C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CEP76 C2 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q857_LEIMA

TriTrypDb:

LmjF.28.2090 , LMJLV39_280028900 , LMJSD75_280028500

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005814	centriole	5	2
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q857

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q857

Function

Biological processes
Term	Name	Level	Count
GO:0010564	regulation of cell cycle process	5	2
GO:0010824	regulation of centrosome duplication	6	2
GO:0032886	regulation of microtubule-based process	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0046599	regulation of centriole replication	6	2
GO:0046605	regulation of centrosome cycle	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2
GO:1902115	regulation of organelle assembly	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	567	571	PF00656	0.479
CLV_C14_Caspase3-7	590	594	PF00656	0.362
CLV_NRD_NRD_1	199	201	PF00675	0.210
CLV_NRD_NRD_1	268	270	PF00675	0.317
CLV_NRD_NRD_1	283	285	PF00675	0.348
CLV_PCSK_KEX2_1	121	123	PF00082	0.312
CLV_PCSK_KEX2_1	236	238	PF00082	0.268
CLV_PCSK_KEX2_1	268	270	PF00082	0.317
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.312
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.312
CLV_PCSK_SKI1_1	16	20	PF00082	0.607
CLV_PCSK_SKI1_1	200	204	PF00082	0.241
CLV_PCSK_SKI1_1	261	265	PF00082	0.322
CLV_PCSK_SKI1_1	436	440	PF00082	0.455
CLV_PCSK_SKI1_1	557	561	PF00082	0.352
CLV_PCSK_SKI1_1	585	589	PF00082	0.338
CLV_PCSK_SKI1_1	61	65	PF00082	0.554
CLV_PCSK_SKI1_1	66	70	PF00082	0.535
DEG_APCC_DBOX_1	584	592	PF00400	0.382
DEG_COP1_1	78	88	PF00400	0.563
DEG_Nend_UBRbox_3	1	3	PF02207	0.478
DEG_ODPH_VHL_1	114	126	PF01847	0.503
DEG_SPOP_SBC_1	290	294	PF00917	0.488
DOC_ANK_TNKS_1	326	333	PF00023	0.380
DOC_CDC14_PxL_1	475	483	PF14671	0.468
DOC_CKS1_1	171	176	PF01111	0.409
DOC_CYCLIN_yCln2_LP_2	460	466	PF00134	0.301
DOC_MAPK_DCC_7	474	482	PF00069	0.344
DOC_MAPK_FxFP_2	604	607	PF00069	0.339
DOC_MAPK_gen_1	200	210	PF00069	0.409
DOC_MAPK_gen_1	557	566	PF00069	0.297
DOC_MAPK_MEF2A_6	204	212	PF00069	0.409
DOC_MAPK_MEF2A_6	462	471	PF00069	0.310
DOC_MAPK_MEF2A_6	557	566	PF00069	0.297
DOC_MAPK_MEF2A_6	609	617	PF00069	0.452
DOC_MAPK_MEF2A_6	95	102	PF00069	0.512
DOC_MAPK_RevD_3	186	201	PF00069	0.512
DOC_MAPK_RevD_3	223	237	PF00069	0.512
DOC_PP1_RVXF_1	120	127	PF00149	0.512
DOC_PP4_FxxP_1	303	306	PF00568	0.444
