Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q830_LEIMA

TriTrypDb:

LmjF.28.2350 , LMJLV39_280031500 , LMJSD75_280031100

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q830

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q830

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.547
CLV_NRD_NRD_1	256	258	PF00675	0.675
CLV_NRD_NRD_1	261	263	PF00675	0.621
CLV_NRD_NRD_1	38	40	PF00675	0.527
CLV_NRD_NRD_1	67	69	PF00675	0.608
CLV_PCSK_KEX2_1	132	134	PF00082	0.579
CLV_PCSK_KEX2_1	256	258	PF00082	0.739
CLV_PCSK_KEX2_1	67	69	PF00082	0.608
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.681
CLV_PCSK_PC7_1	252	258	PF00082	0.665
CLV_PCSK_SKI1_1	133	137	PF00082	0.580
CLV_PCSK_SKI1_1	153	157	PF00082	0.549
CLV_PCSK_SKI1_1	96	100	PF00082	0.510
DEG_APCC_DBOX_1	27	35	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_SPOP_SBC_1	221	225	PF00917	0.688
DOC_MAPK_DCC_7	3	11	PF00069	0.675
DOC_MAPK_gen_1	86	95	PF00069	0.587
DOC_MAPK_MEF2A_6	3	11	PF00069	0.642
DOC_PP1_RVXF_1	78	84	PF00149	0.706
DOC_PP4_FxxP_1	4	7	PF00568	0.639
DOC_SPAK_OSR1_1	3	7	PF12202	0.688
DOC_USP7_MATH_1	233	237	PF00917	0.704
DOC_USP7_MATH_1	242	246	PF00917	0.640
DOC_USP7_MATH_1	281	285	PF00917	0.729
DOC_USP7_UBL2_3	132	136	PF12436	0.660
DOC_USP7_UBL2_3	37	41	PF12436	0.543
DOC_WW_Pin1_4	180	185	PF00397	0.726
DOC_WW_Pin1_4	22	27	PF00397	0.519
LIG_14-3-3_CanoR_1	113	117	PF00244	0.547
LIG_14-3-3_CanoR_1	256	260	PF00244	0.740
LIG_14-3-3_CanoR_1	3	7	PF00244	0.627
LIG_14-3-3_CanoR_1	88	93	PF00244	0.594
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.671
LIG_CSL_BTD_1	181	184	PF09270	0.731
LIG_FHA_1	120	126	PF00498	0.562
LIG_FHA_1	141	147	PF00498	0.490
LIG_FHA_1	256	262	PF00498	0.722
LIG_FHA_1	267	273	PF00498	0.727
LIG_FHA_1	30	36	PF00498	0.542
LIG_FHA_1	68	74	PF00498	0.514
LIG_Integrin_RGD_1	192	194	PF01839	0.718
LIG_LIR_Apic_2	178	184	PF02991	0.701
LIG_LIR_Gen_1	103	111	PF02991	0.528
LIG_LIR_Nem_3	103	108	PF02991	0.446
LIG_LIR_Nem_3	48	53	PF02991	0.615
LIG_Pex14_1	150	154	PF04695	0.486
LIG_Pex14_2	131	135	PF04695	0.611
LIG_SH2_CRK	105	109	PF00017	0.626
LIG_SH2_NCK_1	105	109	PF00017	0.538
LIG_SH2_PTP2	154	157	PF00017	0.498
LIG_SH2_STAP1	176	180	PF00017	0.608
LIG_SH2_STAT5	111	114	PF00017	0.601
LIG_SH2_STAT5	154	157	PF00017	0.498
LIG_SH2_STAT5	45	48	PF00017	0.557
LIG_SH2_STAT5	72	75	PF00017	0.566
LIG_SUMO_SIM_par_1	32	38	PF11976	0.551
