AMP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AMP-binding enzyme/Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4Q861_LEIMA

TriTrypDb:

LmjF.28.2050 , LMJLV39_280028500 , LMJSD75_280028100

Length:

1003

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q861

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q861

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019748	secondary metabolic process	2	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043038	amino acid activation	4	2
GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0044550	secondary metabolite biosynthetic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0019842	vitamin binding	3	2
GO:0031177	phosphopantetheine binding	3	2
GO:0033218	amide binding	2	2
GO:0036094	small molecule binding	2	2
GO:0072341	modified amino acid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	546	550	PF00656	0.528
CLV_C14_Caspase3-7	613	617	PF00656	0.533
CLV_NRD_NRD_1	159	161	PF00675	0.311
CLV_NRD_NRD_1	187	189	PF00675	0.247
CLV_NRD_NRD_1	492	494	PF00675	0.305
CLV_NRD_NRD_1	579	581	PF00675	0.414
CLV_NRD_NRD_1	6	8	PF00675	0.370
CLV_NRD_NRD_1	785	787	PF00675	0.540
CLV_NRD_NRD_1	82	84	PF00675	0.403
CLV_NRD_NRD_1	847	849	PF00675	0.438
CLV_NRD_NRD_1	91	93	PF00675	0.464
CLV_NRD_NRD_1	946	948	PF00675	0.631
CLV_NRD_NRD_1	960	962	PF00675	0.609
CLV_NRD_NRD_1	976	978	PF00675	0.423
CLV_PCSK_FUR_1	490	494	PF00082	0.357
CLV_PCSK_FUR_1	984	988	PF00082	0.421
CLV_PCSK_KEX2_1	158	160	PF00082	0.310
CLV_PCSK_KEX2_1	465	467	PF00082	0.362
CLV_PCSK_KEX2_1	492	494	PF00082	0.305
CLV_PCSK_KEX2_1	579	581	PF00082	0.414
CLV_PCSK_KEX2_1	6	8	PF00082	0.372
CLV_PCSK_KEX2_1	70	72	PF00082	0.489
CLV_PCSK_KEX2_1	785	787	PF00082	0.540
CLV_PCSK_KEX2_1	81	83	PF00082	0.374
CLV_PCSK_KEX2_1	847	849	PF00082	0.438
CLV_PCSK_KEX2_1	91	93	PF00082	0.522
CLV_PCSK_KEX2_1	944	946	PF00082	0.642
CLV_PCSK_KEX2_1	976	978	PF00082	0.576
CLV_PCSK_KEX2_1	986	988	PF00082	0.401
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.226
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.489
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.374
CLV_PCSK_PC1ET2_1	944	946	PF00082	0.693
CLV_PCSK_PC1ET2_1	986	988	PF00082	0.472
CLV_PCSK_PC7_1	154	160	PF00082	0.462
CLV_PCSK_SKI1_1	242	246	PF00082	0.357
CLV_PCSK_SKI1_1	338	342	PF00082	0.325
CLV_PCSK_SKI1_1	465	469	PF00082	0.257
CLV_PCSK_SKI1_1	503	507	PF00082	0.449
