Putative cyclin dependent kinase-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin dependent kinase-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q841_LEIMA

TriTrypDb:

LmjF.28.2230 , LMJLV39_280030400 , LMJSD75_280030000

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q841

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q841

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0044237	cellular metabolic process	2	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051726	regulation of cell cycle	4	6
GO:0065007	biological regulation	1	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.686
CLV_C14_Caspase3-7	450	454	PF00656	0.685
CLV_C14_Caspase3-7	585	589	PF00656	0.727
CLV_C14_Caspase3-7	59	63	PF00656	0.743
CLV_C14_Caspase3-7	604	608	PF00656	0.716
CLV_C14_Caspase3-7	67	71	PF00656	0.781
CLV_C14_Caspase3-7	97	101	PF00656	0.713
CLV_NRD_NRD_1	192	194	PF00675	0.777
CLV_NRD_NRD_1	205	207	PF00675	0.560
CLV_NRD_NRD_1	225	227	PF00675	0.517
CLV_NRD_NRD_1	358	360	PF00675	0.727
CLV_NRD_NRD_1	459	461	PF00675	0.736
CLV_NRD_NRD_1	466	468	PF00675	0.656
CLV_NRD_NRD_1	571	573	PF00675	0.702
CLV_NRD_NRD_1	613	615	PF00675	0.733
CLV_NRD_NRD_1	636	638	PF00675	0.693
CLV_NRD_NRD_1	659	661	PF00675	0.743
CLV_NRD_NRD_1	679	681	PF00675	0.534
CLV_NRD_NRD_1	711	713	PF00675	0.566
CLV_NRD_NRD_1	758	760	PF00675	0.454
CLV_NRD_NRD_1	801	803	PF00675	0.460
CLV_NRD_NRD_1	834	836	PF00675	0.515
CLV_PCSK_FUR_1	203	207	PF00082	0.653
CLV_PCSK_FUR_1	223	227	PF00082	0.517
CLV_PCSK_FUR_1	380	384	PF00082	0.851
CLV_PCSK_FUR_1	457	461	PF00082	0.718
CLV_PCSK_FUR_1	656	660	PF00082	0.836
CLV_PCSK_FUR_1	832	836	PF00082	0.491
CLV_PCSK_KEX2_1	191	193	PF00082	0.791
CLV_PCSK_KEX2_1	205	207	PF00082	0.547
CLV_PCSK_KEX2_1	222	224	PF00082	0.742
CLV_PCSK_KEX2_1	225	227	PF00082	0.517
CLV_PCSK_KEX2_1	340	342	PF00082	0.732
CLV_PCSK_KEX2_1	358	360	PF00082	0.550
CLV_PCSK_KEX2_1	382	384	PF00082	0.850
CLV_PCSK_KEX2_1	459	461	PF00082	0.723
CLV_PCSK_KEX2_1	466	468	PF00082	0.672
CLV_PCSK_KEX2_1	523	525	PF00082	0.782
CLV_PCSK_KEX2_1	571	573	PF00082	0.702
CLV_PCSK_KEX2_1	613	615	PF00082	0.733
CLV_PCSK_KEX2_1	636	638	PF00082	0.693
CLV_PCSK_KEX2_1	658	660	PF00082	0.739
CLV_PCSK_KEX2_1	710	712	PF00082	0.569
CLV_PCSK_KEX2_1	834	836	PF00082	0.515
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.742
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.815
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.850
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.782
CLV_PCSK_PC7_1	462	468	PF00082	0.681
CLV_PCSK_PC7_1	632	638	PF00082	0.623
CLV_PCSK_SKI1_1	106	110	PF00082	0.705
CLV_PCSK_SKI1_1	219	223	PF00082	0.726
