TKL protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

TKL protein kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q818_LEIMA

TriTrypDb:

LmjF.28.2450 , LMJLV39_280032700 , LMJSD75_280032300

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q818

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q818

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.491
CLV_NRD_NRD_1	738	740	PF00675	0.618
CLV_NRD_NRD_1	804	806	PF00675	0.428
CLV_PCSK_KEX2_1	804	806	PF00082	0.414
CLV_PCSK_SKI1_1	208	212	PF00082	0.671
CLV_PCSK_SKI1_1	313	317	PF00082	0.616
CLV_PCSK_SKI1_1	460	464	PF00082	0.615
CLV_PCSK_SKI1_1	777	781	PF00082	0.487
CLV_PCSK_SKI1_1	92	96	PF00082	0.629
DEG_APCC_DBOX_1	516	524	PF00400	0.416
DEG_SPOP_SBC_1	202	206	PF00917	0.519
DEG_SPOP_SBC_1	359	363	PF00917	0.426
DEG_SPOP_SBC_1	719	723	PF00917	0.558
DOC_CDC14_PxL_1	85	93	PF14671	0.467
DOC_CKS1_1	427	432	PF01111	0.430
DOC_CKS1_1	546	551	PF01111	0.430
DOC_CKS1_1	755	760	PF01111	0.430
DOC_CYCLIN_RxL_1	774	782	PF00134	0.332
DOC_CYCLIN_RxL_1	89	98	PF00134	0.439
DOC_MAPK_gen_1	517	525	PF00069	0.410
DOC_MAPK_MEF2A_6	22	29	PF00069	0.676
DOC_MAPK_MEF2A_6	241	250	PF00069	0.462
DOC_MAPK_MEF2A_6	313	322	PF00069	0.338
DOC_MAPK_MEF2A_6	517	525	PF00069	0.348
DOC_MAPK_NFAT4_5	313	321	PF00069	0.415
DOC_PP2B_LxvP_1	355	358	PF13499	0.504
DOC_PP2B_LxvP_1	498	501	PF13499	0.344
DOC_PP2B_LxvP_1	523	526	PF13499	0.313
DOC_PP2B_LxvP_1	86	89	PF13499	0.480
DOC_PP4_FxxP_1	240	243	PF00568	0.511
DOC_USP7_MATH_1	112	116	PF00917	0.423
DOC_USP7_MATH_1	154	158	PF00917	0.507
DOC_USP7_MATH_1	200	204	PF00917	0.500
DOC_USP7_MATH_1	222	226	PF00917	0.509
DOC_USP7_MATH_1	359	363	PF00917	0.508
DOC_USP7_MATH_1	364	368	PF00917	0.506
DOC_USP7_MATH_1	412	416	PF00917	0.478
DOC_USP7_MATH_1	492	496	PF00917	0.515
DOC_USP7_MATH_1	554	558	PF00917	0.379
DOC_USP7_MATH_1	633	637	PF00917	0.484
DOC_WW_Pin1_4	20	25	PF00397	0.594
DOC_WW_Pin1_4	426	431	PF00397	0.436
DOC_WW_Pin1_4	545	550	PF00397	0.386
DOC_WW_Pin1_4	71	76	PF00397	0.449
DOC_WW_Pin1_4	754	759	PF00397	0.384
DOC_WW_Pin1_4	809	814	PF00397	0.714
LIG_14-3-3_CanoR_1	103	111	PF00244	0.344
LIG_14-3-3_CanoR_1	123	129	PF00244	0.484
LIG_14-3-3_CanoR_1	132	140	PF00244	0.498
LIG_14-3-3_CanoR_1	141	150	PF00244	0.355
LIG_14-3-3_CanoR_1	348	357	PF00244	0.355
LIG_14-3-3_CanoR_1	460	465	PF00244	0.442
LIG_14-3-3_CanoR_1	711	719	PF00244	0.449
LIG_14-3-3_CanoR_1	92	97	PF00244	0.348
LIG_Actin_WH2_2	696	713	PF00022	0.434
LIG_Actin_WH2_2	784	801	PF00022	0.464
LIG_BRCT_BRCA1_1	236	240	PF00533	0.520
LIG_BRCT_BRCA1_1	65	69	PF00533	0.440
LIG_Clathr_ClatBox_1	693	697	PF01394	0.396
LIG_deltaCOP1_diTrp_1	477	484	PF00928	0.430
LIG_Dynein_DLC8_1	730	736	PF01221	0.355
LIG_eIF4E_1	298	304	PF01652	0.436
LIG_eIF4E_1	503	509	PF01652	0.421
