Putative glycerophosphoryl diester phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerophosphoryl diester phosphodiesterase, putative

Species:

Leishmania major

UniProt:

Q4Q855_LEIMA

TriTrypDb:

LmjF.28.2100 , LMJLV39_280029100 , LMJSD75_280028700

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q855

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q855

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	2
GO:0009395	phospholipid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	11
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046475	glycerophospholipid catabolic process	6	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046503	glycerolipid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	11
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	5
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.505
CLV_C14_Caspase3-7	81	85	PF00656	0.509
CLV_NRD_NRD_1	221	223	PF00675	0.344
CLV_NRD_NRD_1	270	272	PF00675	0.558
CLV_NRD_NRD_1	30	32	PF00675	0.428
CLV_PCSK_FUR_1	27	31	PF00082	0.368
CLV_PCSK_KEX2_1	125	127	PF00082	0.310
CLV_PCSK_KEX2_1	223	225	PF00082	0.333
CLV_PCSK_KEX2_1	29	31	PF00082	0.422
CLV_PCSK_KEX2_1	339	341	PF00082	0.611
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.337
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.348
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.430
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.611
CLV_PCSK_SKI1_1	32	36	PF00082	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.402
DOC_MAPK_FxFP_2	39	42	PF00069	0.601
DOC_MAPK_gen_1	125	132	PF00069	0.490
DOC_MAPK_gen_1	162	169	PF00069	0.553
DOC_MAPK_gen_1	80	89	PF00069	0.512
DOC_MAPK_MEF2A_6	125	132	PF00069	0.529
DOC_MAPK_MEF2A_6	162	171	PF00069	0.558
DOC_MAPK_NFAT4_5	125	133	PF00069	0.537
DOC_MAPK_RevD_3	17	30	PF00069	0.508
DOC_PP4_FxxP_1	228	231	PF00568	0.513
DOC_PP4_FxxP_1	256	259	PF00568	0.295
DOC_PP4_FxxP_1	285	288	PF00568	0.378
DOC_PP4_FxxP_1	39	42	PF00568	0.601
DOC_USP7_MATH_1	142	146	PF00917	0.462
DOC_USP7_MATH_1	25	29	PF00917	0.578
DOC_USP7_UBL2_3	115	119	PF12436	0.570
DOC_USP7_UBL2_3	174	178	PF12436	0.535
DOC_USP7_UBL2_3	32	36	PF12436	0.667
DOC_WW_Pin1_4	284	289	PF00397	0.338
LIG_14-3-3_CanoR_1	2	9	PF00244	0.194
LIG_14-3-3_CanoR_1	30	35	PF00244	0.586
LIG_APCC_ABBA_1	167	172	PF00400	0.471
LIG_BRCT_BRCA1_1	176	180	PF00533	0.517
LIG_CaM_IQ_9	19	34	PF13499	0.555
LIG_FHA_1	125	131	PF00498	0.547
LIG_FHA_1	149	155	PF00498	0.492
LIG_FHA_1	235	241	PF00498	0.407
LIG_FHA_1	4	10	PF00498	0.445
LIG_LIR_Apic_2	254	259	PF02991	0.277
LIG_LIR_Gen_1	237	246	PF02991	0.360
LIG_LIR_Gen_1	250	261	PF02991	0.319
LIG_LIR_Gen_1	59	69	PF02991	0.533
LIG_LIR_LC3C_4	110	113	PF02991	0.552
LIG_LIR_Nem_3	102	106	PF02991	0.523
LIG_LIR_Nem_3	233	238	PF02991	0.321
LIG_LIR_Nem_3	250	256	PF02991	0.318
LIG_PCNA_yPIPBox_3	317	330	PF02747	0.394
LIG_PTB_Apo_2	208	215	PF02174	0.563
LIG_REV1ctd_RIR_1	232	240	PF16727	0.477
LIG_SH2_CRK	103	107	PF00017	0.529
LIG_SH2_CRK	242	246	PF00017	0.397