CLV_PCSK_SKI1_1	52	56	PF00082	0.703
CLV_PCSK_SKI1_1	680	684	PF00082	0.631
CLV_PCSK_SKI1_1	730	734	PF00082	0.509
CLV_PCSK_SKI1_1	751	755	PF00082	0.497
CLV_PCSK_SKI1_1	759	763	PF00082	0.454
CLV_PCSK_SKI1_1	85	89	PF00082	0.731
DEG_APCC_DBOX_1	344	352	PF00400	0.702
DEG_APCC_DBOX_1	84	92	PF00400	0.723
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DEG_SCF_TRCP1_1	588	593	PF00400	0.730
DEG_SPOP_SBC_1	112	116	PF00917	0.708
DEG_SPOP_SBC_1	367	371	PF00917	0.635
DEG_SPOP_SBC_1	581	585	PF00917	0.734
DOC_CKS1_1	182	187	PF01111	0.754
DOC_CYCLIN_RxL_1	435	447	PF00134	0.722
DOC_CYCLIN_RxL_1	899	912	PF00134	0.476
DOC_MAPK_gen_1	340	348	PF00069	0.804
DOC_MAPK_gen_1	710	717	PF00069	0.555
DOC_MAPK_gen_1	759	767	PF00069	0.453
DOC_PP1_RVXF_1	345	351	PF00149	0.703
DOC_PP2B_LxvP_1	118	121	PF13499	0.665
DOC_PP4_FxxP_1	921	924	PF00568	0.511
DOC_USP7_MATH_1	113	117	PF00917	0.715
DOC_USP7_MATH_1	133	137	PF00917	0.570
DOC_USP7_MATH_1	22	26	PF00917	0.671
DOC_USP7_MATH_1	279	283	PF00917	0.843
DOC_USP7_MATH_1	367	371	PF00917	0.635
DOC_USP7_MATH_1	376	380	PF00917	0.644
DOC_USP7_MATH_1	512	516	PF00917	0.730
DOC_USP7_UBL2_3	382	386	PF12436	0.845
DOC_USP7_UBL2_3	730	734	PF12436	0.509
DOC_USP7_UBL2_3	799	803	PF12436	0.476
DOC_WW_Pin1_4	181	186	PF00397	0.723
DOC_WW_Pin1_4	252	257	PF00397	0.741
DOC_WW_Pin1_4	363	368	PF00397	0.768
DOC_WW_Pin1_4	381	386	PF00397	0.776
DOC_WW_Pin1_4	423	428	PF00397	0.814
DOC_WW_Pin1_4	475	480	PF00397	0.635
DOC_WW_Pin1_4	920	925	PF00397	0.630
LIG_14-3-3_CanoR_1	111	121	PF00244	0.719
LIG_14-3-3_CanoR_1	164	174	PF00244	0.593
LIG_14-3-3_CanoR_1	29	37	PF00244	0.798
LIG_14-3-3_CanoR_1	358	367	PF00244	0.685
LIG_14-3-3_CanoR_1	439	444	PF00244	0.721
LIG_14-3-3_CanoR_1	492	497	PF00244	0.696
LIG_14-3-3_CanoR_1	592	597	PF00244	0.708
LIG_14-3-3_CanoR_1	619	628	PF00244	0.747
LIG_14-3-3_CanoR_1	712	718	PF00244	0.506
LIG_14-3-3_CanoR_1	721	725	PF00244	0.434
LIG_Actin_WH2_2	746	761	PF00022	0.491
LIG_BRCT_BRCA1_1	917	921	PF00533	0.528
LIG_FHA_1	107	113	PF00498	0.764
LIG_FHA_1	29	35	PF00498	0.795
LIG_FHA_1	542	548	PF00498	0.575
LIG_FHA_1	576	582	PF00498	0.737
LIG_FHA_1	591	597	PF00498	0.550
LIG_FHA_1	700	706	PF00498	0.646
LIG_FHA_1	817	823	PF00498	0.496
LIG_FHA_2	485	491	PF00498	0.740
LIG_FHA_2	546	552	PF00498	0.605
LIG_FHA_2	602	608	PF00498	0.729
LIG_FHA_2	704	710	PF00498	0.561
LIG_FHA_2	79	85	PF00498	0.800
LIG_FHA_2	898	904	PF00498	0.463
LIG_FHA_2	910	916	PF00498	0.504
LIG_FHA_2	95	101	PF00498	0.529
LIG_LIR_Apic_2	918	924	PF02991	0.525
LIG_LIR_Gen_1	551	559	PF02991	0.692
LIG_LIR_Gen_1	886	891	PF02991	0.481
LIG_LIR_LC3C_4	789	793	PF02991	0.439
LIG_LIR_Nem_3	551	557	PF02991	0.691