LIG_eIF4E_1	515	521	PF01652	0.406
LIG_EVH1_1	86	90	PF00568	0.440
LIG_FHA_1	103	109	PF00498	0.388
LIG_FHA_1	144	150	PF00498	0.473
LIG_FHA_1	387	393	PF00498	0.401
LIG_FHA_1	419	425	PF00498	0.507
LIG_FHA_1	461	467	PF00498	0.414
LIG_FHA_1	563	569	PF00498	0.506
LIG_FHA_1	611	617	PF00498	0.490
LIG_FHA_1	705	711	PF00498	0.351
LIG_FHA_1	714	720	PF00498	0.455
LIG_FHA_1	72	78	PF00498	0.445
LIG_FHA_1	732	738	PF00498	0.264
LIG_FHA_1	773	779	PF00498	0.448
LIG_FHA_1	783	789	PF00498	0.335
LIG_FHA_1	81	87	PF00498	0.438
LIG_FHA_2	156	162	PF00498	0.532
LIG_FHA_2	225	231	PF00498	0.415
LIG_FHA_2	389	395	PF00498	0.347
LIG_FHA_2	415	421	PF00498	0.454
LIG_FHA_2	546	552	PF00498	0.387
LIG_FHA_2	615	621	PF00498	0.503
LIG_FHA_2	661	667	PF00498	0.405
LIG_FHA_2	675	681	PF00498	0.316
LIG_FHA_2	720	726	PF00498	0.527
LIG_FHA_2	755	761	PF00498	0.446
LIG_FHA_2	93	99	PF00498	0.443
LIG_GBD_Chelix_1	780	788	PF00786	0.443
LIG_HCF-1_HBM_1	342	345	PF13415	0.404
LIG_LIR_Apic_2	237	243	PF02991	0.520
LIG_LIR_Apic_2	744	748	PF02991	0.422
LIG_LIR_Apic_2	809	813	PF02991	0.708
LIG_LIR_Gen_1	429	439	PF02991	0.351
LIG_LIR_Gen_1	475	485	PF02991	0.332
LIG_LIR_Gen_1	663	669	PF02991	0.432
LIG_LIR_Gen_1	671	679	PF02991	0.369
LIG_LIR_Gen_1	697	708	PF02991	0.340
LIG_LIR_Nem_3	209	214	PF02991	0.449
LIG_LIR_Nem_3	429	434	PF02991	0.308
LIG_LIR_Nem_3	475	481	PF02991	0.376
LIG_LIR_Nem_3	495	499	PF02991	0.220
LIG_LIR_Nem_3	527	532	PF02991	0.336
LIG_LIR_Nem_3	663	667	PF02991	0.430
LIG_LIR_Nem_3	671	676	PF02991	0.419
LIG_LIR_Nem_3	697	703	PF02991	0.355
LIG_LIR_Nem_3	741	745	PF02991	0.430
LIG_LIR_Nem_3	773	779	PF02991	0.383
LIG_MLH1_MIPbox_1	65	69	PF16413	0.465
LIG_NRBOX	34	40	PF00104	0.548
LIG_PDZ_Class_1	809	814	PF00595	0.714
LIG_Pex14_1	294	298	PF04695	0.442
LIG_Pex14_2	107	111	PF04695	0.377
LIG_Pex14_2	211	215	PF04695	0.454
LIG_PTAP_UEV_1	503	508	PF05743	0.420
LIG_SH2_CRK	431	435	PF00017	0.344
LIG_SH2_CRK	776	780	PF00017	0.311
LIG_SH2_GRB2like	629	632	PF00017	0.426
LIG_SH2_NCK_1	464	468	PF00017	0.331
LIG_SH2_SRC	629	632	PF00017	0.487
LIG_SH2_SRC	85	88	PF00017	0.460
LIG_SH2_STAP1	129	133	PF00017	0.510
LIG_SH2_STAP1	345	349	PF00017	0.404
LIG_SH2_STAP1	605	609	PF00017	0.520
LIG_SH2_STAT5	298	301	PF00017	0.437
LIG_SH2_STAT5	464	467	PF00017	0.416
LIG_SH2_STAT5	639	642	PF00017	0.339
LIG_SH2_STAT5	68	71	PF00017	0.424
LIG_SH2_STAT5	702	705	PF00017	0.329
LIG_SH2_STAT5	706	709	PF00017	0.302
LIG_SH2_STAT5	745	748	PF00017	0.432
LIG_SH2_STAT5	770	773	PF00017	0.378
LIG_SH2_STAT5	85	88	PF00017	0.435
LIG_SH3_2	87	92	PF14604	0.428
LIG_SH3_3	240	246	PF00018	0.477
LIG_SH3_3	289	295	PF00018	0.504
LIG_SH3_3	421	427	PF00018	0.502
LIG_SH3_3	433	439	PF00018	0.340
LIG_SH3_3	498	504	PF00018	0.384
LIG_SH3_3	506	512	PF00018	0.389
LIG_SH3_3	756	762	PF00018	0.350