CLV_PCSK_SKI1_1	580	584	PF00082	0.441
CLV_PCSK_SKI1_1	83	87	PF00082	0.424
CLV_PCSK_SKI1_1	847	851	PF00082	0.342
DEG_APCC_DBOX_1	356	364	PF00400	0.328
DEG_APCC_DBOX_1	502	510	PF00400	0.449
DEG_SCF_FBW7_2	100	107	PF00400	0.538
DOC_ANK_TNKS_1	6	13	PF00023	0.356
DOC_CKS1_1	278	283	PF01111	0.351
DOC_CKS1_1	311	316	PF01111	0.292
DOC_CKS1_1	591	596	PF01111	0.548
DOC_CKS1_1	897	902	PF01111	0.437
DOC_CYCLIN_RxL_1	841	853	PF00134	0.353
DOC_CYCLIN_yClb5_NLxxxL_5	233	240	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.469
DOC_MAPK_gen_1	188	195	PF00069	0.247
DOC_MAPK_gen_1	490	499	PF00069	0.301
DOC_MAPK_gen_1	597	605	PF00069	0.491
DOC_MAPK_gen_1	667	676	PF00069	0.362
DOC_MAPK_gen_1	785	796	PF00069	0.602
DOC_MAPK_gen_1	860	870	PF00069	0.292
DOC_MAPK_MEF2A_6	144	152	PF00069	0.431
DOC_MAPK_MEF2A_6	667	676	PF00069	0.382
DOC_MAPK_MEF2A_6	739	747	PF00069	0.469
DOC_MAPK_MEF2A_6	789	798	PF00069	0.533
DOC_PP1_RVXF_1	578	585	PF00149	0.409
DOC_PP2B_LxvP_1	570	573	PF13499	0.362
DOC_PP2B_LxvP_1	645	648	PF13499	0.477
DOC_PP2B_LxvP_1	690	693	PF13499	0.490
DOC_PP4_FxxP_1	266	269	PF00568	0.351
DOC_PP4_FxxP_1	575	578	PF00568	0.407
DOC_USP7_MATH_1	449	453	PF00917	0.313
DOC_USP7_MATH_1	752	756	PF00917	0.616
DOC_USP7_MATH_1	797	801	PF00917	0.349
DOC_USP7_MATH_1	839	843	PF00917	0.328
DOC_USP7_MATH_1	871	875	PF00917	0.351
DOC_USP7_MATH_1	930	934	PF00917	0.651
DOC_WW_Pin1_4	100	105	PF00397	0.695
DOC_WW_Pin1_4	261	266	PF00397	0.316
DOC_WW_Pin1_4	277	282	PF00397	0.171
DOC_WW_Pin1_4	310	315	PF00397	0.292
DOC_WW_Pin1_4	452	457	PF00397	0.396
DOC_WW_Pin1_4	532	537	PF00397	0.518
DOC_WW_Pin1_4	590	595	PF00397	0.523
DOC_WW_Pin1_4	789	794	PF00397	0.439
DOC_WW_Pin1_4	825	830	PF00397	0.270
DOC_WW_Pin1_4	896	901	PF00397	0.444
LIG_14-3-3_CanoR_1	325	330	PF00244	0.284
LIG_14-3-3_CanoR_1	345	351	PF00244	0.328
LIG_14-3-3_CanoR_1	475	484	PF00244	0.370
LIG_14-3-3_CanoR_1	528	536	PF00244	0.481
LIG_14-3-3_CanoR_1	635	641	PF00244	0.515
LIG_14-3-3_CanoR_1	789	793	PF00244	0.476
LIG_14-3-3_CanoR_1	863	868	PF00244	0.294
LIG_14-3-3_CanoR_1	91	95	PF00244	0.500
LIG_14-3-3_CanoR_1	961	966	PF00244	0.593
LIG_APCC_ABBA_1	437	442	PF00400	0.313
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_BRCT_BRCA1_1	262	266	PF00533	0.294
LIG_BRCT_BRCA1_1	412	416	PF00533	0.341
LIG_deltaCOP1_diTrp_1	894	903	PF00928	0.382
LIG_FHA_1	137	143	PF00498	0.370
LIG_FHA_1	306	312	PF00498	0.292