LIG_LIR_Nem_3	678	682	PF02991	0.629
LIG_LIR_Nem_3	876	882	PF02991	0.536
LIG_LIR_Nem_3	886	890	PF02991	0.451
LIG_Pex14_2	196	200	PF04695	0.714
LIG_Pex14_2	829	833	PF04695	0.406
LIG_PTB_Apo_2	557	564	PF02174	0.698
LIG_PTB_Apo_2	688	695	PF02174	0.575
LIG_PTB_Phospho_1	557	563	PF10480	0.698
LIG_PTB_Phospho_1	932	938	PF10480	0.576
LIG_SH2_CRK	679	683	PF00017	0.634
LIG_SH2_CRK	933	937	PF00017	0.573
LIG_SH2_GRB2like	926	929	PF00017	0.549
LIG_SH2_GRB2like	933	936	PF00017	0.577
LIG_SH2_PTP2	882	885	PF00017	0.454
LIG_SH2_SRC	926	929	PF00017	0.549
LIG_SH2_STAP1	783	787	PF00017	0.427
LIG_SH2_STAP1	917	921	PF00017	0.497
LIG_SH2_STAP1	933	937	PF00017	0.573
LIG_SH2_STAT3	204	207	PF00017	0.670
LIG_SH2_STAT5	563	566	PF00017	0.699
LIG_SH2_STAT5	698	701	PF00017	0.513
LIG_SH2_STAT5	742	745	PF00017	0.446
LIG_SH2_STAT5	787	790	PF00017	0.542
LIG_SH2_STAT5	828	831	PF00017	0.470
LIG_SH2_STAT5	882	885	PF00017	0.454
LIG_SH2_STAT5	926	929	PF00017	0.549
LIG_SH3_3	169	175	PF00018	0.692
LIG_SH3_3	499	505	PF00018	0.693
LIG_SH3_4	330	337	PF00018	0.826
LIG_SUMO_SIM_par_1	713	719	PF11976	0.550
LIG_SUMO_SIM_par_1	774	781	PF11976	0.464
LIG_SxIP_EBH_1	164	177	PF03271	0.694
LIG_TRAF2_1	81	84	PF00917	0.772
LIG_TRAF2_1	912	915	PF00917	0.509
LIG_TRFH_1	887	891	PF08558	0.482
LIG_UBA3_1	811	815	PF00899	0.437
LIG_UBA3_1	822	830	PF00899	0.476
LIG_WRC_WIRS_1	724	729	PF05994	0.525
MOD_CDK_SPK_2	381	386	PF00069	0.845
MOD_CK1_1	131	137	PF00069	0.809
MOD_CK1_1	138	144	PF00069	0.669
MOD_CK1_1	181	187	PF00069	0.754
MOD_CK1_1	229	235	PF00069	0.703
MOD_CK1_1	236	242	PF00069	0.744
MOD_CK1_1	252	258	PF00069	0.664
MOD_CK1_1	260	266	PF00069	0.800
MOD_CK1_1	296	302	PF00069	0.793
MOD_CK1_1	360	366	PF00069	0.749
MOD_CK1_1	368	374	PF00069	0.715
MOD_CK1_1	406	412	PF00069	0.724
MOD_CK1_1	431	437	PF00069	0.733
MOD_CK1_1	442	448	PF00069	0.792
MOD_CK1_1	449	455	PF00069	0.736
MOD_CK1_1	475	481	PF00069	0.625
MOD_CK1_1	510	516	PF00069	0.729
MOD_CK1_1	517	523	PF00069	0.725
MOD_CK1_1	525	531	PF00069	0.705
MOD_CK1_1	532	538	PF00069	0.618
MOD_CK1_1	539	545	PF00069	0.699
MOD_CK1_1	58	64	PF00069	0.810
MOD_CK1_1	583	589	PF00069	0.709
MOD_CK1_1	595	601	PF00069	0.720
MOD_CK1_1	606	612	PF00069	0.742
MOD_CK1_1	617	623	PF00069	0.821
MOD_CK1_1	624	630	PF00069	0.658
MOD_CK1_1	631	637	PF00069	0.690
MOD_CK1_1	638	644	PF00069	0.752
MOD_CK1_1	645	651	PF00069	0.753
MOD_CK1_1	716	722	PF00069	0.533
MOD_CK1_1	723	729	PF00069	0.522
MOD_CK2_1	113	119	PF00069	0.722
MOD_CK2_1	242	248	PF00069	0.825
MOD_CK2_1	484	490	PF00069	0.728
MOD_CK2_1	50	56	PF00069	0.622
MOD_CK2_1	703	709	PF00069	0.560
MOD_CK2_1	78	84	PF00069	0.802
MOD_CK2_1	897	903	PF00069	0.426
MOD_CK2_1	909	915	PF00069	0.502