LIG_SH3_3	81	87	PF00018	0.507
LIG_SUMO_SIM_anti_2	179	184	PF11976	0.386
LIG_SUMO_SIM_anti_2	273	281	PF11976	0.354
LIG_SUMO_SIM_anti_2	371	377	PF11976	0.429
LIG_SUMO_SIM_anti_2	785	790	PF11976	0.299
LIG_SUMO_SIM_par_1	273	281	PF11976	0.364
LIG_SUMO_SIM_par_1	28	33	PF11976	0.631
LIG_SUMO_SIM_par_1	469	475	PF11976	0.413
LIG_SUMO_SIM_par_1	530	536	PF11976	0.325
LIG_SUMO_SIM_par_1	777	782	PF11976	0.288
LIG_SUMO_SIM_par_1	92	98	PF11976	0.418
LIG_SxIP_EBH_1	580	589	PF03271	0.295
LIG_TYR_ITSM	427	434	PF00017	0.421
LIG_Vh1_VBS_1	30	48	PF01044	0.425
LIG_WW_1	295	298	PF00397	0.454
LIG_WW_3	294	298	PF00397	0.315
MOD_CDK_SPxxK_3	754	761	PF00069	0.430
MOD_CK1_1	115	121	PF00069	0.390
MOD_CK1_1	128	134	PF00069	0.489
MOD_CK1_1	155	161	PF00069	0.531
MOD_CK1_1	187	193	PF00069	0.405
MOD_CK1_1	198	204	PF00069	0.448
MOD_CK1_1	206	212	PF00069	0.348
MOD_CK1_1	225	231	PF00069	0.395
MOD_CK1_1	234	240	PF00069	0.481
MOD_CK1_1	281	287	PF00069	0.468
MOD_CK1_1	308	314	PF00069	0.422
MOD_CK1_1	353	359	PF00069	0.480
MOD_CK1_1	369	375	PF00069	0.338
MOD_CK1_1	414	420	PF00069	0.454
MOD_CK1_1	443	449	PF00069	0.462
MOD_CK1_1	454	460	PF00069	0.308
MOD_CK1_1	502	508	PF00069	0.340
MOD_CK1_1	566	572	PF00069	0.498
MOD_CK1_1	607	613	PF00069	0.530
MOD_CK1_1	644	650	PF00069	0.460
MOD_CK1_1	728	734	PF00069	0.519
MOD_CK2_1	206	212	PF00069	0.481
MOD_CK2_1	674	680	PF00069	0.449
MOD_CK2_1	719	725	PF00069	0.520
MOD_GlcNHglycan	154	157	PF01048	0.718
MOD_GlcNHglycan	167	170	PF01048	0.571
MOD_GlcNHglycan	2	5	PF01048	0.775
MOD_GlcNHglycan	200	203	PF01048	0.697
MOD_GlcNHglycan	208	211	PF01048	0.672
MOD_GlcNHglycan	352	355	PF01048	0.668
MOD_GlcNHglycan	362	365	PF01048	0.708
MOD_GlcNHglycan	366	369	PF01048	0.692
MOD_GlcNHglycan	442	445	PF01048	0.660
MOD_GlcNHglycan	453	456	PF01048	0.549
MOD_GlcNHglycan	504	507	PF01048	0.591
MOD_GlcNHglycan	539	542	PF01048	0.695
MOD_GlcNHglycan	551	555	PF01048	0.554
MOD_GlcNHglycan	556	559	PF01048	0.497
MOD_GlcNHglycan	641	644	PF01048	0.543
MOD_GSK3_1	102	109	PF00069	0.436
MOD_GSK3_1	128	135	PF00069	0.472
MOD_GSK3_1	150	157	PF00069	0.460
MOD_GSK3_1	194	201	PF00069	0.438
MOD_GSK3_1	202	209	PF00069	0.464
MOD_GSK3_1	221	228	PF00069	0.340
MOD_GSK3_1	280	287	PF00069	0.398
MOD_GSK3_1	360	367	PF00069	0.506
MOD_GSK3_1	410	417	PF00069	0.442
MOD_GSK3_1	418	425	PF00069	0.484
MOD_GSK3_1	443	450	PF00069	0.418
MOD_GSK3_1	462	469	PF00069	0.389
MOD_GSK3_1	488	495	PF00069	0.475
MOD_GSK3_1	533	540	PF00069	0.398
MOD_GSK3_1	541	548	PF00069	0.357
MOD_GSK3_1	550	557	PF00069	0.270
MOD_GSK3_1	562	569	PF00069	0.433
MOD_GSK3_1	603	610	PF00069	0.450
MOD_GSK3_1	635	642	PF00069	0.447
MOD_GSK3_1	64	71	PF00069	0.438
MOD_GSK3_1	656	663	PF00069	0.406
MOD_GSK3_1	668	675	PF00069	0.380
MOD_GSK3_1	710	717	PF00069	0.428
