.755
MOD_Plk_1	439	445	PF00069	0.687
MOD_Plk_4	430	436	PF00069	0.760
MOD_Plk_4	455	461	PF00069	0.697
MOD_Plk_4	530	536	PF00069	0.628
MOD_ProDKin_1	2	8	PF00069	0.758
MOD_ProDKin_1	261	267	PF00069	0.756
MOD_ProDKin_1	365	371	PF00069	0.784
MOD_ProDKin_1	412	418	PF00069	0.652
MOD_ProDKin_1	489	495	PF00069	0.753
MOD_ProDKin_1	498	504	PF00069	0.592
MOD_SUMO_rev_2	55	64	PF00179	0.577
TRG_ENDOCYTIC_2	163	166	PF00928	0.494
TRG_ENDOCYTIC_2	241	244	PF00928	0.474
TRG_ENDOCYTIC_2	316	319	PF00928	0.541
TRG_ENDOCYTIC_2	447	450	PF00928	0.554
TRG_ER_diArg_1	125	128	PF00400	0.584
TRG_ER_diArg_1	166	169	PF00400	0.555
TRG_ER_diArg_1	267	269	PF00400	0.621
TRG_ER_diArg_1	421	423	PF00400	0.785
TRG_ER_diArg_1	50	52	PF00400	0.565
TRG_NES_CRM1_1	530	543	PF08389	0.540
TRG_NES_CRM1_1	72	86	PF08389	0.484
TRG_NLS_Bipartite_1	90	109	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.771
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF9	Leptomonas seymouri	54%	93%
A0A1X0NR42	Trypanosomatidae	31%	98%
A0A3S5IQW4	Trypanosoma rangeli	32%	94%
A0A3S7X1P3	Leishmania donovani	95%	100%
A4HGQ6	Leishmania braziliensis	81%	100%
A4I3T0	Leishmania infantum	95%	100%
D0A877	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B022	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AWM8	Trypanosoma cruzi	31%	100%