CactinC_cactus domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cactus-binding C-terminus of cactin protein, putative

Species:

Leishmania major

UniProt:

Q4Q831_LEIMA

TriTrypDb:

LmjF.28.2330 , LMJLV39_280031400 , LMJSD75_280031000

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005681	spliceosomal complex	3	2
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q831

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q831

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045292	mRNA cis splicing, via spliceosome	9	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.714
CLV_NRD_NRD_1	11	13	PF00675	0.439
CLV_NRD_NRD_1	211	213	PF00675	0.636
CLV_NRD_NRD_1	75	77	PF00675	0.486
CLV_NRD_NRD_1	854	856	PF00675	0.279
CLV_NRD_NRD_1	862	864	PF00675	0.275
CLV_PCSK_FUR_1	9	13	PF00082	0.438
CLV_PCSK_KEX2_1	11	13	PF00082	0.439
CLV_PCSK_KEX2_1	209	211	PF00082	0.619
CLV_PCSK_KEX2_1	75	77	PF00082	0.486
CLV_PCSK_KEX2_1	816	818	PF00082	0.277
CLV_PCSK_KEX2_1	862	864	PF00082	0.320
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.619
CLV_PCSK_PC1ET2_1	816	818	PF00082	0.277
CLV_PCSK_PC7_1	205	211	PF00082	0.735
CLV_PCSK_PC7_1	7	13	PF00082	0.437
CLV_PCSK_SKI1_1	263	267	PF00082	0.494
CLV_PCSK_SKI1_1	349	353	PF00082	0.404
CLV_PCSK_SKI1_1	464	468	PF00082	0.582
CLV_PCSK_SKI1_1	820	824	PF00082	0.320
CLV_PCSK_SKI1_1	877	881	PF00082	0.277
DEG_APCC_DBOX_1	463	471	PF00400	0.583
DEG_APCC_DBOX_1	6	14	PF00400	0.433
DEG_Nend_UBRbox_1	1	4	PF02207	0.468
DEG_SPOP_SBC_1	252	256	PF00917	0.668
DEG_SPOP_SBC_1	298	302	PF00917	0.455
DEG_SPOP_SBC_1	581	585	PF00917	0.690
DEG_SPOP_SBC_1	740	744	PF00917	0.602
DOC_CYCLIN_yClb5_NLxxxL_5	655	664	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	807	813	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.461
DOC_MAPK_gen_1	138	147	PF00069	0.431
DOC_MAPK_gen_1	189	196	PF00069	0.435
DOC_MAPK_gen_1	263	273	PF00069	0.451
DOC_MAPK_gen_1	461	470	PF00069	0.526
DOC_MAPK_gen_1	7	15	PF00069	0.439
DOC_MAPK_gen_1	75	83	PF00069	0.434
DOC_MAPK_gen_1	862	870	PF00069	0.520
DOC_MAPK_MEF2A_6	141	149	PF00069	0.414
DOC_MAPK_MEF2A_6	189	196	PF00069	0.435
DOC_MAPK_MEF2A_6	263	272	PF00069	0.455
DOC_MAPK_MEF2A_6	461	470	PF00069	0.586
DOC_MAPK_MEF2A_6	862	870	PF00069	0.520
DOC_PP1_RVXF_1	865	871	PF00149	0.495
DOC_PP1_RVXF_1	875	881	PF00149	0.453
DOC_PP2B_LxvP_1	103	106	PF13499	0.473
