Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q834_LEIMA

TriTrypDb:

LmjF.28.2300 , LMJLV39_280031100 , LMJSD75_280030700

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q834

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q834

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.595
CLV_MEL_PAP_1	120	126	PF00089	0.482
CLV_NRD_NRD_1	128	130	PF00675	0.447
CLV_NRD_NRD_1	167	169	PF00675	0.650
CLV_NRD_NRD_1	181	183	PF00675	0.426
CLV_NRD_NRD_1	282	284	PF00675	0.617
CLV_NRD_NRD_1	354	356	PF00675	0.641
CLV_NRD_NRD_1	454	456	PF00675	0.688
CLV_NRD_NRD_1	544	546	PF00675	0.383
CLV_NRD_NRD_1	565	567	PF00675	0.460
CLV_NRD_NRD_1	85	87	PF00675	0.453
CLV_PCSK_FUR_1	352	356	PF00082	0.628
CLV_PCSK_KEX2_1	128	130	PF00082	0.450
CLV_PCSK_KEX2_1	167	169	PF00082	0.650
CLV_PCSK_KEX2_1	181	183	PF00082	0.426
CLV_PCSK_KEX2_1	282	284	PF00082	0.615
CLV_PCSK_KEX2_1	354	356	PF00082	0.619
CLV_PCSK_KEX2_1	453	455	PF00082	0.706
CLV_PCSK_KEX2_1	544	546	PF00082	0.383
CLV_PCSK_KEX2_1	565	567	PF00082	0.460
CLV_PCSK_KEX2_1	85	87	PF00082	0.453
CLV_PCSK_PC7_1	450	456	PF00082	0.671
CLV_PCSK_PC7_1	540	546	PF00082	0.375
CLV_PCSK_SKI1_1	595	599	PF00082	0.584
CLV_PCSK_SKI1_1	86	90	PF00082	0.450
DEG_APCC_DBOX_1	594	602	PF00400	0.578
DEG_APCC_DBOX_1	84	92	PF00400	0.449
DEG_APCC_KENBOX_2	239	243	PF00400	0.591
DEG_SPOP_SBC_1	14	18	PF00917	0.581
DOC_ANK_TNKS_1	513	520	PF00023	0.648
DOC_PP2B_LxvP_1	510	513	PF13499	0.721
DOC_USP7_MATH_1	122	126	PF00917	0.525
DOC_USP7_MATH_1	14	18	PF00917	0.502
DOC_USP7_MATH_1	235	239	PF00917	0.670
DOC_USP7_MATH_1	263	267	PF00917	0.702
DOC_USP7_MATH_1	28	32	PF00917	0.508
DOC_USP7_MATH_1	370	374	PF00917	0.611
DOC_USP7_MATH_1	443	447	PF00917	0.615
DOC_USP7_MATH_1	480	484	PF00917	0.757
DOC_USP7_MATH_1	490	494	PF00917	0.823
DOC_USP7_MATH_1	498	502	PF00917	0.629
DOC_WW_Pin1_4	253	258	PF00397	0.601
DOC_WW_Pin1_4	276	281	PF00397	0.614
DOC_WW_Pin1_4	29	34	PF00397	0.701
DOC_WW_Pin1_4	296	301	PF00397	0.610
DOC_WW_Pin1_4	302	307	PF00397	0.550
DOC_WW_Pin1_4	346	351	PF00397	0.716
DOC_WW_Pin1_4	377	382	PF00397	0.721
DOC_WW_Pin1_4	393	398	PF00397	0.524
DOC_WW_Pin1_4	407	412	PF00397	0.583
DOC_WW_Pin1_4	439	444	PF00397	0.773
DOC_WW_Pin1_4	455	460	PF00397	0.579
DOC_WW_Pin1_4	465	470	PF00397	0.599
LIG_14-3-3_CanoR_1	143	152	PF00244	0.459
LIG_14-3-3_CanoR_1	181	185	PF00244	0.632
LIG_14-3-3_CanoR_1	197	202	PF00244	0.595
LIG_14-3-3_CanoR_1	250	254	PF00244	0.684
LIG_14-3-3_CanoR_1	264	268	PF00244	0.544
LIG_14-3-3_CanoR_1	302	306	PF00244	0.581
LIG_14-3-3_CanoR_1	530	539	PF00244	0.605
LIG_Actin_WH2_2	191	208	PF00022	0.525
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BRCT_BRCA1_1	15	19	PF00533	0.525
LIG_BRCT_BRCA1_1	463	467	PF00533	0.745
LIG_CtBP_PxDLS_1	50	54	PF00389	0.595
LIG_DLG_GKlike_1	197	205	PF00625	0.595
LIG_EH1_1	308	316	PF00400	0.650
