Translation initiation factor eIF-2B subunit epsilon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF-2B subunit epsilon, putative

Species:

Leishmania major

UniProt:

Q4Q835_LEIMA

TriTrypDb:

LmjF.28.2290 , LMJLV39_280031000 , LMJSD75_280030600

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

Q4Q835

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q835

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003743	translation initiation factor activity	4	4
GO:0005085	guanyl-nucleotide exchange factor activity	3	2
GO:0005488	binding	1	4
GO:0005515	protein binding	2	2
GO:0008135	translation factor activity, RNA binding	3	4
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0031369	translation initiation factor binding	3	2
GO:0045182	translation regulator activity	1	4
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0090079	translation regulator activity, nucleic acid binding	2	4
GO:0097159	organic cyclic compound binding	2	4
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2
GO:0140678	molecular function inhibitor activity	2	2
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.549
CLV_C14_Caspase3-7	588	592	PF00656	0.621
CLV_C14_Caspase3-7	785	789	PF00656	0.694
CLV_NRD_NRD_1	125	127	PF00675	0.468
CLV_NRD_NRD_1	174	176	PF00675	0.495
CLV_NRD_NRD_1	370	372	PF00675	0.444
CLV_NRD_NRD_1	459	461	PF00675	0.440
CLV_NRD_NRD_1	607	609	PF00675	0.512
CLV_NRD_NRD_1	7	9	PF00675	0.510
CLV_NRD_NRD_1	761	763	PF00675	0.527
CLV_PCSK_KEX2_1	125	127	PF00082	0.467
CLV_PCSK_KEX2_1	370	372	PF00082	0.444
CLV_PCSK_KEX2_1	459	461	PF00082	0.440
CLV_PCSK_KEX2_1	607	609	PF00082	0.512
CLV_PCSK_KEX2_1	7	9	PF00082	0.542
CLV_PCSK_KEX2_1	761	763	PF00082	0.527
CLV_PCSK_SKI1_1	125	129	PF00082	0.436
CLV_PCSK_SKI1_1	190	194	PF00082	0.502
CLV_PCSK_SKI1_1	370	374	PF00082	0.389
CLV_PCSK_SKI1_1	460	464	PF00082	0.434
CLV_PCSK_SKI1_1	488	492	PF00082	0.443
CLV_PCSK_SKI1_1	552	556	PF00082	0.563
CLV_PCSK_SKI1_1	674	678	PF00082	0.525
CLV_PCSK_SKI1_1	762	766	PF00082	0.494
CLV_PCSK_SKI1_1	830	834	PF00082	0.648
CLV_Separin_Metazoa	236	240	PF03568	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.550
DEG_SPOP_SBC_1	284	288	PF00917	0.532
DEG_SPOP_SBC_1	389	393	PF00917	0.473
DOC_CYCLIN_RxL_1	367	376	PF00134	0.433
DOC_MAPK_FxFP_2	640	643	PF00069	0.467
DOC_MAPK_gen_1	250	257	PF00069	0.466
DOC_PP2B_LxvP_1	150	153	PF13499	0.347
DOC_PP4_FxxP_1	640	643	PF00568	0.467
DOC_USP7_MATH_1	345	349	PF00917	0.467
DOC_USP7_MATH_1	353	357	PF00917	0.355
DOC_USP7_MATH_1	389	393	PF00917	0.451
DOC_USP7_MATH_1	406	410	PF00917	0.377
DOC_USP7_MATH_1	585	589	PF00917	0.707
DOC_WW_Pin1_4	212	217	PF00397	0.564
DOC_WW_Pin1_4	274	279	PF00397	0.528
