Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0220), putative

Species:

Leishmania major

UniProt:

Q4Q856_LEIMA

TriTrypDb:

LmjF.28.2095 , LMJLV39_280029000 , LMJSD75_280028600

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q856

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q856

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007034	vacuolar transport	4	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0032509	endosome transport via multivesicular body sorting pathway	5	2
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	2
GO:0045324	late endosome to vacuole transport	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071985	multivesicular body sorting pathway	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.358
CLV_PCSK_KEX2_1	3	5	PF00082	0.359
CLV_PCSK_SKI1_1	78	82	PF00082	0.295
DOC_CDC14_PxL_1	40	48	PF14671	0.413
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.475
DOC_MAPK_gen_1	3	10	PF00069	0.562
DOC_MAPK_gen_1	78	85	PF00069	0.520
DOC_PP1_RVXF_1	107	114	PF00149	0.381
DOC_USP7_MATH_1	105	109	PF00917	0.278
LIG_14-3-3_CanoR_1	3	10	PF00244	0.563
LIG_AP_GAE_1	67	73	PF02883	0.414
LIG_APCC_ABBA_1	20	25	PF00400	0.413
LIG_BRCT_BRCA1_1	81	85	PF00533	0.542
LIG_BRCT_BRCA1_1	93	97	PF00533	0.311
LIG_Clathr_ClatBox_1	21	25	PF01394	0.475
LIG_CSL_BTD_1	41	44	PF09270	0.344
LIG_FHA_1	5	11	PF00498	0.568
LIG_FHA_1	50	56	PF00498	0.399
LIG_GBD_Chelix_1	119	127	PF00786	0.439
LIG_LIR_Nem_3	98	103	PF02991	0.355
LIG_MLH1_MIPbox_1	81	85	PF16413	0.562
LIG_NRBOX	45	51	PF00104	0.475
LIG_NRBOX	85	91	PF00104	0.401
LIG_SH2_CRK	37	41	PF00017	0.310
LIG_SH2_STAT5	62	65	PF00017	0.554
LIG_SH3_3	108	114	PF00018	0.362
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.449
LIG_SUMO_SIM_anti_2	45	52	PF11976	0.448
LIG_SUMO_SIM_par_1	6	12	PF11976	0.560
LIG_TYR_ITIM	35	40	PF00017	0.317
LIG_WRC_WIRS_1	50	55	PF05994	0.406
MOD_GlcNHglycan	11	14	PF01048	0.368
MOD_GSK3_1	49	56	PF00069	0.488
MOD_GSK3_1	91	98	PF00069	0.441
MOD_NEK2_1	119	124	PF00069	0.421
MOD_NEK2_1	49	54	PF00069	0.369
MOD_NEK2_1	90	95	PF00069	0.383
MOD_PKA_1	3	9	PF00069	0.539
MOD_PKA_2	3	9	PF00069	0.566
MOD_Plk_1	73	79	PF00069	0.557
MOD_Plk_4	119	125	PF00069	0.355
MOD_Plk_4	4	10	PF00069	0.552
MOD_Plk_4	42	48	PF00069	0.340
MOD_Plk_4	49	55	PF00069	0.337
MOD_Plk_4	79	85	PF00069	0.521
TRG_ENDOCYTIC_2	37	40	PF00928	0.313
TRG_ER_diArg_1	3	5	PF00400	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6R2	Leptomonas seymouri	61%	100%
A0A0S4IPW8	Bodo saltans	37%	77%
A0A0S4IVS2	Bodo saltans	27%	92%
A0A1X0NQU1	Trypanosomatidae	37%	100%
A0A3S7X1P5	Leishmania donovani	93%	100%
A0A422NBE9	Trypanosoma rangeli	33%	100%
A4HGR3	Leishmania braziliensis	79%	100%
A4I3T8	Leishmania infantum	92%	100%
D0A870	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B030	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%