DNA topoisomerase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase 2

Gene product:

DNA topoisomerase ii

Species:

Leishmania major

UniProt:

Q4Q836_LEIMA

TriTrypDb:

LmjF.28.2280 , LMJLV39_280030900 , LMJSD75_280030500

Length:

1497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q836

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0000712	resolution of meiotic recombination intermediates	4	2
GO:0000819	sister chromatid segregation	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0007059	chromosome segregation	2	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0061982	meiosis I cell cycle process	3	2
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0098813	nuclear chromosome segregation	3	2
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1903046	meiotic cell cycle process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016853	isomerase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016491	oxidoreductase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1259	1263	PF00656	0.678
CLV_C14_Caspase3-7	1270	1274	PF00656	0.444
CLV_C14_Caspase3-7	1328	1332	PF00656	0.776
CLV_C14_Caspase3-7	1460	1464	PF00656	0.662
CLV_C14_Caspase3-7	1471	1475	PF00656	0.696
CLV_C14_Caspase3-7	1487	1491	PF00656	0.420
CLV_C14_Caspase3-7	430	434	PF00656	0.366
CLV_C14_Caspase3-7	493	497	PF00656	0.451
CLV_C14_Caspase3-7	683	687	PF00656	0.303
CLV_MEL_PAP_1	271	277	PF00089	0.251
CLV_NRD_NRD_1	1003	1005	PF00675	0.298
CLV_NRD_NRD_1	1028	1030	PF00675	0.305
CLV_NRD_NRD_1	1040	1042	PF00675	0.300
CLV_NRD_NRD_1	1099	1101	PF00675	0.388
CLV_NRD_NRD_1	1132	1134	PF00675	0.430
CLV_NRD_NRD_1	1173	1175	PF00675	0.489
CLV_NRD_NRD_1	1184	1186	PF00675	0.491
CLV_NRD_NRD_1	1216	1218	PF00675	0.649
CLV_NRD_NRD_1	1249	1251	PF00675	0.636
CLV_NRD_NRD_1	1317	1319	PF00675	0.776
CLV_NRD_NRD_1	1343	1345	PF00675	0.688
CLV_NRD_NRD_1	1457	1459	PF00675	0.625
CLV_NRD_NRD_1	161	163	PF00675	0.369
CLV_NRD_NRD_1	216	218	PF00675	0.347
CLV_NRD_NRD_1	256	258	PF00675	0.451
CLV_NRD_NRD_1	401	403	PF00675	0.471
CLV_NRD_NRD_1	48	50	PF00675	0.405
CLV_NRD_NRD_1	634	636	PF00675	0.272
CLV_NRD_NRD_1	692	694	PF00675	0.299
CLV_NRD_NRD_1	750	752	PF00675	0.424
CLV_NRD_NRD_1	993	995	PF00675	0.306
CLV_PCSK_FUR_1	1130	1134	PF00082	0.417
CLV_PCSK_FUR_1	1454	1458	PF00082	0.672
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.303
CLV_PCSK_KEX2_1	1028	1030	PF00082	0.303
CLV_PCSK_KEX2_1	1040	1042	PF00082	0.303
CLV_PCSK_KEX2_1	1099	1101	PF00082	0.388
CLV_PCSK_KEX2_1	1132	1134	PF00082	0.372
CLV_PCSK_KEX2_1	1184	1186	PF00082	0.480
CLV_PCSK_KEX2_1	1215	1217	PF00082	0.605
CLV_PCSK_KEX2_1	1248	1250	PF00082	0.622
