Putative glycosomal membrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane protein, putative

Species:

Leishmania major

UniProt:

Q4Q838_LEIMA

TriTrypDb:

LmjF.28.2260 , LMJLV39_280030700 , LMJSD75_280030300

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0005778	peroxisomal membrane	6	2
GO:0016020	membrane	2	2
GO:0020015	glycosome	7	2
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q838

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q838

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	13
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0016559	peroxisome fission	6	13
GO:0032535	regulation of cellular component size	4	2
GO:0044375	regulation of peroxisome size	5	2
GO:0048285	organelle fission	5	13
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071840	cellular component organization or biogenesis	2	13
GO:0090066	regulation of anatomical structure size	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.583
CLV_MEL_PAP_1	153	159	PF00089	0.480
CLV_PCSK_KEX2_1	155	157	PF00082	0.497
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.526
CLV_PCSK_SKI1_1	128	132	PF00082	0.356
CLV_PCSK_SKI1_1	150	154	PF00082	0.385
CLV_PCSK_SKI1_1	165	169	PF00082	0.518
CLV_PCSK_SKI1_1	6	10	PF00082	0.324
DOC_MAPK_gen_1	164	174	PF00069	0.306
DOC_MAPK_gen_1	42	49	PF00069	0.656
DOC_MAPK_gen_1	90	98	PF00069	0.580
DOC_MAPK_MEF2A_6	176	185	PF00069	0.335
DOC_PP1_RVXF_1	89	96	PF00149	0.553
DOC_USP7_MATH_1	35	39	PF00917	0.531
DOC_USP7_UBL2_3	124	128	PF12436	0.561
DOC_USP7_UBL2_3	164	168	PF12436	0.379
DOC_WW_Pin1_4	193	198	PF00397	0.426
LIG_Actin_WH2_2	136	152	PF00022	0.358
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_CSL_BTD_1	194	197	PF09270	0.294
LIG_LIR_Gen_1	2	11	PF02991	0.497
LIG_LIR_Gen_1	94	103	PF02991	0.553
LIG_LIR_Nem_3	132	138	PF02991	0.444
LIG_LIR_Nem_3	18	24	PF02991	0.506
LIG_LIR_Nem_3	2	7	PF02991	0.561
LIG_LIR_Nem_3	94	98	PF02991	0.550
LIG_NRBOX	6	12	PF00104	0.601
LIG_Pex14_2	135	139	PF04695	0.356
LIG_PTB_Apo_2	98	105	PF02174	0.518
LIG_PTB_Phospho_1	98	104	PF10480	0.518
LIG_SH2_CRK	21	25	PF00017	0.518
LIG_SH2_GRB2like	215	218	PF00017	0.525
LIG_SH2_PTP2	46	49	PF00017	0.510
LIG_SH2_STAP1	129	133	PF00017	0.500
LIG_SH2_STAT5	104	107	PF00017	0.501
LIG_SH2_STAT5	190	193	PF00017	0.318
LIG_SH2_STAT5	215	218	PF00017	0.558
LIG_SH2_STAT5	46	49	PF00017	0.510
LIG_SUMO_SIM_par_1	170	175	PF11976	0.383
LIG_UBA3_1	23	29	PF00899	0.554
LIG_UBA3_1	59	64	PF00899	0.533
MOD_CK1_1	158	164	PF00069	0.289
MOD_CK1_1	193	199	PF00069	0.316
MOD_CK1_1	38	44	PF00069	0.587
MOD_CK1_1	52	58	PF00069	0.508
MOD_CK2_1	160	166	PF00069	0.316
MOD_GlcNHglycan	208	211	PF01048	0.343
MOD_GlcNHglycan	54	57	PF01048	0.388
MOD_GSK3_1	155	162	PF00069	0.323
MOD_GSK3_1	172	179	PF00069	0.432
MOD_GSK3_1	34	41	PF00069	0.550
MOD_N-GLC_1	216	221	PF02516	0.507
MOD_NEK2_1	216	221	PF00069	0.643
MOD_PIKK_1	35	41	PF00454	0.620
MOD_PKA_1	155	161	PF00069	0.311
MOD_PKA_2	155	161	PF00069	0.313
MOD_Plk_4	190	196	PF00069	0.327
MOD_Plk_4	211	217	PF00069	0.400
MOD_Plk_4	99	105	PF00069	0.604
MOD_ProDKin_1	193	199	PF00069	0.426
MOD_SUMO_rev_2	161	170	PF00179	0.307
TRG_DiLeu_BaEn_2	87	93	PF01217	0.605
TRG_ENDOCYTIC_2	21	24	PF00928	0.505
TRG_ENDOCYTIC_2	46	49	PF00928	0.505
TRG_NES_CRM1_1	94	108	PF08389	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG1	Leptomonas seymouri	32%	100%
A0A0N1PCA1	Leptomonas seymouri	81%	100%
A0A0S4IU25	Bodo saltans	49%	100%
A0A1X0NR15	Trypanosomatidae	54%	100%
A0A3S5H7J8	Leishmania donovani	33%	100%
A0A3S7X1W3	Leishmania donovani	95%	100%
A0A422N9F6	Trypanosoma rangeli	56%	100%
A4HGS9	Leishmania braziliensis	33%	100%
A4HGT0	Leishmania braziliensis	84%	100%
A4I3V6	Leishmania infantum	34%	100%
A4I3V7	Leishmania infantum	95%	100%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B046	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B047	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q839	Leishmania major	33%	100%
V5BEE7	Trypanosoma cruzi	60%	100%