LIG_FHA_1	468	474	PF00498	0.305
LIG_FHA_1	533	539	PF00498	0.562
LIG_FHA_1	543	549	PF00498	0.437
LIG_FHA_1	593	599	PF00498	0.551
LIG_FHA_1	651	657	PF00498	0.484
LIG_FHA_1	789	795	PF00498	0.428
LIG_FHA_1	808	814	PF00498	0.544
LIG_FHA_1	877	883	PF00498	0.448
LIG_FHA_2	101	107	PF00498	0.640
LIG_FHA_2	287	293	PF00498	0.357
LIG_FHA_2	351	357	PF00498	0.357
LIG_FHA_2	380	386	PF00498	0.357
LIG_FHA_2	962	968	PF00498	0.599
LIG_GBD_Chelix_1	560	568	PF00786	0.396
LIG_Integrin_RGD_1	26	28	PF01839	0.404
LIG_LIR_Apic_2	263	269	PF02991	0.351
LIG_LIR_Apic_2	574	578	PF02991	0.428
LIG_LIR_Gen_1	122	132	PF02991	0.354
LIG_LIR_Gen_1	139	148	PF02991	0.478
LIG_LIR_Gen_1	370	380	PF02991	0.292
LIG_LIR_Gen_1	953	960	PF02991	0.621
LIG_LIR_Gen_1	967	975	PF02991	0.476
LIG_LIR_Nem_3	122	128	PF02991	0.359
LIG_LIR_Nem_3	139	143	PF02991	0.444
LIG_LIR_Nem_3	30	36	PF02991	0.391
LIG_LIR_Nem_3	359	364	PF02991	0.319
LIG_LIR_Nem_3	370	375	PF02991	0.257
LIG_LIR_Nem_3	432	437	PF02991	0.350
LIG_LIR_Nem_3	631	637	PF02991	0.461
LIG_LIR_Nem_3	754	760	PF02991	0.427
LIG_LIR_Nem_3	953	959	PF02991	0.623
LIG_LIR_Nem_3	964	968	PF02991	0.574
LIG_MLH1_MIPbox_1	263	267	PF16413	0.351
LIG_NRBOX	563	569	PF00104	0.432
LIG_NRBOX	75	81	PF00104	0.279
LIG_NRBOX	845	851	PF00104	0.351
LIG_PCNA_PIPBox_1	514	523	PF02747	0.403
LIG_PCNA_yPIPBox_3	514	528	PF02747	0.326
LIG_Pex3_1	564	575	PF04882	0.437
LIG_REV1ctd_RIR_1	465	473	PF16727	0.328
LIG_RPA_C_Fungi	552	564	PF08784	0.406
LIG_SH2_CRK	125	129	PF00017	0.344
LIG_SH2_CRK	634	638	PF00017	0.445
LIG_SH2_SRC	655	658	PF00017	0.475
LIG_SH2_STAP1	125	129	PF00017	0.344
LIG_SH2_STAT3	440	443	PF00017	0.291
LIG_SH2_STAT5	218	221	PF00017	0.362
LIG_SH2_STAT5	239	242	PF00017	0.292
LIG_SH2_STAT5	286	289	PF00017	0.319
LIG_SH2_STAT5	655	658	PF00017	0.475
LIG_SH2_STAT5	673	676	PF00017	0.389
LIG_SH2_STAT5	708	711	PF00017	0.385
LIG_SH2_STAT5	919	922	PF00017	0.466
LIG_SH2_STAT5	965	968	PF00017	0.620
LIG_SH3_3	142	148	PF00018	0.457
LIG_SH3_3	308	314	PF00018	0.292
LIG_SH3_3	588	594	PF00018	0.501
LIG_SH3_3	690	696	PF00018	0.426
LIG_SH3_3	721	727	PF00018	0.474
LIG_SH3_3	742	748	PF00018	0.581
LIG_SUMO_SIM_par_1	191	197	PF11976	0.247
LIG_TRAF2_1	179	182	PF00917	0.313
LIG_TRAF2_1	22	25	PF00917	0.339
LIG_TRAF2_1	417	420	PF00917	0.291
LIG_TRAF2_1	505	508	PF00917	0.441
LIG_TRAF2_1	563	566	PF00917	0.458
LIG_TRAF2_1	607	610	PF00917	0.436
LIG_TRAF2_1	627	630	PF00917	0.483