DOC_PP2B_LxvP_1	57	60	PF13499	0.444
DOC_PP2B_LxvP_1	682	685	PF13499	0.695
DOC_PP4_FxxP_1	109	112	PF00568	0.470
DOC_PP4_FxxP_1	456	459	PF00568	0.599
DOC_PP4_FxxP_1	89	92	PF00568	0.414
DOC_USP7_MATH_1	252	256	PF00917	0.637
DOC_USP7_MATH_1	579	583	PF00917	0.680
DOC_USP7_MATH_1	739	743	PF00917	0.671
DOC_USP7_MATH_2	494	500	PF00917	0.646
DOC_WW_Pin1_4	2	7	PF00397	0.442
DOC_WW_Pin1_4	412	417	PF00397	0.669
DOC_WW_Pin1_4	490	495	PF00397	0.686
DOC_WW_Pin1_4	582	587	PF00397	0.721
DOC_WW_Pin1_4	595	600	PF00397	0.607
DOC_WW_Pin1_4	646	651	PF00397	0.488
DOC_WW_Pin1_4	67	72	PF00397	0.459
DOC_WW_Pin1_4	825	830	PF00397	0.556
LIG_14-3-3_CanoR_1	111	117	PF00244	0.426
LIG_14-3-3_CanoR_1	12	22	PF00244	0.435
LIG_14-3-3_CanoR_1	227	234	PF00244	0.444
LIG_14-3-3_CanoR_1	67	71	PF00244	0.466
LIG_14-3-3_CanoR_1	76	82	PF00244	0.423
LIG_14-3-3_CanoR_1	867	871	PF00244	0.477
LIG_14-3-3_CanoR_1	93	101	PF00244	0.420
LIG_BRCT_BRCA1_1	79	83	PF00533	0.445
LIG_BRCT_BRCA1_1	97	101	PF00533	0.453
LIG_CtBP_PxDLS_1	650	654	PF00389	0.492
LIG_deltaCOP1_diTrp_1	434	442	PF00928	0.439
LIG_deltaCOP1_diTrp_1	800	808	PF00928	0.520
LIG_eIF4E_1	462	468	PF01652	0.580
LIG_eIF4E_1	560	566	PF01652	0.596
LIG_eIF4E_1	873	879	PF01652	0.556
LIG_FHA_1	17	23	PF00498	0.432
LIG_FHA_1	298	304	PF00498	0.430
LIG_FHA_1	490	496	PF00498	0.590
LIG_FHA_2	197	203	PF00498	0.704
LIG_FHA_2	211	217	PF00498	0.560
LIG_FHA_2	329	335	PF00498	0.505
LIG_FHA_2	336	342	PF00498	0.484
LIG_FHA_2	360	366	PF00498	0.637
LIG_FHA_2	491	497	PF00498	0.680
LIG_FHA_2	537	543	PF00498	0.755
LIG_FHA_2	647	653	PF00498	0.546
LIG_FHA_2	711	717	PF00498	0.551
LIG_FHA_2	785	791	PF00498	0.477
LIG_FHA_2	813	819	PF00498	0.477
LIG_Integrin_RGD_1	363	365	PF01839	0.659
LIG_LIR_Apic_2	108	113	PF02991	0.429
LIG_LIR_Apic_2	202	206	PF02991	0.733
LIG_LIR_Gen_1	142	152	PF02991	0.410
LIG_LIR_Gen_1	391	401	PF02991	0.679
LIG_LIR_Gen_1	434	443	PF02991	0.438
LIG_LIR_Gen_1	700	707	PF02991	0.503
LIG_LIR_Gen_1	804	813	PF02991	0.477
LIG_LIR_Gen_1	834	843	PF02991	0.477
LIG_LIR_Nem_3	142	147	PF02991	0.415
LIG_LIR_Nem_3	391	397	PF02991	0.675
LIG_LIR_Nem_3	434	439	PF02991	0.447
LIG_LIR_Nem_3	620	626	PF02991	0.451
LIG_LIR_Nem_3	700	706	PF02991	0.506
LIG_LIR_Nem_3	780	784	PF02991	0.477
LIG_LIR_Nem_3	799	805	PF02991	0.477
LIG_LIR_Nem_3	80	86	PF02991	0.444
LIG_LIR_Nem_3	806	812	PF02991	0.477
LIG_LIR_Nem_3	834	839	PF02991	0.477
LIG_LIR_Nem_3	869	873	PF02991	0.533