LIG_SH2_CRK	273	277	PF00017	0.404
LIG_SH2_STAT5	14	17	PF00017	0.307
LIG_SH2_STAT5	213	216	PF00017	0.527
LIG_SH2_STAT5	238	241	PF00017	0.309
LIG_SH2_STAT5	242	245	PF00017	0.293
LIG_SH2_STAT5	248	251	PF00017	0.374
LIG_SH2_STAT5	293	296	PF00017	0.352
LIG_SH2_STAT5	61	64	PF00017	0.489
LIG_SH3_1	162	168	PF00018	0.505
LIG_SH3_3	162	168	PF00018	0.457
LIG_SUMO_SIM_anti_2	194	202	PF11976	0.467
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.402
LIG_SUMO_SIM_par_1	126	131	PF11976	0.560
LIG_SUMO_SIM_par_1	5	10	PF11976	0.394
LIG_SUMO_SIM_par_1	73	78	PF11976	0.471
LIG_TYR_ITIM	240	245	PF00017	0.377
LIG_TYR_ITIM	246	251	PF00017	0.460
LIG_UBA3_1	107	115	PF00899	0.394
LIG_UBA3_1	21	29	PF00899	0.406
LIG_WRC_WIRS_1	60	65	PF05994	0.503
MOD_GlcNHglycan	9	12	PF01048	0.335
MOD_GSK3_1	194	201	PF00069	0.498
MOD_GSK3_1	3	10	PF00069	0.367
MOD_GSK3_1	37	44	PF00069	0.642
MOD_GSK3_1	91	98	PF00069	0.517
MOD_NEK2_1	198	203	PF00069	0.513
MOD_NEK2_1	234	239	PF00069	0.420
MOD_NEK2_1	240	245	PF00069	0.372
MOD_NEK2_1	261	266	PF00069	0.382
MOD_NEK2_1	283	288	PF00069	0.371
MOD_NEK2_1	3	8	PF00069	0.228
MOD_NEK2_1	95	100	PF00069	0.491
MOD_NEK2_2	56	61	PF00069	0.450
MOD_PIKK_1	199	205	PF00454	0.506
MOD_PKA_1	30	36	PF00069	0.666
MOD_PKA_1	37	43	PF00069	0.617
MOD_PKA_2	134	140	PF00069	0.512
MOD_PKA_2	192	198	PF00069	0.529
MOD_PKA_2	30	36	PF00069	0.626
MOD_PKA_2	79	85	PF00069	0.503
MOD_Plk_1	149	155	PF00069	0.488
MOD_Plk_1	56	62	PF00069	0.449
MOD_Plk_1	91	97	PF00069	0.470
MOD_Plk_4	234	240	PF00069	0.375
MOD_Plk_4	30	36	PF00069	0.677
MOD_Plk_4	49	55	PF00069	0.420
MOD_Plk_4	56	62	PF00069	0.427
MOD_ProDKin_1	284	290	PF00069	0.332
MOD_SUMO_for_1	173	176	PF00179	0.496
MOD_SUMO_rev_2	172	180	PF00179	0.537
TRG_DiLeu_BaEn_1	194	199	PF01217	0.450
TRG_DiLeu_BaEn_2	175	181	PF01217	0.505
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.404
TRG_ENDOCYTIC_2	103	106	PF00928	0.534
TRG_ENDOCYTIC_2	14	17	PF00928	0.399
TRG_ENDOCYTIC_2	225	228	PF00928	0.512
TRG_ENDOCYTIC_2	238	241	PF00928	0.245
TRG_ENDOCYTIC_2	242	245	PF00928	0.207
TRG_ENDOCYTIC_2	248	251	PF00928	0.408
TRG_ENDOCYTIC_2	253	256	PF00928	0.316
TRG_ENDOCYTIC_2	273	276	PF00928	0.404
TRG_ENDOCYTIC_2	61	64	PF00928	0.537
TRG_ER_diArg_1	221	224	PF00400	0.550
TRG_NLS_MonoCore_2	28	33	PF00514	0.614
TRG_NLS_MonoExtC_3	221	226	PF00514	0.559
TRG_NLS_MonoExtN_4	219	226	PF00514	0.596
TRG_NLS_MonoExtN_4	27	33	PF00514	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E4	Leptomonas seymouri	53%	99%
A0A0S4IJ80	Bodo saltans	36%	85%
A0A1X0NRF0	Trypanosomatidae	46%	98%
A0A3R7NHN9	Trypanosoma rangeli	46%	99%
A0A3S7X1Q6	Leishmania donovani	91%	100%
A4HGR4	Leishmania braziliensis	77%	100%
A4I3T9	Leishmania infantum	91%	100%
D0A869	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B031	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q0VGK4	Rattus norvegicus	29%	100%
Q7L5L3	Homo sapiens	26%	100%
Q8N9F7	Homo sapiens	30%	100%
Q99LY2	Mus musculus	25%	100%
Q9CRY7	Mus musculus	29%	100%