Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q850_LEIMA

TriTrypDb:

LmjF.28.2150 , LMJLV39_280029600 , LMJSD75_280029200

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q850

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q850

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.422
CLV_C14_Caspase3-7	642	646	PF00656	0.555
CLV_NRD_NRD_1	100	102	PF00675	0.595
CLV_NRD_NRD_1	103	105	PF00675	0.591
CLV_NRD_NRD_1	19	21	PF00675	0.524
CLV_NRD_NRD_1	537	539	PF00675	0.545
CLV_NRD_NRD_1	772	774	PF00675	0.723
CLV_NRD_NRD_1	826	828	PF00675	0.528
CLV_NRD_NRD_1	89	91	PF00675	0.627
CLV_NRD_NRD_1	97	99	PF00675	0.577
CLV_PCSK_FUR_1	87	91	PF00082	0.609
CLV_PCSK_FUR_1	98	102	PF00082	0.608
CLV_PCSK_KEX2_1	100	102	PF00082	0.599
CLV_PCSK_KEX2_1	103	105	PF00082	0.597
CLV_PCSK_KEX2_1	18	20	PF00082	0.527
CLV_PCSK_KEX2_1	537	539	PF00082	0.700
CLV_PCSK_KEX2_1	762	764	PF00082	0.570
CLV_PCSK_KEX2_1	828	830	PF00082	0.543
CLV_PCSK_KEX2_1	89	91	PF00082	0.620
CLV_PCSK_KEX2_1	97	99	PF00082	0.580
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.570
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.543
CLV_PCSK_PC7_1	824	830	PF00082	0.532
CLV_PCSK_SKI1_1	259	263	PF00082	0.602
CLV_PCSK_SKI1_1	269	273	PF00082	0.521
CLV_PCSK_SKI1_1	44	48	PF00082	0.579
CLV_PCSK_SKI1_1	488	492	PF00082	0.503
CLV_PCSK_SKI1_1	501	505	PF00082	0.454
CLV_PCSK_SKI1_1	545	549	PF00082	0.654
CLV_PCSK_SKI1_1	591	595	PF00082	0.454
CLV_PCSK_SKI1_1	604	608	PF00082	0.489
CLV_PCSK_SKI1_1	714	718	PF00082	0.542
CLV_Separin_Metazoa	84	88	PF03568	0.601
DEG_APCC_DBOX_1	411	419	PF00400	0.467
DEG_APCC_DBOX_1	470	478	PF00400	0.466
DEG_APCC_DBOX_1	590	598	PF00400	0.463
DEG_Nend_UBRbox_3	1	3	PF02207	0.573
DEG_SCF_FBW7_2	176	183	PF00400	0.558
DOC_CDC14_PxL_1	235	243	PF14671	0.409
DOC_CDC14_PxL_1	272	280	PF14671	0.523
DOC_CKS1_1	546	551	PF01111	0.561
DOC_MAPK_FxFP_2	47	50	PF00069	0.590
DOC_MAPK_gen_1	269	277	PF00069	0.559
DOC_MAPK_gen_1	483	492	PF00069	0.423
DOC_MAPK_gen_1	589	597	PF00069	0.520
DOC_MAPK_gen_1	762	769	PF00069	0.565
DOC_MAPK_HePTP_8	482	494	PF00069	0.483
DOC_MAPK_MEF2A_6	270	279	PF00069	0.534
DOC_MAPK_MEF2A_6	456	463	PF00069	0.372
DOC_MAPK_MEF2A_6	485	494	PF00069	0.490
DOC_MAPK_MEF2A_6	740	747	PF00069	0.578
DOC_MAPK_MEF2A_6	762	771	PF00069	0.569
DOC_PP1_RVXF_1	200	206	PF00149	0.421
DOC_PP1_RVXF_1	618	625	PF00149	0.489
DOC_PP2B_LxvP_1	220	223	PF13499	0.593
DOC_PP2B_LxvP_1	509	512	PF13499	0.588
DOC_PP4_FxxP_1	328	331	PF00568	0.608
DOC_PP4_FxxP_1	47	50	PF00568	0.590
DOC_PP4_FxxP_1	550	553	PF00568	0.538
DOC_USP7_MATH_1	271	275	PF00917	0.547
DOC_USP7_MATH_1	28	32	PF00917	0.588
DOC_USP7_MATH_1	373	377	PF00917	0.486
DOC_USP7_MATH_1	398	402	PF00917	0.457
DOC_USP7_MATH_1	587	591	PF00917	0.535
DOC_USP7_MATH_1	605	609	PF00917	0.418
DOC_USP7_MATH_1	670	674	PF00917	0.592
DOC_USP7_MATH_1	677	681	PF00917	0.683
DOC_USP7_MATH_1	781	785	PF00917	0.554
DOC_USP7_MATH_1	93	97	PF00917	0.611
DOC_WW_Pin1_4	134	139	PF00397	0.526
DOC_WW_Pin1_4	169	174	PF00397	0.560
DOC_WW_Pin1_4	176	181	PF00397	0.589
DOC_WW_Pin1_4	384	389	PF00397	0.395
DOC_WW_Pin1_4	545	550	PF00397	0.596
LIG_14-3-3_CanoR_1	103	112	PF00244	0.550
LIG_14-3-3_CanoR_1	168	172	PF00244	0.400
LIG_14-3-3_CanoR_1	202	212	PF00244	0.468
LIG_14-3-3_CanoR_1	213	223	PF00244	0.499
LIG_14-3-3_CanoR_1	381	387	PF00244	0.391
LIG_14-3-3_CanoR_1	447	453	PF00244	0.441
LIG_14-3-3_CanoR_1	501	507	PF00244	0.451
LIG_14-3-3_CanoR_1	52	58	PF00244	0.602
LIG_14-3-3_CanoR_1	538	544	PF00244	0.563
LIG_14-3-3_CanoR_1	59	64	PF00244	0.579
LIG_14-3-3_CanoR_1	648	654	PF00244	0.573
LIG_14-3-3_CanoR_1	751	757	PF00244	0.538
LIG_14-3-3_CanoR_1	780	786	PF00244	0.699
LIG_BIR_III_4	391	395	PF00653	0.503
LIG_BRCT_BRCA1_1	160	164	PF00533	0.522
LIG_BRCT_BRCA1_1	324	328	PF00533	0.633
LIG_deltaCOP1_diTrp_1	428	432	PF00928	0.432
LIG_deltaCOP1_diTrp_1	571	581	PF00928	0.580
LIG_EVH1_2	444	448	PF00568	0.437
LIG_FHA_1	215	221	PF00498	0.561
LIG_FHA_1	503	509	PF00498	0.544
LIG_FHA_2	117	123	PF00498	0.556
LIG_FHA_2	232	238	PF00498	0.416
LIG_FHA_2	508	514	PF00498	0.547
LIG_FHA_2	640	646	PF00498	0.565
LIG_FHA_2	674	680	PF00498	0.793
LIG_FHA_2	684	690	PF00498	0.589
LIG_FHA_2	79	85	PF00498	0.589
LIG_Integrin_isoDGR_2	410	412	PF01839	0.480
LIG_LIR_Apic_2	325	331	PF02991	0.615
LIG_LIR_Apic_2	548	553	PF02991	0.537
LIG_LIR_Gen_1	118	128	PF02991	0.539
LIG_LIR_Gen_1	401	409	PF02991	0.383
LIG_LIR_Gen_1	607	614	PF02991	0.562
LIG_LIR_Gen_1	689	699	PF02991	0.490
LIG_LIR_Gen_1	803	814	PF02991	0.640
LIG_LIR_Gen_1	820	830	PF02991	0.466
LIG_LIR_LC3C_4	287	292	PF02991	0.368
LIG_LIR_Nem_3	3	7	PF02991	0.501
LIG_LIR_Nem_3	365	370	PF02991	0.430
LIG_LIR_Nem_3	401	405	PF02991	0.375
LIG_LIR_Nem_3	484	490	PF02991	0.456
LIG_LIR_Nem_3	607	613	PF02991	0.566
LIG_LIR_Nem_3	618	622	PF02991	0.473
LIG_LIR_Nem_3	676	681	PF02991	0.808
LIG_LIR_Nem_3	689	694	PF02991	0.502
LIG_LIR_Nem_3	803	809	PF02991	0.641
LIG_LIR_Nem_3	820	825	PF02991	0.456
LIG_NRBOX	111	117	PF00104	0.624
LIG_Pex14_1	487	491	PF04695	0.425
LIG_PTAP_UEV_1	671	676	PF05743	0.561
LIG_REV1ctd_RIR_1	769	778	PF16727	0.573
LIG_SH2_CRK	691	695	PF00017	0.539
LIG_SH2_GRB2like	473	476	PF00017	0.415
LIG_SH2_STAT3	145	148	PF00017	0.483
LIG_SH2_STAT5	145	148	PF00017	0.483
LIG_SH2_STAT5	243	246	PF00017	0.432
LIG_SH2_STAT5	367	370	PF00017	0.485
LIG_SH2_STAT5	404	407	PF00017	0.367
