NTP_transferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q820_LEIMA

TriTrypDb:

LmjF.28.2440 , LMJLV39_280032500 , LMJSD75_280032100

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	2
GO:0032045	guanyl-nucleotide exchange factor complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2

Expansion

Sequence features

Q4Q820

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q820

Function

Biological processes
Term	Name	Level	Count
GO:0002183	cytoplasmic translational initiation	4	2
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2
GO:0009058	biosynthetic process	2	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003743	translation initiation factor activity	4	2
GO:0003824	catalytic activity	1	8
GO:0005085	guanyl-nucleotide exchange factor activity	3	2
GO:0005488	binding	1	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0045182	translation regulator activity	1	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2
GO:0140678	molecular function inhibitor activity	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.392
CLV_C14_Caspase3-7	450	454	PF00656	0.559
CLV_C14_Caspase3-7	589	593	PF00656	0.594
CLV_NRD_NRD_1	228	230	PF00675	0.650
CLV_NRD_NRD_1	292	294	PF00675	0.643
CLV_NRD_NRD_1	353	355	PF00675	0.443
CLV_NRD_NRD_1	390	392	PF00675	0.537
CLV_PCSK_KEX2_1	230	232	PF00082	0.726
CLV_PCSK_KEX2_1	292	294	PF00082	0.643
CLV_PCSK_KEX2_1	353	355	PF00082	0.443
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.726
CLV_PCSK_PC7_1	226	232	PF00082	0.655
CLV_PCSK_SKI1_1	110	114	PF00082	0.510
CLV_PCSK_SKI1_1	190	194	PF00082	0.406
CLV_PCSK_SKI1_1	33	37	PF00082	0.328
CLV_PCSK_SKI1_1	373	377	PF00082	0.496
CLV_PCSK_SKI1_1	392	396	PF00082	0.535
CLV_PCSK_SKI1_1	524	528	PF00082	0.676
CLV_PCSK_SKI1_1	57	61	PF00082	0.385
DEG_APCC_DBOX_1	372	380	PF00400	0.492
DEG_APCC_DBOX_1	523	531	PF00400	0.770
DEG_SCF_FBW7_2	48	53	PF00400	0.475
DEG_SPOP_SBC_1	285	289	PF00917	0.690
DOC_CKS1_1	413	418	PF01111	0.538
DOC_MAPK_gen_1	108	115	PF00069	0.578
DOC_MAPK_gen_1	353	359	PF00069	0.462
DOC_MAPK_gen_1	391	397	PF00069	0.538
DOC_MAPK_gen_1	419	426	PF00069	0.566
DOC_MAPK_MEF2A_6	131	140	PF00069	0.545
DOC_MAPK_MEF2A_6	341	348	PF00069	0.513
DOC_MAPK_MEF2A_6	419	426	PF00069	0.566
DOC_PP1_RVXF_1	39	46	PF00149	0.449
DOC_PP2B_LxvP_1	446	449	PF13499	0.629
DOC_PP4_FxxP_1	413	416	PF00568	0.472
DOC_PP4_FxxP_1	525	528	PF00568	0.752
DOC_USP7_MATH_1	122	126	PF00917	0.634
DOC_USP7_MATH_1	160	164	PF00917	0.811
DOC_USP7_MATH_1	255	259	PF00917	0.588
DOC_USP7_MATH_1	281	285	PF00917	0.684
DOC_USP7_MATH_1	286	290	PF00917	0.687
DOC_USP7_MATH_1	299	303	PF00917	0.623
DOC_USP7_MATH_1	305	309	PF00917	0.695
DOC_USP7_MATH_1	383	387	PF00917	0.523
DOC_USP7_MATH_1	491	495	PF00917	0.613
DOC_USP7_MATH_1	526	530	PF00917	0.758
DOC_USP7_MATH_1	555	559	PF00917	0.669
DOC_USP7_MATH_1	563	567	PF00917	0.589
DOC_USP7_MATH_1	633	637	PF00917	0.456
DOC_USP7_UBL2_3	104	108	PF12436	0.468
DOC_WW_Pin1_4	142	147	PF00397	0.761
DOC_WW_Pin1_4	310	315	PF00397	0.721
DOC_WW_Pin1_4	412	417	PF00397	0.543
DOC_WW_Pin1_4	46	51	PF00397	0.445