LIG_TYR_ITIM	966	971	PF00017	0.454
LIG_TYR_ITSM	368	375	PF00017	0.351
LIG_WRC_WIRS_1	572	577	PF05994	0.515
MOD_CDK_SPxxK_3	590	597	PF00069	0.535
MOD_CK1_1	120	126	PF00069	0.446
MOD_CK1_1	220	226	PF00069	0.292
MOD_CK1_1	318	324	PF00069	0.434
MOD_CK1_1	452	458	PF00069	0.365
MOD_CK1_1	800	806	PF00069	0.455
MOD_CK1_1	922	928	PF00069	0.584
MOD_CK2_1	176	182	PF00069	0.454
MOD_CK2_1	379	385	PF00069	0.365
MOD_CK2_1	475	481	PF00069	0.322
MOD_CK2_1	624	630	PF00069	0.624
MOD_CK2_1	722	728	PF00069	0.553
MOD_CK2_1	961	967	PF00069	0.661
MOD_CK2_1	992	998	PF00069	0.468
MOD_Cter_Amidation	463	466	PF01082	0.226
MOD_Cter_Amidation	490	493	PF01082	0.305
MOD_GlcNHglycan	15	18	PF01048	0.399
MOD_GlcNHglycan	178	181	PF01048	0.282
MOD_GlcNHglycan	182	186	PF01048	0.290
MOD_GlcNHglycan	219	222	PF01048	0.292
MOD_GlcNHglycan	428	431	PF01048	0.332
MOD_GlcNHglycan	52	55	PF01048	0.543
MOD_GlcNHglycan	530	533	PF01048	0.639
MOD_GlcNHglycan	57	61	PF01048	0.546
MOD_GlcNHglycan	841	844	PF01048	0.351
MOD_GlcNHglycan	873	876	PF01048	0.303
MOD_GlcNHglycan	922	925	PF01048	0.528
MOD_GlcNHglycan	927	930	PF01048	0.550
MOD_GSK3_1	164	171	PF00069	0.313
MOD_GSK3_1	194	201	PF00069	0.379
MOD_GSK3_1	216	223	PF00069	0.294
MOD_GSK3_1	280	287	PF00069	0.299
MOD_GSK3_1	305	312	PF00069	0.325
MOD_GSK3_1	315	322	PF00069	0.292
MOD_GSK3_1	325	332	PF00069	0.171
MOD_GSK3_1	367	374	PF00069	0.343
MOD_GSK3_1	528	535	PF00069	0.551
MOD_GSK3_1	586	593	PF00069	0.474
MOD_GSK3_1	918	925	PF00069	0.512
MOD_GSK3_1	950	957	PF00069	0.631
MOD_N-GLC_1	950	955	PF02516	0.647
MOD_NEK2_1	128	133	PF00069	0.306
MOD_NEK2_1	136	141	PF00069	0.347
MOD_NEK2_1	217	222	PF00069	0.327
MOD_NEK2_1	260	265	PF00069	0.292
MOD_NEK2_1	350	355	PF00069	0.351
MOD_NEK2_1	426	431	PF00069	0.313
MOD_NEK2_1	49	54	PF00069	0.574
MOD_NEK2_1	666	671	PF00069	0.387
MOD_NEK2_1	837	842	PF00069	0.403
MOD_NEK2_1	918	923	PF00069	0.515
MOD_NEK2_2	752	757	PF00069	0.397
MOD_PIKK_1	117	123	PF00454	0.315
MOD_PIKK_1	286	292	PF00454	0.351
MOD_PIKK_1	344	350	PF00454	0.343
MOD_PIKK_1	519	525	PF00454	0.426
MOD_PIKK_1	598	604	PF00454	0.485
MOD_PK_1	325	331	PF00069	0.284
MOD_PKA_1	961	967	PF00069	0.597
MOD_PKA_2	344	350	PF00069	0.328
MOD_PKA_2	66	72	PF00069	0.384
MOD_PKA_2	788	794	PF00069	0.496
MOD_PKA_2	90	96	PF00069	0.516
MOD_PKA_2	954	960	PF00069	0.678
MOD_Plk_1	168	174	PF00069	0.501
MOD_Plk_1	208	214	PF00069	0.370
MOD_Plk_1	367	373	PF00069	0.292
