Hd phosphohydrolase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hd phosphohydrolase family protein

Species:

Leishmania major

UniProt:

Q4Q840_LEIMA

TriTrypDb:

LmjF.28.2240 , LMJLV39_280030500 , LMJSD75_280030100

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q840

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q840

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.528
CLV_PCSK_SKI1_1	287	291	PF00082	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DEG_SPOP_SBC_1	26	30	PF00917	0.492
DEG_SPOP_SBC_1	91	95	PF00917	0.528
DOC_CDC14_PxL_1	138	146	PF14671	0.551
DOC_CKS1_1	265	270	PF01111	0.435
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.572
DOC_MAPK_gen_1	165	172	PF00069	0.491
DOC_MAPK_MEF2A_6	204	212	PF00069	0.473
DOC_PP2B_LxvP_1	178	181	PF13499	0.557
DOC_USP7_MATH_1	112	116	PF00917	0.593
DOC_USP7_MATH_1	118	122	PF00917	0.750
DOC_USP7_MATH_1	137	141	PF00917	0.472
DOC_USP7_MATH_1	185	189	PF00917	0.616
DOC_USP7_MATH_1	26	30	PF00917	0.586
DOC_USP7_MATH_1	92	96	PF00917	0.634
DOC_WW_Pin1_4	128	133	PF00397	0.769
DOC_WW_Pin1_4	180	185	PF00397	0.631
DOC_WW_Pin1_4	264	269	PF00397	0.455
LIG_14-3-3_CanoR_1	156	164	PF00244	0.306
LIG_APCC_ABBA_1	208	213	PF00400	0.341
LIG_BIR_III_2	129	133	PF00653	0.619
LIG_BRCT_BRCA1_1	54	58	PF00533	0.418
LIG_FHA_1	158	164	PF00498	0.560
LIG_FHA_1	288	294	PF00498	0.522
LIG_FHA_1	46	52	PF00498	0.396
LIG_FHA_2	122	128	PF00498	0.744
LIG_FHA_2	187	193	PF00498	0.607
LIG_FHA_2	36	42	PF00498	0.558
LIG_FHA_2	64	70	PF00498	0.522
LIG_Integrin_RGD_1	67	69	PF01839	0.510
LIG_LIR_Gen_1	55	65	PF02991	0.416
LIG_LIR_Nem_3	238	242	PF02991	0.463
LIG_LIR_Nem_3	267	272	PF02991	0.468
LIG_LIR_Nem_3	55	61	PF02991	0.415
LIG_Pex14_1	14	18	PF04695	0.510
LIG_Pex14_2	254	258	PF04695	0.364
LIG_REV1ctd_RIR_1	268	277	PF16727	0.485
LIG_SH2_CRK	265	269	PF00017	0.435
LIG_SH2_NCK_1	138	142	PF00017	0.609
LIG_SH2_NCK_1	242	246	PF00017	0.367
LIG_SH2_STAP1	231	235	PF00017	0.391
LIG_SH2_STAT5	162	165	PF00017	0.432
LIG_SH2_STAT5	269	272	PF00017	0.421
LIG_SH3_3	129	135	PF00018	0.741
LIG_SH3_3	171	177	PF00018	0.596
LIG_SH3_3	178	184	PF00018	0.586
LIG_SH3_3	20	26	PF00018	0.475
LIG_SH3_3	59	65	PF00018	0.386
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.351
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.383
LIG_SUMO_SIM_par_1	32	38	PF11976	0.371
LIG_SUMO_SIM_par_1	48	55	PF11976	0.403
LIG_TRAF2_1	282	285	PF00917	0.545
LIG_WW_1	135	138	PF00397	0.638
MOD_CK1_1	121	127	PF00069	0.705
MOD_CK1_1	158	164	PF00069	0.473
MOD_CK1_1	240	246	PF00069	0.374
MOD_CK1_1	93	99	PF00069	0.565
MOD_CK2_1	121	127	PF00069	0.722
MOD_CK2_1	180	186	PF00069	0.609
MOD_GlcNHglycan	114	117	PF01048	0.520
MOD_GlcNHglycan	118	121	PF01048	0.553
MOD_GlcNHglycan	139	142	PF01048	0.681
MOD_GlcNHglycan	189	192	PF01048	0.526
MOD_GlcNHglycan	196	199	PF01048	0.565
MOD_GlcNHglycan	255	258	PF01048	0.300
MOD_GlcNHglycan	29	32	PF01048	0.672
MOD_GlcNHglycan	71	76	PF01048	0.456
MOD_GlcNHglycan	96	99	PF01048	0.635
MOD_GSK3_1	112	119	PF00069	0.674
MOD_GSK3_1	86	93	PF00069	0.524
MOD_N-GLC_1	156	161	PF02516	0.417
MOD_NEK2_1	52	57	PF00069	0.440
MOD_PKA_2	155	161	PF00069	0.452
MOD_PKA_2	86	92	PF00069	0.570
MOD_Plk_1	237	243	PF00069	0.480
MOD_Plk_4	158	164	PF00069	0.510
MOD_Plk_4	47	53	PF00069	0.398
MOD_ProDKin_1	128	134	PF00069	0.769
MOD_ProDKin_1	180	186	PF00069	0.633
MOD_ProDKin_1	264	270	PF00069	0.455
MOD_SUMO_rev_2	168	177	PF00179	0.594
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.535
TRG_ER_diArg_1	227	230	PF00400	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I496	Leptomonas seymouri	47%	93%
A0A1X0NQQ5	Trypanosomatidae	32%	96%
A0A3Q8IER6	Leishmania donovani	93%	100%
A0A422N9C9	Trypanosoma rangeli	37%	96%
A4HGS8	Leishmania braziliensis	80%	100%
A4I3V5	Leishmania infantum	93%	100%
D0A923	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B045	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5D5P4	Trypanosoma cruzi	40%	99%