LIG_14-3-3_CanoR_1	182	189	PF00244	0.643
LIG_14-3-3_CanoR_1	212	218	PF00244	0.537
LIG_14-3-3_CanoR_1	318	327	PF00244	0.545
LIG_14-3-3_CanoR_1	345	349	PF00244	0.498
LIG_14-3-3_CanoR_1	471	476	PF00244	0.460
LIG_14-3-3_CanoR_1	617	624	PF00244	0.492
LIG_Actin_WH2_2	100	116	PF00022	0.536
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	74	78	PF00533	0.490
LIG_Clathr_ClatBox_1	201	205	PF01394	0.532
LIG_EVH1_2	596	600	PF00568	0.578
LIG_FHA_1	197	203	PF00498	0.542
LIG_FHA_1	219	225	PF00498	0.496
LIG_FHA_1	258	264	PF00498	0.605
LIG_FHA_1	269	275	PF00498	0.429
LIG_FHA_1	450	456	PF00498	0.531
LIG_FHA_1	47	53	PF00498	0.378
LIG_FHA_1	517	523	PF00498	0.734
LIG_FHA_1	600	606	PF00498	0.451
LIG_FHA_1	617	623	PF00498	0.353
LIG_FHA_1	640	646	PF00498	0.407
LIG_FHA_2	118	124	PF00498	0.646
LIG_FHA_2	26	32	PF00498	0.475
LIG_FHA_2	413	419	PF00498	0.535
LIG_FHA_2	458	464	PF00498	0.381
LIG_FHA_2	572	578	PF00498	0.635
LIG_FHA_2	96	102	PF00498	0.328
LIG_LIR_Apic_2	410	416	PF02991	0.500
LIG_LIR_Gen_1	211	222	PF02991	0.499
LIG_LIR_Gen_1	65	74	PF02991	0.382
LIG_LIR_Gen_1	82	92	PF02991	0.295
LIG_LIR_Nem_3	211	217	PF02991	0.517
LIG_LIR_Nem_3	479	484	PF02991	0.395
LIG_LIR_Nem_3	53	59	PF02991	0.366
LIG_LIR_Nem_3	65	70	PF02991	0.288
LIG_LIR_Nem_3	75	81	PF02991	0.363
LIG_LIR_Nem_3	82	88	PF02991	0.273
LIG_MAD2	651	659	PF02301	0.418
LIG_MYND_1	528	532	PF01753	0.750
LIG_Pex14_1	374	378	PF04695	0.405
LIG_Pex14_2	56	60	PF04695	0.449
LIG_SH2_CRK	214	218	PF00017	0.459
LIG_SH2_CRK	225	229	PF00017	0.462
LIG_SH2_CRK	481	485	PF00017	0.512
LIG_SH2_CRK	67	71	PF00017	0.344
LIG_SH2_GRB2like	334	337	PF00017	0.587
LIG_SH2_PTP2	85	88	PF00017	0.449
LIG_SH2_SRC	334	337	PF00017	0.531
LIG_SH2_STAP1	214	218	PF00017	0.518
LIG_SH2_STAP1	259	263	PF00017	0.479
LIG_SH2_STAT5	106	109	PF00017	0.394
LIG_SH2_STAT5	259	262	PF00017	0.493
LIG_SH2_STAT5	334	337	PF00017	0.511
LIG_SH2_STAT5	369	372	PF00017	0.344
LIG_SH2_STAT5	73	76	PF00017	0.344
LIG_SH2_STAT5	85	88	PF00017	0.344
LIG_SH3_3	566	572	PF00018	0.585
LIG_SH3_3	591	597	PF00018	0.614
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.427
LIG_SUMO_SIM_par_1	198	205	PF11976	0.505
LIG_SUMO_SIM_par_1	570	577	PF11976	0.606
LIG_TRAF2_1	267	270	PF00917	0.419
LIG_TRFH_1	85	89	PF08558	0.344
LIG_TYR_ITAM	211	228	PF00017	0.565
LIG_WRC_WIRS_1	206	211	PF05994	0.512
LIG_WRC_WIRS_1	587	592	PF05994	0.578
MOD_CDK_SPxxK_3	412	419	PF00069	0.540
MOD_CK1_1	147	153	PF00069	0.636
MOD_CK1_1	196	202	PF00069	0.372
MOD_CK1_1	2	8	PF00069	0.588
MOD_CK1_1	216	222	PF00069	0.402
MOD_CK1_1	251	257	PF00069	0.695
MOD_CK1_1	284	290	PF00069	0.720
MOD_CK1_1	386	392	PF00069	0.543
MOD_CK1_1	401	407	PF00069	0.355
MOD_CK1_1	436	442	PF00069	0.603
MOD_CK1_1	474	480	PF00069	0.330
MOD_CK2_1	117	123	PF00069	0.702
MOD_CK2_1	147	153	PF00069	0.790
MOD_CK2_1	205	211	PF00069	0.539
MOD_CK2_1	25	31	PF00069	0.449
MOD_CK2_1	310	316	PF00069	0.762
MOD_CK2_1	444	450	PF00069	0.652
MOD_CK2_1	457	463	PF00069	0.347
MOD_CK2_1	571	577	PF00069	0.635
MOD_CK2_1	667	673	PF00069	0.582
MOD_GlcNHglycan	132	136	PF01048	0.769
MOD_GlcNHglycan	139	143	PF01048	0.732