CLV_PCSK_KEX2_1	1310	1312	PF00082	0.742
CLV_PCSK_KEX2_1	1342	1344	PF00082	0.653
CLV_PCSK_KEX2_1	1435	1437	PF00082	0.645
CLV_PCSK_KEX2_1	1454	1456	PF00082	0.458
CLV_PCSK_KEX2_1	1457	1459	PF00082	0.623
CLV_PCSK_KEX2_1	215	217	PF00082	0.349
CLV_PCSK_KEX2_1	701	703	PF00082	0.293
CLV_PCSK_KEX2_1	993	995	PF00082	0.303
CLV_PCSK_PC1ET2_1	1028	1030	PF00082	0.382
CLV_PCSK_PC1ET2_1	1248	1250	PF00082	0.628
CLV_PCSK_PC1ET2_1	1310	1312	PF00082	0.742
CLV_PCSK_PC1ET2_1	1435	1437	PF00082	0.629
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.432
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.303
CLV_PCSK_PC1ET2_1	993	995	PF00082	0.388
CLV_PCSK_PC7_1	1306	1312	PF00082	0.742
CLV_PCSK_SKI1_1	1003	1007	PF00082	0.351
CLV_PCSK_SKI1_1	1032	1036	PF00082	0.340
CLV_PCSK_SKI1_1	1099	1103	PF00082	0.388
CLV_PCSK_SKI1_1	1175	1179	PF00082	0.584
CLV_PCSK_SKI1_1	1196	1200	PF00082	0.493
CLV_PCSK_SKI1_1	1205	1209	PF00082	0.513
CLV_PCSK_SKI1_1	1250	1254	PF00082	0.716
CLV_PCSK_SKI1_1	1359	1363	PF00082	0.537
CLV_PCSK_SKI1_1	1435	1439	PF00082	0.618
CLV_PCSK_SKI1_1	1443	1447	PF00082	0.745
CLV_PCSK_SKI1_1	227	231	PF00082	0.425
CLV_PCSK_SKI1_1	517	521	PF00082	0.411
CLV_PCSK_SKI1_1	693	697	PF00082	0.302
CLV_PCSK_SKI1_1	770	774	PF00082	0.303
CLV_PCSK_SKI1_1	781	785	PF00082	0.303
CLV_PCSK_SKI1_1	902	906	PF00082	0.303
DEG_APCC_DBOX_1	606	614	PF00400	0.475
DEG_COP1_1	107	115	PF00400	0.360
DEG_SCF_TRCP1_1	1328	1333	PF00400	0.539
DOC_ANK_TNKS_1	1016	1023	PF00023	0.424
DOC_CDC14_PxL_1	405	413	PF14671	0.500
DOC_CKS1_1	541	546	PF01111	0.455
DOC_CYCLIN_RxL_1	1028	1037	PF00134	0.338
DOC_CYCLIN_RxL_1	1193	1202	PF00134	0.592
DOC_CYCLIN_RxL_1	689	698	PF00134	0.388
DOC_MAPK_gen_1	104	112	PF00069	0.303
DOC_MAPK_gen_1	1040	1046	PF00069	0.412
DOC_MAPK_gen_1	1184	1190	PF00069	0.498
DOC_MAPK_gen_1	402	408	PF00069	0.479
DOC_MAPK_MEF2A_6	205	214	PF00069	0.447
DOC_MAPK_MEF2A_6	268	275	PF00069	0.451
DOC_MAPK_MEF2A_6	327	334	PF00069	0.451
DOC_PP1_RVXF_1	556	563	PF00149	0.475
DOC_PP1_RVXF_1	607	613	PF00149	0.451
DOC_PP1_RVXF_1	691	698	PF00149	0.303
DOC_PP2B_LxvP_1	110	113	PF13499	0.319
DOC_PP2B_LxvP_1	1186	1189	PF13499	0.464
DOC_PP2B_LxvP_1	532	535	PF13499	0.344
DOC_PP4_FxxP_1	541	544	PF00568	0.451
DOC_PP4_FxxP_1	563	566	PF00568	0.451
DOC_PP4_FxxP_1	806	809	PF00568	0.412
DOC_PP4_FxxP_1	931	934	PF00568	0.319
DOC_USP7_MATH_1	1070	1074	PF00917	0.409
DOC_USP7_MATH_1	1083	1087	PF00917	0.218
DOC_USP7_MATH_1	1203	1207	PF00917	0.598
DOC_USP7_MATH_1	1252	1256	PF00917	0.652
DOC_USP7_MATH_1	1374	1378	PF00917	0.581
DOC_USP7_MATH_1	1399	1403	PF00917	0.725
DOC_USP7_MATH_1	1475	1479	PF00917	0.666
DOC_USP7_MATH_1	183	187	PF00917	0.475
DOC_USP7_MATH_1	42	46	PF00917	0.325