LIG_FHA_1	306	312	PF00498	0.549
LIG_FHA_1	58	64	PF00498	0.411
LIG_FHA_1	87	93	PF00498	0.470
LIG_FHA_2	145	151	PF00498	0.492
LIG_FHA_2	435	441	PF00498	0.593
LIG_FHA_2	469	475	PF00498	0.656
LIG_LIR_Apic_2	35	40	PF02991	0.584
LIG_LIR_Gen_1	161	171	PF02991	0.583
LIG_LIR_Gen_1	266	274	PF02991	0.559
LIG_LIR_Gen_1	609	619	PF02991	0.541
LIG_LIR_Nem_3	161	166	PF02991	0.576
LIG_LIR_Nem_3	384	390	PF02991	0.637
LIG_LIR_Nem_3	609	615	PF02991	0.420
LIG_RPA_C_Fungi	97	109	PF08784	0.534
LIG_SH2_CRK	330	334	PF00017	0.682
LIG_SH2_CRK	37	41	PF00017	0.597
LIG_SH2_CRK	70	74	PF00017	0.449
LIG_SH2_NCK_1	37	41	PF00017	0.581
LIG_SH2_STAP1	612	616	PF00017	0.541
LIG_SH2_STAT5	267	270	PF00017	0.554
LIG_SH2_STAT5	323	326	PF00017	0.562
LIG_SH2_STAT5	607	610	PF00017	0.424
LIG_SH3_1	360	366	PF00018	0.683
LIG_SH3_2	509	514	PF14604	0.674
LIG_SH3_3	241	247	PF00018	0.657
LIG_SH3_3	288	294	PF00018	0.591
LIG_SH3_3	360	366	PF00018	0.726
LIG_SH3_3	456	462	PF00018	0.672
LIG_SH3_3	483	489	PF00018	0.786
LIG_SH3_3	505	511	PF00018	0.791
LIG_SH3_5	33	37	PF00018	0.522
LIG_SH3_CIN85_PxpxPR_1	509	514	PF14604	0.642
LIG_SUMO_SIM_anti_2	613	621	PF11976	0.487
LIG_SUMO_SIM_par_1	47	54	PF11976	0.610
LIG_TRAF2_1	176	179	PF00917	0.594
LIG_TRAF2_1	45	48	PF00917	0.504
LIG_TYR_ITIM	328	333	PF00017	0.677
LIG_TYR_ITIM	68	73	PF00017	0.532
LIG_UBA3_1	567	574	PF00899	0.439
LIG_WW_3	380	384	PF00397	0.608
LIG_WW_3	511	515	PF00397	0.660
MOD_CDC14_SPxK_1	279	282	PF00782	0.614
MOD_CDC14_SPxK_1	299	302	PF00782	0.691
MOD_CDC14_SPxK_1	349	352	PF00782	0.675
MOD_CDK_SPK_2	465	470	PF00069	0.711
MOD_CDK_SPxK_1	276	282	PF00069	0.613
MOD_CDK_SPxK_1	296	302	PF00069	0.695
MOD_CDK_SPxK_1	346	352	PF00069	0.680
MOD_CDK_SPxK_1	377	383	PF00069	0.640
MOD_CDK_SPxxK_3	276	283	PF00069	0.593
MOD_CDK_SPxxK_3	441	448	PF00069	0.725
MOD_CDK_SPxxK_3	465	472	PF00069	0.604
MOD_CK1_1	17	23	PF00069	0.516
MOD_CK1_1	193	199	PF00069	0.396
MOD_CK1_1	248	254	PF00069	0.616
MOD_CK1_1	305	311	PF00069	0.662
MOD_CK1_1	32	38	PF00069	0.479
MOD_CK1_1	400	406	PF00069	0.656
MOD_CK1_1	419	425	PF00069	0.658
MOD_CK1_1	441	447	PF00069	0.702
MOD_CK1_1	468	474	PF00069	0.633
MOD_CK1_1	493	499	PF00069	0.755
MOD_CK1_1	8	14	PF00069	0.512
MOD_CK2_1	173	179	PF00069	0.600
MOD_CK2_1	235	241	PF00069	0.684
MOD_CK2_1	42	48	PF00069	0.546
MOD_CK2_1	434	440	PF00069	0.570
MOD_CK2_1	468	474	PF00069	0.652
MOD_CK2_1	51	57	PF00069	0.483
MOD_DYRK1A_RPxSP_1	302	306	PF00069	0.571
MOD_GlcNHglycan	1	4	PF01048	0.717
MOD_GlcNHglycan	20	23	PF01048	0.483
MOD_GlcNHglycan	230	233	PF01048	0.641
MOD_GlcNHglycan	291	294	PF01048	0.633
MOD_GlcNHglycan	377	380	PF01048	0.591
MOD_GlcNHglycan	426	429	PF01048	0.674
MOD_GlcNHglycan	434	437	PF01048	0.636
MOD_GlcNHglycan	445	448	PF01048	0.556
MOD_GlcNHglycan	482	485	PF01048	0.723
MOD_GlcNHglycan	7	10	PF01048	0.625
MOD_GSK3_1	13	20	PF00069	0.626
