CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM69, putative

Species:

Leishmania major

UniProt:

Q4Q848_LEIMA

TriTrypDb:

LmjF.28.2170 , LMJLV39_280029800 , LMJSD75_280029400

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0005742	mitochondrial outer membrane translocase complex	4	2
GO:0016020	membrane	2	4
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0032991	protein-containing complex	1	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098799	outer mitochondrial membrane protein complex	3	2
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q848

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q848

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006626	protein targeting to mitochondrion	5	2
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0030150	protein import into mitochondrial matrix	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0044743	protein transmembrane import into intracellular organelle	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0065002	intracellular protein transmembrane transport	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071806	protein transmembrane transport	3	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:1990542	mitochondrial transmembrane transport	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.620
CLV_NRD_NRD_1	489	491	PF00675	0.394
CLV_NRD_NRD_1	585	587	PF00675	0.616
CLV_PCSK_KEX2_1	355	357	PF00082	0.348
CLV_PCSK_KEX2_1	489	491	PF00082	0.385
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.408
CLV_PCSK_SKI1_1	174	178	PF00082	0.519
CLV_PCSK_SKI1_1	179	183	PF00082	0.587
CLV_PCSK_SKI1_1	236	240	PF00082	0.349
CLV_PCSK_SKI1_1	348	352	PF00082	0.310
CLV_PCSK_SKI1_1	355	359	PF00082	0.307
CLV_PCSK_SKI1_1	380	384	PF00082	0.320
CLV_PCSK_SKI1_1	39	43	PF00082	0.348
CLV_PCSK_SKI1_1	395	399	PF00082	0.299
CLV_PCSK_SKI1_1	414	418	PF00082	0.397
CLV_PCSK_SKI1_1	507	511	PF00082	0.482
CLV_PCSK_SKI1_1	620	624	PF00082	0.357
CLV_Separin_Metazoa	486	490	PF03568	0.690
DEG_APCC_DBOX_1	120	128	PF00400	0.599
DEG_SCF_FBW7_2	109	115	PF00400	0.551
DEG_SPOP_SBC_1	519	523	PF00917	0.689
DOC_CDC14_PxL_1	635	643	PF14671	0.434
DOC_CKS1_1	109	114	PF01111	0.553
DOC_CYCLIN_yCln2_LP_2	532	538	PF00134	0.802
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.359
DOC_MAPK_gen_1	118	126	PF00069	0.605
DOC_MAPK_gen_1	37	45	PF00069	0.548
DOC_MAPK_JIP1_4	37	43	PF00069	0.598
DOC_MAPK_MEF2A_6	37	45	PF00069	0.548
DOC_MAPK_MEF2A_6	489	496	PF00069	0.570
DOC_PP1_RVXF_1	57	64	PF00149	0.662
DOC_PP2B_LxvP_1	532	535	PF13499	0.675
DOC_PP2B_LxvP_1	99	102	PF13499	0.506
DOC_USP7_MATH_1	181	185	PF00917	0.701
DOC_USP7_MATH_1	251	255	PF00917	0.628
DOC_USP7_MATH_1	416	420	PF00917	0.610
DOC_USP7_MATH_1	429	433	PF00917	0.639
