Glycosomal membrane protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane protein-like protein

Species:

Leishmania major

UniProt:

Q4Q839_LEIMA

TriTrypDb:

LmjF.28.2250 , LMJLV39_280030600 , LMJSD75_280030200

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q839

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q839

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016559	peroxisome fission	6	12
GO:0032535	regulation of cellular component size	4	1
GO:0044375	regulation of peroxisome size	5	1
GO:0048285	organelle fission	5	12
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090066	regulation of anatomical structure size	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.635
CLV_C14_Caspase3-7	147	151	PF00656	0.427
CLV_NRD_NRD_1	125	127	PF00675	0.311
CLV_NRD_NRD_1	152	154	PF00675	0.553
CLV_PCSK_SKI1_1	167	171	PF00082	0.533
CLV_PCSK_SKI1_1	20	24	PF00082	0.331
CLV_PCSK_SKI1_1	54	58	PF00082	0.286
CLV_PCSK_SKI1_1	87	91	PF00082	0.326
DOC_CYCLIN_RxL_1	85	95	PF00134	0.432
DOC_MAPK_gen_1	126	134	PF00069	0.449
DOC_MAPK_gen_1	58	67	PF00069	0.621
DOC_PP1_RVXF_1	86	93	PF00149	0.548
DOC_USP7_MATH_1	198	202	PF00917	0.354
DOC_WW_Pin1_4	194	199	PF00397	0.464
LIG_14-3-3_CanoR_1	126	131	PF00244	0.607
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	59	63	PF00533	0.515
LIG_EH1_1	66	74	PF00400	0.641
LIG_FHA_1	13	19	PF00498	0.678
LIG_FHA_1	181	187	PF00498	0.383
LIG_FHA_1	33	39	PF00498	0.435
LIG_FHA_2	93	99	PF00498	0.546
LIG_LIR_Gen_1	212	219	PF02991	0.287
LIG_LIR_Nem_3	212	217	PF02991	0.444
LIG_LIR_Nem_3	91	96	PF02991	0.525
LIG_NRBOX	144	150	PF00104	0.285
LIG_Pex14_2	63	67	PF04695	0.506
LIG_Pex14_2	89	93	PF04695	0.584
LIG_REV1ctd_RIR_1	90	98	PF16727	0.562
LIG_SH2_CRK	157	161	PF00017	0.405
LIG_SH2_GRB2like	214	217	PF00017	0.540
LIG_SH2_GRB2like	43	46	PF00017	0.500
LIG_SH2_NCK_1	157	161	PF00017	0.414
LIG_SH2_SRC	157	160	PF00017	0.428
LIG_SH2_SRC	43	46	PF00017	0.514
LIG_SH2_STAP1	43	47	PF00017	0.537
LIG_SH2_STAT5	214	217	PF00017	0.561
LIG_UBA3_1	145	154	PF00899	0.285
LIG_UBA3_1	62	68	PF00899	0.437
MOD_CDK_SPK_2	194	199	PF00069	0.458
MOD_CK2_1	68	74	PF00069	0.523
MOD_GlcNHglycan	191	194	PF01048	0.518
MOD_GlcNHglycan	200	203	PF01048	0.320
MOD_GlcNHglycan	207	210	PF01048	0.304
MOD_GlcNHglycan	45	48	PF01048	0.485
MOD_GSK3_1	167	174	PF00069	0.487
MOD_GSK3_1	194	201	PF00069	0.418
MOD_GSK3_1	205	212	PF00069	0.294
MOD_GSK3_1	27	34	PF00069	0.468
MOD_LATS_1	124	130	PF00433	0.490
MOD_NEK2_1	138	143	PF00069	0.407
MOD_NEK2_1	31	36	PF00069	0.541
MOD_NEK2_1	57	62	PF00069	0.480
MOD_NEK2_1	6	11	PF00069	0.579
MOD_NEK2_1	63	68	PF00069	0.535
MOD_NEK2_1	92	97	PF00069	0.411
MOD_NEK2_2	200	205	PF00069	0.408
MOD_NEK2_2	209	214	PF00069	0.444
MOD_PK_1	14	20	PF00069	0.413
MOD_PKA_1	126	132	PF00069	0.352
MOD_PKA_2	171	177	PF00069	0.485
MOD_PKA_2	198	204	PF00069	0.424
MOD_PKA_2	57	63	PF00069	0.579
MOD_Plk_4	138	144	PF00069	0.427
MOD_Plk_4	209	215	PF00069	0.325
MOD_Plk_4	68	74	PF00069	0.447
MOD_ProDKin_1	194	200	PF00069	0.579
MOD_SUMO_for_1	38	41	PF00179	0.340
TRG_DiLeu_BaEn_2	84	90	PF01217	0.495
TRG_ENDOCYTIC_2	214	217	PF00928	0.292
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG1	Leptomonas seymouri	51%	100%
A0A0N1PCA1	Leptomonas seymouri	31%	100%
A0A0S4IU25	Bodo saltans	29%	100%
A0A1X0NR15	Trypanosomatidae	29%	100%
A0A3S5H7J8	Leishmania donovani	91%	100%
A0A3S7X1W3	Leishmania donovani	33%	100%
A0A422N9F6	Trypanosoma rangeli	31%	100%
A4HGS9	Leishmania braziliensis	63%	100%
A4HGT0	Leishmania braziliensis	31%	100%
A4I3V6	Leishmania infantum	90%	100%
A4I3V7	Leishmania infantum	33%	100%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B046	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B047	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q838	Leishmania major	33%	100%
V5BEE7	Trypanosoma cruzi	27%	100%