DOC_USP7_MATH_2	835	841	PF00917	0.372
DOC_USP7_UBL2_3	1028	1032	PF12436	0.371
DOC_USP7_UBL2_3	1175	1179	PF12436	0.456
DOC_USP7_UBL2_3	1201	1205	PF12436	0.514
DOC_USP7_UBL2_3	1243	1247	PF12436	0.638
DOC_USP7_UBL2_3	1316	1320	PF12436	0.696
DOC_USP7_UBL2_3	1446	1450	PF12436	0.655
DOC_USP7_UBL2_3	164	168	PF12436	0.473
DOC_USP7_UBL2_3	314	318	PF12436	0.455
DOC_USP7_UBL2_3	547	551	PF12436	0.451
DOC_USP7_UBL2_3	868	872	PF12436	0.321
DOC_WW_Pin1_4	1139	1144	PF00397	0.319
DOC_WW_Pin1_4	1298	1303	PF00397	0.663
DOC_WW_Pin1_4	51	56	PF00397	0.397
DOC_WW_Pin1_4	540	545	PF00397	0.317
LIG_14-3-3_CanoR_1	1003	1012	PF00244	0.424
LIG_14-3-3_CanoR_1	1436	1444	PF00244	0.658
LIG_14-3-3_CanoR_1	237	247	PF00244	0.461
LIG_14-3-3_CanoR_1	257	263	PF00244	0.239
LIG_14-3-3_CanoR_1	398	406	PF00244	0.543
LIG_14-3-3_CanoR_1	424	428	PF00244	0.437
LIG_14-3-3_CanoR_1	489	493	PF00244	0.380
LIG_14-3-3_CanoR_1	49	54	PF00244	0.390
LIG_14-3-3_CanoR_1	657	662	PF00244	0.511
LIG_14-3-3_CanoR_1	83	93	PF00244	0.424
LIG_APCC_ABBA_1	36	41	PF00400	0.438
LIG_BRCT_BRCA1_1	148	152	PF00533	0.303
LIG_Clathr_ClatBox_1	200	204	PF01394	0.347
LIG_Clathr_ClatBox_1	985	989	PF01394	0.303
LIG_CSL_BTD_1	110	113	PF09270	0.319
LIG_CSL_BTD_1	52	55	PF09270	0.381
LIG_CtBP_PxDLS_1	1095	1099	PF00389	0.217
LIG_deltaCOP1_diTrp_1	109	117	PF00928	0.338
LIG_deltaCOP1_diTrp_1	1264	1269	PF00928	0.635
LIG_deltaCOP1_diTrp_1	637	642	PF00928	0.537
LIG_DLG_GKlike_1	464	471	PF00625	0.498
LIG_eIF4E_1	195	201	PF01652	0.348
LIG_eIF4E_1	771	777	PF01652	0.424
LIG_EVH1_1	1044	1048	PF00568	0.424
LIG_FHA_1	1004	1010	PF00498	0.378
LIG_FHA_1	1021	1027	PF00498	0.182
LIG_FHA_1	304	310	PF00498	0.466
LIG_FHA_1	31	37	PF00498	0.438
LIG_FHA_1	359	365	PF00498	0.384
LIG_FHA_1	424	430	PF00498	0.426
LIG_FHA_1	438	444	PF00498	0.368
LIG_FHA_1	52	58	PF00498	0.319
LIG_FHA_1	541	547	PF00498	0.451
LIG_FHA_1	817	823	PF00498	0.303
LIG_FHA_1	919	925	PF00498	0.424
LIG_FHA_1	957	963	PF00498	0.303
LIG_FHA_2	1055	1061	PF00498	0.340
LIG_FHA_2	11	17	PF00498	0.483
LIG_FHA_2	1140	1146	PF00498	0.334
LIG_FHA_2	1154	1160	PF00498	0.441
LIG_FHA_2	1358	1364	PF00498	0.530
LIG_FHA_2	18	24	PF00498	0.493
LIG_FHA_2	240	246	PF00498	0.378
LIG_FHA_2	250	256	PF00498	0.378
LIG_FHA_2	428	434	PF00498	0.379
LIG_FHA_2	862	868	PF00498	0.314
LIG_LIR_Apic_2	561	566	PF02991	0.451
LIG_LIR_Apic_2	803	809	PF02991	0.303
LIG_LIR_Apic_2	929	934	PF02991	0.319
LIG_LIR_Gen_1	1102	1113	PF02991	0.309
LIG_LIR_Gen_1	186	196	PF02991	0.333
LIG_LIR_Gen_1	197	206	PF02991	0.303
LIG_LIR_Gen_1	245	253	PF02991	0.377
LIG_LIR_Gen_1	261	267	PF02991	0.396
LIG_LIR_Gen_1	600	610	PF02991	0.451
LIG_LIR_Gen_1	87	94	PF02991	0.424
LIG_LIR_Gen_1	925	936	PF02991	0.303
