NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH dehydrogenase subunit NB6M, putative

Species:

Leishmania major

UniProt:

Q4Q863_LEIMA

TriTrypDb:

LmjF.28.2030 , LMJLV39_280028300 , LMJSD75_280027900

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005747	mitochondrial respiratory chain complex I	4	10
GO:0030964	NADH dehydrogenase complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0045271	respiratory chain complex I	4	10
GO:0098796	membrane protein complex	2	10
GO:0098798	mitochondrial protein-containing complex	2	10
GO:0098800	inner mitochondrial membrane protein complex	3	10
GO:0098803	respiratory chain complex	3	10
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	10
GO:1902495	transmembrane transporter complex	3	10
GO:1990204	oxidoreductase complex	3	10
GO:1990351	transporter complex	2	10

Expansion

Sequence features

Q4Q863

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q863

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.449
CLV_NRD_NRD_1	7	9	PF00675	0.467
CLV_PCSK_KEX2_1	113	115	PF00082	0.436
CLV_PCSK_KEX2_1	51	53	PF00082	0.249
CLV_PCSK_KEX2_1	7	9	PF00082	0.494
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.436
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.249
CLV_PCSK_SKI1_1	135	139	PF00082	0.455
CLV_PCSK_SKI1_1	52	56	PF00082	0.284
DEG_APCC_DBOX_1	144	152	PF00400	0.249
DEG_APCC_KENBOX_2	118	122	PF00400	0.282
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DOC_MAPK_gen_1	77	86	PF00069	0.236
DOC_MAPK_MEF2A_6	79	88	PF00069	0.331
DOC_USP7_MATH_1	162	166	PF00917	0.457
LIG_EH1_1	79	87	PF00400	0.249
LIG_eIF4E_1	117	123	PF01652	0.249
LIG_FHA_1	98	104	PF00498	0.331
LIG_LIR_Apic_2	142	147	PF02991	0.269
LIG_LIR_Nem_3	110	115	PF02991	0.295
LIG_LIR_Nem_3	124	130	PF02991	0.198
LIG_LIR_Nem_3	131	137	PF02991	0.242
LIG_LYPXL_SIV_4	97	105	PF13949	0.236
LIG_LYPXL_yS_3	40	43	PF13949	0.449
LIG_Pex14_1	168	172	PF04695	0.384
LIG_Pex14_2	134	138	PF04695	0.249
LIG_Pex14_2	21	25	PF04695	0.569
LIG_SH2_CRK	159	163	PF00017	0.393
LIG_SH2_GRB2like	139	142	PF00017	0.317
LIG_SH2_PTP2	127	130	PF00017	0.282
LIG_SH2_STAT5	127	130	PF00017	0.295
LIG_SH2_STAT5	156	159	PF00017	0.474
LIG_SH2_STAT5	22	25	PF00017	0.677
LIG_SH3_3	140	146	PF00018	0.236
LIG_SH3_3	7	13	PF00018	0.617
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.368
MOD_Cter_Amidation	49	52	PF01082	0.249
MOD_GlcNHglycan	25	28	PF01048	0.397
MOD_GSK3_1	162	169	PF00069	0.379
MOD_N-GLC_1	166	171	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_2	64	69	PF00069	0.289
MOD_Plk_1	166	172	PF00069	0.379
MOD_Plk_4	20	26	PF00069	0.565
MOD_SUMO_rev_2	12	21	PF00179	0.589
TRG_DiLeu_BaEn_1	118	123	PF01217	0.249
TRG_ENDOCYTIC_2	127	130	PF00928	0.282
TRG_ENDOCYTIC_2	22	25	PF00928	0.572
TRG_ENDOCYTIC_2	40	43	PF00928	0.449
TRG_ER_diArg_1	7	9	PF00400	0.692
TRG_NLS_MonoExtC_3	112	118	PF00514	0.236
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ7	Leptomonas seymouri	87%	100%
A0A1X0NSH9	Trypanosomatidae	87%	100%
A0A3Q8IQR1	Leishmania donovani	99%	100%
A0A3R7MHX5	Trypanosoma rangeli	65%	100%
A4HGQ7	Leishmania braziliensis	95%	100%
A4I3T1	Leishmania infantum	99%	100%
D0A876	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
E9B023	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BL90	Trypanosoma cruzi	84%	100%