LIG_LYPXL_S_1	808	812	PF13949	0.277
LIG_LYPXL_yS_3	809	812	PF13949	0.477
LIG_NRBOX	221	227	PF00104	0.471
LIG_NRBOX	465	471	PF00104	0.524
LIG_NRP_CendR_1	888	889	PF00754	0.277
LIG_PTB_Apo_2	881	888	PF02174	0.477
LIG_PTB_Phospho_1	881	887	PF10480	0.477
LIG_REV1ctd_RIR_1	107	111	PF16727	0.435
LIG_REV1ctd_RIR_1	877	885	PF16727	0.477
LIG_RPA_C_Fungi	624	636	PF08784	0.488
LIG_SH2_CRK	152	156	PF00017	0.458
LIG_SH2_CRK	394	398	PF00017	0.652
LIG_SH2_CRK	623	627	PF00017	0.441
LIG_SH2_CRK	836	840	PF00017	0.320
LIG_SH2_NCK_1	152	156	PF00017	0.458
LIG_SH2_NCK_1	371	375	PF00017	0.668
LIG_SH2_NCK_1	847	851	PF00017	0.320
LIG_SH2_PTP2	148	151	PF00017	0.431
LIG_SH2_SRC	148	151	PF00017	0.431
LIG_SH2_SRC	371	374	PF00017	0.667
LIG_SH2_SRC	382	385	PF00017	0.591
LIG_SH2_SRC	847	850	PF00017	0.320
LIG_SH2_STAP1	462	466	PF00017	0.520
LIG_SH2_STAP1	703	707	PF00017	0.551
LIG_SH2_STAP1	803	807	PF00017	0.320
LIG_SH2_STAP1	847	851	PF00017	0.320
LIG_SH2_STAP1	97	101	PF00017	0.437
LIG_SH2_STAT5	116	119	PF00017	0.454
LIG_SH2_STAT5	148	151	PF00017	0.431
LIG_SH2_STAT5	279	282	PF00017	0.368
LIG_SH2_STAT5	696	699	PF00017	0.514
LIG_SH2_STAT5	729	732	PF00017	0.549
LIG_SH2_STAT5	836	839	PF00017	0.320
LIG_SH3_2	71	76	PF14604	0.438
LIG_SH3_3	303	309	PF00018	0.406
LIG_SH3_3	410	416	PF00018	0.650
LIG_SH3_3	52	58	PF00018	0.436
LIG_SH3_3	547	553	PF00018	0.660
LIG_SH3_3	573	579	PF00018	0.660
LIG_SH3_3	68	74	PF00018	0.437
LIG_SH3_3	682	688	PF00018	0.691
LIG_SH3_3	730	736	PF00018	0.654
LIG_SH3_3	826	832	PF00018	0.357
LIG_SH3_3	840	846	PF00018	0.260
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.415
LIG_SUMO_SIM_anti_2	465	471	PF11976	0.584
LIG_SUMO_SIM_par_1	568	573	PF11976	0.572
LIG_TRAF2_1	213	216	PF00917	0.558
LIG_TRAF2_1	398	401	PF00917	0.712
LIG_TRAF2_1	525	528	PF00917	0.583
LIG_TYR_ITIM	807	812	PF00017	0.320
LIG_WW_1	459	462	PF00397	0.604
LIG_WW_3	458	462	PF00397	0.597
LIG_WW_3	795	799	PF00397	0.320
MOD_CDC14_SPxK_1	73	76	PF00782	0.448
MOD_CDK_SPK_2	2	7	PF00069	0.442
MOD_CDK_SPK_2	70	75	PF00069	0.440
MOD_CDK_SPxK_1	70	76	PF00069	0.442
MOD_CDK_SPxxK_3	2	9	PF00069	0.440
MOD_CK1_1	16	22	PF00069	0.431
MOD_CK1_1	248	254	PF00069	0.678
MOD_CK1_1	395	401	PF00069	0.705
MOD_CK1_1	447	453	PF00069	0.476
MOD_CK1_1	49	55	PF00069	0.424
MOD_CK1_1	499	505	PF00069	0.738
MOD_CK1_1	582	588	PF00069	0.809
MOD_CK1_1	598	604	PF00069	0.607