LIG_SH2_STAT5	473	476	PF00017	0.516
LIG_SH3_2	512	517	PF14604	0.522
LIG_SH3_3	135	141	PF00018	0.484
LIG_SH3_3	191	197	PF00018	0.438
LIG_SH3_3	233	239	PF00018	0.491
LIG_SH3_3	374	380	PF00018	0.440
LIG_SH3_3	487	493	PF00018	0.440
LIG_SH3_3	509	515	PF00018	0.510
LIG_SH3_3	554	560	PF00018	0.569
LIG_SH3_3	666	672	PF00018	0.635
LIG_SH3_3	700	706	PF00018	0.514
LIG_SUMO_SIM_anti_2	287	292	PF11976	0.346
LIG_SUMO_SIM_anti_2	374	379	PF11976	0.467
LIG_SUMO_SIM_anti_2	419	424	PF11976	0.323
LIG_SUMO_SIM_anti_2	505	510	PF11976	0.373
LIG_SUMO_SIM_par_1	478	484	PF11976	0.391
LIG_SUMO_SIM_par_1	504	510	PF11976	0.454
LIG_SUMO_SIM_par_1	724	731	PF11976	0.515
LIG_TRAF2_1	31	34	PF00917	0.596
LIG_TRAF2_1	53	56	PF00917	0.573
LIG_TYR_ITIM	46	51	PF00017	0.639
LIG_WRC_WIRS_1	399	404	PF05994	0.373
LIG_WRC_WIRS_1	678	683	PF05994	0.585
LIG_WW_3	222	226	PF00397	0.497
LIG_WW_3	444	448	PF00397	0.437
MOD_CDK_SPxxK_3	545	552	PF00069	0.561
MOD_CK1_1	131	137	PF00069	0.500
MOD_CK1_1	172	178	PF00069	0.629
MOD_CK1_1	198	204	PF00069	0.406
MOD_CK1_1	246	252	PF00069	0.534
MOD_CK1_1	302	308	PF00069	0.593
MOD_CK1_1	530	536	PF00069	0.525
MOD_CK1_1	61	67	PF00069	0.617
MOD_CK1_1	651	657	PF00069	0.667
MOD_CK1_1	673	679	PF00069	0.596
MOD_CK1_1	68	74	PF00069	0.623
MOD_CK1_1	684	690	PF00069	0.554
MOD_CK1_1	727	733	PF00069	0.513
MOD_CK1_1	755	761	PF00069	0.580
MOD_CK1_1	96	102	PF00069	0.637
MOD_CK2_1	103	109	PF00069	0.653
MOD_CK2_1	116	122	PF00069	0.527
MOD_CK2_1	28	34	PF00069	0.592
MOD_CK2_1	413	419	PF00069	0.464
MOD_CK2_1	565	571	PF00069	0.680
MOD_CK2_1	683	689	PF00069	0.543
MOD_CK2_1	78	84	PF00069	0.619
MOD_Cter_Amidation	267	270	PF01082	0.570
MOD_GlcNHglycan	13	16	PF01048	0.538
MOD_GlcNHglycan	183	187	PF01048	0.546
MOD_GlcNHglycan	205	208	PF01048	0.488
MOD_GlcNHglycan	356	359	PF01048	0.465
MOD_GlcNHglycan	518	522	PF01048	0.670
MOD_GlcNHglycan	581	584	PF01048	0.557
MOD_GlcNHglycan	607	610	PF01048	0.619
MOD_GlcNHglycan	637	640	PF01048	0.596
MOD_GlcNHglycan	672	675	PF01048	0.611
MOD_GlcNHglycan	70	73	PF01048	0.607
MOD_GlcNHglycan	757	760	PF01048	0.528
MOD_GlcNHglycan	799	802	PF01048	0.551
MOD_GSK3_1	103	110	PF00069	0.526
MOD_GSK3_1	127	134	PF00069	0.516
MOD_GSK3_1	158	165	PF00069	0.477
MOD_GSK3_1	172	179	PF00069	0.550
MOD_GSK3_1	255	262	PF00069	0.657
MOD_GSK3_1	302	309	PF00069	0.638
MOD_GSK3_1	338	345	PF00069	0.511
MOD_GSK3_1	426	433	PF00069	0.421
MOD_GSK3_1	527	534	PF00069	0.590
MOD_GSK3_1	555	562	PF00069	0.593
MOD_GSK3_1	57	64	PF00069	0.623
MOD_GSK3_1	579	586	PF00069	0.579
MOD_GSK3_1	635	642	PF00069	0.574
MOD_GSK3_1	647	654	PF00069	0.604
MOD_GSK3_1	673	680	PF00069	0.639
MOD_GSK3_1	730	737	PF00069	0.590