DOC_USP7_MATH_1	479	483	PF00917	0.554
DOC_USP7_MATH_1	562	566	PF00917	0.703
DOC_USP7_MATH_1	67	71	PF00917	0.637
DOC_WW_Pin1_4	108	113	PF00397	0.648
DOC_WW_Pin1_4	343	348	PF00397	0.523
DOC_WW_Pin1_4	515	520	PF00397	0.710
LIG_14-3-3_CanoR_1	118	128	PF00244	0.603
LIG_14-3-3_CanoR_1	250	256	PF00244	0.607
LIG_14-3-3_CanoR_1	414	422	PF00244	0.525
LIG_14-3-3_CanoR_1	575	583	PF00244	0.702
LIG_Actin_WH2_2	398	416	PF00022	0.533
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	449	453	PF00533	0.503
LIG_BRCT_BRCA1_1	567	571	PF00533	0.689
LIG_BRCT_BRCA1_1	594	598	PF00533	0.655
LIG_EH1_1	616	624	PF00400	0.359
LIG_FHA_1	301	307	PF00498	0.555
LIG_FHA_1	332	338	PF00498	0.542
LIG_FHA_1	4	10	PF00498	0.662
LIG_FHA_1	40	46	PF00498	0.550
LIG_FHA_1	547	553	PF00498	0.695
LIG_FHA_1	56	62	PF00498	0.548
LIG_FHA_2	13	19	PF00498	0.607
LIG_FHA_2	175	181	PF00498	0.759
LIG_FHA_2	20	26	PF00498	0.573
LIG_FHA_2	222	228	PF00498	0.662
LIG_FHA_2	229	235	PF00498	0.628
LIG_FHA_2	264	270	PF00498	0.545
LIG_Integrin_RGD_1	104	106	PF01839	0.321
LIG_LIR_Nem_3	608	613	PF02991	0.331
LIG_MLH1_MIPbox_1	449	453	PF16413	0.517
LIG_NRBOX	164	170	PF00104	0.607
LIG_PCNA_PIPBox_1	405	414	PF02747	0.487
LIG_PCNA_yPIPBox_3	368	380	PF02747	0.574
LIG_PDZ_Class_1	646	651	PF00595	0.519
LIG_Pex14_2	382	386	PF04695	0.488
LIG_Rb_pABgroove_1	369	377	PF01858	0.569
LIG_SH2_CRK	341	345	PF00017	0.549
LIG_SH2_CRK	628	632	PF00017	0.383
LIG_SH2_CRK	66	70	PF00017	0.583
LIG_SH2_NCK_1	613	617	PF00017	0.315
LIG_SH2_NCK_1	628	632	PF00017	0.370
LIG_SH2_NCK_1	66	70	PF00017	0.526
LIG_SH2_SRC	476	479	PF00017	0.660
LIG_SH2_STAP1	613	617	PF00017	0.300
LIG_SH2_STAT3	391	394	PF00017	0.503
LIG_SH2_STAT5	391	394	PF00017	0.474
LIG_SH2_STAT5	452	455	PF00017	0.528
LIG_SH2_STAT5	476	479	PF00017	0.566
LIG_SH2_STAT5	613	616	PF00017	0.302
LIG_SH3_1	489	495	PF00018	0.608
LIG_SH3_3	122	128	PF00018	0.538
LIG_SH3_3	23	29	PF00018	0.631
LIG_SH3_3	381	387	PF00018	0.499
LIG_SH3_3	489	495	PF00018	0.650
LIG_TRAF2_1	423	426	PF00917	0.669
LIG_TRAF2_1	511	514	PF00917	0.702
LIG_UBA3_1	50	56	PF00899	0.561
MOD_CDK_SPK_2	343	348	PF00069	0.523
MOD_CK1_1	223	229	PF00069	0.674
MOD_CK1_1	254	260	PF00069	0.597
MOD_CK1_1	361	367	PF00069	0.629
MOD_CK1_1	420	426	PF00069	0.632
MOD_CK1_1	565	571	PF00069	0.705
MOD_CK1_1	611	617	PF00069	0.427
MOD_CK1_1	629	635	PF00069	0.327
MOD_CK2_1	12	18	PF00069	0.587
MOD_CK2_1	130	136	PF00069	0.696
MOD_CK2_1	174	180	PF00069	0.747
MOD_CK2_1	181	187	PF00069	0.796
MOD_CK2_1	19	25	PF00069	0.592
MOD_CK2_1	221	227	PF00069	0.682
MOD_CK2_1	228	234	PF00069	0.654
MOD_CK2_1	254	260	PF00069	0.614
MOD_CK2_1	287	293	PF00069	0.607
MOD_CK2_1	420	426	PF00069	0.631
MOD_CK2_1	51	57	PF00069	0.668
MOD_GlcNHglycan	142	145	PF01048	0.593
MOD_GlcNHglycan	359	363	PF01048	0.409
