Threonylcarbamoyl-AMP synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family, putative

Species:

Leishmania major

UniProt:

Q4Q859_LEIMA

TriTrypDb:

LmjF.28.2070 , LMJLV39_280028700 , LMJSD75_280028300

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q859

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q859

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006450	regulation of translational fidelity	3	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	2
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003725	double-stranded RNA binding	5	12
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016779	nucleotidyltransferase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0061710	L-threonylcarbamoyladenylate synthase	5	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.165
CLV_NRD_NRD_1	13	15	PF00675	0.371
CLV_NRD_NRD_1	199	201	PF00675	0.231
CLV_PCSK_KEX2_1	13	15	PF00082	0.371
CLV_PCSK_KEX2_1	199	201	PF00082	0.231
CLV_PCSK_SKI1_1	332	336	PF00082	0.245
DOC_CKS1_1	255	260	PF01111	0.407
DOC_MAPK_gen_1	199	205	PF00069	0.231
DOC_MAPK_gen_1	276	283	PF00069	0.523
DOC_MAPK_MEF2A_6	199	207	PF00069	0.377
DOC_PP1_RVXF_1	333	340	PF00149	0.439
DOC_USP7_MATH_1	141	145	PF00917	0.253
DOC_USP7_MATH_1	44	48	PF00917	0.276
DOC_USP7_UBL2_3	188	192	PF12436	0.358
DOC_WW_Pin1_4	149	154	PF00397	0.279
DOC_WW_Pin1_4	236	241	PF00397	0.442
DOC_WW_Pin1_4	245	250	PF00397	0.345
DOC_WW_Pin1_4	254	259	PF00397	0.397
DOC_WW_Pin1_4	306	311	PF00397	0.500
DOC_WW_Pin1_4	5	10	PF00397	0.465
LIG_14-3-3_CanoR_1	200	206	PF00244	0.246
LIG_14-3-3_CterR_2	383	386	PF00244	0.541
LIG_BIR_II_1	1	5	PF00653	0.338
LIG_Clathr_ClatBox_1	170	174	PF01394	0.246
LIG_CtBP_PxDLS_1	9	13	PF00389	0.447
LIG_FHA_1	27	33	PF00498	0.240
LIG_FHA_1	284	290	PF00498	0.451
LIG_FHA_1	326	332	PF00498	0.459
LIG_FHA_1	368	374	PF00498	0.444
LIG_FHA_1	55	61	PF00498	0.222
LIG_FHA_2	105	111	PF00498	0.230
LIG_FHA_2	217	223	PF00498	0.417
LIG_FHA_2	5	11	PF00498	0.385
LIG_GBD_Chelix_1	85	93	PF00786	0.377
LIG_LIR_Gen_1	304	310	PF02991	0.443
LIG_LIR_Gen_1	316	327	PF02991	0.401
LIG_LIR_LC3C_4	191	196	PF02991	0.280
LIG_LIR_Nem_3	147	151	PF02991	0.231
LIG_LIR_Nem_3	290	294	PF02991	0.470
LIG_LIR_Nem_3	316	322	PF02991	0.426
LIG_SH2_STAP1	160	164	PF00017	0.377
LIG_SH2_STAT5	118	121	PF00017	0.377
LIG_SH2_STAT5	273	276	PF00017	0.464
LIG_SH2_STAT5	294	297	PF00017	0.500
LIG_SH2_STAT5	65	68	PF00017	0.239
LIG_SH3_1	103	109	PF00018	0.290
LIG_SH3_3	103	109	PF00018	0.261
LIG_SH3_3	121	127	PF00018	0.165
LIG_SH3_3	133	139	PF00018	0.234
LIG_SH3_3	22	28	PF00018	0.231
LIG_SH3_3	246	252	PF00018	0.421
LIG_SH3_3	53	59	PF00018	0.393
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.237
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.265
LIG_SUMO_SIM_par_1	169	174	PF11976	0.252
LIG_SUMO_SIM_par_1	23	31	PF11976	0.273
LIG_SUMO_SIM_par_1	285	290	PF11976	0.438
MOD_CK1_1	144	150	PF00069	0.263
MOD_CK1_1	152	158	PF00069	0.302
MOD_CK1_1	254	260	PF00069	0.424
MOD_CK1_1	367	373	PF00069	0.451
MOD_CK2_1	216	222	PF00069	0.443
MOD_CK2_1	4	10	PF00069	0.435
MOD_GlcNHglycan	115	118	PF01048	0.249
MOD_GlcNHglycan	143	146	PF01048	0.253
MOD_GlcNHglycan	177	180	PF01048	0.407
MOD_GlcNHglycan	266	269	PF01048	0.256
MOD_GlcNHglycan	366	369	PF01048	0.248
MOD_GlcNHglycan	380	383	PF01048	0.482
MOD_GlcNHglycan	42	45	PF01048	0.377
MOD_GSK3_1	250	257	PF00069	0.396
MOD_GSK3_1	378	385	PF00069	0.667
MOD_GSK3_1	40	47	PF00069	0.354
MOD_NEK2_1	283	288	PF00069	0.434
MOD_NEK2_1	40	45	PF00069	0.382
MOD_NEK2_1	85	90	PF00069	0.422
MOD_NEK2_2	28	33	PF00069	0.231
MOD_NEK2_2	327	332	PF00069	0.500
MOD_NEK2_2	44	49	PF00069	0.230
MOD_PKA_2	223	229	PF00069	0.382
MOD_PKA_2	325	331	PF00069	0.407
MOD_Plk_1	182	188	PF00069	0.274
MOD_Plk_4	203	209	PF00069	0.502
MOD_Plk_4	251	257	PF00069	0.470
MOD_Plk_4	28	34	PF00069	0.241
MOD_Plk_4	283	289	PF00069	0.416
MOD_Plk_4	44	50	PF00069	0.230
MOD_Plk_4	96	102	PF00069	0.236
MOD_ProDKin_1	149	155	PF00069	0.279
MOD_ProDKin_1	236	242	PF00069	0.442
MOD_ProDKin_1	245	251	PF00069	0.345
MOD_ProDKin_1	254	260	PF00069	0.397
MOD_ProDKin_1	306	312	PF00069	0.500
MOD_ProDKin_1	5	11	PF00069	0.460
MOD_SUMO_for_1	187	190	PF00179	0.377
MOD_SUMO_rev_2	184	194	PF00179	0.358
TRG_DiLeu_BaEn_1	190	195	PF01217	0.296
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.422
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.231
TRG_ENDOCYTIC_2	160	163	PF00928	0.377
TRG_ENDOCYTIC_2	305	308	PF00928	0.407
TRG_ENDOCYTIC_2	319	322	PF00928	0.407
TRG_ER_diArg_1	12	14	PF00400	0.372
TRG_ER_diArg_1	198	200	PF00400	0.231

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P4	Leptomonas seymouri	78%	100%
A0A0S4J813	Bodo saltans	44%	81%
A0A1X0NQV4	Trypanosomatidae	55%	100%
A0A3R7RHL4	Trypanosoma rangeli	55%	100%
A0A3S5H7J7	Leishmania donovani	95%	100%
A4I3T5	Leishmania infantum	95%	100%
D0A873	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AIT1	Leishmania braziliensis	88%	100%
E9B027	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q970S6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
V5BC26	Trypanosoma cruzi	55%	100%