MOD_GSK3_1	88	95	PF00069	0.674
MOD_N-GLC_1	302	307	PF02516	0.614
MOD_N-GLC_1	615	620	PF02516	0.481
MOD_N-GLC_1	684	689	PF02516	0.562
MOD_N-GLC_1	789	794	PF02516	0.539
MOD_NEK2_1	115	120	PF00069	0.569
MOD_NEK2_1	158	163	PF00069	0.500
MOD_NEK2_1	203	208	PF00069	0.526
MOD_NEK2_1	214	219	PF00069	0.481
MOD_NEK2_1	260	265	PF00069	0.618
MOD_NEK2_1	286	291	PF00069	0.391
MOD_NEK2_1	310	315	PF00069	0.689
MOD_NEK2_1	349	354	PF00069	0.382
MOD_NEK2_1	448	453	PF00069	0.379
MOD_NEK2_1	65	70	PF00069	0.555
MOD_NEK2_1	681	686	PF00069	0.589
MOD_NEK2_1	734	739	PF00069	0.555
MOD_NEK2_2	306	311	PF00069	0.604
MOD_PIKK_1	246	252	PF00454	0.507
MOD_PIKK_1	625	631	PF00454	0.751
MOD_PIKK_1	718	724	PF00454	0.558
MOD_PK_1	59	65	PF00069	0.627
MOD_PKA_1	103	109	PF00069	0.569
MOD_PKA_2	103	109	PF00069	0.522
MOD_PKA_2	167	173	PF00069	0.406
MOD_PKA_2	51	57	PF00069	0.613
MOD_PKA_2	58	64	PF00069	0.566
MOD_PKA_2	647	653	PF00069	0.614
MOD_PKA_2	88	94	PF00069	0.660
MOD_PKA_2	96	102	PF00069	0.572
MOD_PKB_1	101	109	PF00069	0.579
MOD_Plk_1	108	114	PF00069	0.603
MOD_Plk_1	255	261	PF00069	0.785
MOD_Plk_1	286	292	PF00069	0.370
MOD_Plk_1	530	536	PF00069	0.620
MOD_Plk_1	730	736	PF00069	0.587
MOD_Plk_1	741	747	PF00069	0.513
MOD_Plk_1	820	826	PF00069	0.564
MOD_Plk_4	116	122	PF00069	0.557
MOD_Plk_4	195	201	PF00069	0.388
MOD_Plk_4	286	292	PF00069	0.393
MOD_Plk_4	349	355	PF00069	0.439
MOD_Plk_4	362	368	PF00069	0.309
MOD_Plk_4	373	379	PF00069	0.475
MOD_Plk_4	426	432	PF00069	0.407
MOD_Plk_4	724	730	PF00069	0.514
MOD_Plk_4	741	747	PF00069	0.552
MOD_Plk_4	781	787	PF00069	0.584
MOD_ProDKin_1	134	140	PF00069	0.524
MOD_ProDKin_1	169	175	PF00069	0.570
MOD_ProDKin_1	176	182	PF00069	0.591
MOD_ProDKin_1	384	390	PF00069	0.400
MOD_ProDKin_1	545	551	PF00069	0.596
MOD_SUMO_rev_2	32	41	PF00179	0.630
MOD_SUMO_rev_2	600	606	PF00179	0.557
TRG_DiLeu_BaEn_1	457	462	PF01217	0.425
TRG_ENDOCYTIC_2	121	124	PF00928	0.547
TRG_ENDOCYTIC_2	367	370	PF00928	0.485
TRG_ENDOCYTIC_2	48	51	PF00928	0.592
TRG_ENDOCYTIC_2	691	694	PF00928	0.524
TRG_ENDOCYTIC_2	9	12	PF00928	0.513
TRG_ER_diArg_1	101	104	PF00400	0.579
TRG_ER_diArg_1	18	20	PF00400	0.527
TRG_ER_diArg_1	22	25	PF00400	0.562
TRG_ER_diArg_1	482	485	PF00400	0.385
TRG_ER_diArg_1	827	830	PF00400	0.599
TRG_ER_diArg_1	86	89	PF00400	0.616
TRG_ER_diArg_1	97	100	PF00400	0.595
TRG_NLS_MonoExtC_3	826	831	PF00514	0.539
TRG_NLS_MonoExtN_4	824	831	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	828	832	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P734	Leptomonas seymouri	47%	97%
A0A3S7X1T8	Leishmania donovani	91%	100%
A4HGR9	Leishmania braziliensis	80%	100%
E9B036	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%