LIG_LIR_LC3C_4	1021	1026	PF02991	0.428
LIG_LIR_LC3C_4	910	915	PF02991	0.450
LIG_LIR_Nem_3	1102	1108	PF02991	0.309
LIG_LIR_Nem_3	114	120	PF02991	0.303
LIG_LIR_Nem_3	186	192	PF02991	0.338
LIG_LIR_Nem_3	193	198	PF02991	0.307
LIG_LIR_Nem_3	241	246	PF02991	0.348
LIG_LIR_Nem_3	261	265	PF02991	0.223
LIG_LIR_Nem_3	447	453	PF02991	0.346
LIG_LIR_Nem_3	600	605	PF02991	0.451
LIG_LIR_Nem_3	660	664	PF02991	0.452
LIG_LIR_Nem_3	803	808	PF02991	0.303
LIG_LIR_Nem_3	87	93	PF02991	0.424
LIG_LIR_Nem_3	898	904	PF02991	0.303
LIG_LIR_Nem_3	925	931	PF02991	0.303
LIG_LIR_Nem_3	982	986	PF02991	0.319
LIG_LYPXL_S_1	194	198	PF13949	0.318
LIG_LYPXL_S_1	249	253	PF13949	0.399
LIG_LYPXL_yS_3	250	253	PF13949	0.400
LIG_Pex14_1	638	642	PF04695	0.462
LIG_Pex14_1	857	861	PF04695	0.303
LIG_Pex14_1	897	901	PF04695	0.303
LIG_Pex14_2	148	152	PF04695	0.303
LIG_Pex14_2	165	169	PF04695	0.390
LIG_Pex14_2	194	198	PF04695	0.318
LIG_Pex14_2	523	527	PF04695	0.379
LIG_Pex14_2	537	541	PF04695	0.244
LIG_PTB_Apo_2	337	344	PF02174	0.451
LIG_SH2_CRK	1105	1109	PF00017	0.303
LIG_SH2_CRK	189	193	PF00017	0.322
LIG_SH2_CRK	262	266	PF00017	0.372
LIG_SH2_CRK	587	591	PF00017	0.451
LIG_SH2_GRB2like	492	495	PF00017	0.511
LIG_SH2_NCK_1	189	193	PF00017	0.322
LIG_SH2_NCK_1	219	223	PF00017	0.337
LIG_SH2_NCK_1	262	266	PF00017	0.396
LIG_SH2_NCK_1	39	43	PF00017	0.440
LIG_SH2_NCK_1	973	977	PF00017	0.412
LIG_SH2_PTP2	246	249	PF00017	0.374
LIG_SH2_PTP2	807	810	PF00017	0.303
LIG_SH2_PTP2	90	93	PF00017	0.424
LIG_SH2_SRC	219	222	PF00017	0.292
LIG_SH2_SRC	39	42	PF00017	0.443
LIG_SH2_SRC	492	495	PF00017	0.395
LIG_SH2_SRC	807	810	PF00017	0.303
LIG_SH2_SRC	955	958	PF00017	0.317
LIG_SH2_STAP1	1105	1109	PF00017	0.303
LIG_SH2_STAT5	1043	1046	PF00017	0.338
LIG_SH2_STAT5	1107	1110	PF00017	0.303
LIG_SH2_STAT5	189	192	PF00017	0.324
LIG_SH2_STAT5	246	249	PF00017	0.444
LIG_SH2_STAT5	25	28	PF00017	0.392
LIG_SH2_STAT5	300	303	PF00017	0.451
LIG_SH2_STAT5	371	374	PF00017	0.464
LIG_SH2_STAT5	450	453	PF00017	0.368
LIG_SH2_STAT5	568	571	PF00017	0.451
LIG_SH2_STAT5	601	604	PF00017	0.451
LIG_SH2_STAT5	716	719	PF00017	0.303
LIG_SH2_STAT5	771	774	PF00017	0.300
LIG_SH2_STAT5	807	810	PF00017	0.303
LIG_SH2_STAT5	858	861	PF00017	0.303
LIG_SH2_STAT5	90	93	PF00017	0.424
LIG_SH2_STAT5	955	958	PF00017	0.317
LIG_SH2_STAT5	984	987	PF00017	0.342
LIG_SH2_STAT5	997	1000	PF00017	0.303
LIG_SH3_2	1290	1295	PF14604	0.674
LIG_SH3_3	1042	1048	PF00018	0.338
LIG_SH3_3	1174	1180	PF00018	0.567
LIG_SH3_3	1233	1239	PF00018	0.509
LIG_SH3_3	1287	1293	PF00018	0.704
LIG_SH3_3	1299	1305	PF00018	0.550
LIG_SH3_3	1441	1447	PF00018	0.739
LIG_SH3_3	177	183	PF00018	0.387
LIG_SH3_3	70	76	PF00018	0.319