DOC_WW_Pin1_4	44	49	PF00397	0.516
DOC_WW_Pin1_4	62	67	PF00397	0.382
DOC_WW_Pin1_4	662	667	PF00397	0.600
LIG_14-3-3_CanoR_1	125	131	PF00244	0.452
LIG_14-3-3_CanoR_1	198	202	PF00244	0.515
LIG_14-3-3_CanoR_1	232	240	PF00244	0.614
LIG_14-3-3_CanoR_1	241	246	PF00244	0.689
LIG_14-3-3_CanoR_1	252	256	PF00244	0.407
LIG_14-3-3_CanoR_1	39	43	PF00244	0.525
LIG_14-3-3_CanoR_1	404	413	PF00244	0.575
LIG_14-3-3_CanoR_1	567	574	PF00244	0.602
LIG_BRCT_BRCA1_1	575	579	PF00533	0.580
LIG_BRCT_BRCA1_1	636	640	PF00533	0.483
LIG_Clathr_ClatBox_1	151	155	PF01394	0.408
LIG_Clathr_ClatBox_1	751	755	PF01394	0.476
LIG_eIF4E_1	70	76	PF01652	0.342
LIG_FHA_1	242	248	PF00498	0.616
LIG_FHA_1	252	258	PF00498	0.388
LIG_FHA_1	260	266	PF00498	0.336
LIG_FHA_1	324	330	PF00498	0.436
LIG_FHA_1	394	400	PF00498	0.437
LIG_FHA_1	548	554	PF00498	0.641
LIG_FHA_1	573	579	PF00498	0.528
LIG_FHA_1	63	69	PF00498	0.319
LIG_FHA_1	631	637	PF00498	0.562
LIG_FHA_1	648	654	PF00498	0.447
LIG_FHA_1	82	88	PF00498	0.429
LIG_FHA_2	117	123	PF00498	0.464
LIG_FHA_2	127	133	PF00498	0.540
LIG_FHA_2	167	173	PF00498	0.440
LIG_FHA_2	516	522	PF00498	0.631
LIG_FHA_2	658	664	PF00498	0.656
LIG_GBD_Chelix_1	193	201	PF00786	0.533
LIG_GBD_Chelix_1	22	30	PF00786	0.410
LIG_Integrin_isoDGR_2	558	560	PF01839	0.537
LIG_Integrin_RGD_1	525	527	PF01839	0.652
LIG_LIR_Apic_2	637	643	PF02991	0.481
LIG_LIR_Apic_2	679	683	PF02991	0.430
LIG_LIR_Gen_1	148	157	PF02991	0.357
LIG_LIR_Gen_1	159	167	PF02991	0.384
LIG_LIR_Gen_1	319	329	PF02991	0.439
LIG_LIR_Gen_1	479	490	PF02991	0.436
LIG_LIR_Gen_1	740	751	PF02991	0.498
LIG_LIR_Nem_3	148	152	PF02991	0.315
LIG_LIR_Nem_3	159	163	PF02991	0.353
LIG_LIR_Nem_3	319	324	PF02991	0.402
LIG_LIR_Nem_3	332	338	PF02991	0.365
LIG_LIR_Nem_3	479	485	PF02991	0.433
LIG_LIR_Nem_3	740	746	PF02991	0.511
LIG_LYPXL_yS_3	642	645	PF13949	0.467
LIG_PCNA_yPIPBox_3	691	701	PF02747	0.553
LIG_Pex14_1	680	684	PF04695	0.413
LIG_Pex14_2	684	688	PF04695	0.420
LIG_SH2_CRK	243	247	PF00017	0.561
LIG_SH2_CRK	335	339	PF00017	0.487
LIG_SH2_CRK	743	747	PF00017	0.501
LIG_SH2_GRB2like	685	688	PF00017	0.402
LIG_SH2_PTP2	482	485	PF00017	0.374
LIG_SH2_STAP1	180	184	PF00017	0.313
LIG_SH2_STAP1	568	572	PF00017	0.595
LIG_SH2_STAP1	685	689	PF00017	0.425
LIG_SH2_STAT3	721	724	PF00017	0.513
LIG_SH2_STAT5	243	246	PF00017	0.523
LIG_SH2_STAT5	360	363	PF00017	0.326
LIG_SH2_STAT5	398	401	PF00017	0.397
LIG_SH2_STAT5	482	485	PF00017	0.374
LIG_SH2_STAT5	70	73	PF00017	0.308
LIG_SH2_STAT5	743	746	PF00017	0.505
LIG_SH2_STAT5	768	771	PF00017	0.554
LIG_SH3_1	243	249	PF00018	0.568
LIG_SH3_3	213	219	PF00018	0.619
LIG_SH3_3	243	249	PF00018	0.509
LIG_SH3_3	275	281	PF00018	0.587