DOC_PP4_FxxP_1	604	607	PF00568	0.339
DOC_USP7_MATH_1	21	25	PF00917	0.562
DOC_USP7_MATH_1	290	294	PF00917	0.404
DOC_USP7_MATH_1	401	405	PF00917	0.446
DOC_USP7_MATH_1	449	453	PF00917	0.468
DOC_USP7_MATH_1	50	54	PF00917	0.466
DOC_USP7_MATH_1	84	88	PF00917	0.601
DOC_WW_Pin1_4	170	175	PF00397	0.409
DOC_WW_Pin1_4	302	307	PF00397	0.349
DOC_WW_Pin1_4	312	317	PF00397	0.277
DOC_WW_Pin1_4	345	350	PF00397	0.425
DOC_WW_Pin1_4	416	421	PF00397	0.430
DOC_WW_Pin1_4	8	13	PF00397	0.631
LIG_14-3-3_CanoR_1	268	277	PF00244	0.406
LIG_14-3-3_CanoR_1	287	297	PF00244	0.482
LIG_14-3-3_CanoR_1	321	326	PF00244	0.287
LIG_14-3-3_CanoR_1	499	505	PF00244	0.373
LIG_14-3-3_CanoR_1	579	584	PF00244	0.459
LIG_14-3-3_CanoR_1	609	614	PF00244	0.392
LIG_Actin_WH2_2	189	206	PF00022	0.420
LIG_Actin_WH2_2	483	501	PF00022	0.297
LIG_APCC_ABBA_1	502	507	PF00400	0.233
LIG_APCC_ABBA_1	542	547	PF00400	0.410
LIG_BIR_III_4	157	161	PF00653	0.429
LIG_BIR_III_4	400	404	PF00653	0.535
LIG_BRCT_BRCA1_1	122	126	PF00533	0.512
LIG_BRCT_BRCA1_1	171	175	PF00533	0.476
LIG_BRCT_BRCA1_1	593	597	PF00533	0.386
LIG_Clathr_ClatBox_1	153	157	PF01394	0.409
LIG_deltaCOP1_diTrp_1	342	352	PF00928	0.481
LIG_eIF4E_1	475	481	PF01652	0.351
LIG_EVH1_1	475	479	PF00568	0.380
LIG_FHA_1	209	215	PF00498	0.437
LIG_FHA_1	299	305	PF00498	0.303
LIG_FHA_1	331	337	PF00498	0.520
LIG_FHA_1	550	556	PF00498	0.415
LIG_FHA_2	255	261	PF00498	0.354
LIG_FHA_2	278	284	PF00498	0.438
LIG_FHA_2	411	417	PF00498	0.375
LIG_FHA_2	449	455	PF00498	0.382
LIG_FHA_2	511	517	PF00498	0.333
LIG_FHA_2	588	594	PF00498	0.450
LIG_GBD_Chelix_1	486	494	PF00786	0.335
LIG_LIR_Apic_2	301	306	PF02991	0.441
LIG_LIR_Apic_2	343	349	PF02991	0.434
LIG_LIR_Gen_1	29	39	PF02991	0.398
LIG_LIR_Gen_1	425	433	PF02991	0.420
LIG_LIR_Gen_1	541	549	PF02991	0.474
LIG_LIR_Gen_1	612	621	PF02991	0.274
LIG_LIR_Nem_3	198	202	PF02991	0.410
LIG_LIR_Nem_3	205	210	PF02991	0.411
LIG_LIR_Nem_3	260	266	PF02991	0.315
LIG_LIR_Nem_3	272	277	PF02991	0.328
LIG_LIR_Nem_3	29	35	PF02991	0.397
LIG_LIR_Nem_3	348	353	PF02991	0.299
LIG_LIR_Nem_3	377	382	PF02991	0.285
LIG_LIR_Nem_3	425	429	PF02991	0.437
LIG_LIR_Nem_3	450	456	PF02991	0.420
LIG_LIR_Nem_3	458	464	PF02991	0.347
LIG_LIR_Nem_3	541	545	PF02991	0.440
LIG_LIR_Nem_3	558	562	PF02991	0.199
LIG_LIR_Nem_3	612	617	PF02991	0.271
LIG_NRBOX	366	372	PF00104	0.271
LIG_PCNA_yPIPBox_3	181	192	PF02747	0.512
LIG_Pex14_1	270	274	PF04695	0.301
LIG_Pex14_1	346	350	PF04695	0.310