MOD_CK1_1	646	652	PF00069	0.544
MOD_CK1_1	70	76	PF00069	0.442
MOD_CK1_1	744	750	PF00069	0.697
MOD_CK1_1	95	101	PF00069	0.431
MOD_CK2_1	210	216	PF00069	0.605
MOD_CK2_1	27	33	PF00069	0.467
MOD_CK2_1	298	304	PF00069	0.462
MOD_CK2_1	335	341	PF00069	0.509
MOD_CK2_1	395	401	PF00069	0.686
MOD_CK2_1	490	496	PF00069	0.685
MOD_CK2_1	522	528	PF00069	0.622
MOD_CK2_1	536	542	PF00069	0.751
MOD_CK2_1	646	652	PF00069	0.544
MOD_CK2_1	710	716	PF00069	0.550
MOD_Cter_Amidation	207	210	PF01082	0.737
MOD_DYRK1A_RPxSP_1	412	416	PF00069	0.732
MOD_GlcNHglycan	175	178	PF01048	0.543
MOD_GlcNHglycan	206	209	PF01048	0.709
MOD_GlcNHglycan	255	258	PF01048	0.685
MOD_GlcNHglycan	449	452	PF01048	0.523
MOD_GlcNHglycan	502	505	PF01048	0.695
MOD_GlcNHglycan	562	565	PF01048	0.595
MOD_GlcNHglycan	590	593	PF01048	0.697
MOD_GlcNHglycan	600	603	PF01048	0.640
MOD_GlcNHglycan	607	610	PF01048	0.482
MOD_GlcNHglycan	645	648	PF01048	0.532
MOD_GlcNHglycan	678	681	PF01048	0.682
MOD_GlcNHglycan	756	759	PF01048	0.755
MOD_GlcNHglycan	94	97	PF01048	0.467
MOD_GSK3_1	13	20	PF00069	0.434
MOD_GSK3_1	136	143	PF00069	0.454
MOD_GSK3_1	156	163	PF00069	0.500
MOD_GSK3_1	164	171	PF00069	0.542
MOD_GSK3_1	173	180	PF00069	0.504
MOD_GSK3_1	248	255	PF00069	0.677
MOD_GSK3_1	310	317	PF00069	0.571
MOD_GSK3_1	496	503	PF00069	0.703
MOD_GSK3_1	577	584	PF00069	0.737
MOD_GSK3_1	594	601	PF00069	0.581
MOD_GSK3_1	66	73	PF00069	0.509
MOD_GSK3_1	740	747	PF00069	0.709
MOD_GSK3_1	784	791	PF00069	0.380
MOD_N-GLC_1	49	54	PF02516	0.429
MOD_N-GLC_1	744	749	PF02516	0.751
MOD_N-GLC_1	784	789	PF02516	0.320
MOD_NEK2_1	226	231	PF00069	0.410
MOD_NEK2_1	253	258	PF00069	0.649
MOD_NEK2_1	280	285	PF00069	0.414
MOD_NEK2_1	322	327	PF00069	0.425
MOD_NEK2_1	425	430	PF00069	0.427
MOD_NEK2_1	442	447	PF00069	0.400
MOD_NEK2_1	500	505	PF00069	0.679
MOD_NEK2_1	570	575	PF00069	0.602
MOD_NEK2_1	77	82	PF00069	0.447
MOD_NEK2_1	779	784	PF00069	0.380
MOD_NEK2_1	812	817	PF00069	0.320
MOD_NEK2_1	839	844	PF00069	0.320
MOD_NEK2_1	880	885	PF00069	0.380
MOD_NEK2_2	803	808	PF00069	0.320
MOD_PIKK_1	158	164	PF00454	0.533
MOD_PIKK_1	166	172	PF00454	0.546
MOD_PIKK_1	245	251	PF00454	0.679
MOD_PIKK_1	49	55	PF00454	0.424
MOD_PIKK_1	779	785	PF00454	0.320
MOD_PKA_1	210	216	PF00069	0.605
MOD_PKA_2	124	130	PF00069	0.468
MOD_PKA_2	140	146	PF00069	0.422
MOD_PKA_2	156	162	PF00069	0.499
MOD_PKA_2	172	178	PF00069	0.516
MOD_PKA_2	204	210	PF00069	0.707