MOD_Plk_1	449	455	PF00069	0.473
MOD_Plk_1	997	1003	PF00069	0.465
MOD_Plk_2-3	967	973	PF00069	0.385
MOD_Plk_4	120	126	PF00069	0.368
MOD_Plk_4	169	175	PF00069	0.357
MOD_Plk_4	280	286	PF00069	0.466
MOD_Plk_4	325	331	PF00069	0.382
MOD_Plk_4	367	373	PF00069	0.292
MOD_Plk_4	571	577	PF00069	0.429
MOD_Plk_4	636	642	PF00069	0.522
MOD_Plk_4	752	758	PF00069	0.407
MOD_Plk_4	863	869	PF00069	0.319
MOD_Plk_4	961	967	PF00069	0.605
MOD_ProDKin_1	100	106	PF00069	0.696
MOD_ProDKin_1	261	267	PF00069	0.316
MOD_ProDKin_1	277	283	PF00069	0.171
MOD_ProDKin_1	310	316	PF00069	0.292
MOD_ProDKin_1	452	458	PF00069	0.396
MOD_ProDKin_1	532	538	PF00069	0.505
MOD_ProDKin_1	590	596	PF00069	0.531
MOD_ProDKin_1	789	795	PF00069	0.430
MOD_ProDKin_1	825	831	PF00069	0.270
MOD_ProDKin_1	896	902	PF00069	0.441
MOD_SUMO_rev_2	220	229	PF00179	0.292
MOD_SUMO_rev_2	494	499	PF00179	0.357
TRG_DiLeu_BaEn_1	878	883	PF01217	0.351
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.465
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.226
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.409
TRG_DiLeu_BaLyEn_6	845	850	PF01217	0.424
TRG_DiLeu_LyEn_5	878	883	PF01217	0.357
TRG_ENDOCYTIC_2	125	128	PF00928	0.345
TRG_ENDOCYTIC_2	372	375	PF00928	0.292
TRG_ENDOCYTIC_2	434	437	PF00928	0.345
TRG_ENDOCYTIC_2	634	637	PF00928	0.447
TRG_ENDOCYTIC_2	673	676	PF00928	0.389
TRG_ENDOCYTIC_2	968	971	PF00928	0.447
TRG_ER_diArg_1	158	160	PF00400	0.313
TRG_ER_diArg_1	256	259	PF00400	0.267
TRG_ER_diArg_1	36	39	PF00400	0.432
TRG_ER_diArg_1	396	399	PF00400	0.357
TRG_ER_diArg_1	489	492	PF00400	0.357
TRG_ER_diArg_1	5	7	PF00400	0.369
TRG_ER_diArg_1	578	580	PF00400	0.411
TRG_ER_diArg_1	82	84	PF00400	0.403
TRG_ER_diArg_1	846	848	PF00400	0.313
TRG_ER_diArg_1	945	947	PF00400	0.696
TRG_ER_diArg_1	976	978	PF00400	0.470
TRG_NES_CRM1_1	807	819	PF08389	0.351
TRG_NLS_Bipartite_1	70	85	PF00514	0.333
TRG_NLS_Bipartite_1	944	965	PF00514	0.648
TRG_NLS_MonoCore_2	943	948	PF00514	0.638
TRG_NLS_MonoExtN_4	958	965	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	847	851	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	881	885	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5E5	Leptomonas seymouri	52%	98%
A0A0S4JM65	Bodo saltans	30%	84%
A0A3Q8IEY8	Leishmania donovani	94%	100%
A4HGQ9	Leishmania braziliensis	79%	100%
A4I3T3	Leishmania infantum	95%	100%
E9B025	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%