MOD_LATS_1	601	607	PF00433	0.487
MOD_N-GLC_1	112	117	PF02516	0.596
MOD_N-GLC_1	187	192	PF02516	0.598
MOD_N-GLC_1	194	199	PF02516	0.572
MOD_N-GLC_1	284	289	PF02516	0.726
MOD_N-GLC_1	308	313	PF02516	0.627
MOD_N-GLC_1	410	415	PF02516	0.648
MOD_N-GLC_1	725	730	PF02516	0.725
MOD_N-GLC_1	79	84	PF02516	0.723
MOD_NEK2_1	107	112	PF00069	0.411
MOD_NEK2_1	194	199	PF00069	0.427
MOD_NEK2_1	280	285	PF00069	0.427
MOD_NEK2_1	288	293	PF00069	0.519
MOD_NEK2_1	403	408	PF00069	0.380
MOD_NEK2_1	462	467	PF00069	0.419
MOD_NEK2_1	532	537	PF00069	0.332
MOD_NEK2_1	550	555	PF00069	0.326
MOD_NEK2_1	563	568	PF00069	0.495
MOD_NEK2_1	585	590	PF00069	0.362
MOD_NEK2_1	641	646	PF00069	0.338
MOD_NEK2_1	679	684	PF00069	0.390
MOD_NEK2_1	69	74	PF00069	0.503
MOD_NEK2_1	696	701	PF00069	0.296
MOD_NEK2_1	710	715	PF00069	0.341
MOD_NEK2_1	733	738	PF00069	0.452
MOD_NEK2_1	779	784	PF00069	0.384
MOD_PIKK_1	308	314	PF00454	0.458
MOD_PIKK_1	337	343	PF00454	0.441
MOD_PIKK_1	348	354	PF00454	0.420
MOD_PIKK_1	674	680	PF00454	0.352
MOD_PIKK_1	687	693	PF00454	0.367
MOD_PIKK_1	710	716	PF00454	0.451
MOD_PIKK_1	731	737	PF00454	0.483
MOD_PIKK_1	9	15	PF00454	0.612
MOD_PKA_2	102	108	PF00069	0.392
MOD_PKA_2	122	128	PF00069	0.446
MOD_PKA_2	281	287	PF00069	0.495
MOD_PKA_2	337	343	PF00069	0.398
MOD_PKA_2	440	446	PF00069	0.462
MOD_PKA_2	710	716	PF00069	0.440
MOD_Plk_1	112	118	PF00069	0.436
MOD_Plk_1	194	200	PF00069	0.418
MOD_Plk_1	234	240	PF00069	0.495
MOD_Plk_1	284	290	PF00069	0.529
MOD_Plk_1	696	702	PF00069	0.389
MOD_Plk_1	704	710	PF00069	0.326
MOD_Plk_1	725	731	PF00069	0.519
MOD_Plk_2-3	388	394	PF00069	0.420
MOD_Plk_4	115	121	PF00069	0.370
MOD_Plk_4	187	193	PF00069	0.373
MOD_Plk_4	25	31	PF00069	0.654
MOD_Plk_4	369	375	PF00069	0.460
MOD_Plk_4	37	43	PF00069	0.497
MOD_Plk_4	64	70	PF00069	0.464
MOD_Plk_4	741	747	PF00069	0.427
MOD_Plk_4	80	86	PF00069	0.499
MOD_Plk_4	92	98	PF00069	0.294
MOD_ProDKin_1	20	26	PF00069	0.589
MOD_ProDKin_1	426	432	PF00069	0.431
MOD_ProDKin_1	545	551	PF00069	0.387
MOD_ProDKin_1	71	77	PF00069	0.450
MOD_ProDKin_1	754	760	PF00069	0.387
MOD_SUMO_rev_2	157	167	PF00179	0.502
MOD_SUMO_rev_2	721	729	PF00179	0.523
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.691
TRG_ENDOCYTIC_2	431	434	PF00928	0.321
TRG_ENDOCYTIC_2	776	779	PF00928	0.386
TRG_ER_diArg_1	803	805	PF00400	0.649
TRG_NES_CRM1_1	173	185	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A4	Leptomonas seymouri	54%	100%
A0A0S4JR51	Bodo saltans	24%	100%
A0A1X0NQP9	Trypanosomatidae	26%	100%
A0A3Q8IB65	Leishmania donovani	93%	100%
A0A3R7KTE0	Trypanosoma rangeli	29%	100%
A4I3X7	Leishmania infantum	93%	100%
D0A945	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B067	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DCU8	Trypanosoma cruzi	28%	100%