LIG_SH3_3	806	812	PF00018	0.303
LIG_SH3_4	1316	1323	PF00018	0.738
LIG_SH3_4	1446	1453	PF00018	0.697
LIG_SUMO_SIM_anti_2	1410	1417	PF11976	0.562
LIG_SUMO_SIM_par_1	1021	1027	PF11976	0.390
LIG_SUMO_SIM_par_1	425	431	PF11976	0.416
LIG_SUMO_SIM_par_1	834	840	PF11976	0.315
LIG_TRAF2_1	1058	1061	PF00917	0.424
LIG_TRAF2_1	1263	1266	PF00917	0.631
LIG_TRAF2_1	1479	1482	PF00917	0.727
LIG_TRAF2_1	473	476	PF00917	0.452
LIG_TRAF2_1	864	867	PF00917	0.331
LIG_TYR_ITIM	498	503	PF00017	0.401
LIG_UBA3_1	1108	1112	PF00899	0.388
LIG_UBA3_1	1413	1420	PF00899	0.587
LIG_UBA3_1	210	215	PF00899	0.419
LIG_UBA3_1	301	308	PF00899	0.556
LIG_UBA3_1	405	410	PF00899	0.500
LIG_WRC_WIRS_1	1158	1163	PF05994	0.555
LIG_WRC_WIRS_1	191	196	PF05994	0.317
MOD_CDC14_SPxK_1	1301	1304	PF00782	0.657
MOD_CDK_SPK_2	1139	1144	PF00069	0.319
MOD_CDK_SPK_2	1298	1303	PF00069	0.663
MOD_CDK_SPxK_1	1298	1304	PF00069	0.661
MOD_CDK_SPxxK_3	540	547	PF00069	0.303
MOD_CK1_1	1055	1061	PF00069	0.303
MOD_CK1_1	1335	1341	PF00069	0.714
MOD_CK1_1	1379	1385	PF00069	0.548
MOD_CK1_1	1461	1467	PF00069	0.671
MOD_CK1_1	1476	1482	PF00069	0.609
MOD_CK1_1	1483	1489	PF00069	0.617
MOD_CK1_1	1491	1497	PF00069	0.475
MOD_CK1_1	288	294	PF00069	0.451
MOD_CK1_1	434	440	PF00069	0.488
MOD_CK1_1	561	567	PF00069	0.443
MOD_CK1_1	680	686	PF00069	0.303
MOD_CK1_1	718	724	PF00069	0.388
MOD_CK2_1	1004	1010	PF00069	0.338
MOD_CK2_1	1054	1060	PF00069	0.391
MOD_CK2_1	1153	1159	PF00069	0.489
MOD_CK2_1	1260	1266	PF00069	0.678
MOD_CK2_1	1475	1481	PF00069	0.724
MOD_CK2_1	239	245	PF00069	0.337
MOD_CK2_1	249	255	PF00069	0.387
MOD_CK2_1	590	596	PF00069	0.528
MOD_CK2_1	837	843	PF00069	0.370
MOD_CK2_1	861	867	PF00069	0.343
MOD_CK2_1	971	977	PF00069	0.372
MOD_Cter_Amidation	1213	1216	PF01082	0.634
MOD_GlcNHglycan	1085	1088	PF01048	0.459
MOD_GlcNHglycan	1230	1233	PF01048	0.615
MOD_GlcNHglycan	1325	1331	PF01048	0.757
MOD_GlcNHglycan	1334	1337	PF01048	0.694
MOD_GlcNHglycan	1350	1353	PF01048	0.631
MOD_GlcNHglycan	1376	1379	PF01048	0.609
MOD_GlcNHglycan	1381	1384	PF01048	0.629
MOD_GlcNHglycan	1440	1443	PF01048	0.613
MOD_GlcNHglycan	1474	1478	PF01048	0.717
MOD_GlcNHglycan	1481	1486	PF01048	0.630
MOD_GlcNHglycan	185	188	PF01048	0.467
MOD_GlcNHglycan	374	377	PF01048	0.468
MOD_GlcNHglycan	433	436	PF01048	0.363
MOD_GlcNHglycan	592	595	PF01048	0.262
MOD_GlcNHglycan	719	723	PF01048	0.376
MOD_GSK3_1	1020	1027	PF00069	0.338
MOD_GSK3_1	1153	1160	PF00069	0.528
MOD_GSK3_1	1326	1333	PF00069	0.705
MOD_GSK3_1	1399	1406	PF00069	0.676
MOD_GSK3_1	142	149	PF00069	0.303
MOD_GSK3_1	1431	1438	PF00069	0.685
MOD_GSK3_1	1457	1464	PF00069	0.669
MOD_GSK3_1	1469	1476	PF00069	0.630
MOD_GSK3_1	1480	1487	PF00069	0.558