MOD_PKA_2	226	232	PF00069	0.452
MOD_PKA_2	395	401	PF00069	0.694
MOD_PKA_2	643	649	PF00069	0.523
MOD_PKA_2	66	72	PF00069	0.463
MOD_PKA_2	866	872	PF00069	0.320
MOD_PKA_2	880	886	PF00069	0.319
MOD_PKA_2	92	98	PF00069	0.427
MOD_Plk_1	49	55	PF00069	0.424
MOD_Plk_1	513	519	PF00069	0.559
MOD_Plk_1	651	657	PF00069	0.504
MOD_Plk_1	784	790	PF00069	0.320
MOD_Plk_1	803	809	PF00069	0.319
MOD_Plk_2-3	536	542	PF00069	0.703
MOD_Plk_4	105	111	PF00069	0.430
MOD_Plk_4	112	118	PF00069	0.423
MOD_Plk_4	140	146	PF00069	0.428
MOD_Plk_4	17	23	PF00069	0.432
MOD_Plk_4	322	328	PF00069	0.439
MOD_ProDKin_1	2	8	PF00069	0.440
MOD_ProDKin_1	412	418	PF00069	0.662
MOD_ProDKin_1	490	496	PF00069	0.687
MOD_ProDKin_1	582	588	PF00069	0.721
MOD_ProDKin_1	595	601	PF00069	0.604
MOD_ProDKin_1	646	652	PF00069	0.495
MOD_ProDKin_1	67	73	PF00069	0.460
MOD_ProDKin_1	825	831	PF00069	0.430
MOD_SUMO_for_1	509	512	PF00179	0.681
MOD_SUMO_for_1	517	520	PF00179	0.718
TRG_DiLeu_BaEn_1	463	468	PF01217	0.578
TRG_DiLeu_BaEn_2	340	346	PF01217	0.460
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.437
TRG_ENDOCYTIC_2	144	147	PF00928	0.436
TRG_ENDOCYTIC_2	148	151	PF00928	0.428
TRG_ENDOCYTIC_2	152	155	PF00928	0.445
TRG_ENDOCYTIC_2	394	397	PF00928	0.707
TRG_ENDOCYTIC_2	623	626	PF00928	0.439
TRG_ENDOCYTIC_2	627	630	PF00928	0.423
TRG_ENDOCYTIC_2	703	706	PF00928	0.556
TRG_ENDOCYTIC_2	809	812	PF00928	0.320
TRG_ENDOCYTIC_2	836	839	PF00928	0.320
TRG_ENDOCYTIC_2	847	850	PF00928	0.320
TRG_ENDOCYTIC_2	876	879	PF00928	0.320
TRG_ER_diArg_1	10	12	PF00400	0.434
TRG_ER_diArg_1	189	192	PF00400	0.426
TRG_ER_diArg_1	210	212	PF00400	0.668
TRG_ER_diArg_1	236	239	PF00400	0.445
TRG_ER_diArg_1	6	9	PF00400	0.426
TRG_ER_diArg_1	74	76	PF00400	0.472
TRG_ER_diArg_1	852	855	PF00400	0.380
TRG_ER_diArg_1	887	889	PF00400	0.320
TRG_NLS_MonoCore_2	208	213	PF00514	0.662
TRG_NLS_MonoExtC_3	208	214	PF00514	0.588
TRG_NLS_MonoExtC_3	854	860	PF00514	0.380
TRG_NLS_MonoExtN_4	206	213	PF00514	0.717
TRG_NLS_MonoExtN_4	853	859	PF00514	0.380
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	554	558	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P4	Leptomonas seymouri	62%	100%
A0A1X0NRC2	Trypanosomatidae	37%	100%
A0A3S7X1V8	Leishmania donovani	95%	100%
A4HGT7	Leishmania braziliensis	78%	100%
A4I3W4	Leishmania infantum	95%	100%
E9B054	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%