LIG_Pex14_2	126	130	PF04695	0.560
LIG_Pex14_2	148	152	PF04695	0.420
LIG_PTB_Apo_2	129	136	PF02174	0.464
LIG_PTB_Apo_2	432	439	PF02174	0.397
LIG_SH2_CRK	274	278	PF00017	0.472
LIG_SH2_CRK	32	36	PF00017	0.415
LIG_SH2_CRK	379	383	PF00017	0.272
LIG_SH2_NCK_1	621	625	PF00017	0.444
LIG_SH2_SRC	568	571	PF00017	0.363
LIG_SH2_STAP1	266	270	PF00017	0.302
LIG_SH2_STAP1	515	519	PF00017	0.378
LIG_SH2_STAT3	530	533	PF00017	0.453
LIG_SH2_STAT5	207	210	PF00017	0.434
LIG_SH2_STAT5	379	382	PF00017	0.256
LIG_SH2_STAT5	42	45	PF00017	0.440
LIG_SH2_STAT5	521	524	PF00017	0.303
LIG_SH2_STAT5	568	571	PF00017	0.430
LIG_SH2_STAT5	97	100	PF00017	0.409
LIG_SH3_1	470	476	PF00018	0.345
LIG_SH3_3	168	174	PF00018	0.452
LIG_SH3_3	406	412	PF00018	0.406
LIG_SH3_3	470	476	PF00018	0.415
LIG_SUMO_SIM_par_1	167	173	PF11976	0.431
LIG_TRAF2_1	340	343	PF00917	0.628
LIG_UBA3_1	59	66	PF00899	0.484
LIG_WRC_WIRS_1	22	27	PF05994	0.515
MOD_CK1_1	117	123	PF00069	0.412
MOD_CK1_1	17	23	PF00069	0.482
MOD_CK1_1	291	297	PF00069	0.492
MOD_CK1_1	396	402	PF00069	0.410
MOD_CK1_1	418	424	PF00069	0.430
MOD_CK1_1	78	84	PF00069	0.609
MOD_CK1_1	8	14	PF00069	0.547
MOD_CK2_1	244	250	PF00069	0.456
MOD_CK2_1	256	262	PF00069	0.502
MOD_CK2_1	337	343	PF00069	0.568
MOD_CK2_1	410	416	PF00069	0.443
MOD_CK2_1	448	454	PF00069	0.337
MOD_CK2_1	485	491	PF00069	0.393
MOD_GlcNHglycan	136	139	PF01048	0.363
MOD_GlcNHglycan	142	145	PF01048	0.312
MOD_GlcNHglycan	19	22	PF01048	0.649
MOD_GlcNHglycan	204	207	PF01048	0.276
MOD_GlcNHglycan	403	406	PF01048	0.427
MOD_GlcNHglycan	413	416	PF01048	0.353
MOD_GlcNHglycan	56	59	PF01048	0.493
MOD_GlcNHglycan	593	596	PF01048	0.433
MOD_GlcNHglycan	621	624	PF01048	0.445
MOD_GSK3_1	17	24	PF00069	0.449
MOD_GSK3_1	298	305	PF00069	0.290
MOD_GSK3_1	326	333	PF00069	0.557
MOD_GSK3_1	337	344	PF00069	0.505
MOD_GSK3_1	4	11	PF00069	0.660
MOD_GSK3_1	401	408	PF00069	0.473
MOD_GSK3_1	411	418	PF00069	0.439
MOD_GSK3_1	486	493	PF00069	0.440
MOD_GSK3_1	50	57	PF00069	0.501
MOD_GSK3_1	511	518	PF00069	0.341
MOD_GSK3_1	545	552	PF00069	0.395
MOD_GSK3_1	587	594	PF00069	0.465
MOD_GSK3_1	71	78	PF00069	0.509
MOD_N-GLC_1	434	439	PF02516	0.350
MOD_N-GLC_1	564	569	PF02516	0.304
MOD_N-GLC_1	619	624	PF02516	0.392
MOD_NEK2_1	26	31	PF00069	0.433
MOD_NEK2_1	264	269	PF00069	0.416
MOD_NEK2_1	288	293	PF00069	0.351
MOD_NEK2_1	341	346	PF00069	0.460
MOD_NEK2_1	366	371	PF00069	0.264
MOD_NEK2_1	393	398	PF00069	0.297
MOD_NEK2_1	4	9	PF00069	0.732
MOD_NEK2_1	498	503	PF00069	0.299