LIG_TRAF2_1	139	142	PF00917	0.562
LIG_TYR_ITIM	152	157	PF00017	0.496
LIG_UBA3_1	156	162	PF00899	0.554
LIG_UBA3_1	33	41	PF00899	0.538
MOD_CDK_SPxK_1	22	28	PF00069	0.512
MOD_CK1_1	119	125	PF00069	0.544
MOD_CK1_1	185	191	PF00069	0.650
MOD_CK1_1	223	229	PF00069	0.628
MOD_CK1_1	264	270	PF00069	0.738
MOD_CK1_1	273	279	PF00069	0.609
MOD_GlcNHglycan	225	228	PF01048	0.659
MOD_GlcNHglycan	230	233	PF01048	0.650
MOD_GlcNHglycan	237	240	PF01048	0.623
MOD_GlcNHglycan	249	252	PF01048	0.476
MOD_GSK3_1	100	107	PF00069	0.475
MOD_GSK3_1	112	119	PF00069	0.477
MOD_GSK3_1	120	127	PF00069	0.403
MOD_GSK3_1	219	226	PF00069	0.732
MOD_GSK3_1	228	235	PF00069	0.734
MOD_GSK3_1	266	273	PF00069	0.718
MOD_GSK3_1	84	91	PF00069	0.587
MOD_N-GLC_1	109	114	PF02516	0.566
MOD_N-GLC_1	88	93	PF02516	0.544
MOD_NEK2_1	100	105	PF00069	0.508
MOD_NEK2_1	120	125	PF00069	0.413
MOD_NEK2_1	2	7	PF00069	0.620
MOD_NEK2_1	220	225	PF00069	0.690
MOD_NEK2_1	255	260	PF00069	0.715
MOD_NEK2_1	29	34	PF00069	0.554
MOD_PIKK_1	100	106	PF00454	0.516
MOD_PIKK_1	261	267	PF00454	0.528
MOD_PKA_1	161	167	PF00069	0.581
MOD_PKA_1	67	73	PF00069	0.601
MOD_PKA_2	112	118	PF00069	0.544
MOD_PKA_2	2	8	PF00069	0.611
MOD_PKA_2	255	261	PF00069	0.693
MOD_PKA_2	67	73	PF00069	0.601
MOD_PKB_1	86	94	PF00069	0.556
MOD_Plk_1	109	115	PF00069	0.586
MOD_Plk_1	116	122	PF00069	0.521
MOD_Plk_1	140	146	PF00069	0.588
MOD_Plk_1	29	35	PF00069	0.553
MOD_Plk_1	88	94	PF00069	0.539
MOD_Plk_4	161	167	PF00069	0.595
MOD_Plk_4	29	35	PF00069	0.548
MOD_Plk_4	88	94	PF00069	0.539
MOD_ProDKin_1	180	186	PF00069	0.723
MOD_ProDKin_1	22	28	PF00069	0.520
MOD_SUMO_for_1	139	142	PF00179	0.640
MOD_SUMO_rev_2	264	272	PF00179	0.728
TRG_DiLeu_BaEn_1	30	35	PF01217	0.579
TRG_ENDOCYTIC_2	105	108	PF00928	0.662
TRG_ENDOCYTIC_2	111	114	PF00928	0.607
TRG_ENDOCYTIC_2	154	157	PF00928	0.482
TRG_ER_diArg_1	255	257	PF00400	0.672
TRG_ER_diArg_1	66	68	PF00400	0.631
TRG_NLS_MonoExtC_3	39	44	PF00514	0.538
TRG_NLS_MonoExtN_4	37	44	PF00514	0.533
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ2	Leptomonas seymouri	59%	100%
A0A0S4IRF0	Bodo saltans	43%	100%
A0A1X0NQP5	Trypanosomatidae	46%	100%
A0A3Q8IB55	Leishmania donovani	98%	100%
A4HGT8	Leishmania braziliensis	80%	100%
A4I3W5	Leishmania infantum	97%	100%
D0A933	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B055	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5D5Q3	Trypanosoma cruzi	49%	90%