Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q837_LEIMA

TriTrypDb:

LmjF.28.2270 , LMJLV39_280030800 , LMJSD75_280030400

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q837

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q837

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	8
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	8
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	8
GO:0010556	regulation of macromolecule biosynthetic process	5	8
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	8
GO:0019222	regulation of metabolic process	3	8
GO:0031323	regulation of cellular metabolic process	4	8
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	8
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045944	positive regulation of transcription by RNA polymerase II	8	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	8
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0080090	regulation of primary metabolic process	4	8
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	8
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	8

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0003824	catalytic activity	1	8
GO:0004402	histone acetyltransferase activity	4	8
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008080	N-acetyltransferase activity	6	8
GO:0016407	acetyltransferase activity	5	8
GO:0016410	N-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0034212	peptide N-acetyltransferase activity	7	8
GO:0042393	histone binding	3	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:0140110	transcription regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.731
CLV_C14_Caspase3-7	459	463	PF00656	0.811
CLV_NRD_NRD_1	284	286	PF00675	0.355
CLV_NRD_NRD_1	326	328	PF00675	0.303
CLV_NRD_NRD_1	365	367	PF00675	0.504
CLV_NRD_NRD_1	435	437	PF00675	0.771
CLV_NRD_NRD_1	455	457	PF00675	0.725
CLV_NRD_NRD_1	65	67	PF00675	0.598
CLV_PCSK_FUR_1	63	67	PF00082	0.596
CLV_PCSK_KEX2_1	284	286	PF00082	0.355
CLV_PCSK_KEX2_1	326	328	PF00082	0.292
CLV_PCSK_KEX2_1	365	367	PF00082	0.485
CLV_PCSK_KEX2_1	435	437	PF00082	0.771
CLV_PCSK_KEX2_1	457	459	PF00082	0.676
CLV_PCSK_KEX2_1	498	500	PF00082	0.783
CLV_PCSK_KEX2_1	65	67	PF00082	0.598
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.676
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.798
CLV_PCSK_SKI1_1	152	156	PF00082	0.497
CLV_PCSK_SKI1_1	212	216	PF00082	0.316
CLV_PCSK_SKI1_1	219	223	PF00082	0.333
CLV_PCSK_SKI1_1	355	359	PF00082	0.368
CLV_PCSK_SKI1_1	499	503	PF00082	0.746
CLV_PCSK_SKI1_1	545	549	PF00082	0.476
CLV_Separin_Metazoa	577	581	PF03568	0.499
DEG_APCC_DBOX_1	43	51	PF00400	0.646
DEG_APCC_DBOX_1	64	72	PF00400	0.614
DEG_SPOP_SBC_1	17	21	PF00917	0.611
DEG_SPOP_SBC_1	493	497	PF00917	0.720
DEG_SPOP_SBC_1	512	516	PF00917	0.494
DOC_ANK_TNKS_1	180	187	PF00023	0.519
DOC_ANK_TNKS_1	434	441	PF00023	0.767
DOC_CYCLIN_RxL_1	207	220	PF00134	0.519
DOC_MAPK_gen_1	365	372	PF00069	0.594
DOC_MAPK_gen_1	498	504	PF00069	0.815