MOD_GlcNHglycan	160	163	PF01048	0.821
MOD_GlcNHglycan	184	187	PF01048	0.631
MOD_GlcNHglycan	233	236	PF01048	0.727
MOD_GlcNHglycan	250	253	PF01048	0.746
MOD_GlcNHglycan	283	286	PF01048	0.713
MOD_GlcNHglycan	295	298	PF01048	0.756
MOD_GlcNHglycan	305	308	PF01048	0.770
MOD_GlcNHglycan	320	323	PF01048	0.503
MOD_GlcNHglycan	381	384	PF01048	0.469
MOD_GlcNHglycan	434	438	PF01048	0.665
MOD_GlcNHglycan	489	492	PF01048	0.545
MOD_GlcNHglycan	506	509	PF01048	0.438
MOD_GlcNHglycan	519	522	PF01048	0.599
MOD_GlcNHglycan	551	554	PF01048	0.654
MOD_GlcNHglycan	557	560	PF01048	0.508
MOD_GSK3_1	138	145	PF00069	0.759
MOD_GSK3_1	166	173	PF00069	0.768
MOD_GSK3_1	251	258	PF00069	0.682
MOD_GSK3_1	280	287	PF00069	0.715
MOD_GSK3_1	293	300	PF00069	0.556
MOD_GSK3_1	379	386	PF00069	0.490
MOD_GSK3_1	398	405	PF00069	0.484
MOD_GSK3_1	487	494	PF00069	0.580
MOD_GSK3_1	586	593	PF00069	0.534
MOD_GSK3_1	635	642	PF00069	0.397
MOD_N-GLC_1	665	670	PF02516	0.590
MOD_NEK2_1	303	308	PF00069	0.678
MOD_NEK2_1	398	403	PF00069	0.429
MOD_NEK2_1	590	595	PF00069	0.520
MOD_NEK2_2	299	304	PF00069	0.526
MOD_NEK2_2	305	310	PF00069	0.501
MOD_PIKK_1	297	303	PF00454	0.740
MOD_PIKK_1	398	404	PF00454	0.432
MOD_PIKK_1	491	497	PF00454	0.626
MOD_PK_1	144	150	PF00069	0.700
MOD_PKA_2	344	350	PF00069	0.539
MOD_PKA_2	616	622	PF00069	0.410
MOD_PKB_1	229	237	PF00069	0.537
MOD_Plk_1	131	137	PF00069	0.685
MOD_Plk_1	255	261	PF00069	0.611
MOD_Plk_1	355	361	PF00069	0.446
MOD_Plk_1	386	392	PF00069	0.550
MOD_Plk_2-3	117	123	PF00069	0.633
MOD_Plk_2-3	205	211	PF00069	0.539
MOD_Plk_4	144	150	PF00069	0.727
MOD_Plk_4	196	202	PF00069	0.372
MOD_Plk_4	205	211	PF00069	0.395
MOD_Plk_4	305	311	PF00069	0.675
MOD_Plk_4	31	37	PF00069	0.437
MOD_Plk_4	457	463	PF00069	0.393
MOD_Plk_4	526	532	PF00069	0.766
MOD_Plk_4	563	569	PF00069	0.557
MOD_Plk_4	586	592	PF00069	0.553
MOD_Plk_4	618	624	PF00069	0.428
MOD_Plk_4	635	641	PF00069	0.392
MOD_Plk_4	652	658	PF00069	0.278
MOD_Plk_4	667	673	PF00069	0.471
MOD_ProDKin_1	142	148	PF00069	0.763
MOD_ProDKin_1	310	316	PF00069	0.722
MOD_ProDKin_1	412	418	PF00069	0.544
MOD_ProDKin_1	46	52	PF00069	0.449
MOD_SUMO_for_1	178	181	PF00179	0.696
TRG_DiLeu_BaEn_4	269	275	PF01217	0.600
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.413
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.493
TRG_ENDOCYTIC_2	214	217	PF00928	0.433
TRG_ENDOCYTIC_2	225	228	PF00928	0.416
TRG_ENDOCYTIC_2	481	484	PF00928	0.426
TRG_ENDOCYTIC_2	67	70	PF00928	0.344
TRG_ENDOCYTIC_2	85	88	PF00928	0.344
TRG_ER_diArg_1	228	231	PF00400	0.672
TRG_ER_diArg_1	292	294	PF00400	0.643
TRG_ER_diArg_1	353	355	PF00400	0.452
TRG_NLS_MonoExtN_4	226	233	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH8	Leptomonas seymouri	66%	100%
A0A0S4IV50	Bodo saltans	33%	100%
A0A1X0NS55	Trypanosomatidae	38%	100%
A0A3R7REE6	Trypanosoma rangeli	34%	100%
A0A3S7X1Y8	Leishmania donovani	95%	100%
A4HGU7	Leishmania braziliensis	83%	100%
A4I3X5	Leishmania infantum	95%	100%
D0A943	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B065	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BC43	Trypanosoma cruzi	35%	100%