MOD_Cter_Amidation	380	383	PF01082	0.855
MOD_GlcNHglycan	115	118	PF01048	0.750
MOD_GlcNHglycan	13	16	PF01048	0.640
MOD_GlcNHglycan	130	133	PF01048	0.643
MOD_GlcNHglycan	137	140	PF01048	0.676
MOD_GlcNHglycan	24	27	PF01048	0.548
MOD_GlcNHglycan	251	254	PF01048	0.809
MOD_GlcNHglycan	259	262	PF01048	0.692
MOD_GlcNHglycan	281	284	PF01048	0.840
MOD_GlcNHglycan	294	298	PF01048	0.658
MOD_GlcNHglycan	34	37	PF01048	0.682
MOD_GlcNHglycan	373	376	PF01048	0.752
MOD_GlcNHglycan	415	418	PF01048	0.707
MOD_GlcNHglycan	422	426	PF01048	0.691
MOD_GlcNHglycan	474	477	PF01048	0.622
MOD_GlcNHglycan	56	61	PF01048	0.808
MOD_GlcNHglycan	588	591	PF01048	0.740
MOD_GlcNHglycan	670	673	PF01048	0.802
MOD_GlcNHglycan	7	10	PF01048	0.719
MOD_GlcNHglycan	839	842	PF01048	0.541
MOD_GSK3_1	131	138	PF00069	0.798
MOD_GSK3_1	141	148	PF00069	0.662
MOD_GSK3_1	210	217	PF00069	0.663
MOD_GSK3_1	226	233	PF00069	0.741
MOD_GSK3_1	234	241	PF00069	0.743
MOD_GSK3_1	252	259	PF00069	0.780
MOD_GSK3_1	28	35	PF00069	0.791
MOD_GSK3_1	357	364	PF00069	0.740
MOD_GSK3_1	366	373	PF00069	0.712
MOD_GSK3_1	429	436	PF00069	0.726
MOD_GSK3_1	437	444	PF00069	0.740
MOD_GSK3_1	445	452	PF00069	0.657
MOD_GSK3_1	507	514	PF00069	0.723
MOD_GSK3_1	518	525	PF00069	0.726
MOD_GSK3_1	52	59	PF00069	0.806
MOD_GSK3_1	526	533	PF00069	0.727
MOD_GSK3_1	535	542	PF00069	0.767
MOD_GSK3_1	576	583	PF00069	0.717
MOD_GSK3_1	586	593	PF00069	0.710
MOD_GSK3_1	595	602	PF00069	0.718
MOD_GSK3_1	60	67	PF00069	0.679
MOD_GSK3_1	603	610	PF00069	0.610
MOD_GSK3_1	613	620	PF00069	0.794
MOD_GSK3_1	623	630	PF00069	0.605
MOD_GSK3_1	631	638	PF00069	0.606
MOD_GSK3_1	641	648	PF00069	0.618
MOD_GSK3_1	68	75	PF00069	0.583
MOD_GSK3_1	699	706	PF00069	0.639
MOD_GSK3_1	716	723	PF00069	0.348
MOD_LATS_1	224	230	PF00433	0.763
MOD_LATS_1	611	617	PF00433	0.727
MOD_N-GLC_1	106	111	PF02516	0.710
MOD_N-GLC_1	227	232	PF02516	0.732
MOD_N-GLC_1	257	262	PF02516	0.783
MOD_N-GLC_1	510	515	PF02516	0.726
MOD_N-GLC_1	617	622	PF02516	0.718
MOD_N-GLC_1	703	708	PF02516	0.558
MOD_N-GLC_1	837	842	PF02516	0.574
MOD_N-GLC_1	909	914	PF02516	0.500
MOD_NEK2_1	167	172	PF00069	0.776
MOD_NEK2_1	214	219	PF00069	0.775
MOD_NEK2_1	430	435	PF00069	0.724
MOD_NEK2_1	437	442	PF00069	0.756
MOD_NEK2_1	443	448	PF00069	0.642
MOD_NEK2_1	596	601	PF00069	0.719
MOD_NEK2_1	699	704	PF00069	0.643
MOD_NEK2_1	72	77	PF00069	0.833
MOD_NEK2_1	776	781	PF00069	0.451
MOD_NEK2_1	885	890	PF00069	0.478
MOD_NEK2_2	101	106	PF00069	0.697
MOD_NEK2_2	198	203	PF00069	0.771
MOD_PIKK_1	131	137	PF00454	0.822
MOD_PIKK_1	178	184	PF00454	0.841
MOD_PIKK_1	313	319	PF00454	0.699
MOD_PIKK_1	617	623	PF00454	0.842
MOD_PIKK_1	910	916	PF00454	0.604
MOD_PKA_1	358	364	PF00069	0.826