MOD_GSK3_1	193	200	PF00069	0.525
MOD_GSK3_1	24	31	PF00069	0.731
MOD_GSK3_1	245	252	PF00069	0.620
MOD_GSK3_1	253	260	PF00069	0.529
MOD_GSK3_1	301	308	PF00069	0.581
MOD_GSK3_1	371	378	PF00069	0.652
MOD_GSK3_1	393	400	PF00069	0.615
MOD_GSK3_1	401	408	PF00069	0.654
MOD_GSK3_1	410	417	PF00069	0.738
MOD_GSK3_1	418	425	PF00069	0.603
MOD_GSK3_1	434	441	PF00069	0.536
MOD_GSK3_1	461	468	PF00069	0.642
MOD_GSK3_1	493	500	PF00069	0.725
MOD_GSK3_1	554	561	PF00069	0.467
MOD_LATS_1	84	90	PF00433	0.451
MOD_N-GLC_1	525	530	PF02516	0.557
MOD_NEK2_1	110	115	PF00069	0.452
MOD_NEK2_1	152	157	PF00069	0.588
MOD_NEK2_1	375	380	PF00069	0.560
MOD_NEK2_1	399	404	PF00069	0.632
MOD_NEK2_1	51	56	PF00069	0.569
MOD_NEK2_1	525	530	PF00069	0.579
MOD_NEK2_2	434	439	PF00069	0.551
MOD_PIKK_1	257	263	PF00454	0.559
MOD_PIKK_1	558	564	PF00454	0.449
MOD_PIKK_1	86	92	PF00454	0.447
MOD_PKA_1	245	251	PF00069	0.542
MOD_PKA_2	122	128	PF00069	0.528
MOD_PKA_2	142	148	PF00069	0.643
MOD_PKA_2	180	186	PF00069	0.595
MOD_PKA_2	249	255	PF00069	0.617
MOD_PKA_2	263	269	PF00069	0.560
MOD_PKA_2	301	307	PF00069	0.569
MOD_PKA_2	57	63	PF00069	0.446
MOD_PKB_1	195	203	PF00069	0.591
MOD_Plk_1	152	158	PF00069	0.603
MOD_Plk_1	86	92	PF00069	0.447
MOD_Plk_2-3	42	48	PF00069	0.591
MOD_Plk_4	8	14	PF00069	0.641
MOD_ProDKin_1	253	259	PF00069	0.599
MOD_ProDKin_1	276	282	PF00069	0.616
MOD_ProDKin_1	29	35	PF00069	0.699
MOD_ProDKin_1	296	302	PF00069	0.612
MOD_ProDKin_1	346	352	PF00069	0.716
MOD_ProDKin_1	377	383	PF00069	0.725
MOD_ProDKin_1	393	399	PF00069	0.524
MOD_ProDKin_1	407	413	PF00069	0.580
MOD_ProDKin_1	439	445	PF00069	0.772
MOD_ProDKin_1	455	461	PF00069	0.578
MOD_ProDKin_1	465	471	PF00069	0.600
MOD_SUMO_rev_2	570	576	PF00179	0.536
TRG_DiLeu_BaEn_1	87	92	PF01217	0.500
TRG_DiLeu_BaEn_4	161	167	PF01217	0.580
TRG_ENDOCYTIC_2	267	270	PF00928	0.554
TRG_ENDOCYTIC_2	330	333	PF00928	0.681
TRG_ENDOCYTIC_2	387	390	PF00928	0.657
TRG_ENDOCYTIC_2	612	615	PF00928	0.442
TRG_ENDOCYTIC_2	70	73	PF00928	0.444
TRG_ER_diArg_1	128	131	PF00400	0.545
TRG_ER_diArg_1	166	168	PF00400	0.615
TRG_ER_diArg_1	194	197	PF00400	0.502
TRG_ER_diArg_1	324	327	PF00400	0.562
TRG_ER_diArg_1	351	354	PF00400	0.622
TRG_ER_diArg_1	360	363	PF00400	0.587
TRG_ER_diArg_1	453	455	PF00400	0.703
TRG_ER_diArg_1	462	465	PF00400	0.583
TRG_ER_diArg_1	469	472	PF00400	0.556
TRG_ER_diArg_1	543	545	PF00400	0.388
TRG_ER_diArg_1	564	566	PF00400	0.462
TRG_ER_diArg_1	592	595	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	530	535	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	565	570	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD1	Leptomonas seymouri	46%	100%
A0A3S7X1S1	Leishmania donovani	89%	96%
A4HGT4	Leishmania braziliensis	71%	97%
A4I3W1	Leishmania infantum	90%	100%
E9B051	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%