DOC_MAPK_MEF2A_6	401	409	PF00069	0.566
DOC_PP1_RVXF_1	567	574	PF00149	0.504
DOC_PP2B_LxvP_1	182	185	PF13499	0.444
DOC_PP2B_LxvP_1	564	567	PF13499	0.508
DOC_PP4_FxxP_1	155	158	PF00568	0.455
DOC_USP7_MATH_1	121	125	PF00917	0.778
DOC_USP7_MATH_1	136	140	PF00917	0.479
DOC_USP7_MATH_1	295	299	PF00917	0.716
DOC_USP7_MATH_1	300	304	PF00917	0.591
DOC_USP7_MATH_1	493	497	PF00917	0.795
DOC_USP7_MATH_1	512	516	PF00917	0.517
DOC_USP7_UBL2_3	379	383	PF12436	0.746
DOC_WW_Pin1_4	18	23	PF00397	0.692
DOC_WW_Pin1_4	291	296	PF00397	0.623
DOC_WW_Pin1_4	329	334	PF00397	0.517
DOC_WW_Pin1_4	507	512	PF00397	0.819
DOC_WW_Pin1_4	52	57	PF00397	0.628
DOC_WW_Pin1_4	78	83	PF00397	0.498
LIG_14-3-3_CanoR_1	162	168	PF00244	0.455
LIG_14-3-3_CanoR_1	195	200	PF00244	0.504
LIG_14-3-3_CanoR_1	284	292	PF00244	0.775
LIG_14-3-3_CanoR_1	478	488	PF00244	0.812
LIG_14-3-3_CanoR_1	555	562	PF00244	0.566
LIG_14-3-3_CanoR_1	80	86	PF00244	0.501
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BIR_III_3	1	5	PF00653	0.608
LIG_BIR_III_4	135	139	PF00653	0.691
LIG_eIF4E_1	101	107	PF01652	0.518
LIG_eIF4E_1	70	76	PF01652	0.602
LIG_FHA_1	123	129	PF00498	0.686
LIG_FHA_1	489	495	PF00498	0.801
LIG_FHA_2	441	447	PF00498	0.729
LIG_FHA_2	463	469	PF00498	0.747
LIG_FHA_2	495	501	PF00498	0.727
LIG_FHA_2	526	532	PF00498	0.550
LIG_LIR_Apic_2	153	158	PF02991	0.414
LIG_LIR_Gen_1	165	172	PF02991	0.467
LIG_LIR_Gen_1	48	59	PF02991	0.584
LIG_LIR_Gen_1	572	579	PF02991	0.488
LIG_LIR_Nem_3	48	54	PF02991	0.594
LIG_LIR_Nem_3	84	90	PF02991	0.413
LIG_NRBOX	543	549	PF00104	0.467
LIG_Pex14_2	155	159	PF04695	0.452
LIG_Pex14_2	258	262	PF04695	0.517
LIG_PTB_Apo_2	105	112	PF02174	0.572
LIG_PTB_Apo_2	230	237	PF02174	0.545
LIG_PTB_Phospho_1	105	111	PF10480	0.570
LIG_Rb_pABgroove_1	569	577	PF01858	0.488
LIG_SH2_GRB2like	90	93	PF00017	0.487
LIG_SH2_NCK_1	321	325	PF00017	0.517
LIG_SH2_STAP1	164	168	PF00017	0.593
LIG_SH2_STAP1	321	325	PF00017	0.494
LIG_SH2_STAP1	467	471	PF00017	0.590
LIG_SH2_STAP1	575	579	PF00017	0.509
LIG_SH2_STAT5	210	213	PF00017	0.517
LIG_SH2_STAT5	235	238	PF00017	0.517
LIG_SH2_STAT5	245	248	PF00017	0.517
LIG_SH2_STAT5	249	252	PF00017	0.517
LIG_SH2_STAT5	257	260	PF00017	0.503
LIG_SH2_STAT5	570	573	PF00017	0.492
LIG_SH2_STAT5	70	73	PF00017	0.592
LIG_SH2_STAT5	87	90	PF00017	0.307
LIG_SH2_STAT5	94	97	PF00017	0.306
LIG_SH3_3	110	116	PF00018	0.354
LIG_SH3_3	247	253	PF00018	0.570
LIG_SH3_3	289	295	PF00018	0.693
LIG_SH3_3	330	336	PF00018	0.522
LIG_SH3_3	387	393	PF00018	0.627
LIG_SH3_3	92	98	PF00018	0.482
LIG_SUMO_SIM_par_1	415	423	PF11976	0.628
LIG_TRAF2_1	185	188	PF00917	0.545
LIG_UBA3_1	214	219	PF00899	0.517
LIG_WW_3	304	308	PF00397	0.616
MOD_CDK_SPxK_1	329	335	PF00069	0.517
MOD_CK1_1	251	257	PF00069	0.555
MOD_CK1_1	396	402	PF00069	0.755
MOD_CK1_1	434	440	PF00069	0.765
MOD_CK1_1	597	603	PF00069	0.688
MOD_CK2_1	217	223	PF00069	0.517
MOD_CK2_1	440	446	PF00069	0.791
MOD_CK2_1	462	468	PF00069	0.748
MOD_CK2_1	494	500	PF00069	0.725