MOD_PKA_1	522	528	PF00069	0.775
MOD_PKA_1	613	619	PF00069	0.729
MOD_PKA_2	28	34	PF00069	0.790
MOD_PKA_2	321	327	PF00069	0.830
MOD_PKA_2	357	363	PF00069	0.822
MOD_PKA_2	371	377	PF00069	0.601
MOD_PKA_2	411	417	PF00069	0.661
MOD_PKA_2	458	464	PF00069	0.717
MOD_PKA_2	491	497	PF00069	0.693
MOD_PKA_2	515	521	PF00069	0.762
MOD_PKA_2	523	529	PF00069	0.670
MOD_PKA_2	613	619	PF00069	0.752
MOD_PKA_2	631	637	PF00069	0.725
MOD_PKA_2	638	644	PF00069	0.751
MOD_PKA_2	645	651	PF00069	0.789
MOD_PKA_2	720	726	PF00069	0.514
MOD_PKB_1	637	645	PF00069	0.732
MOD_Plk_1	106	112	PF00069	0.708
MOD_Plk_1	198	204	PF00069	0.770
MOD_Plk_1	214	220	PF00069	0.533
MOD_Plk_1	575	581	PF00069	0.815
MOD_Plk_1	771	777	PF00069	0.510
MOD_Plk_1	885	891	PF00069	0.476
MOD_Plk_2-3	771	777	PF00069	0.510
MOD_Plk_4	433	439	PF00069	0.803
MOD_Plk_4	481	487	PF00069	0.607
MOD_Plk_4	492	498	PF00069	0.681
MOD_Plk_4	576	582	PF00069	0.753
MOD_Plk_4	592	598	PF00069	0.621
MOD_Plk_4	720	726	PF00069	0.518
MOD_Plk_4	771	777	PF00069	0.510
MOD_ProDKin_1	181	187	PF00069	0.723
MOD_ProDKin_1	252	258	PF00069	0.738
MOD_ProDKin_1	363	369	PF00069	0.768
MOD_ProDKin_1	381	387	PF00069	0.777
MOD_ProDKin_1	423	429	PF00069	0.814
MOD_ProDKin_1	475	481	PF00069	0.631
MOD_ProDKin_1	920	926	PF00069	0.633
MOD_SUMO_for_1	339	342	PF00179	0.717
MOD_SUMO_for_1	761	764	PF00179	0.454
MOD_SUMO_rev_2	723	733	PF00179	0.519
MOD_SUMO_rev_2	747	756	PF00179	0.503
TRG_DiLeu_BaEn_1	771	776	PF01217	0.511
TRG_DiLeu_BaEn_1	818	823	PF01217	0.601
TRG_DiLeu_BaEn_2	552	558	PF01217	0.691
TRG_DiLeu_BaEn_4	83	89	PF01217	0.786
TRG_DiLeu_BaLyEn_6	901	906	PF01217	0.451
TRG_ENDOCYTIC_2	352	355	PF00928	0.811
TRG_ENDOCYTIC_2	554	557	PF00928	0.691
TRG_ENDOCYTIC_2	679	682	PF00928	0.632
TRG_ENDOCYTIC_2	785	788	PF00928	0.368
TRG_ENDOCYTIC_2	882	885	PF00928	0.454
TRG_ENDOCYTIC_2	933	936	PF00928	0.577
TRG_ER_diArg_1	191	193	PF00400	0.776
TRG_ER_diArg_1	204	206	PF00400	0.569
TRG_ER_diArg_1	223	226	PF00400	0.615
TRG_ER_diArg_1	320	323	PF00400	0.828
TRG_ER_diArg_1	345	348	PF00400	0.702
TRG_ER_diArg_1	457	460	PF00400	0.729
TRG_ER_diArg_1	466	469	PF00400	0.674
TRG_ER_diArg_1	636	639	PF00400	0.695
TRG_ER_diArg_1	656	659	PF00400	0.735
TRG_ER_diArg_1	710	712	PF00400	0.569
TRG_ER_diArg_1	833	835	PF00400	0.501
TRG_NLS_Bipartite_1	205	226	PF00514	0.787
TRG_NLS_MonoExtC_3	221	226	PF00514	0.843
TRG_NLS_MonoExtC_3	758	764	PF00514	0.454
TRG_NLS_MonoExtN_4	219	226	PF00514	0.837
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z2	Leptomonas seymouri	61%	100%
A0A3S7X1Q4	Leishmania donovani	91%	100%
A4HGS7	Leishmania braziliensis	78%	100%
E9B044	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%