MOD_NEK2_1	545	550	PF00069	0.416
MOD_NEK2_1	564	569	PF00069	0.234
MOD_NEK2_2	381	386	PF00069	0.373
MOD_NEK2_2	500	505	PF00069	0.409
MOD_OFUCOSY	380	385	PF10250	0.409
MOD_PIKK_1	181	187	PF00454	0.499
MOD_PIKK_1	351	357	PF00454	0.284
MOD_PIKK_1	5	11	PF00454	0.640
MOD_PIKK_1	521	527	PF00454	0.317
MOD_PIKK_1	71	77	PF00454	0.575
MOD_PK_1	579	585	PF00069	0.461
MOD_PK_1	609	615	PF00069	0.409
MOD_PKA_2	277	283	PF00069	0.385
MOD_PKA_2	326	332	PF00069	0.506
MOD_PKA_2	396	402	PF00069	0.429
MOD_PKA_2	498	504	PF00069	0.399
MOD_PKA_2	505	511	PF00069	0.398
MOD_PKA_2	78	84	PF00069	0.669
MOD_Plk_1	181	187	PF00069	0.481
MOD_Plk_1	434	440	PF00069	0.368
MOD_Plk_1	490	496	PF00069	0.379
MOD_Plk_1	515	521	PF00069	0.367
MOD_Plk_1	564	570	PF00069	0.305
MOD_Plk_2-3	570	576	PF00069	0.430
MOD_Plk_4	21	27	PF00069	0.492
MOD_Plk_4	321	327	PF00069	0.351
MOD_Plk_4	366	372	PF00069	0.280
MOD_Plk_4	38	44	PF00069	0.348
MOD_Plk_4	434	440	PF00069	0.390
MOD_Plk_4	517	523	PF00069	0.365
MOD_Plk_4	564	570	PF00069	0.433
MOD_Plk_4	587	593	PF00069	0.344
MOD_ProDKin_1	170	176	PF00069	0.409
MOD_ProDKin_1	302	308	PF00069	0.360
MOD_ProDKin_1	312	318	PF00069	0.275
MOD_ProDKin_1	345	351	PF00069	0.420
MOD_ProDKin_1	416	422	PF00069	0.435
MOD_ProDKin_1	8	14	PF00069	0.630
TRG_DiLeu_BaEn_2	388	394	PF01217	0.435
TRG_DiLeu_BaEn_4	342	348	PF01217	0.438
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.370
TRG_ENDOCYTIC_2	207	210	PF00928	0.434
TRG_ENDOCYTIC_2	274	277	PF00928	0.469
TRG_ENDOCYTIC_2	32	35	PF00928	0.411
TRG_ENDOCYTIC_2	379	382	PF00928	0.256
TRG_ENDOCYTIC_2	97	100	PF00928	0.409
TRG_ER_diArg_1	237	240	PF00400	0.420
TRG_ER_diArg_1	268	270	PF00400	0.317
TRG_NLS_MonoExtC_3	234	239	PF00514	0.512
TRG_NLS_MonoExtN_4	235	240	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	492	497	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I031	Leptomonas seymouri	76%	100%
A0A0S4JE49	Bodo saltans	42%	96%
A0A1X0NQS1	Trypanosomatidae	48%	98%
A0A3R7KWK7	Trypanosoma rangeli	46%	99%
A0A3S7X1S9	Leishmania donovani	96%	100%
A4HGR2	Leishmania braziliensis	90%	100%
A4I3T7	Leishmania infantum	96%	100%
A7E2V1	Danio rerio	28%	95%
D0A871	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9B029	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q0VEJ0	Mus musculus	29%	95%
Q28DH9	Xenopus tropicalis	29%	95%
Q5RCP7	Pongo abelii	29%	95%
Q6DDX8	Xenopus laevis	28%	95%
Q8TAP6	Homo sapiens	29%	95%
V5BGP3	Trypanosoma cruzi	47%	99%