LeishMANIAdb
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Serine hydroxymethyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine hydroxymethyltransferase
Gene product:
serine hydroxymethyltransferase (SHMT-L)
Species:
Leishmania major
UniProt:
Q4Q828_LEIMA
TriTrypDb:
LmjF.28.2370 * , LMJLV39_280031700 * , LMJSD75_280031300 *
Length:
474

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 2
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 3
GO:0005739 mitochondrion 5 2
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

Q4Q828
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q828

Function

Biological processes
TermNameLevelCount
GO:0006082 organic acid metabolic process 3 13
GO:0006520 amino acid metabolic process 3 13
GO:0006544 glycine metabolic process 6 13
GO:0006545 glycine biosynthetic process 7 13
GO:0006563 L-serine metabolic process 6 13
GO:0006565 L-serine catabolic process 5 3
GO:0006575 cellular modified amino acid metabolic process 3 13
GO:0006725 cellular aromatic compound metabolic process 3 13
GO:0006730 one-carbon metabolic process 3 13
GO:0006760 folic acid-containing compound metabolic process 4 13
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 13
GO:0004372 glycine hydroxymethyltransferase activity 5 13
GO:0005488 binding 1 13
GO:0008168 methyltransferase activity 4 10
GO:0008270 zinc ion binding 6 3
GO:0016597 amino acid binding 4 3
GO:0016740 transferase activity 2 13
GO:0016741 transferase activity, transferring one-carbon groups 3 13
GO:0016742 hydroxymethyl-, formyl- and related transferase activity 4 13
GO:0019842 vitamin binding 3 13
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 40 42 PF00675 0.231
CLV_NRD_NRD_1 410 412 PF00675 0.332
CLV_NRD_NRD_1 96 98 PF00675 0.292
CLV_PCSK_KEX2_1 156 158 PF00082 0.239
CLV_PCSK_KEX2_1 209 211 PF00082 0.211
CLV_PCSK_KEX2_1 40 42 PF00082 0.235
CLV_PCSK_KEX2_1 410 412 PF00082 0.308
CLV_PCSK_KEX2_1 96 98 PF00082 0.295
CLV_PCSK_PC1ET2_1 156 158 PF00082 0.304
CLV_PCSK_PC1ET2_1 209 211 PF00082 0.239
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HSI5 Leptomonas seymouri 60% 100%
A0A0N1I2Y4 Leptomonas seymouri 78% 99%
A0A0S4IKW4 Bodo saltans 58% 89%
A0A0S4IVF6 Bodo saltans 68% 100%
A0A0S4JPH2 Bodo saltans 58% 100%
A0A1X0NNF7 Trypanosomatidae 56% 100%
A0A1X0NSD5 Trypanosomatidae 69% 100%
A0A3Q8IA22 Leishmania donovani 59% 100%
A0A3Q8IF07 Leishmania donovani 96% 100%
A0ALM4 Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8) 47% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS