Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q849_LEIMA

TriTrypDb:

LmjF.28.2160 , LMJLV39_280029700 , LMJSD75_280029300

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q849

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q849

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.394
CLV_PCSK_KEX2_1	171	173	PF00082	0.512
CLV_PCSK_KEX2_1	184	186	PF00082	0.482
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.516
CLV_PCSK_SKI1_1	184	188	PF00082	0.447
CLV_PCSK_SKI1_1	205	209	PF00082	0.408
CLV_PCSK_SKI1_1	41	45	PF00082	0.347
CLV_PCSK_SKI1_1	74	78	PF00082	0.393
DOC_CKS1_1	178	183	PF01111	0.412
DOC_CYCLIN_RxL_1	181	191	PF00134	0.358
DOC_MAPK_gen_1	122	129	PF00069	0.443
DOC_MAPK_gen_1	184	195	PF00069	0.443
DOC_MAPK_gen_1	7	15	PF00069	0.618
DOC_USP7_MATH_1	34	38	PF00917	0.494
DOC_USP7_MATH_1	48	52	PF00917	0.449
DOC_USP7_UBL2_3	118	122	PF12436	0.297
DOC_USP7_UBL2_3	184	188	PF12436	0.460
DOC_WW_Pin1_4	149	154	PF00397	0.474
DOC_WW_Pin1_4	177	182	PF00397	0.412
LIG_14-3-3_CanoR_1	171	175	PF00244	0.408
LIG_14-3-3_CanoR_1	235	241	PF00244	0.579
LIG_APCC_ABBA_1	13	18	PF00400	0.406
LIG_BRCT_BRCA1_1	129	133	PF00533	0.276
LIG_CaM_IQ_9	163	179	PF13499	0.425
LIG_Clathr_ClatBox_1	105	109	PF01394	0.297
LIG_eIF4E_1	226	232	PF01652	0.397
LIG_FHA_1	178	184	PF00498	0.417
LIG_FHA_1	226	232	PF00498	0.449
LIG_FHA_1	28	34	PF00498	0.550
LIG_FHA_1	47	53	PF00498	0.450
LIG_FHA_2	189	195	PF00498	0.448
LIG_FHA_2	197	203	PF00498	0.403
LIG_FHA_2	77	83	PF00498	0.291
LIG_LIR_Gen_1	130	140	PF02991	0.285
LIG_LIR_Nem_3	130	136	PF02991	0.312
LIG_LIR_Nem_3	194	198	PF02991	0.412
LIG_LIR_Nem_3	37	43	PF02991	0.337
LIG_Pex14_2	129	133	PF04695	0.276
LIG_Pex14_2	165	169	PF04695	0.312
LIG_SH2_NCK_1	83	87	PF00017	0.253
LIG_SH2_PTP2	178	181	PF00017	0.392
LIG_SH2_STAP1	200	204	PF00017	0.418
LIG_SH2_STAP1	28	32	PF00017	0.418
LIG_SH2_STAP1	83	87	PF00017	0.273
LIG_SH2_STAT3	226	229	PF00017	0.473
LIG_SH2_STAT5	128	131	PF00017	0.276
LIG_SH2_STAT5	178	181	PF00017	0.409
LIG_SH2_STAT5	87	90	PF00017	0.300
LIG_SH3_3	152	158	PF00018	0.503
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.391
LIG_SUMO_SIM_par_1	11	18	PF11976	0.517
LIG_TRAF2_1	207	210	PF00917	0.546
MOD_CDK_SPxxK_3	177	184	PF00069	0.418
MOD_CK1_1	22	28	PF00069	0.555
MOD_GlcNHglycan	129	132	PF01048	0.296
MOD_GlcNHglycan	89	92	PF01048	0.425
MOD_GSK3_1	221	228	PF00069	0.479
MOD_GSK3_1	70	77	PF00069	0.406
MOD_N-GLC_1	116	121	PF02516	0.355
MOD_NEK2_1	127	132	PF00069	0.319
MOD_NEK2_1	76	81	PF00069	0.316
MOD_PIKK_1	135	141	PF00454	0.380
MOD_PIKK_1	163	169	PF00454	0.333
MOD_PIKK_1	225	231	PF00454	0.468
MOD_PKA_1	74	80	PF00069	0.344
MOD_PKA_2	170	176	PF00069	0.389
MOD_PKA_2	236	242	PF00069	0.541
MOD_Plk_1	196	202	PF00069	0.439
MOD_Plk_4	129	135	PF00069	0.300
MOD_Plk_4	221	227	PF00069	0.476
MOD_Plk_4	48	54	PF00069	0.346
MOD_Plk_4	60	66	PF00069	0.245
MOD_ProDKin_1	149	155	PF00069	0.473
MOD_ProDKin_1	177	183	PF00069	0.413
TRG_DiLeu_BaEn_2	169	175	PF01217	0.448
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.425
TRG_ENDOCYTIC_2	40	43	PF00928	0.417
TRG_ER_diArg_1	235	238	PF00400	0.478
TRG_NES_CRM1_1	125	139	PF08389	0.372
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P1	Leptomonas seymouri	74%	100%
A0A0S4IRT5	Bodo saltans	47%	98%
A0A1X0NQR6	Trypanosomatidae	50%	100%
A0A3Q8IGV9	Leishmania donovani	96%	100%
A0A422N7I7	Trypanosoma rangeli	39%	100%
A4HGS0	Leishmania braziliensis	88%	100%
A4I3U5	Leishmania infantum	96%	100%
E9B037	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%