MOD_GSK3_1	183	190	PF00069	0.451
MOD_GSK3_1	281	288	PF00069	0.451
MOD_GSK3_1	289	296	PF00069	0.451
MOD_GSK3_1	353	360	PF00069	0.488
MOD_GSK3_1	392	399	PF00069	0.603
MOD_GSK3_1	419	426	PF00069	0.441
MOD_GSK3_1	427	434	PF00069	0.383
MOD_GSK3_1	488	495	PF00069	0.383
MOD_GSK3_1	637	644	PF00069	0.511
MOD_GSK3_1	726	733	PF00069	0.293
MOD_GSK3_1	817	824	PF00069	0.312
MOD_GSK3_1	918	925	PF00069	0.424
MOD_GSK3_1	971	978	PF00069	0.372
MOD_N-GLC_1	577	582	PF02516	0.337
MOD_N-GLC_1	648	653	PF02516	0.275
MOD_N-GLC_1	816	821	PF02516	0.303
MOD_NEK2_1	1024	1029	PF00069	0.303
MOD_NEK2_1	1054	1059	PF00069	0.360
MOD_NEK2_1	120	125	PF00069	0.304
MOD_NEK2_1	1387	1392	PF00069	0.676
MOD_NEK2_1	1480	1485	PF00069	0.596
MOD_NEK2_1	167	172	PF00069	0.437
MOD_NEK2_1	285	290	PF00069	0.451
MOD_NEK2_1	384	389	PF00069	0.492
MOD_NEK2_1	590	595	PF00069	0.462
MOD_NEK2_1	704	709	PF00069	0.303
MOD_NEK2_1	730	735	PF00069	0.303
MOD_NEK2_1	741	746	PF00069	0.301
MOD_NEK2_1	826	831	PF00069	0.432
MOD_NEK2_1	859	864	PF00069	0.319
MOD_NEK2_1	86	91	PF00069	0.340
MOD_NEK2_2	1203	1208	PF00069	0.417
MOD_NEK2_2	42	47	PF00069	0.442
MOD_PIKK_1	10	16	PF00454	0.436
MOD_PIKK_1	342	348	PF00454	0.451
MOD_PIKK_1	895	901	PF00454	0.303
MOD_PKA_1	1003	1009	PF00069	0.424
MOD_PKA_1	1052	1058	PF00069	0.319
MOD_PKA_1	1099	1105	PF00069	0.424
MOD_PKA_1	1132	1138	PF00069	0.372
MOD_PKA_1	1435	1441	PF00069	0.700
MOD_PKA_1	1457	1463	PF00069	0.584
MOD_PKA_1	316	322	PF00069	0.495
MOD_PKA_1	49	55	PF00069	0.384
MOD_PKA_2	1003	1009	PF00069	0.424
MOD_PKA_2	1099	1105	PF00069	0.424
MOD_PKA_2	1132	1138	PF00069	0.372
MOD_PKA_2	1321	1327	PF00069	0.672
MOD_PKA_2	1400	1406	PF00069	0.718
MOD_PKA_2	1435	1441	PF00069	0.694
MOD_PKA_2	1457	1463	PF00069	0.598
MOD_PKA_2	273	279	PF00069	0.460
MOD_PKA_2	397	403	PF00069	0.539
MOD_PKA_2	423	429	PF00069	0.433
MOD_PKA_2	488	494	PF00069	0.380
MOD_PKB_1	1130	1138	PF00069	0.418
MOD_PKB_1	1455	1463	PF00069	0.635
MOD_Plk_1	1203	1209	PF00069	0.571
MOD_Plk_1	1221	1227	PF00069	0.413
MOD_Plk_1	1491	1497	PF00069	0.615
MOD_Plk_1	187	193	PF00069	0.327
MOD_Plk_1	225	231	PF00069	0.339
MOD_Plk_1	378	384	PF00069	0.495
MOD_Plk_1	42	48	PF00069	0.442
MOD_Plk_1	464	470	PF00069	0.397
MOD_Plk_1	648	654	PF00069	0.458
MOD_Plk_1	677	683	PF00069	0.338
MOD_Plk_1	718	724	PF00069	0.330
MOD_Plk_1	726	732	PF00069	0.271
MOD_Plk_1	922	928	PF00069	0.303
MOD_Plk_2-3	1258	1264	PF00069	0.617
MOD_Plk_2-3	204	210	PF00069	0.379
MOD_Plk_2-3	30	36	PF00069	0.373
MOD_Plk_2-3	798	804	PF00069	0.310
MOD_Plk_4	1020	1026	PF00069	0.338
MOD_Plk_4	1157	1163	PF00069	0.527
MOD_Plk_4	187	193	PF00069	0.327
MOD_Plk_4	281	287	PF00069	0.451
MOD_Plk_4	364	370	PF00069	0.373