MOD_GlcNHglycan	449	452	PF01048	0.291
MOD_GlcNHglycan	481	484	PF01048	0.363
MOD_GlcNHglycan	504	510	PF01048	0.469
MOD_GlcNHglycan	565	568	PF01048	0.525
MOD_GlcNHglycan	579	582	PF01048	0.478
MOD_GlcNHglycan	590	593	PF01048	0.441
MOD_GlcNHglycan	628	631	PF01048	0.638
MOD_GlcNHglycan	90	93	PF01048	0.402
MOD_GSK3_1	126	133	PF00069	0.679
MOD_GSK3_1	216	223	PF00069	0.662
MOD_GSK3_1	251	258	PF00069	0.566
MOD_GSK3_1	296	303	PF00069	0.607
MOD_GSK3_1	339	346	PF00069	0.531
MOD_GSK3_1	416	423	PF00069	0.536
MOD_GSK3_1	505	512	PF00069	0.674
MOD_GSK3_1	51	58	PF00069	0.583
MOD_GSK3_1	514	521	PF00069	0.738
MOD_GSK3_1	571	578	PF00069	0.792
MOD_GSK3_1	588	595	PF00069	0.695
MOD_N-GLC_1	220	225	PF02516	0.472
MOD_N-GLC_1	296	301	PF02516	0.403
MOD_NEK2_1	119	124	PF00069	0.585
MOD_NEK2_1	263	268	PF00069	0.538
MOD_NEK2_1	358	363	PF00069	0.636
MOD_NEK2_1	466	471	PF00069	0.577
MOD_NEK2_1	51	56	PF00069	0.577
MOD_NEK2_1	571	576	PF00069	0.716
MOD_NEK2_1	626	631	PF00069	0.545
MOD_NEK2_1	641	646	PF00069	0.385
MOD_NEK2_2	605	610	PF00069	0.453
MOD_NEK2_2	646	651	PF00069	0.519
MOD_PIKK_1	119	125	PF00454	0.629
MOD_PIKK_1	12	18	PF00454	0.540
MOD_PIKK_1	244	250	PF00454	0.599
MOD_PIKK_1	251	257	PF00454	0.567
MOD_PIKK_1	263	269	PF00454	0.443
MOD_PIKK_1	339	345	PF00454	0.539
MOD_PIKK_1	509	515	PF00454	0.671
MOD_PK_1	46	52	PF00069	0.636
MOD_PKA_2	12	18	PF00069	0.557
MOD_PKB_1	37	45	PF00069	0.590
MOD_Plk_1	19	25	PF00069	0.592
MOD_Plk_1	216	222	PF00069	0.643
MOD_Plk_1	330	336	PF00069	0.511
MOD_Plk_1	39	45	PF00069	0.513
MOD_Plk_2-3	132	138	PF00069	0.656
MOD_Plk_2-3	20	26	PF00069	0.604
MOD_Plk_2-3	287	293	PF00069	0.606
MOD_Plk_4	331	337	PF00069	0.511
MOD_Plk_4	417	423	PF00069	0.553
MOD_Plk_4	46	52	PF00069	0.534
MOD_Plk_4	605	611	PF00069	0.373
MOD_ProDKin_1	108	114	PF00069	0.651
MOD_ProDKin_1	343	349	PF00069	0.518
MOD_ProDKin_1	515	521	PF00069	0.709
MOD_SUMO_for_1	195	198	PF00179	0.612
MOD_SUMO_for_1	460	463	PF00179	0.546
MOD_SUMO_rev_2	175	184	PF00179	0.773
MOD_SUMO_rev_2	499	509	PF00179	0.652
MOD_SUMO_rev_2	86	91	PF00179	0.661
TRG_DiLeu_BaEn_1	331	336	PF01217	0.526
TRG_ENDOCYTIC_2	341	344	PF00928	0.521
TRG_ENDOCYTIC_2	628	631	PF00928	0.357
TRG_ENDOCYTIC_2	66	69	PF00928	0.517
TRG_ER_diArg_1	36	39	PF00400	0.635
TRG_ER_diArg_1	488	490	PF00400	0.619
TRG_ER_diArg_1	583	586	PF00400	0.726
TRG_NLS_MonoExtC_3	209	215	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF2	Leptomonas seymouri	73%	100%
A0A0S4IMM1	Bodo saltans	43%	91%
A0A1X0NQQ8	Trypanosomatidae	49%	100%
A0A3Q8IE19	Leishmania donovani	98%	100%
A0A3R7RF21	Trypanosoma rangeli	49%	100%
A4HGS1	Leishmania braziliensis	88%	100%
D0A915	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9B038	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BCV7	Trypanosoma cruzi	48%	100%