LIG_SH3_3	347	353	PF00018	0.407
LIG_SH3_3	39	45	PF00018	0.496
LIG_SH3_3	418	424	PF00018	0.391
LIG_SH3_3	50	56	PF00018	0.475
LIG_SH3_3	581	587	PF00018	0.752
LIG_SH3_5	66	70	PF00018	0.354
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.429
LIG_SUMO_SIM_par_1	340	348	PF11976	0.425
LIG_SUMO_SIM_par_1	81	91	PF11976	0.474
LIG_SUMO_SIM_par_1	816	821	PF11976	0.526
LIG_TRAF2_1	596	599	PF00917	0.692
LIG_TRFH_1	149	153	PF08558	0.397
LIG_TYR_ITIM	480	485	PF00017	0.426
LIG_UBA3_1	255	260	PF00899	0.428
LIG_WRC_WIRS_1	157	162	PF05994	0.436
LIG_WRC_WIRS_1	320	325	PF05994	0.420
MOD_CDK_SPK_2	49	54	PF00069	0.484
MOD_CDK_SPxxK_3	47	54	PF00069	0.485
MOD_CK1_1	212	218	PF00069	0.666
MOD_CK1_1	322	328	PF00069	0.392
MOD_CK1_1	445	451	PF00069	0.459
MOD_CK1_1	47	53	PF00069	0.512
MOD_CK1_1	533	539	PF00069	0.682
MOD_CK1_1	747	753	PF00069	0.536
MOD_CK1_1	786	792	PF00069	0.711
MOD_CK1_1	793	799	PF00069	0.775
MOD_CK1_1	91	97	PF00069	0.285
MOD_CK2_1	116	122	PF00069	0.466
MOD_CK2_1	166	172	PF00069	0.380
MOD_CK2_1	308	314	PF00069	0.370
MOD_CK2_1	389	395	PF00069	0.482
MOD_CK2_1	537	543	PF00069	0.692
MOD_CK2_1	587	593	PF00069	0.706
MOD_CK2_1	619	625	PF00069	0.524
MOD_CK2_1	799	805	PF00069	0.526
MOD_Cter_Amidation	457	460	PF01082	0.431
MOD_GlcNHglycan	222	225	PF01048	0.751
MOD_GlcNHglycan	287	290	PF01048	0.513
MOD_GlcNHglycan	347	350	PF01048	0.467
MOD_GlcNHglycan	355	358	PF01048	0.453
MOD_GlcNHglycan	496	499	PF01048	0.537
MOD_GlcNHglycan	513	518	PF01048	0.582
MOD_GlcNHglycan	575	578	PF01048	0.575
MOD_GlcNHglycan	637	640	PF01048	0.487
MOD_GlcNHglycan	746	749	PF01048	0.541
MOD_GlcNHglycan	90	93	PF01048	0.396
MOD_GSK3_1	112	119	PF00069	0.424
MOD_GSK3_1	227	234	PF00069	0.669
MOD_GSK3_1	259	266	PF00069	0.454
MOD_GSK3_1	285	292	PF00069	0.495
MOD_GSK3_1	319	326	PF00069	0.430
MOD_GSK3_1	389	396	PF00069	0.428
MOD_GSK3_1	419	426	PF00069	0.402
MOD_GSK3_1	530	537	PF00069	0.712
MOD_GSK3_1	573	580	PF00069	0.608
MOD_GSK3_1	619	626	PF00069	0.508
MOD_GSK3_1	630	637	PF00069	0.328
MOD_GSK3_1	683	690	PF00069	0.426
MOD_GSK3_1	782	789	PF00069	0.707
MOD_GSK3_1	790	797	PF00069	0.758
MOD_GSK3_1	87	94	PF00069	0.408
MOD_GSK3_1	97	104	PF00069	0.397
MOD_N-GLC_1	116	121	PF02516	0.500
MOD_N-GLC_1	145	150	PF02516	0.443
MOD_N-GLC_1	241	246	PF02516	0.502
MOD_N-GLC_1	87	92	PF02516	0.348
MOD_NEK2_1	112	117	PF00069	0.509
MOD_NEK2_1	185	190	PF00069	0.432
MOD_NEK2_1	197	202	PF00069	0.536
MOD_NEK2_1	285	290	PF00069	0.476
MOD_NEK2_1	323	328	PF00069	0.423
MOD_NEK2_1	399	404	PF00069	0.406
MOD_NEK2_1	429	434	PF00069	0.432
MOD_NEK2_1	606	611	PF00069	0.484
MOD_NEK2_1	657	662	PF00069	0.561
MOD_NEK2_1	676	681	PF00069	0.499
MOD_NEK2_1	86	91	PF00069	0.424