MOD_CK2_1	580	586	PF00069	0.522
MOD_Cter_Amidation	282	285	PF01082	0.355
MOD_GlcNHglycan	13	17	PF01048	0.733
MOD_GlcNHglycan	252	256	PF01048	0.319
MOD_GlcNHglycan	398	401	PF01048	0.804
MOD_GlcNHglycan	410	413	PF01048	0.510
MOD_GlcNHglycan	426	429	PF01048	0.551
MOD_GlcNHglycan	436	439	PF01048	0.717
MOD_GlcNHglycan	453	456	PF01048	0.827
MOD_GlcNHglycan	47	50	PF01048	0.555
MOD_GlcNHglycan	5	8	PF01048	0.734
MOD_GlcNHglycan	504	507	PF01048	0.697
MOD_GlcNHglycan	515	518	PF01048	0.636
MOD_GlcNHglycan	591	594	PF01048	0.431
MOD_GSK3_1	12	19	PF00069	0.726
MOD_GSK3_1	202	209	PF00069	0.536
MOD_GSK3_1	291	298	PF00069	0.724
MOD_GSK3_1	488	495	PF00069	0.699
MOD_GSK3_1	507	514	PF00069	0.610
MOD_GSK3_1	521	528	PF00069	0.499
MOD_GSK3_1	597	604	PF00069	0.694
MOD_N-GLC_1	202	207	PF02516	0.317
MOD_N-GLC_1	9	14	PF02516	0.551
MOD_NEK2_1	357	362	PF00069	0.555
MOD_NEK2_1	488	493	PF00069	0.808
MOD_NEK2_1	494	499	PF00069	0.651
MOD_NEK2_1	502	507	PF00069	0.565
MOD_NEK2_1	58	63	PF00069	0.523
MOD_NEK2_1	594	599	PF00069	0.588
MOD_NEK2_2	440	445	PF00069	0.731
MOD_PIKK_1	202	208	PF00454	0.555
MOD_PIKK_1	521	527	PF00454	0.675
MOD_PIKK_1	58	64	PF00454	0.600
MOD_PKA_1	284	290	PF00069	0.770
MOD_PKA_1	327	333	PF00069	0.562
MOD_PKA_1	456	462	PF00069	0.760
MOD_PKA_2	283	289	PF00069	0.751
MOD_PKA_2	393	399	PF00069	0.814
MOD_PKA_2	434	440	PF00069	0.771
MOD_PKA_2	525	531	PF00069	0.560
MOD_PKA_2	554	560	PF00069	0.573
MOD_PKA_2	597	603	PF00069	0.688
MOD_Plk_1	12	18	PF00069	0.722
MOD_Plk_1	581	587	PF00069	0.515
MOD_Plk_2-3	462	468	PF00069	0.800
MOD_Plk_4	195	201	PF00069	0.545
MOD_Plk_4	217	223	PF00069	0.505
MOD_Plk_4	90	96	PF00069	0.447
MOD_ProDKin_1	18	24	PF00069	0.690
MOD_ProDKin_1	291	297	PF00069	0.624
MOD_ProDKin_1	329	335	PF00069	0.517
MOD_ProDKin_1	507	513	PF00069	0.818
MOD_ProDKin_1	52	58	PF00069	0.621
MOD_ProDKin_1	78	84	PF00069	0.492
MOD_SUMO_for_1	463	466	PF00179	0.822
MOD_SUMO_rev_2	220	227	PF00179	0.517
MOD_SUMO_rev_2	375	385	PF00179	0.731
MOD_SUMO_rev_2	433	443	PF00179	0.810
MOD_SUMO_rev_2	459	465	PF00179	0.824
TRG_DiLeu_BaEn_4	539	545	PF01217	0.465
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.544
TRG_ENDOCYTIC_2	101	104	PF00928	0.440
TRG_ENDOCYTIC_2	111	114	PF00928	0.530
TRG_ENDOCYTIC_2	167	170	PF00928	0.466
TRG_ENDOCYTIC_2	235	238	PF00928	0.517
TRG_ENDOCYTIC_2	345	348	PF00928	0.606
TRG_ENDOCYTIC_2	51	54	PF00928	0.612
TRG_ENDOCYTIC_2	575	578	PF00928	0.433
TRG_ER_diArg_1	181	184	PF00400	0.510
TRG_ER_diArg_1	288	291	PF00400	0.676
TRG_ER_diArg_1	325	327	PF00400	0.503
TRG_ER_diArg_1	364	366	PF00400	0.488
TRG_ER_diArg_1	63	66	PF00400	0.595
TRG_NLS_MonoExtC_3	455	460	PF00514	0.698
TRG_NLS_MonoExtN_4	453	460	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIW1	Leptomonas seymouri	61%	81%
A0A2D1QVA5	Leishmania donovani	95%	100%
A4HGT1	Leishmania braziliensis	78%	100%
A4I3V8	Leishmania infantum	95%	100%
D0A925	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B048	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	78%