MOD_Plk_4	423	429	PF00069	0.433
MOD_Plk_4	680	686	PF00069	0.295
MOD_Plk_4	726	732	PF00069	0.303
MOD_Plk_4	77	83	PF00069	0.388
MOD_Plk_4	86	92	PF00069	0.388
MOD_Plk_4	975	981	PF00069	0.360
MOD_ProDKin_1	1139	1145	PF00069	0.319
MOD_ProDKin_1	1298	1304	PF00069	0.661
MOD_ProDKin_1	51	57	PF00069	0.391
MOD_ProDKin_1	540	546	PF00069	0.317
MOD_SUMO_for_1	1421	1424	PF00179	0.499
MOD_SUMO_rev_2	1145	1154	PF00179	0.392
MOD_SUMO_rev_2	124	134	PF00179	0.303
MOD_SUMO_rev_2	255	260	PF00179	0.418
MOD_SUMO_rev_2	395	405	PF00179	0.532
MOD_SUMO_rev_2	564	574	PF00179	0.475
TRG_DiLeu_BaEn_1	208	213	PF01217	0.363
TRG_DiLeu_BaEn_2	868	874	PF01217	0.303
TRG_DiLeu_BaEn_4	947	953	PF01217	0.319
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.319
TRG_ENDOCYTIC_2	1043	1046	PF00928	0.303
TRG_ENDOCYTIC_2	1105	1108	PF00928	0.303
TRG_ENDOCYTIC_2	189	192	PF00928	0.324
TRG_ENDOCYTIC_2	195	198	PF00928	0.319
TRG_ENDOCYTIC_2	246	249	PF00928	0.374
TRG_ENDOCYTIC_2	250	253	PF00928	0.384
TRG_ENDOCYTIC_2	262	265	PF00928	0.402
TRG_ENDOCYTIC_2	450	453	PF00928	0.368
TRG_ENDOCYTIC_2	500	503	PF00928	0.417
TRG_ENDOCYTIC_2	58	61	PF00928	0.303
TRG_ENDOCYTIC_2	587	590	PF00928	0.451
TRG_ENDOCYTIC_2	661	664	PF00928	0.451
TRG_ENDOCYTIC_2	807	810	PF00928	0.303
TRG_ENDOCYTIC_2	833	836	PF00928	0.305
TRG_ENDOCYTIC_2	858	861	PF00928	0.303
TRG_ENDOCYTIC_2	90	93	PF00928	0.424
TRG_ENDOCYTIC_2	901	904	PF00928	0.303
TRG_ER_diArg_1	1002	1004	PF00400	0.358
TRG_ER_diArg_1	1040	1042	PF00400	0.422
TRG_ER_diArg_1	1098	1100	PF00400	0.388
TRG_ER_diArg_1	1130	1133	PF00400	0.334
TRG_ER_diArg_1	1184	1187	PF00400	0.458
TRG_ER_diArg_1	1215	1217	PF00400	0.658
TRG_ER_diArg_1	1295	1298	PF00400	0.529
TRG_ER_diArg_1	1341	1344	PF00400	0.728
TRG_ER_diArg_1	1454	1457	PF00400	0.634
TRG_ER_diArg_1	216	218	PF00400	0.350
TRG_ER_diArg_1	607	610	PF00400	0.462
TRG_NES_CRM1_1	475	487	PF08389	0.396
TRG_NES_CRM1_1	637	650	PF08389	0.537
TRG_NES_CRM1_1	75	88	PF08389	0.388
TRG_NLS_Bipartite_1	1040	1055	PF00514	0.372
TRG_NLS_Bipartite_1	1303	1323	PF00514	0.728
TRG_NLS_MonoCore_2	1027	1032	PF00514	0.424
TRG_NLS_MonoCore_2	1246	1251	PF00514	0.666
TRG_NLS_MonoCore_2	1302	1307	PF00514	0.729
TRG_NLS_MonoCore_2	313	318	PF00514	0.537
TRG_NLS_MonoExtC_3	1027	1032	PF00514	0.424
TRG_NLS_MonoExtC_3	1173	1178	PF00514	0.604
TRG_NLS_MonoExtC_3	1246	1251	PF00514	0.625
TRG_NLS_MonoExtC_3	1317	1322	PF00514	0.684
TRG_NLS_MonoExtC_3	214	220	PF00514	0.429
TRG_NLS_MonoExtC_3	313	318	PF00514	0.452
TRG_NLS_MonoExtN_4	1048	1055	PF00514	0.338
TRG_NLS_MonoExtN_4	1174	1179	PF00514	0.603
TRG_NLS_MonoExtN_4	1247	1252	PF00514	0.636
TRG_NLS_MonoExtN_4	1302	1307	PF00514	0.726
TRG_NLS_MonoExtN_4	1316	1323	PF00514	0.610