MOD_NEK2_2	227	232	PF00069	0.649
MOD_PIKK_1	210	216	PF00454	0.602
MOD_PIKK_1	259	265	PF00454	0.443
MOD_PIKK_1	585	591	PF00454	0.631
MOD_PKA_1	125	131	PF00069	0.396
MOD_PKA_1	175	181	PF00069	0.453
MOD_PKA_2	125	131	PF00069	0.396
MOD_PKA_2	197	203	PF00069	0.555
MOD_PKA_2	231	237	PF00069	0.556
MOD_PKA_2	251	257	PF00069	0.531
MOD_PKA_2	376	382	PF00069	0.407
MOD_PKA_2	38	44	PF00069	0.489
MOD_PKA_2	566	572	PF00069	0.605
MOD_PKA_2	585	591	PF00069	0.643
MOD_PKA_2	606	612	PF00069	0.488
MOD_PKA_2	766	772	PF00069	0.553
MOD_PKA_2	782	788	PF00069	0.671
MOD_PKB_1	173	181	PF00069	0.448
MOD_PKB_1	239	247	PF00069	0.507
MOD_Plk_1	116	122	PF00069	0.413
MOD_Plk_1	419	425	PF00069	0.566
MOD_Plk_1	442	448	PF00069	0.454
MOD_Plk_1	478	484	PF00069	0.390
MOD_Plk_1	624	630	PF00069	0.488
MOD_Plk_1	81	87	PF00069	0.410
MOD_Plk_2-3	308	314	PF00069	0.429
MOD_Plk_2-3	625	631	PF00069	0.481
MOD_Plk_4	116	122	PF00069	0.375
MOD_Plk_4	145	151	PF00069	0.360
MOD_Plk_4	180	186	PF00069	0.312
MOD_Plk_4	197	203	PF00069	0.434
MOD_Plk_4	251	257	PF00069	0.412
MOD_Plk_4	263	269	PF00069	0.366
MOD_Plk_4	308	314	PF00069	0.336
MOD_Plk_4	319	325	PF00069	0.331
MOD_Plk_4	38	44	PF00069	0.510
MOD_Plk_4	393	399	PF00069	0.357
MOD_Plk_4	406	412	PF00069	0.411
MOD_Plk_4	429	435	PF00069	0.416
MOD_Plk_4	478	484	PF00069	0.473
MOD_Plk_4	747	753	PF00069	0.536
MOD_Plk_4	81	87	PF00069	0.402
MOD_ProDKin_1	212	218	PF00069	0.566
MOD_ProDKin_1	274	280	PF00069	0.528
MOD_ProDKin_1	44	50	PF00069	0.511
MOD_ProDKin_1	62	68	PF00069	0.379
MOD_ProDKin_1	662	668	PF00069	0.597
MOD_SUMO_rev_2	807	817	PF00179	0.571
TRG_DiLeu_BaEn_1	308	313	PF01217	0.426
TRG_DiLeu_BaEn_1	813	818	PF01217	0.526
TRG_DiLeu_BaEn_1	82	87	PF01217	0.409
TRG_DiLeu_BaEn_4	805	811	PF01217	0.558
TRG_ENDOCYTIC_2	321	324	PF00928	0.426
TRG_ENDOCYTIC_2	335	338	PF00928	0.452
TRG_ENDOCYTIC_2	482	485	PF00928	0.426
TRG_ENDOCYTIC_2	642	645	PF00928	0.467
TRG_ENDOCYTIC_2	685	688	PF00928	0.488
TRG_ENDOCYTIC_2	743	746	PF00928	0.505
TRG_ENDOCYTIC_2	768	771	PF00928	0.554
TRG_ER_diArg_1	125	127	PF00400	0.468
TRG_ER_diArg_1	238	241	PF00400	0.609
TRG_ER_diArg_1	370	372	PF00400	0.441
TRG_ER_diArg_1	6	8	PF00400	0.634
TRG_ER_diArg_1	606	608	PF00400	0.509
TRG_NES_CRM1_1	644	655	PF08389	0.397
TRG_Pf-PMV_PEXEL_1	808	812	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B8	Leptomonas seymouri	69%	100%
A0A0S4IRE8	Bodo saltans	31%	100%
A0A3Q8IDY2	Leishmania donovani	98%	100%
A4HGT3	Leishmania braziliensis	85%	100%
A4I3W0	Leishmania infantum	98%	100%
D0A928	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B050	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P56287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%