TRG_NLS_MonoExtN_4	160	166	PF00514	0.370
TRG_NLS_MonoExtN_4	314	319	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	1032	1036	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	1196	1200	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P778	Leptomonas seymouri	33%	100%
A0A0N1HUJ9	Leptomonas seymouri	78%	100%
A0A0S4IZ11	Bodo saltans	72%	100%
A0A0S4JGE3	Bodo saltans	36%	100%
A0A1X0NUH3	Trypanosomatidae	36%	100%
A0A3Q8II93	Leishmania donovani	96%	100%
A0A3R7MTQ1	Trypanosoma rangeli	36%	100%
A0A3S7WTK8	Leishmania donovani	33%	100%
A0A422N9B0	Trypanosoma rangeli	67%	100%
A4H891	Leishmania braziliensis	32%	100%
A4HGT2	Leishmania braziliensis	91%	100%
A4HWL4	Leishmania infantum	33%	100%
A4I3V9	Leishmania infantum	98%	100%
C9ZXS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A926	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D0A927	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AQC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B049	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O16140	Bombyx mori	45%	97%
O24308	Pisum sativum	44%	100%
O42130	Gallus gallus	44%	96%
O42131	Gallus gallus	43%	92%
O61078	Leishmania chagasi	32%	100%
O93794	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
P06786	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P08096	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
P0C9C0	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	25%	100%
P0C9C1	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	25%	100%
P0C9C2	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	25%	100%
P11388	Homo sapiens	45%	98%
P12531	Trypanosoma brucei brucei	33%	100%
P15348	Drosophila melanogaster	45%	100%
P27570	Crithidia fasciculata	33%	100%
P30182	Arabidopsis thaliana	44%	100%
P30190	Trypanosoma cruzi	36%	100%
P34203	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	25%	100%
P34534	Caenorhabditis elegans	38%	100%
P41515	Cricetulus griseus	40%	98%
P41516	Rattus norvegicus	40%	98%
P87078	Candida albicans	44%	100%
P90520	Dictyostelium discoideum	41%	100%
Q00942	African swine fever virus (strain Badajoz 1971 Vero-adapted)	25%	100%
Q01320	Mus musculus	40%	98%
Q01879	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	43%	100%
Q02880	Homo sapiens	45%	92%
Q196X4	Invertebrate iridescent virus 3	34%	100%
Q23670	Caenorhabditis elegans	45%	98%
Q4QF53	Leishmania major	32%	100%
Q55BP5	Dictyostelium discoideum	42%	98%
Q64399	Cricetulus longicaudatus	45%	93%
Q64511	Mus musculus	45%	93%
Q9QSK1	Invertebrate iridescent virus 6	31%	100%
Q9Y8G8	Penicillium chrysogenum	46%	94%
V5B5B2	Trypanosoma cruzi	71%	100%
V5BUD4	Trypanosoma cruzi	36%	100%